{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T10:19:57Z","timestamp":1792405197273,"version":"4.4.0"},"reference-count":131,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2020,9,13]],"date-time":"2020-09-13T00:00:00Z","timestamp":1599955200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Thiamine is a crucial cofactor involved in the maintenance of carbohydrate metabolism and participates in multiple cellular metabolic processes. Although thiamine can be obtained from various food sources, some common food groups are deficient in thiamine, and it can be denatured by high temperature and pH. Additionally, different drugs can alter thiamine metabolism. In addition, the half-life of thiamine in the body is between 1 and 3 weeks. All these factors could provide an explanation for the relatively short period needed to develop thiamine deficiency and observe the consequent clinical symptoms. Thiamine deficiency could lead to neurological and cardiological problems. These clinical conditions could be severe or even fatal. Marginal deficiency too may promote weaker symptoms that might be overlooked. Patients undergoing upper gastrointestinal or pancreatic surgery could have or develop thiamine deficiency for many different reasons. To achieve the best outcome for these patients, we strongly recommend the execution of both an adequate preoperative nutritional assessment, which includes thiamine evaluation, and a close nutritional follow up to avoid a nutrient deficit in the postoperative period.<\/jats:p>","DOI":"10.3390\/nu12092810","type":"journal-article","created":{"date-parts":[[2020,9,13]],"date-time":"2020-09-13T21:11:32Z","timestamp":1600031492000},"page":"2810","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["The Relevance of Thiamine Evaluation in a Practical Setting"],"prefix":"10.3390","volume":"12","author":[{"given":"Federico","family":"Pacei","sequence":"first","affiliation":[{"name":"ASST Nord Milano, UOC Neurologia, Ospedale Bassini, 20092 Cinisello Balsamo, Italy"},{"name":"Department of Physical Rehabilitation, Casa di Cura Bonvicini, Via Michael Pacher 12, 39100 Bolzano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Tesone","sequence":"additional","affiliation":[{"name":"Department of Physical Rehabilitation, Casa di Cura Bonvicini, Via Michael Pacher 12, 39100 Bolzano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazzareno","family":"Laudi","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Surgery, Medizinische Universitat Innsbruck, Christoph-Probst-Platz 1, Innrain 52 A, 6020 Innsbruck, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuele","family":"Laudi","sequence":"additional","affiliation":[{"name":"Department of Physical Rehabilitation, Casa di Cura Bonvicini, Via Michael Pacher 12, 39100 Bolzano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Cretti","sequence":"additional","affiliation":[{"name":"Department of Physical Rehabilitation, Casa di Cura Bonvicini, Via Michael Pacher 12, 39100 Bolzano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shira","family":"Pnini","sequence":"additional","affiliation":[{"name":"Department of Physical Rehabilitation, Casa di Cura Bonvicini, Via Michael Pacher 12, 39100 Bolzano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Varesco","sequence":"additional","affiliation":[{"name":"Department of Physical Rehabilitation, Casa di Cura Bonvicini, Via Michael Pacher 12, 39100 Bolzano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Colombo","sequence":"additional","affiliation":[{"name":"Lombardy Regional Course for General Practitioner, PoliS-Lombardia, Via Taramelli 12\/F, 20100 Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,9,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/nyas.13919","article-title":"Thiamine deficiency disorders: Diagnosis, prevalence, and a roadmap for global control programs","volume":"1430","author":"Whitfield","year":"2018","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1001\/jama.1943.02840460017005","article-title":"The biosynthesis of thiamine in man and its implications in human nutrition","volume":"123","author":"Najjar","year":"1943","journal-title":"J. Am. Med. Assoc."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/BF00315284","article-title":"Kinetics of thiamin and thiamin phosphate esters in human blood, plasma and urine after 50 mg intravenously or orally","volume":"44","author":"Tallaksen","year":"1993","journal-title":"Eur. J. Clin. Pharmacol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/j.numecd.2018.06.013","article-title":"Thiamine deficiency and cardiovascular disorders","volume":"28","author":"Eshak","year":"2018","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1093\/ecam\/nek009","article-title":"A review of the biochemestry, metabolism and clinical benefits of thiamine and its derivates","volume":"3","author":"Lonsdale","year":"2006","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1007\/s11695-007-9349-y","article-title":"Nutritional deficiencies in morbidly obese patients: A newform of malnutrition?","volume":"18","author":"Person","year":"2008","journal-title":"Part A Vitamins. Obes. Surg."