{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T20:11:52Z","timestamp":1780603912299,"version":"3.54.1"},"reference-count":28,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2020,9,11]],"date-time":"2020-09-11T00:00:00Z","timestamp":1599782400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004569","name":"Ministerstwo Nauki i Szkolnictwa Wy\u017cszego","doi-asserted-by":"publisher","award":["002 \/ RID \/ 2019\/20"],"award-info":[{"award-number":["002 \/ RID \/ 2019\/20"]}],"id":[{"id":"10.13039\/501100004569","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background: Burned patients have an increased need for vitamin D supply related to the maintenance of calcium\u2013phosphate homeostasis and the regulation of cell proliferation\/differentiation. This study aimed to analyze the concentration of 25-hydroxycholecalciferol and its relationship with severe condition after burn injury. Methods: 126 patients were enrolled in the study. Patients were qualified due to thermal burns\u2014over 10% of total body surface area. On the day of admission, the following parameters were assessed: 25-hydroxycholecalciferol concentration, total protein concentration, albumin concentration, aspartate transaminase activity, alanine transaminase activity, albumin concentration, creatinine concentration, c-reactive protein concentration, procalcitonin concentration, and interleukin-6 concentration. Results: Almost all patients (92%) in the study group had an improper level of vitamin D (&lt;30 ng\/mL), with the average of 11.6 \u00b1 10.7 ng\/mL; 17.5% of patients had levels of vitamin D below the limit of determination\u2014under 3 ng\/mL. The study showed that there are several factors which correlated with vitamin D concentration during the acute phase of burn injury, including: total protein (r = 0.42, p &lt; 0.01), albumin, (r = 0.62, p &lt; 0.01), percentage of body burns (r = 0.36, p &lt; 0.05), aspartate aminotransferase (r = 0.21, p &lt; 0.05), and c-reactive protein (r = 0.22, p &lt; 0.05). We did not find any significant correlation between vitamin D concentration and body mass index. Conclusions: The burn injury has an enormous impact on the metabolism and the risk factors of the deficiency for the general population (BMI) have an effect on burned patients. Our study showed that concentration of 25-hydroxycholecalciferol is strongly correlated with serum albumin level, even more than total burn surface area and burn degrees as expected. We suspect that increased supplementation of vitamin D should be based on albumin level and last until albumin levels are balanced.<\/jats:p>","DOI":"10.3390\/nu12092780","type":"journal-article","created":{"date-parts":[[2020,9,11]],"date-time":"2020-09-11T09:05:16Z","timestamp":1599815116000},"page":"2780","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["25-Hydroxycholecalciferol Concentration Is Associated with Protein Loss and Serum Albumin Level during the Acute Phase of Burn Injury"],"prefix":"10.3390","volume":"12","author":[{"given":"Andrzej","family":"Krajewski","sequence":"first","affiliation":[{"name":"West Pomeranian Center of Treating Severe Burns and Plastic Surgery in Gryfice, 72-300 Gryfice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krzysztof","family":"Piorun","sequence":"additional","affiliation":[{"name":"West Pomeranian Center of Treating Severe Burns and Plastic Surgery in Gryfice, 72-300 Gryfice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2293-6489","authenticated-orcid":false,"given":"Dominika","family":"Maciejewska-Markiewicz","sequence":"additional","affiliation":[{"name":"Department of Human Nutrition and Metabolomics, Pomeranian Medical University in Szczecin, 71-460, Szczecin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Markowska","sequence":"additional","affiliation":[{"name":"Clinic of Plastic, Endocrine and General Surgery, Pomeranian Medical University in Szczecin, 72-010 Police, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3430-9079","authenticated-orcid":false,"given":"Karolina","family":"Skonieczna-\u017bydecka","sequence":"additional","affiliation":[{"name":"Department of Human Nutrition and Metabolomics, Pomeranian Medical University in Szczecin, 71-460, Szczecin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewa","family":"Stachowska","sequence":"additional","affiliation":[{"name":"Department of Human Nutrition and Metabolomics, Pomeranian Medical University in Szczecin, 71-460, Szczecin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zofia","family":"Polakowska","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, Pomeranian Medical University in Szczecin, 71-010 Police, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4710-1282","authenticated-orcid":false,"given":"Maciej","family":"Mazurek","sequence":"additional","affiliation":[{"name":"West Pomeranian Center of Treating Severe Burns and Plastic Surgery in Gryfice, 72-300 Gryfice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9808-0624","authenticated-orcid":false,"given":"Ma\u0142gorzata","family":"Szczuko","sequence":"additional","affiliation":[{"name":"Department of Human Nutrition and Metabolomics, Pomeranian Medical University in Szczecin, 71-460, Szczecin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,9,11]]},"reference":[{"key":"ref_1","first-page":"410","article-title":"Burn analysis in adult patients hospitalized in the East Centre of Burn Treatment and Reconstructive Surgery in \u0141\u0119czna","volume":"7","author":"Chemperek","year":"2017","journal-title":"J. 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