{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T17:05:08Z","timestamp":1767373508992,"version":"build-2065373602"},"reference-count":41,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2020,8,31]],"date-time":"2020-08-31T00:00:00Z","timestamp":1598832000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Vitamin B1, or thiamine, is one of the most relevant vitamins in obtaining energy for the nervous system. Thiamine deficiency or lack of activity causes neurological manifestations, especially symptoms of depression, intrinsic to multiple sclerosis (MS) and related to its pathogenesis. On this basis, the aim of this study was to determine the possible relationship between the nutritional habits of patients with MS and the presence of depression. Therefore, a cross-sectional and observational descriptive study was conducted. An analysis of dietary habits and vitamin B1 consumption in a Spanish population of 51 MS patients was performed by recording the frequency of food consumption. Results showed a vitamin B1 intake within the established range, mainly provided by the consumption of ultra-processed products such as cold meats or pastries, and a total carbohydrate consumption lower than recommended, which stands out for its high content of simple carbohydrates deriving from processed foods such as dairy desserts, juice, snacks, pastries, chocolate bars, soft drinks and fermented alcohol. In addition, a significant negative correlation between depression and the intake of thiamine and total carbohydrates was observed. These findings could explain the influence of MS patients\u2019 eating habits, and consequently vitamin B1 activity, on depression levels.<\/jats:p>","DOI":"10.3390\/nu12092655","type":"journal-article","created":{"date-parts":[[2020,8,31]],"date-time":"2020-08-31T08:11:19Z","timestamp":1598861479000},"page":"2655","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Vitamin B1 Intake in Multiple Sclerosis Patients and its Impact on Depression Presence: A Pilot Study"],"prefix":"10.3390","volume":"12","author":[{"given":"Jose Enrique de la Rubia","family":"Ort\u00ed","sequence":"first","affiliation":[{"name":"Department of Nursing, Catholic University of Valencia San Vicente Martir, 46001 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda","family":"Cuerda-Ballester","sequence":"additional","affiliation":[{"name":"Doctoral Degree School, Catholic University of Valencia San Vicente Martir, 46001 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eraci","family":"Drehmer","sequence":"additional","affiliation":[{"name":"Department of Physical Activity and Sports Sciences, Catholic University San Vicente Martir, 46900 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Carrera-Juli\u00e1","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Dietetics, Catholic University of Valencia San Vicente M\u00e1rtir, 46001 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda","family":"Motos-Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Department of Nursing, Catholic University of Valencia San Vicente Martir, 46001 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Cunha-P\u00e9rez","sequence":"additional","affiliation":[{"name":"Department of Nursing, Catholic University of Valencia San Vicente Martir, 46001 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3342-6732","authenticated-orcid":false,"given":"Mar\u00eda","family":"Benlloch","sequence":"additional","affiliation":[{"name":"Department of Nursing, Catholic University of Valencia San Vicente Martir, 46001 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8810-520X","authenticated-orcid":false,"given":"Mar\u00eda Mar","family":"L\u00f3pez-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Department of Nursing, Physiotherapy and Medicine, University of Almer\u00eda, 04120 Almer\u00eda, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,8,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1016\/S0140-6736(02)08220-X","article-title":"Multiple Sclerosis","volume":"359","author":"Compstor","year":"2002","journal-title":"Lancet"},{"key":"ref_2","first-page":"813","article-title":"Involvement of mitochondria in neurodegeneration in multiple sclerosis","volume":"87","author":"Kozin","year":"2018","journal-title":"Biochemistry"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/nrneurol.2014.37","article-title":"Mechanisms of neurodegeneration and axonal dysfunction in multiple sclerosis","volume":"10","author":"Friese","year":"2014","journal-title":"Nat. Rev. Neurol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.3892\/mmr.2015.3626","article-title":"Apoptosis-inducing factor and calpain up regulation in glutamate-induced injury of rat spiral ganglion neurons","volume":"12","author":"Ding","year":"2015","journal-title":"Mol. Med. Rep."