},{"key":"ref_7","unstructured":"Alan, R. (1988). Thiamine (vitamin B1). Current Topics in Nutrition and Disease, Liss Inc."},{"key":"ref_8","first-page":"93","article-title":"Clinical Chemistry of Thiamin","volume":"23","author":"Davis","year":"1983","journal-title":"Adv. Appl. Microbiol."},{"key":"ref_9","unstructured":"Kennedy, A.R. (2001). The Potential Role of Thiamine in the Pathogenesis and Treatment of Alzheimer\u2019s Disease. [Master\u2019s Thesis, University of Manitoba]."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1016\/j.jand.2013.10.012","article-title":"Fortified Foods Are Major Contributors to Nutrient Intakes in Diets of US Children and Adolescents","volume":"114","author":"Berner","year":"2014","journal-title":"J. Acad. Nutr. Diet."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"S17","DOI":"10.3177\/jnsv.36.4-SupplementI_S17","article-title":"Cooking Losses of Thiamin in Food and Its Nutritional Significance","volume":"36","author":"Kimura","year":"1990","journal-title":"J. Nutr. Sci. Vitaminol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/B978-0-12-375083-9.00266-X","article-title":"Thiamin: Physiology","volume":"4","author":"Thurnham","year":"2013","journal-title":"Encycl. Hum. Nutr."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Khounnorath, S., Chamberlain, K., Taylor, A.M., Soukaloun, D., Mayxay, M., Lee, S.J., Phengdy, B., Luangxay, K., Sisouk, K., and Soumphonphakdy, B. (2011). Clinically Unapparent Infantile Thiamin Deficiency in Vientiane, Laos. PLoS Negl. Trop. Dis., 5.","DOI":"10.1371\/journal.pntd.0000969"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"769","DOI":"10.4314\/ahs.v14i3.38","article-title":"Seasonal ataxia: A case report of a disappearing disease","volume":"14","author":"Moyo","year":"2014","journal-title":"Afr. Heal. Sci."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1177\/0884533611426149","article-title":"Thiamine in Nutrition Therapy","volume":"27","author":"Sriram","year":"2012","journal-title":"Nutr. Clin. Pract."},{"key":"ref_16","first-page":"184","article-title":"Thiamine deficiency in congestive heart failure patients receiving long term furosemide therapy","volume":"10","author":"Zenuk","year":"2003","journal-title":"Can. J. Clin. Pharmacol."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Bugiardini, E., Pope, S., Feichtinger, R.G., Poole, O.V., Pittman, A.M., Woodward, C.E., Heales, S.J., Quinlivan, R., Houlden, H., and Mayr, J.A. (2019). Utility of Whole Blood Thiamine Pyrophosphate Evaluation in TPK1-Related Diseases. J. Clin. Med., 8.","DOI":"10.3390\/jcm8070991"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1002\/jimd.12125","article-title":"Genetic defects of thiamine transport and metabolism: A review of clinical phenotypes, genetics, and functional studies","volume":"42","year":"2019","journal-title":"J. Inherit. Metab. Dis."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.2337\/db17-0821","article-title":"Loss-of-Function Mutation in Thiamine Transporter 1 in a Family With Autosomal Dominant Diabetes","volume":"68","author":"Jungtrakoon","year":"2019","journal-title":"Diabetes"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"083","DOI":"10.1055\/s-0037-1607191","article-title":"SLC19A3 Gene Defects Sorting the Phenotype and Acronyms: Review","volume":"49","author":"Tabarki","year":"2017","journal-title":"Neuropediatrics"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1111\/bpa.12117","article-title":"Stress-Induced Upregulation of SLC19A3 is Impaired in Biotin-Thiamine-Responsive Basal Ganglia Disease","volume":"24","author":"Ondrouschek","year":"2014","journal-title":"Brain Pathol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1038\/s10038-019-0666-5","article-title":"Functional analysis of the third identified SLC25A19 mutation causative for the thiamine metabolism dysfunction syndrome 4","volume":"64","author":"Bottega","year":"2019","journal-title":"J. Hum. Genet."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1002\/ana.24998","article-title":"Thiamine deficiency in childhood with attention to genetic causes: Survival and outcome predictors","volume":"82","author":"Alfadhel","year":"2017","journal-title":"Ann. Neurol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2917","DOI":"10.1111\/j.1742-4658.2009.07019.x","article-title":"Thiamin diphosphate in biological chemistry: New aspects of thiamin metabolism, especially triphosphate derivatives acting other than as cofactors","volume":"276","author":"Bettendorff","year":"2009","journal-title":"FEBS J."