{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:50:50Z","timestamp":1792457450642,"version":"4.5.0"},"reference-count":88,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2020,8,31]],"date-time":"2020-08-31T00:00:00Z","timestamp":1598832000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Formulas adapted to infant feeding, although most of the time made from cow\u2019s milk proteins, can be made from hydrolyzed rice protein but they must be classified as \u201cformulas for specific medical needs\u201d, according to European regulations. The nutritional quality of rice proteins is thus suitable to be used in infant formulas giving that it is supplemented by certain amino acids which can be lacking. Besides, hydrolysis is required to facilitate their water solubility and digestibility. Owing to a low allergenicity of rice and to the absence of the cross-allergy between milk proteins and rice proteins, these formulas are adapted to the diet of children with cow\u2019s milk protein allergy (CMPA), which explains their growing use in some countries. However, CMPA, an expanding disorder, has consequences for growth, bone mineralization, and often has an association with allergy to other foods, including cow\u2019s milk extensive hydrolysate, so that a surveillance of the adaption of hydrolyzed rice protein formulas (HRPF) to CMPA, the absence of unexpected side effects, and the appropriate response to its various health hazards seems mandatory. This paper analyses the health problem deriving from CMPA, the industrial development of hydrolyzed rice protein formulas, and the limited number of clinical studies, which confirms, at the moment, a good allergic tolerance and safety. The goal is to better advise heath care professionals on their use of HRPFs during CMPA.<\/jats:p>","DOI":"10.3390\/nu12092654","type":"journal-article","created":{"date-parts":[[2020,8,31]],"date-time":"2020-08-31T08:11:19Z","timestamp":1598861479000},"page":"2654","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":62,"title":["Hydrolyzed Rice Protein-Based Formulas, a Vegetal Alternative in Cow\u2019s Milk Allergy"],"prefix":"10.3390","volume":"12","author":[{"given":"Christophe","family":"Dupont","sequence":"first","affiliation":[{"name":"Pediatric Gastroenterology Department, Paris-Descartes University, 75006 Paris, France"},{"name":"Pediatric Gastroenterology Department, APHP Necker-Enfants Malades Hospital, 750015 Paris, France"},{"name":"Marcel Sembat Clinic, 92100 Boulogne, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Bocquet","sequence":"additional","affiliation":[{"name":"Association Fran\u00e7aise de P\u00e9diatrie Ambulatoire (French Association of Ambulatory Paediatrics), 33400 Talence, France"},{"name":"Medical and Pharmacy School, Franche-Comt\u00e9 University, 25000 Besan\u00e7on, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Tom\u00e9","sequence":"additional","affiliation":[{"name":"UMR Nutrition Physiology and Ingestive Behavior, AgroParisTech, INRA, Paris-Saclay University, 75005 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Bernard","sequence":"additional","affiliation":[{"name":"Charles Nicolle Hospital, 76031 Rouen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8566-3345","authenticated-orcid":false,"given":"Florence","family":"Campeotto","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology Department, APHP Necker-Enfants Malades Hospital, 750015 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascale","family":"Dumond","sequence":"additional","affiliation":[{"name":"Pediatric Allergy Department, Children\u2019s Hospital, University Hospital of Nancy, 54000 Vandoeuvre les Nancy, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Essex","sequence":"additional","affiliation":[{"name":"Sodilac Employee, Sodilac, 92000 Levallois, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Laure","family":"Frelut","sequence":"additional","affiliation":[{"name":"Association Fran\u00e7aise de P\u00e9diatrie Ambulatoire (French Association of 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Paris Sud for Rare Diseases, 75005 Paris, France"},{"name":"APHP, Endocrinology and Diabetes for Children, 75005 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Payot","sequence":"additional","affiliation":[{"name":"Pediatric Practice, 69006 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0928-8608","authenticated-orcid":false,"given":"Alain","family":"Taieb","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Pediatric Dermatology, Bordeaux University Hospital, 33000 Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4525-0276","authenticated-orcid":false,"given":"Nicolas","family":"Kalach","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Saint Antoine Paediatric Hospital, Saint Vincent de Paul Hospital, Groupement des H\u00f4pitaux de l\u2019Institut 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