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1002\/ana.24241","article-title":"Spinal cord gray matter atrophy correlates with multiple sclarosis disability","volume":"76","author":"Schlaeger","year":"2014","journal-title":"Ann. Neurol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1080\/14737175.2017.1247695","article-title":"Pathophysiology, assessment and management of multiple sclerosis fatigue: An update","volume":"17","author":"Rottoli","year":"2017","journal-title":"Expert Rev. Neurother."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1212\/WNL.0000000000000013","article-title":"Evidence-based guideline: Assessment and management of psychiatric disorders in individuals with MS: Report of the guideline development subcommittee of the American academy of neurology","volume":"82","author":"Minden","year":"2014","journal-title":"Neurology"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1080\/09540261.2017.1322555","article-title":"Depression in multiple sclerosis","volume":"29","author":"Patten","year":"2017","journal-title":"Int. Rev. Psychiatry"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1111\/j.1600-0404.2009.01232.x","article-title":"Predictors of depression in multiple sclerosis patients","volume":"121","author":"Gay","year":"2010","journal-title":"Acta Neurol. Scand."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1038\/nrneurol.2014.139","article-title":"The link between multiple sclerosis and depression","volume":"10","author":"Feinstein","year":"2014","journal-title":"Nat. Rev. Neurol."},{"key":"ref_11","first-page":"1633","article-title":"Review of pharmacological efficacies and side effects of antidepressants","volume":"65","author":"Yoshimura","year":"2007","journal-title":"Nihon Rinsho"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"97","DOI":"10.5498\/wjp.v8.i3.97","article-title":"Antidepressant foods: An evidence-based nutrient profiling system for depression","volume":"8","author":"LaChance","year":"2018","journal-title":"World J. Psychiatry"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1056\/NEJMra1203528","article-title":"Behavioral and dietary risk factors for noncommunicable diseases","volume":"369","author":"Ezzati","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1002\/ana.24998","article-title":"Thiamine deficiency in childhood with attention to genetic causes: Survival and outcome predictors","volume":"82","author":"Alfadhel","year":"2017","journal-title":"Ann. Neurol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1007\/s11064-014-1430-z","article-title":"Thiamine deficiency: An update of pathophysiologic mechanisms and future therapeutic considerations","volume":"40","author":"Abdou","year":"2015","journal-title":"Neurochem. Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1002\/1873-3468.13013","article-title":"Mitochondrial dysfunction and axon degeneration in progressive multiple sclerosis","volume":"592","author":"Campbell","year":"2018","journal-title":"FEBS Lett."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.expneurol.2013.12.003","article-title":"Multiple sclerosis: Lessons from molecular neuropathology","volume":"262","author":"Lassmann","year":"2014","journal-title":"Exp. Neurol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1079\/NRR200367","article-title":"Thiamin deficiency and brain disorders","volume":"16","author":"Butterworth","year":"2003","journal-title":"Nutr. Res. Rev."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"53","DOI":"10.3945\/jn.112.167007","article-title":"Thiamine nutritional status and depressive symptoms are inversely associate among older Chinese adults","volume":"143","author":"Zhang","year":"2013","journal-title":"J. Nutr."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.neuroscience.2003.10.051","article-title":"Effect of kami-untan-to on the impairment of learning and memory induced by thiamine-deficient feeding in mice","volume":"125","author":"Nakagawasai","year":"2004","journal-title":"Neuroscience"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.bbr.2006.11.024","article-title":"Preventive effect of kami-untan-to on performance in the forced swimming test in thiamine-deficient mice: Relationship to functions of catecholaminergic neurons","volume":"177","author":"Nakagawasai","year":"2007","journal-title":"Behav. Brain Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.mcn.2017.05.005","article-title":"Thiamine and benfotiamine prevent stress-induced suppression of hippocampal neurogenesis in mice exposed to predation without affecting brain thiamine diphosphate levels","volume":"82","author":"Vignisse","year":"2017","journal-title":"Mol. Cell Neurosci."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"4317","DOI":"10.2174\/0929867323666160920110810","article-title":"The effects of Vitamin B in depression","volume":"23","author":"Mikkelsen","year":"2016","journal-title":"Curr. Med. Chem."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1159\/000430229","article-title":"Nutritional aspects of depression","volume":"37","author":"Lang","year":"2015","journal-title":"Cell Physiol. Biochem."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1080\/1028415X.2017.1303016","article-title":"The role of diet in multiple sclerosis: A review","volume":"21","author":"Esposito","year":"2018","journal-title":"Nutr. Neurosci."