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1021\/bi401618y","article-title":"Thiamin Function, Metabolism, Uptake, and Transport","volume":"53","author":"Manzetti","year":"2014","journal-title":"Biochemistry"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1093\/clinchem\/46.5.704","article-title":"Vitamin B1 Status Assessed by Direct Measurement of Thiamin Pyrophosphate in Erythrocytes or Whole Blood by HPLC: Comparison with Erythrocyte Transketolase Activation Assay","volume":"46","author":"Talwar","year":"2000","journal-title":"Clin. Chem."},{"key":"ref_27","unstructured":"FAO, and World Health Organization (2005). Vitamin and Mineral Requirements in Human Nutrition, World Health Organization. [2nd ed.]."},{"key":"ref_28","unstructured":"U.S. Department of Agriculture, and Agricultural Research Service (2011). USDA National Nutrient Database for Standard Reference, Release 24."},{"key":"ref_29","unstructured":"(2020, July 06). Istituto Nazionale di Ricerca per gli Alimenti e la Nutrizione (INRAN), Stazione Sperimentale Industria delle Conserve Alimentari (SSICA), Available online: https:\/\/www.crea.gov.it\/web\/alimenti-e-nutrizione\/banche-dati."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"333","DOI":"10.7205\/MILMED.171.4.333","article-title":"The great disease enemy, Kak\u2019ke (beriberi) and the Imperial Japanese Army","volume":"171","author":"Hawk","year":"2006","journal-title":"Mil. Med."},{"key":"ref_31","first-page":"799","article-title":"A case of Wernicke\u2019s encephalopathy due to oesophageal achalasia","volume":"34","author":"Federico","year":"2012","journal-title":"Neurol. Sci."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1007\/s11695-009-0068-4","article-title":"Fewer nutrient deficiencies after laparoscopic sleeve gastrectomythan after laparoscopic Roux-Y-gastric bypass (LRYGB) a pro-spective study","volume":"20","author":"Gehrer","year":"2010","journal-title":"Obes. Surg."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1212\/01.wnl.0000256812.29648.86","article-title":"Wernicke encephalopathy after obesity surgery: A systematic review","volume":"68","author":"Singh","year":"2007","journal-title":"Neurology"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"608534","DOI":"10.1155\/2012\/608534","article-title":"The Neurological Complications of Nutritional Deficiency following Bariatric Surgery","volume":"2012","author":"Becker","year":"2012","journal-title":"J. Obes."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1007\/s11695-007-9208-x","article-title":"Nutritional deficiencies after bariatric surgery","volume":"17","author":"Davies","year":"2007","journal-title":"Obes. Surg."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1111\/j.1468-1331.2010.03153.x","article-title":"EFNS guidelines for diagnosis, therapy and prevention of Wernicke encephalopathy","volume":"17","author":"Galvin","year":"2010","journal-title":"Eur. J. Neurol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1136\/jnnp.62.1.51","article-title":"Operational criteria for the classification of chronic alcoholics: Identification of Wernicke\u2019s encephalopathy","volume":"62","author":"Caine","year":"1997","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1093\/alcalc\/agn118","article-title":"The Korsakoff Syndrome: Clinical Aspects, Psychology and Treatment","volume":"44","author":"Kopelman","year":"2009","journal-title":"Alcohol Alcohol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/S0278-5846(03)00155-6","article-title":"Neuropathological alterations in alcoholic brains. Studies arising from the New South Wales Tissue Resource Centre","volume":"27","author":"Harper","year":"2003","journal-title":"Prog. Neuro-Psychopharmacol. Boil. Psychiatry"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"2875","DOI":"10.2147\/NDT.S130078","article-title":"Korsakoff\u2019s Syndrome: A Critical Review","volume":"13","author":"Arts","year":"2017","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"ref_41","first-page":"544","article-title":"Sopra un\u2019alterazione del corpo calloso osservata in soggetti alcoolisti","volume":"8","author":"Marchiafava","year":"1903","journal-title":"Riv. Patol. Nerv. Ment."