{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T06:49:08Z","timestamp":1791614948419,"version":"4.3.4"},"reference-count":53,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2020,8,27]],"date-time":"2020-08-27T00:00:00Z","timestamp":1598486400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Purpose: To determine the relationship between uric acid (UA) and nutritional and antioxidant status in hemodialysis (HD) patients, given that hyperuricemia could be an indicator of good nutritional status possibly because of the antioxidant properties of UA. Methods: Cross-sectional study with 93 patients on HD. Hyperuricemia was considered as UA \u22656.0 mg\/dL in females and \u22657.0 mg\/dL in males. Nutritional variables were registered. Blood samples were taken before the dialysis session to determine oxidative damage as plasma malondialdehyde (MDA) content, and antioxidant capacity measuring 2,2-diphenyl-piclrylhidrazil radical (DPPH\u25cf) scavenging activity and oxygen radical absorbance capacity (ORAC) value. Results: Patients with hyperuricemia had higher creatinine (11.9 vs. 10.5 mg\/dL; p = 0.004), potassium (5.5 vs. 5.0 mg\/dL; p = 0.014) levels; phase angle (5.8 vs. 4.9; p = 0.005), protein consumption (normalized protein nitrogen appearance, nPNA, 1.03 vs. 0.83; p = 0.013) than normouricemic patients. DPPH\u25cf scavenging activity was higher in hyperuricemic subjects (1.139 vs. 1.049 mM Trolox equivalents; p = 0.007); likewise, hyperuricemic subjects had less oxidant damage measured by MDA (10.6 vs. 12.7 nmol\/mL; p = 0.020). Subjects with normouricemia were at higher risk of having a reactance to height (Xc\/H) ratio less than 35 (OR 2.79; 95% CI, 1.1\u20137.017, p = 0.028); nPNA &lt; 1.0 (OR 3.78; 95% CI, 1.4\u201310.2, p = 0.007), diagnosis of cachexia (OR 2.95; 95% CI, 1156\u20137.518, p = 0.021), potassium levels &lt;5 (OR 2.97; 95% CI, 1.136\u20137.772, p = 0.023) and PA &lt; 5.5\u00b0 (OR 3.38; 95% CI, 1.309\u20138.749, p = 0.012.) Conclusions: Patients with hyperuricemia had higher antioxidant capacity and better nutritional status. Purines and protein restrictions in HD patients with hyperuricemia need to be reviewed individually for each patient. More studies are needed to stablish a cut point of UA levels in renal population.<\/jats:p>","DOI":"10.3390\/nu12092600","type":"journal-article","created":{"date-parts":[[2020,8,27]],"date-time":"2020-08-27T08:05:18Z","timestamp":1598515518000},"page":"2600","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Association between Serum Uric Acid Levels, Nutritional and Antioxidant Status in Patients on Hemodialysis"],"prefix":"10.3390","volume":"12","author":[{"given":"Etna","family":"Dom\u00ednguez-Zambrano","sequence":"first","affiliation":[{"name":"Department of Nephrology and Mineral Metabolism, Instituto Nacional de Ciencias M\u00e9dicas y Nutricion Salvador Zubir\u00e1n, M\u00e9xico City PC 14080, Mexico"},{"name":"Medicine Faculty, Universidad Nacional Aut\u00f3noma de M\u00e9xico, M\u00e9xico City ZC 04510, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6628-4411","authenticated-orcid":false,"given":"Jos\u00e9","family":"Pedraza-Chaverri","sequence":"additional","affiliation":[{"name":"Chemistry Faculty, Universidad Nacional Aut\u00f3noma de M\u00e9xico, M\u00e9xico City ZC 04510, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Laura","family":"L\u00f3pez-Santos","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Mineral Metabolism, Instituto Nacional de Ciencias M\u00e9dicas y Nutricion Salvador Zubir\u00e1n, M\u00e9xico City PC 14080, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8264-0412","authenticated-orcid":false,"given":"Omar Noel","family":"Medina-Campos","sequence":"additional","affiliation":[{"name":"Chemistry Faculty, Universidad Nacional Aut\u00f3noma de M\u00e9xico, M\u00e9xico City ZC 04510, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristino","family":"Cruz-Rivera","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Mineral Metabolism, Instituto Nacional de Ciencias M\u00e9dicas y Nutricion Salvador Zubir\u00e1n, M\u00e9xico City PC 14080, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Bueno-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Centro de Atenci\u00f3n Renal, Estado de M\u00e9xico ZC 53100, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9153-5155","authenticated-orcid":false,"given":"Angeles","family":"Espinosa-Cuevas","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Mineral Metabolism, Instituto Nacional de Ciencias M\u00e9dicas y Nutricion Salvador Zubir\u00e1n, M\u00e9xico City PC 14080, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,8,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/S0140-6736(20)30045-3","article-title":"Global, regional, and national burden of chronic kidney disease, 1990\u20132017: A systematic analysis for the Global Burden of Disease Study 2017","volume":"395","author":"Bikbov","year":"2020","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Hill, N.R., Fatoba, S.T., Oke, J.L., Hirst, J.A., O\u2019Callaghan, C.A., Lasserson, D.S., and Hobbs, F.D.R. 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