{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T23:47:54Z","timestamp":1790380074095,"version":"4.1.0"},"reference-count":60,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2020,8,31]],"date-time":"2020-08-31T00:00:00Z","timestamp":1598832000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Nutritional optic neuropathy is a cause of bilateral, symmetrical, and progressive visual impairment with loss of central visual acuity and contrast sensitivity, dyschromatopsia, and a central or centrocecal scotoma. The clinical features are not pathognomonic, since hereditary and toxic forms share similar signs and symptoms. It is becoming increasingly common due to the widespread of bariatric surgery and strict vegetarian or vegan diets, so even the scientific interest has recently increased. In particular, recent studies have focused on possible pathogenetic mechanisms, and on novel diagnostic and therapeutic strategies in order to prevent the onset, make a prompt diagnosis and an accurate nutritional supplementation, and to avoid irreversible optic nerve atrophy. Nowadays, there is clear evidence of the role of cobalamin, folic acid, thiamine, and copper, whereas further studies are needed to define the role of niacin, riboflavin, and pyridoxine. This review aims to summarize the etiology, diagnosis, and treatment of nutritional optic neuropathy, and it is addressed not only to ophthalmologists, but to all physicians who could come in contact with a patient with a possible nutritional optic neuropathy, being a fundamental multidisciplinary approach.<\/jats:p>","DOI":"10.3390\/nu12092653","type":"journal-article","created":{"date-parts":[[2020,8,31]],"date-time":"2020-08-31T08:11:19Z","timestamp":1598861479000},"page":"2653","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Nutritional Optic Neuropathies: State of the Art and Emerging Evidences"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9064-4894","authenticated-orcid":false,"given":"Matilde","family":"Roda","sequence":"first","affiliation":[{"name":"Ophthalmology Unit, S. Orsola-Malpighi University Hospital, University of Bologna, 40138 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie","family":"di Geronimo","sequence":"additional","affiliation":[{"name":"Ophthalmology Unit, S. Orsola-Malpighi University Hospital, University of Bologna, 40138 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6419-6941","authenticated-orcid":false,"given":"Marco","family":"Pellegrini","sequence":"additional","affiliation":[{"name":"Ophthalmology Unit, S. Orsola-Malpighi University Hospital, University of Bologna, 40138 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Costantino","family":"Schiavi","sequence":"additional","affiliation":[{"name":"Ophthalmology Unit, S. 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Ophthalmol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.optom.2016.09.003","article-title":"Revisi\u00f3n de las neuropat\u00edas \u00f3pticas mitocondriales: De las formas hereditarias a las adquiridas","volume":"10","author":"Pilz","year":"2017","journal-title":"J. Optom."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/j.soard.2016.12.018","article-title":"American Society for Metabolic and Bariatric Surgery Integrated Health Nutritional Guidelines for the Surgical Weight Loss Patient 2016 Update: Micronutrients","volume":"13","author":"Parrott","year":"2017","journal-title":"Surg. Obes. Relat. Dis."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Rizzo, G., Lagan\u00e0, A.S., Rapisarda, A.M.C., La Ferrera, G.M.G., Buscema, M., Rossetti, P., Nigro, A., Muscia, V., Valenti, G., and Sapia, F. (2016). Vitamin B12 among Vegetarians: Status, Assessment and Supplementation. Nutrients, 8.","DOI":"10.3390\/nu8120767"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1056\/NEJM200003233421217","article-title":"Blindness in a strict vegan","volume":"342","author":"Milea","year":"2000","journal-title":"N. Engl. J. Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/cns.13207","article-title":"B Vitamins in the nervous system: Current knowledge of the biochemical modes of action and synergies of thiamine, pyridoxine, and cobalamin","volume":"26","year":"2020","journal-title":"CNS Neurosci. Ther."