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1136\/jnnp-2013-305979","article-title":"Diagnosis and management of Marchiafava-Bignami disease: A review of CT\/MRI confirmed cases","volume":"85","author":"Hillbom","year":"2013","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1038\/ejcn.2016.267","article-title":"Thiamine deficiency, oxidative metabolic pathways and ethanol-induced neurotoxicity: How poor nutrition contributes to the alcoholic syndrome, as Marchiafava\u2013Bignami disease","volume":"71","author":"Fernandes","year":"2017","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1016\/S1474-4422(10)70223-4","article-title":"Revising the definition of Alzheimer\u2019s disease: A new lexicon","volume":"9","author":"Dubois","year":"2010","journal-title":"Lancet Neurol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.jalz.2011.03.003","article-title":"Toward defining the preclinical stages of Alzheimer\u2019s disease: Recommendations from the National Institute on Aging-Alzheimer\u2019s Association workgroups on diagnostic guidelines for Alzheimer\u2019s disease","volume":"7","author":"Sperling","year":"2011","journal-title":"Alzheimer\u2019s Dement."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/nyas.13031","article-title":"Vitamin B1 (thiamine) and dementia","volume":"1367","author":"Gibson","year":"2016","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/0304-3940(93)90271-L","article-title":"The effects of thiamin and its phosphate esters on dopamine release in the rat striatum","volume":"158","author":"Yamashita","year":"1993","journal-title":"Neurosci. Lett."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1038\/264186a0","article-title":"Possible involvement of thiamine in acetylcholine release","volume":"264","author":"Eder","year":"1976","journal-title":"Nature"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1007\/BF01053581","article-title":"Effect of thiamine on neuromuscular transmission in smooth muscles","volume":"26","author":"Romanenko","year":"1994","journal-title":"Neurophysiology"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.pneurobio.2013.06.004","article-title":"Decoding Alzheimer\u2019s disease from perturbed cerebral glucose metabolism: Implications for diagnostic and therapeutic strategies","volume":"108","author":"Chen","year":"2013","journal-title":"Prog. Neurobiol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1038\/nature08538","article-title":"Multimodal techniques for diagnosis and prognosis of Alzheimer\u2019s disease","volume":"461","author":"Perrin","year":"2009","journal-title":"Nature"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1016\/S0010-9452(08)70876-1","article-title":"FDG-PET Findings in the Wernicke-Korsakoff Syndrome","volume":"39","author":"Kopelman","year":"2003","journal-title":"Cortex"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1001\/archneur.1988.00520320022009","article-title":"Reduced activities of thiamine-dependent enzymes in the brains and peripheral tissues of patients with Alzheimer\u2019s disease","volume":"45","author":"Gibson","year":"1988","journal-title":"Arch. Neurol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1002\/ana.20474","article-title":"Mitochondrial abnormalities in Alzheimer brain: Mechanistic implications","volume":"57","author":"Bubber","year":"2005","journal-title":"Ann. Neurol."},{"key":"ref_55","first-page":"537","article-title":"Impairment of behavior and acetylcholine metabolism in thiamine deficiency","volume":"217","author":"Barclay","year":"1981","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1111\/j.1471-4159.1993.tb07457.x","article-title":"Extracellular Glutamate Is Increased in Thalamus during Thiamine Deficiency-Induced Lesions and Is Blocked by MK-801","volume":"61","author":"Langlais","year":"1993","journal-title":"J. Neurochem."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1111\/j.1471-4159.1993.tb03635.x","article-title":"Cerebral Vulnerability Is Associated with Selective Increase in Extracellular Glutamate Concentration in Experimental Thiamine Deficiency","volume":"61","author":"Hazell","year":"1993","journal-title":"J. Neurochem."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.neuint.2003.09.008","article-title":"Selective response of various brain cell types during neurodegeneration induced by mild impairment of oxidative metabolism","volume":"45","author":"Ke","year":"2004","journal-title":"Neurochem. Int."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1016\/j.neurobiolaging.2007.12.013","article-title":"Thiamine deficiency induces oxidative stress and exacerbates the plaque pathology in Alzheimer\u2019s mouse model","volume":"30","author":"Karuppagounder","year":"2009","journal-title":"Neurobiol. Aging"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.neurobiolaging.2009.01.005","article-title":"Thiamine deficiency increases \u03b2-secretase activity and accumulation of \u03b2-amyloid peptides","volume":"32","author":"Zhang","year":"2011","journal-title":"Neurobiol. Aging"},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Volvert, M.