},{"key":"ref_26","unstructured":"Beck, A.T., and Steer, R.A. (1993). Beck Depression Inventory Manual, Estados Unidos; Psychological Corporation. [2nd ed.]."},{"key":"ref_27","first-page":"242","article-title":"Validation of a short questionnaire on frequency of dietary intake: Reproducibility and validity","volume":"23","author":"Trinidad","year":"2008","journal-title":"Nutr. Hosp."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"207","DOI":"10.3389\/fpsyt.2019.00207","article-title":"Neurological, psychiatric, and biochemical aspects of thiamine deficiency in children and adults","volume":"10","author":"Dhir","year":"2019","journal-title":"Front. Psychiatry"},{"key":"ref_29","unstructured":"Cuervo, M., Abete, I., Baladia, E., Corbal\u00e1n, M., Manera, M., Basulto, J., and Mart\u00ednez, J.A. (2010). Ingestas Diet\u00e9ticas de Referencia (IDR) Para la Poblaci\u00f3n Espa\u00f1ola, Ediciones Universidad de Navarra, SA (EUNSA). [1st ed.]."},{"key":"ref_30","first-page":"178","article-title":"Consenso de la sociedad Espa\u00f1ola de nutrici\u00f3n comunitaria","volume":"17","author":"Aranceta","year":"2011","journal-title":"Rev. Esp. Nutr. Comunitaria"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1212\/WNL.33.11.1444","article-title":"Rating neurologic impairment in multiple sclerosis: An expanded disability status scale (EDSS)","volume":"33","author":"Kurtzke","year":"1983","journal-title":"Neurology"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"World Medical Association (2013). Ethical principles for medical research involving human subjects. JAMA, 310, 2191\u20132194.","DOI":"10.1001\/jama.2013.281053"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Mielgo-Ayuso, J., Aparicio-Ugarriza, R., Olza, J., Aranceta-Bartrina, J., Gil, A., Ortega, R.M., Serra-Majem, L., Varela-Moreiras, G., and Gonz\u00e1lez-Gross, M. (2018). Dietary intake and food sources of niacin, riboflavin, thiamin and vitamin b\u2086 in a representative sample of the Spanish population. The anthropometry, intake, and energy balance in Spain (ANIBES) study. Nutrients, 10.","DOI":"10.3390\/nu10070846"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/1744-859X-11-24","article-title":"No association between dietary patterns and depressive symptoms among a community-dwelling population in Japan","volume":"11","author":"Sugawara","year":"2012","journal-title":"Ann. Gen. Psychiatry"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1111\/j.1468-1331.2008.02304.x","article-title":"Mastery, functional disability and perceived heath status in patients with multiple sclerosis","volume":"15","author":"Krokavcova","year":"2008","journal-title":"Eur. J. Neurol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.2147\/CIA.S114669","article-title":"Inappropriate nutrients intake is associated with lower functional status and inferior quality of life in older adults with depression","volume":"11","author":"Guligowska","year":"2016","journal-title":"Clin. Interv. Aging"},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Drehmer, E., Platero, J.L., Carrera-Juli\u00e1, S., Moreno, M.L., Tvarijonaviciute, A., Navarro, M.A., L\u00f3pez-Rodr\u00edguez, M.M., and de la Rubia, J.E. (2020). The relation between eating habits and abdominal fat, anthropometry, PON1 and IL-6 levels in patients with multiple sclerosis. Nutrients, 12.","DOI":"10.3390\/nu12030744"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.appet.2008.08.008","article-title":"Reported food choices in older women in relation to body mass index and depressive symptoms","volume":"52","author":"Jeffery","year":"2009","journal-title":"Appetite"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1017\/S1368980011001856","article-title":"Fast-food and commercial baked goods consumption and the risk of depression","volume":"15","author":"Toledo","year":"2012","journal-title":"Public Health Nutr."},{"key":"ref_40","first-page":"563","article-title":"Effect of ascorbic acid and thiamine supplementation at different concentrations on lead toxicity in liver","volume":"51","author":"Wang","year":"2007","journal-title":"Ann. Occup. Hyg."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1016\/S1474-4422(18)30309-0","article-title":"The hippocampus in multiple sclerosis","volume":"17","author":"Rocca","year":"2018","journal-title":"Lancet Neurol."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/12\/9\/2655\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T10:05:04Z","timestamp":1760177104000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/12\/9\/2655"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,31]]},"references-count":41,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2020,9]]}},"alternative-id":["nu12092655"],"URL":"https:\/\/doi.org\/10.3390\/nu12092655","relation":{},"ISSN":["2072-6643"],"issn-type":[{"type":"electronic","value":"2072-6643"}],"subject":[],"published":{"date-parts":[[2020,8,31]]}}}