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"599","DOI":"10.4103\/0028-3886.149370","article-title":"Approach to diagnosis and management of optic neuropathy","volume":"62","author":"Mustafa","year":"2014","journal-title":"Neurol. India"},{"key":"ref_10","first-page":"384","article-title":"Vitamin B12 Deficiency: Recognition and Management","volume":"96","author":"Langan","year":"2017","journal-title":"Am. Fam. Physician"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"4521","DOI":"10.3390\/nu5114521","article-title":"Cobalamin Deficiency: Clinical Picture and Radiological Findings","volume":"5","author":"Briani","year":"2013","journal-title":"Nutrients"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"15078","DOI":"10.1021\/ja904670x","article-title":"Vitamin B12 and redox homeostasis: Cob(II)alamin reacts with superoxide at rates approaching superoxide dismutase (SOD)","volume":"131","author":"Yun","year":"2009","journal-title":"J. Am. Chem. Soc."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1016\/j.freeradbiomed.2011.05.034","article-title":"Vitamin B12 protects against superoxide-induced cell injury in human aortic endothelial cells","volume":"51","author":"Moreira","year":"2011","journal-title":"Free Radic. Biol. Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1113\/jphysiol.2003.049478","article-title":"Mitochondrial formation of reactive oxygen species","volume":"552","author":"Turrens","year":"2003","journal-title":"J. Physiol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.ajpath.2017.08.032","article-title":"Cobalamin-Associated Superoxide Scavenging in Neuronal Cells Is a Potential Mechanism for Vitamin B12\u2013Deprivation Optic Neuropathy","volume":"188","author":"Chan","year":"2018","journal-title":"Am. J. Pathol."},{"key":"ref_16","unstructured":"Miller, N.R., and Newman, N.J. (2005). Walsh & Hoyt\u2019s Clinical Neuro-Ophthalmology, Lippincott Williams & Wilkins. [6th ed.]."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1111\/cga.12233","article-title":"Nutritional role of folate","volume":"57","author":"Ebara","year":"2017","journal-title":"Congenit. Anom."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s10545-010-9177-4","article-title":"Overview of homocysteine and folate metabolism. With special references to cardiovascular disease and neural tube defects","volume":"34","author":"Blom","year":"2011","journal-title":"J. Inherit. Metab. Dis."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1159\/000371618","article-title":"The epidemiology of global micronutrient deficiencies","volume":"66","author":"Bailey","year":"2015","journal-title":"Ann. Nutr. Metab."},{"key":"ref_20","first-page":"2","article-title":"Folic acid deficiency optic neuropathy: A case report","volume":"2","author":"Jayamanne","year":"2008","journal-title":"J. Med. Case Rep."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1007\/s00417-019-04304-3","article-title":"Folic acid deficiency and vision: A review","volume":"257","author":"Sijilmassi","year":"2019","journal-title":"Graefe Arch. Clin. Exp. Ophthalmol."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Weng, Q., Wang, J., Wang, J., Tan, B., Wang, J., Wang, H., Zheng, T., Lu, Q.R., Yang, B., and He, Q. (2017). Folate metabolism regulates oligodendrocyte survival and differentiation by modulating AMPK\u03b1 activity. Sci. Rep., 7.","DOI":"10.1038\/s41598-017-01732-1"},{"key":"ref_23","first-page":"53","article-title":"Leber hereditary optic neuropathy: Do folate pathway gene alterations influence the expression of mitochondrial DNA mutation?","volume":"39","author":"Aleyasin","year":"2010","journal-title":"Iran. J. Public Health"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"M\u00e9rida, S., Palacios, E., Navea, A., and Bosch-Morell, F. (2015). Macrophages and uveitis in experimental animal models. Mediat. Inflamm., 2015.","DOI":"10.1155\/2015\/671417"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s00417-018-4176-5","article-title":"Alteration of lens and retina textures from mice embryos with folic acid deficiency: Image processing analysis","volume":"257","author":"Sijilmassi","year":"2019","journal-title":"Graefe Arch. Clin. Exp. Ophthalmol."