-L., Seyen, S., Piette, M., Evrard, B., Gangolf, M., Plumier, J.-C., and Bettendorff, L. (2008). Benfotiamine, a synthetic S-acyl thiamine derivative, has different mechanisms of action and a different pharmacological profile than lipid-soluble thiamine disulfide derivatives. BMC Pharmacol., 8.","DOI":"10.1186\/1471-2210-8-10"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1093\/brain\/awq069","article-title":"Powerful beneficial effects of benfotiamine on cognitive impairment and beta-amyloid deposition in amyloid precursor protein\/presenilin-1 transgenic mice","volume":"133","author":"Pan","year":"2010","journal-title":"Brain"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"4002","DOI":"10.1111\/j.1742-4658.2011.08304.x","article-title":"The prion protein binds thiamine","volume":"278","author":"Bjorndahl","year":"2011","journal-title":"FEBS J."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.1007\/s11064-010-0242-z","article-title":"Thiamine and Oxidants Interact to Modify Cellular Calcium Stores","volume":"35","author":"Huang","year":"2010","journal-title":"Neurochem. Res."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"2325","DOI":"10.1016\/0006-2952(84)90673-7","article-title":"Thiamin antagonists and the release of acetylcholine and norepinephrine from brain slices","volume":"33","author":"Hirsch","year":"1984","journal-title":"Biochem. Pharmacol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1111\/j.1749-6632.1982.tb31212.x","article-title":"Effect of thiamine deficiency on brain and neurotransmitter system","volume":"378","author":"Plaitakis","year":"1982","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"197","DOI":"10.2174\/1566524013363870","article-title":"Molecular Mechanisms of Thiamine Utilization","volume":"1","author":"Singleton","year":"2001","journal-title":"Curr. Mol. Med."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/S0006-3223(00)00971-9","article-title":"The possibility of neurotoxicity in the hippocampus in major depression: A primer on neuron death","volume":"48","author":"Sapolsky","year":"2000","journal-title":"Boil. Psychiatry"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"53","DOI":"10.3945\/jn.112.167007","article-title":"Thiamine nutritional status and depressive symptoms are inversely associated among older Chinese adults","volume":"143","author":"Zhang","year":"2012","journal-title":"J. Nutr."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1192\/bjp.135.3.249","article-title":"Thiamine and Pyridoxine Lack in Newly-Admitted Psychiatric Patients","volume":"135","author":"Carney","year":"1979","journal-title":"Br. J. Psychiatry"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1007\/s11064-008-9594-z","article-title":"Translocation of Amyloid Precursor Protein C-terminal Fragment(s) to the Nucleus Precedes Neuronal Death due to Thiamine Deficiency-induced Mild Impairment of Oxidative Metabolism","volume":"33","author":"Karuppagounder","year":"2008","journal-title":"Neurochem. Res."},{"key":"ref_72","unstructured":"Nguyen-Khoa, D.T., and Busschots, G.V. (2020). Beriberi (Thiamine Deficiency), Medscape."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1007\/s11606-017-4208-6","article-title":"Wet Beriberi Associated with Hikikomori Syndrome","volume":"33","author":"Tanabe","year":"2017","journal-title":"J. Gen. Intern. Med."},{"key":"ref_74","first-page":"1115","article-title":"Le shoshin b\u00e9rib\u00e9ri. Une catastrophe h\u00e9modynamique rapidement curable [Shoshin beriberi. A rapidly curable hemodynamic disaster]","volume":"25","author":"Meurin","year":"1996","journal-title":"Presse Med."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.pcad.2018.01.009","article-title":"Thiamine and Cardiovascular Disease: A Literature Review","volume":"61","author":"DiNicolantonio","year":"2018","journal-title":"Prog. Cardiovasc. Dis."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1111\/chf.12037","article-title":"Thiamine Supplementation for the Treatment of Heart Failure: A Review of the Literature","volume":"19","author":"DiNicolantonio","year":"2013","journal-title":"Congest. Heart Fail."