{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T09:10:35Z","timestamp":1790154635465,"version":"4.0.1"},"reference-count":32,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2020,8,27]],"date-time":"2020-08-27T00:00:00Z","timestamp":1598486400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009338","name":"National Marine Biodiversity Institute of Korea","doi-asserted-by":"publisher","award":["2020M00500"],"award-info":[{"award-number":["2020M00500"]}],"id":[{"id":"10.13039\/501100009338","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Acne vulgaris is a chronic inflammatory condition of skin sebaceous follicles. To explore its effects on acne vulgaris, we investigated the antibacterial and anti-inflammatory activities of Sargassum miyabei Yendo (a brown alga) ethanolic extract (SMYEE) on Cutibacterium acnes (C. acnes)-stimulated inflammatory responses, both in vivo and in vitro. To induce inflammation in vivo, C. acnes was intradermally injected into the dorsal skin of mice, to which SMYEE was applied. The antimicrobial activity of SMYEE was evaluated by the determination of minimum inhibitory concentrations (MICs). To explore in vitro anti-inflammatory effects, HaCaT cells were stimulated with C. acnes after treatment with SMYEE. The levels of IL-8 and the underlying molecular effects in C. acnes-stimulated HaCaT cells were assessed by enzyme-linked immunosorbent assay, Western blotting, and an electrophoretic mobility shift assay. Mouse skin lesions improved after treatment with SMYEE (50 \u03bcg\/mouse). Neutrophil infiltration was significantly reduced in SMYEE-treated compared to SMYEE-untreated skin lesions. SMYEE reversed the C. acnes-induced increase in IL-8 levels in HaCaT cells and suppressed dHL-60 cell migration. SMYEE also inhibited C. acnes-induced phosphorylation of the extracellular signal-regulated kinase and inhibited activator protein-1 signaling. SMYEE may be a useful treatment for C. acnes-induced acne vulgaris.<\/jats:p>","DOI":"10.3390\/nu12092620","type":"journal-article","created":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T09:17:08Z","timestamp":1598606228000},"page":"2620","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Inhibitory Effects of a Sargassum miyabei Yendo on Cutibacterium acnes-Induced Skin Inflammation"],"prefix":"10.3390","volume":"12","author":[{"given":"Mi-Jin","family":"Yim","sequence":"first","affiliation":[{"name":"Department of Genetic Resources, National Marine Biodiversity Institute of Korea, Seocheon 33662, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong Min","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Genetic Resources, National Marine Biodiversity Institute of Korea, Seocheon 33662, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun-Soo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Genetic Resources, National Marine Biodiversity Institute of Korea, Seocheon 33662, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Genetic Resources, National Marine Biodiversity Institute of Korea, Seocheon 33662, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2465-8013","authenticated-orcid":false,"given":"Young-Mog","family":"Kim","sequence":"additional","affiliation":[{"name":"Marine-Integrated Bionics Research Center, Pukyong National University, Busan 48513, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0627-1402","authenticated-orcid":false,"given":"Dae-Sung","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Genetic Resources, National Marine Biodiversity Institute of Korea, Seocheon 33662, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3958-6937","authenticated-orcid":false,"given":"Il-Whan","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, College of Medicine Inje University, Busan 47392, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,8,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1186\/s40168-018-0558-5","article-title":"Host-microbiome interactions and recent progress into understanding the biology of acne vulgaris","volume":"6","author":"Gallo","year":"2018","journal-title":"Microbiome"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/s41429-020-0278-5","article-title":"Anti-inflammatory effects of ozenoxacin, a topical quinolone antimicrobial agent","volume":"73","author":"Tabara","year":"2020","journal-title":"J. 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