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Ota, Y., Capizzano, A.A., Moritani, T., Naganawa, S., Kurokawa, R., and Srinivasan, A. (2020). Comprehensive review of Wernicke encephalopathy: Pathophysiology, clinical symptoms and imaging findings. Jpn. J. Radiol., 1\u201312.","DOI":"10.1007\/s11604-020-00989-3"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1385\/MN:31:1-3:017","article-title":"Role of mitochondrial dysfunction and oxidative stress in the pathogenesis of selective neuronal loss in Wernicke\u2019s encephalopathy","volume":"31","author":"Desjardins","year":"2005","journal-title":"Mol. Neurobiol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.2147\/OPTH.S64228","article-title":"Visual loss and optic nerve head swelling in thiamine deficiency without prolonged dietary deficiency","volume":"8","author":"Gratton","year":"2014","journal-title":"Clin. Ophthalmol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/S1474-4422(07)70104-7","article-title":"Wernicke\u2019s encephalopathy: New clinical settings and recent advances in diagnosis and management","volume":"6","author":"Sechi","year":"2007","journal-title":"Lancet Neurol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.jfma.2012.10.010","article-title":"Thiamine-deficient optic neuropathy associated with Wernicke\u2019s encephalopathy in patients with chronic diarrhea","volume":"112","author":"Yeh","year":"2013","journal-title":"J. Formos. Med. Assoc."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1136\/pgmj.65.764.371","article-title":"Papilloedema delaying diagnosis of Wernicke\u2019s encephalopathy in a comatose patient","volume":"65","author":"Mumford","year":"1989","journal-title":"Postgrad. Med. J."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1097\/WNO.0000000000000243","article-title":"Nerve fiber layer infarcts in thiamine deficiency","volume":"35","author":"Sia","year":"2015","journal-title":"J. Neuro-Ophthalmol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1097\/WNO.0b013e3181ceb4d0","article-title":"Peripapillary nerve fiber layer thickening, telangiectasia, and retinal hemorrhages in Wernicke encephalopathy","volume":"30","author":"Bohnsack","year":"2010","journal-title":"J. Neuro-Ophthalmol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1097\/WNO.0b013e3181ce80c6","article-title":"Irreversible optic neuropathy in Wernicke encephalopathy and leber hereditary optic neuropathy","volume":"30","author":"Li","year":"2010","journal-title":"J. Neuro-Ophthalmol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1097\/MOH.0b013e32834da9d2","article-title":"Update on anemia and neutropenia in copper deficiency","volume":"19","author":"Lazarchick","year":"2012","journal-title":"Curr. Opin. Hematol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1097\/MCG.0000000000000092","article-title":"Optic neuropathy, myelopathy, anemia, and neutropenia caused by acquired copper deficiency after gastric bypass surgery","volume":"48","author":"Yarandi","year":"2014","journal-title":"J. Clin. Gastroenterol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1001\/archneurol.2009.70","article-title":"Acute and bilateral blindness due to optic neuropathy associated with copper deficiency","volume":"66","author":"Naismith","year":"2009","journal-title":"Arch. Neurol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1212\/01.CON.0000453313.37143.9b","article-title":"Metabolic, hereditary, traumatic, and neoplastic optic neuropathies","volume":"20","year":"2014","journal-title":"Contin. Lifelong Learn. Neurol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.preteyeres.2003.10.003","article-title":"Mitochondrial dysfunction as a cause of optic neuropathies","volume":"23","author":"Carelli","year":"2004","journal-title":"Prog. Retin. Eye Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"532","DOI":"10.2169\/internalmedicine.36.532","article-title":"Optic neuropathy from thiamine deficiency","volume":"36","author":"Suzuki","year":"1997","journal-title":"Intern. Med."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1097\/WNO.0000000000000229","article-title":"Retinal ganglion cell layer analysis by optical coherence tomography in toxic and nutritional optic neuropathy","volume":"35","author":"Vieira","year":"2015","journal-title":"J. Neuro-Ophthalmol."},{"key":"ref_42","unstructured":"Grzybowski, A., Obuchowska, I., and Arndt, C. (2016). OCT in Toxic and Nutritional Optic Neuropathies. OCT and Imaging in Central Nervous System Diseases, Springer International Publishing."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1111\/aos.12515","article-title":"Toxic optic neuropathies: An updated review","volume":"93","author":"Grzybowski","year":"2015","journal-title":"Acta Ophthalmol."},{"key":"ref_44","first-page":"265","article-title":"Copper deficiency, a new triad: Anemia, leucopenia, and myeloneuropathy","volume":"7","author":"Wazir","year":"2017","journal-title":"J. Community Hosp. Int. Med. Perspect."