},{"key":"ref_77","first-page":"G197","article-title":"Pancreatic beta cells and islets take up thiamin by a regulated carrier-mediated process: Studies using mice and human pancreatic preparations","volume":"297","author":"Mee","year":"2009","journal-title":"Am. J. Physiol. Liver Physiol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"2164","DOI":"10.1007\/s00125-007-0771-4","article-title":"High prevalence of low plasma thiamine concen-tration in diabetes linked to a marker of vascular disease","volume":"50","author":"Thornalley","year":"2007","journal-title":"Diabetologia"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"2978","DOI":"10.3748\/wjg.v16.i24.2978","article-title":"Small intestinal bacterial overgrowth syndrome","volume":"16","author":"Cyrany","year":"2010","journal-title":"World J. Gastroenterol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1007\/s00125-008-1224-4","article-title":"High-dose thiamine therapy for patients with type 2 diabetesand microalbuminuria: A randomised, double-blind placebo-controlled pilot study","volume":"52","author":"Rabbani","year":"2009","journal-title":"Diabetologia"},{"key":"ref_81","unstructured":"Alam, S.S., Riaz, S., and Akhtar, M.W. (2012). Effect of High Dose Thiamine Therapy on Risk Factors in Type 2 Diabetics. J. Diabetes Metab., 3."},{"key":"ref_82","first-page":"145","article-title":"Effect of thiamine administration on metabolic profile, cytokines and inflammatory markers in drug-na\u00efve patients with type 2 diabetes","volume":"50","year":"2010","journal-title":"Eur. J. Nutr."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1111\/j.1742-1241.2011.02680.x","article-title":"Thiamine deficiency in diabetes mellitus and the impact of thiamine replacement on glucose metabolism and vascular disease","volume":"65","author":"Page","year":"2011","journal-title":"Int. J. Clin. Pract."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"104","DOI":"10.7326\/0003-4819-11-1-104","article-title":"The nature of the cardiovascular disturbances in nutritional deficiency states (beriberi)","volume":"11","author":"Weiss","year":"1937","journal-title":"Ann. Intern. Med."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1161\/01.CIR.58.3.566","article-title":"Fulminant beriberi heart disease with lactic acidosis: Presentation of a case with evaluation of left ventricular function and review of pathophysiologic mechanisms","volume":"58","author":"Attas","year":"1978","journal-title":"Circulation"},{"key":"ref_86","first-page":"968761","article-title":"Benfotiamine counteracts smoking-induced vascular dysfunctionin healthy smokers","volume":"2012","author":"Stirban","year":"2012","journal-title":"Int. J. Vasc. Med."},{"key":"ref_87","first-page":"95","article-title":"Thiamine Deficiency Presenting as Intraventricular Hemorrhage","volume":"47","author":"Nichols","year":"2016","journal-title":"Stroke"},{"key":"ref_88","first-page":"518","article-title":"Immediate recovery of an \u201cischemic stroke\u201d following treatment with intravenous thiamine (vitamin B1)","volume":"16","author":"Blum","year":"2014","journal-title":"Isr. Med Assoc. J."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.soard.2008.03.002","article-title":"Bariatric nutrition: Suggestions for the surgical weight loss patient","volume":"4","author":"Aills","year":"2008","journal-title":"Surg. Obes. Relat. Dis."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1038\/nrendo.2012.48","article-title":"Nutritional deficiencies after bariatric surgery","volume":"8","author":"Bal","year":"2012","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1093\/alcalc\/37.6.513","article-title":"The Royal College of Physicians Report on Alcohol: Guidelines for Managing Wernicke\u2019s Encephalopathy in the Accident and Emergency Department","volume":"37","author":"Thomson","year":"2002","journal-title":"Alcohol Alcohol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.soard.2012.12.010","article-title":"Clinical practice guidelines for the perioperative nutritional, metabolic, and nonsurgical support of the bariatric surgery patient\u20142013 update: Cosponsored by American Association of Clinical Endocrinologists, The Obesity Society and American Society for Metabolic & Bariatric Surgery","volume":"9","author":"Mechanick","year":"2013","journal-title":"Surg. Obes. Relat. Dis."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1177\/0148607114565245","article-title":"Thiamin in Clinical Practice","volume":"39","author":"Frank","year":"2015","journal-title":"J. Parenter. Enter. Nutr."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1093\/alcalc\/agh250","article-title":"The Treatment of Patients at Risk of Developing Wernicke\u2019s Encephalopathy in the Community","volume":"41","author":"Thomson","year":"2005","journal-title":"Alcohol Alcohol."},{"key":"ref_95","unstructured":"U.S. Department of Health and Human Services, and Food and Drug Administration (2000). Parenteral multivitamin products: Drugs for human use; drug efficacy study implementation; amendment. Fed Regist., 65, 21200\u201321201."},{"key":"ref_96","unstructured":"Royal College of Physicians (2001). Alcohol\u2014Can the NHS Afford It? Recommendations for a Coherent Alcohol Strategy for Hospitals, Royal College of Physicians."