{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T09:54:28Z","timestamp":1760954068605,"version":"build-2065373602"},"reference-count":49,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2020,8,24]],"date-time":"2020-08-24T00:00:00Z","timestamp":1598227200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Korean Food Research Institue","award":["E0150302-06"],"award-info":[{"award-number":["E0150302-06"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>The traditional Korean diet (K-diet) is considered to be healthy and circulating microRNAs (miRs) have been proposed as useful markers or targets in diet therapy. We, therefore, investigated the metabolic influence of the K-diet by evaluating the expression of plasma and salivary miRs. Ten women aged 50 to 60 years were divided into either a K-diet or control diet (a Westernized Korean diet) group. Subjects were housed in a metabolic unit-like condition during the two-week dietary intervention. Blood and saliva samples were collected before and after the intervention, and changes in circulating miRs were screened by an miR array and validated by individual RT-qPCRs. In the K-diet group, eight plasma miRs were down-regulated by array (p &lt; 0.05), out of which two miRs linked to diabetes mellitus, hsa-miR26a-5p and hsa-miR126-3p, were validated (p &lt; 0.05). Among five down-regulated salivary miRs, hsa-miR-92-3p and hsa-miR-122a-5p were validated, which are associated with diabetes mellitus, acute coronary syndrome and non-alcoholic fatty liver disease. In the control diet group, validated were down-regulated plasma hsa-miR-25-3p and salivary hsa-miR-31-5p, which are associated with diabetes mellitus, adipogenesis and obesity. The K-diet may influence the metabolic conditions associated with diabetes mellitus, as evidenced by changes in circulating miRs, putative biomarkers for K-diet.<\/jats:p>","DOI":"10.3390\/nu12092558","type":"journal-article","created":{"date-parts":[[2020,8,24]],"date-time":"2020-08-24T10:37:32Z","timestamp":1598265452000},"page":"2558","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["A Traditional Korean Diet Alters the Expression of Circulating MicroRNAs Linked to Diabetes Mellitus in a Pilot Trial"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3935-3132","authenticated-orcid":false,"given":"Phil-Kyung","family":"Shin","sequence":"first","affiliation":[{"name":"CHA Bio Complex, CHA University, Seongnam 13488, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5020-3397","authenticated-orcid":false,"given":"Myung Sunny","family":"Kim","sequence":"additional","affiliation":[{"name":"Research Group of Healthcare, Korea Food Research Institute, Wanju 55365, Korea"},{"name":"Department of Food Biotechnology, Korea University of Science and Technology, Daejeon 34113, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1825-1815","authenticated-orcid":false,"given":"Seon-Joo","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Food and Nutrition, College of BioNano Technology, Gachon University, Seongnam 13120, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dae Young","family":"Kwon","sequence":"additional","affiliation":[{"name":"Research Group of Healthcare, Korea Food Research Institute, Wanju 55365, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min Jung","family":"Kim","sequence":"additional","affiliation":[{"name":"Research Group of Healthcare, Korea Food Research Institute, Wanju 55365, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hye Jeong","family":"Yang","sequence":"additional","affiliation":[{"name":"Research Group of Healthcare, Korea Food Research Institute, Wanju 55365, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soon-Hee","family":"Kim","sequence":"additional","affiliation":[{"name":"Research Group of Healthcare, Korea Food Research Institute, Wanju 55365, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KyongChol","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Healthy Aging, GangNam Major Hospital, Seoul 06279, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sukyung","family":"Chun","sequence":"additional","affiliation":[{"name":"CHA Bio Complex, CHA University, Seongnam 13488, Korea"},{"name":"Chaum Life Center, CHA University, Seoul 06062, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8353-3619","authenticated-orcid":false,"given":"Hae-Jeung","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Food and Nutrition, College of BioNano Technology, Gachon University, Seongnam 13120, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang-Woon","family":"Choi","sequence":"additional","affiliation":[{"name":"CHA Bio Complex, CHA University, Seongnam 13488, Korea"},{"name":"Chaum Life Center, CHA University, Seoul 06062, Korea"},{"name":"Department of Nutrition, School of Public Health and Health Sciences, University of Massachusetts, Amherst, MA 01003, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,8,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.jef.2016.03.002","article-title":"Korean diet: Characteristics and historical background","volume":"3","author":"Kim","year":"2016","journal-title":"J. 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