},{"key":"ref_45","unstructured":"Margolin, E., and Shemesh, A. (2020). Optic Neuropathy, Toxic and Nutritional. StatPearls, StatPearls Publishing."},{"key":"ref_46","first-page":"297","article-title":"Megaloblastic Anemias: Nutritional and Other Causes","volume":"101","author":"Green","year":"2017","journal-title":"Med. Clin."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Carmel, R., Green, R., Rosenblatt, D.S., and Watkins, D. (2003). Update on cobalamin, folate, and homocysteine. Hematol. Am. Soc. Hematol. Educ. Program, 62\u201381.","DOI":"10.1182\/asheducation-2003.1.62"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/nyas.13919","article-title":"Thiamine deficiency disorders: Diagnosis, prevalence, and a roadmap for global control programs","volume":"1430","author":"Whitfield","year":"2018","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1080\/17469899.2020.1735362","article-title":"Challenges and opportunities in the diagnosis of nutritional optic neuropathy","volume":"15","author":"Atan","year":"2020","journal-title":"Expert Rev. Ophthalmol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1097\/WNO.0b013e3182901969","article-title":"Drug-related mitochondrial optic neuropathies","volume":"33","author":"Wang","year":"2013","journal-title":"J. Neuro-Ophthalmol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.spen.2017.06.001","article-title":"Dominant Optic Atrophy and Leber\u2019s Hereditary Optic Neuropathy: Update on Clinical Features and Current Therapeutic Approaches","volume":"24","author":"Chun","year":"2017","journal-title":"Semin. Pediatr. Neurol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1007\/s12325-018-0776-z","article-title":"Current and Emerging Treatment Modalities for Leber\u2019s Hereditary Optic Neuropathy: A Review of the Literature","volume":"35","author":"Karampitianis","year":"2018","journal-title":"Adv. Ther."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Lenaers, G., Hamel, C., Delettre, C., Amati-Bonneau, P., Procaccio, V., Bonneau, D., Reynier, P., and Milea, D. (2012). Dominant optic atrophy. Orphanet J. Rare Dis., 7.","DOI":"10.1186\/1750-1172-7-46"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Almind, G.J., Ek, J., Rosenberg, T., Eiberg, H., Larsen, M., LuCamp, L.C., Br\u00f8ndum-Nielsen, K., and Gr\u00f8nskov, K. (2012). Dominant optic atrophy in Denmark\u2014Report of 15 novel mutations in OPA1, using a strategy with a detection rate of 90%. BMC Med. Genet., 13.","DOI":"10.1186\/1471-2350-13-65"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"e231","DOI":"10.1093\/brain\/aws280","article-title":"Idebenone treatment in patients with OPA1-mutant dominant optic atrophy","volume":"136","author":"Barboni","year":"2013","journal-title":"Brain"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1097\/WNO.0000000000000570","article-title":"International consensus statement on the clinical and therapeutic management of leber hereditary optic neuropathy","volume":"37","author":"Carelli","year":"2017","journal-title":"J. Neuro-Ophthalmol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.ophtha.2015.10.025","article-title":"Gene Therapy for Leber Hereditary Optic Neuropathy: Initial Results","volume":"123","author":"Feuer","year":"2016","journal-title":"Ophthalmology"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"21587","DOI":"10.1038\/srep21587","article-title":"Efficacy and Safety of rAAV2-ND4 Treatment for Leber\u2019s Hereditary Optic Neuropathy","volume":"6","author":"Wan","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.ebiom.2016.07.002","article-title":"Long-term outcomes of gene therapy for the treatment of Leber\u2019s hereditary optic neuropathy","volume":"10","author":"Yang","year":"2016","journal-title":"EBioMedicine"},{"key":"ref_60","unstructured":"Mu, M., Kourti, P., Brouzas, D., Kawasaki, A., Physics, B., Federal, S., Gonin, J., and Hospital, E. (2020). B12 deficiency, optic neuropathy and cyanocobalamin nasal spray. Acta Ophthalmol., 1\u20132."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/12\/9\/2653\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T10:05:04Z","timestamp":1760177104000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/12\/9\/2653"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,31]]},"references-count":60,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2020,9]]}},"alternative-id":["nu12092653"],"URL":"https:\/\/doi.org\/10.3390\/nu12092653","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,31]]}}}