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1007\/s11065-012-9203-4","article-title":"Neuroimaging of Wernicke\u2019s encephalopathy and Korsakoff\u2019s syndrome","volume":"22","author":"Jung","year":"2012","journal-title":"Neuropsychol. Rev."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/S1474-4422(07)70104-7","article-title":"Wernicke\u2019s encephalopathy: New clinical settings and recent advances in diagnosis and management","volume":"6","author":"Sechi","year":"2007","journal-title":"Lancet Neurol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1023\/A:1020657129593","article-title":"Mechanisms of neuronal cell death in Wernicke\u2019s encephalopathy","volume":"13","author":"Hazell","year":"1998","journal-title":"Metab. Brain Dis."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.2214\/ajr.171.4.9763009","article-title":"Usefulness of CT and MR imaging in the diagnosis of acute Wernicke\u2019s encephalopathy","volume":"171","author":"Antunez","year":"1998","journal-title":"Am. J. Roentgenol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/s11547-011-0618-x","article-title":"CT and MRI of Wernicke\u2019s encephalopathy","volume":"116","author":"Cerase","year":"2011","journal-title":"Radiol. Med."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1111\/j.1530-0277.1993.tb05668.x","article-title":"Thiamine-Dependent Enzyme Changes in the Brains of Alcoholics: Relationship to the Wernicke-Korsakoff Syndrome","volume":"17","author":"Butterworth","year":"1993","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"501","DOI":"10.2214\/AJR.07.3959","article-title":"Neuroimaging findings in acute Wernicke\u2019s encephalopathy: Review of the literature","volume":"192","author":"Zuccoli","year":"2009","journal-title":"Am. J. Roentgenol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"164","DOI":"10.3174\/ajnr.A0827","article-title":"Clinical Characteristics and MR Imaging Features of Nonalcoholic Wernicke Encephalopathy","volume":"29","author":"Fei","year":"2008","journal-title":"Am. J. Neuroradiol."},{"key":"ref_105","first-page":"251","article-title":"FLAIR appearance of Wernicke encephalopathy","volume":"15","author":"Ashikaga","year":"1997","journal-title":"Radiat. Med."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/S0720-048X(02)00009-8","article-title":"Diffusion weighted MR imaging of acute Wernicke\u2019s encephalopathy","volume":"45","author":"Chung","year":"2003","journal-title":"Eur. J. Radiol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/S0150-9861(06)77243-1","article-title":"Diffusion weighted imaging of cerebellar lesions in Wernicke\u2019s encephalopathy","volume":"33","author":"Lapergue","year":"2006","journal-title":"J. Neuroradiol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/s002340050741","article-title":"Do acute lesions of Wernicke\u2019s encephalopathy show contrast enhancement? Report of three cases and review of the literature","volume":"41","author":"Mascalchi","year":"1999","journal-title":"Neuroradiology"},{"key":"ref_109","first-page":"952","article-title":"Proton MR spectroscopy in Wernicke encephalopathy","volume":"24","author":"Rugilo","year":"2003","journal-title":"Am. J. Neuroradiol."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0925-4927(01)00304-3","article-title":"Serial MRI and (1)H-MRS of Wernicke\u2019s encephalopathy: Report of a case with remarkable cerebellar lesions on MRI","volume":"108","author":"Murata","year":"2001","journal-title":"Psychiatry Res."},{"key":"ref_111","first-page":"2301","article-title":"MR Imaging of nonalcoholic Wernicke encephalopathy: A follow-up study","volume":"26","author":"Zhong","year":"2005","journal-title":"Am. J. Neuroradiol."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1093\/alcalc\/agn103","article-title":"Neuroimaging of the Wernicke-Korsakoff Syndrome","volume":"44","author":"Sullivan","year":"2009","journal-title":"Alcohol Alcohol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.2214\/ajr.155.6.2122685","article-title":"Wernicke encephalopathy: MR findings in five patients","volume":"155","author":"Gallucci","year":"1990","journal-title":"Am. J. Roentgenol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1080\/09595239300185371","article-title":"Pathophysiologic mechanisms responsible for the reversible (thiamine-responsive) and irreversible (thiamine non-responsive) neurological symptoms of Wernicke\u2019s encephalopathy","volume":"12","author":"Butterworth","year":"1993","journal-title":"Drug Alcohol Rev."