{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T12:49:07Z","timestamp":1790858947644,"version":"4.1.0"},"reference-count":68,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2020,8,19]],"date-time":"2020-08-19T00:00:00Z","timestamp":1597795200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Italian Ministry of Agricultural, Alimentary and Forestry Policies","award":["grant ID 777 HDHL INTIMIC-Knowledge Platform"],"award-info":[{"award-number":["grant ID 777 HDHL INTIMIC-Knowledge Platform"]}]},{"name":"Italian Ministry of Agricultural, Alimentary and Forestry Policies","award":["ID 1170 HDHL INTIMIC METADIS"],"award-info":[{"award-number":["ID 1170 HDHL INTIMIC METADIS"]}]},{"name":"Italian Ministry of Agricultural, Alimentary and Forestry Policies","award":["ID CABALA_diet&health, ERA HDHL"],"award-info":[{"award-number":["ID CABALA_diet&health, ERA HDHL"]}]},{"name":"Italian Ministry of Education, University and Research","award":["ID SALIVAGES, ERA HDHL"],"award-info":[{"award-number":["ID SALIVAGES, ERA HDHL"]}]},{"name":"Italian Ministry of Education, University and Research","award":["ID CABALA_diet&health, ERA HDHL"],"award-info":[{"award-number":["ID CABALA_diet&health, ERA HDHL"]}]},{"name":"German Federal Ministry for Research and Education","award":["01EA1703"],"award-info":[{"award-number":["01EA1703"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Heat-processed diets contain high amounts of advanced glycation end products (AGEs). Here we explore the impact of an AGE-enriched diet on markers of metabolic and inflammatory disorders as well as on gut microbiota composition and plasma proteins glycosylation pattern. C57BL\/6 mice were allocated into control diet (CD, n = 15) and AGE-enriched diet (AGE-D, n = 15) for 22 weeks. AGE-D was prepared replacing casein by methylglyoxal hydroimidazolone-modified casein. AGE-D evoked increased insulin and a significant reduction of GIP\/GLP-1 incretins and ghrelin plasma levels, altered glucose tolerance, and impaired insulin signaling transduction in the skeletal muscle. Moreover, AGE-D modified the systemic glycosylation profile, as analyzed by lectin microarray, and increased N\u03b5-carboxymethyllysine immunoreactivity and AGEs receptor levels in ileum and submandibular glands. These effects were associated to increased systemic levels of cytokines and impaired gut microbial composition and homeostasis. Significant correlations were recorded between changes in bacterial population and in incretins and inflammatory markers levels. Overall, our data indicates that chronic exposure to dietary AGEs lead to a significant unbalance in incretins axis, markers of metabolic inflammation, and a reshape of both the intestinal microbiota and plasma protein glycosylation profile, suggesting intriguing pathological mechanisms underlying AGEs-induced metabolic derangements.<\/jats:p>","DOI":"10.3390\/nu12092497","type":"journal-article","created":{"date-parts":[[2020,8,19]],"date-time":"2020-08-19T09:22:31Z","timestamp":1597828951000},"page":"2497","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":70,"title":["Effects of Exogenous Dietary Advanced Glycation End Products on the Cross-Talk Mechanisms Linking Microbiota to Metabolic Inflammation"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0104-6129","authenticated-orcid":false,"given":"Raffaella","family":"Mastrocola","sequence":"first","affiliation":[{"name":"Department of Clinical and Biological Sciences, University of Turin, 10125 Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debora","family":"Collotta","sequence":"additional","affiliation":[{"name":"Department of Drug Science and Technology, University of Turin, 10125 Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Gaudioso","sequence":"additional","affiliation":[{"name":"Fondazione Edmund Mach, 38010 San Michele all\u2019Adige, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Le Berre","sequence":"additional","affiliation":[{"name":"Biomedical Sciences, National University of Ireland, H91 TK33 Galway, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia Sofia","family":"Cento","sequence":"additional","affiliation":[{"name":"Department of Clinical and Biological Sciences, University of Turin, 10125 Turin, 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Neuroscience, University of Turin, 10124 Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Friederike","family":"Manig","sequence":"additional","affiliation":[{"name":"Chair of Food Chemistry, Technische Universit\u00e4t Dresden, 01062 Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Hellwig","sequence":"additional","affiliation":[{"name":"Chair of Food Chemistry, Technische Universit\u00e4t Dresden, 01062 Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Fava","sequence":"additional","affiliation":[{"name":"Fondazione Edmund Mach, 38010 San Michele all\u2019Adige, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6180-828X","authenticated-orcid":false,"given":"Carlo","family":"Cifani","sequence":"additional","affiliation":[{"name":"Pharmacology Unit, School of Pharmacy, University of Camerino, 62032 Camerino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0453-5235","authenticated-orcid":false,"given":"Manuela","family":"Aragno","sequence":"additional","affiliation":[{"name":"Department of Clinical and Biological Sciences, University of Turin, 10125 Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Henle","sequence":"additional","affiliation":[{"name":"Chair of Food Chemistry, Technische Universit\u00e4t Dresden, 01062 Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lokesh","family":"Joshi","sequence":"additional","affiliation":[{"name":"Biomedical Sciences, National University of Ireland, H91 TK33 Galway, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kieran","family":"Tuohy","sequence":"additional","affiliation":[{"name":"Fondazione Edmund Mach, 38010 San Michele all\u2019Adige, 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