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.nutres.2008.03.002","article-title":"Small intestinal bacterial overgrowth and thiamine deficiency after Roux-en-Y gastric bypass surgery in obese patients","volume":"28","author":"Lakhani","year":"2008","journal-title":"Nutr. Res."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.psym.2012.04.008","article-title":"Wernicke-Korsakoff-Syndrome: Under-Recognized and Under-Treated","volume":"53","author":"Kutner","year":"2012","journal-title":"J. Psychosom. Res."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1024\/0300-9831.71.4.217","article-title":"The Thiamine Status of Adult Humans Depends on Carbohydrate Intake","volume":"71","author":"Elmadfa","year":"2001","journal-title":"Int. J. Vitam. Nutr. Res."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1177\/0148607107031004324","article-title":"Wernicke\u2019s Encephalopathy After Laparoscopic Cardiomyotomy for Achalasia","volume":"31","author":"Kennedy","year":"2007","journal-title":"J. Parenter. Enter. Nutr."},{"key":"ref_119","first-page":"549","article-title":"Metabolic disturbance after gastro-oesophageal resection","volume":"43","author":"Markkanen","year":"1973","journal-title":"Int. J. Vitam. Nutr. Res."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1136\/jnnp.71.3.357","article-title":"Postgastrectomy polyneuropathy with thiamine deficiency","volume":"71","author":"Koike","year":"2001","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1038\/bjc.1993.503","article-title":"Micronutrients in gastrointestinal cancer","volume":"68","author":"Georgiannos","year":"1993","journal-title":"Br. J. Cancer"},{"key":"ref_122","doi-asserted-by":"crossref","unstructured":"Gilliland, T., Villafane-Ferriol, N., Shah, K.P., Shah, R.M., Cao, H.S.T., Massarweh, N.N., Silberfein, E.J., Choi, E.A., Hsu, C., and McElhany, A.L. (2017). Nutritional and Metabolic Derangements in Pancreatic Cancer and Pancreatic Resection. Nutrients, 9.","DOI":"10.3390\/nu9030243"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1016\/j.surg.2018.05.040","article-title":"Nutritional support and therapy in pancreatic surgery: A position paper of the International Study Group on Pancreatic Surgery (ISGPS)","volume":"164","author":"Gianotti","year":"2018","journal-title":"Surgery"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"7267","DOI":"10.3748\/wjg.v19.i42.7267","article-title":"Nutrition in chronic pancreatitis","volume":"19","author":"Rasmussen","year":"2013","journal-title":"World J. Gastroenterol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1038\/s41430-020-0583-x","article-title":"Wernicke\u2019s encephalopathy, refeeding syndrome and wet beriberi after laparoscopic sleeve gastrectomy: The importance of thiamine evaluation","volume":"74","author":"Federico","year":"2020","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1177\/0884533614561793","article-title":"Malnutrition-Induced Wernicke\u2019s Encephalopathy Following a Water-Only Fasting Diet","volume":"30","author":"Hutcheon","year":"2014","journal-title":"Nutr. Clin. Pract."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"2843","DOI":"10.1007\/s11695-016-2227-8","article-title":"Rare Neurological Complications After Sleeve Gastrectomy","volume":"26","author":"Tabbara","year":"2016","journal-title":"Obes. Surg."},{"key":"ref_128","unstructured":"Institute of Medicine Standing Committee on the Scientific Evaluation of Dietary Reference Intakes and Its Panel on Folate, other Vitamin B, and Choline (1998). Dietary References Intakes for Thiamine, Riboflavin, Niacin, Vitamin B6, folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline, Food and Nutrition Board, National Academy Press."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1111\/jgh.12345","article-title":"Refeeding syndrome: Screening, incidence, and treatment during parenteral nutrition","volume":"28","author":"Walmsley","year":"2013","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"625782","DOI":"10.1155\/2010\/625782","article-title":"Nutritional Rehabilitation: Practical Guidelines for Refeeding the Anorectic Patient","volume":"2010","author":"Mehler","year":"2010","journal-title":"J. Nutr. Metab."},{"key":"ref_131","first-page":"472","article-title":"The refeeding syndrome. Importance of phosphorus","volume":"150","year":"2018","journal-title":"Med. Clin."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/12\/9\/2810\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T10:09:38Z","timestamp":1760177378000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/12\/9\/2810"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,13]]},"references-count":131,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2020,9]]}},"alternative-id":["nu12092810"],"URL":"https:\/\/doi.org\/10.3390\/nu12092810","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,13]]}}}