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We added the dietary supplement to the feed mixtures for laboratory animals. The possible toxicological effects and hypocholesterolemic, hepatoprotective activity of the dietary supplement in vivo were studied. After the observation period (6 weeks), no significant changes were found in the mass of organs and blood serum of laboratory animals (p &gt; 0.05). However, there was a decrease in hypercholesterolemic indicators. Regular consumption of sea buckthorn and rosehip oils with added chokeberry extract (dietary supplement \u201cESB-1\u201d) by laboratory animals inhibited the activity of liver enzymes and increased the antioxidant activity of blood serum (after the subcutaneous injection of sunflower oil\/oil solution of carbon tetrachloride) but was not sufficient to bring them to physiological standards. The hypocholesterolemic and antioxidant properties of our dietary supplement already allow us to consider it a component of functional food products or a dietary supplement base. However, the full range of its biologically active properties, including the hepatoprotective function and regulation of metabolic disorders, has not been studied yet, which sets the direction of further research in vivo models and clinical practice to confirm its effectiveness in humans.<\/jats:p>","DOI":"10.3390\/nu12102941","type":"journal-article","created":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T09:15:23Z","timestamp":1601025323000},"page":"2941","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Sea Buckthorn and Rosehip Oils with Chokeberry Extract to Prevent Hypercholesterolemia in Mice Caused by a High-Fat Diet In Vivo"],"prefix":"10.3390","volume":"12","author":[{"given":"Lubov","family":"Tereshchuk","sequence":"first","affiliation":[{"name":"Vegetable Food Technology Department, Kemerovo State University, Krasnaya Street 6, 650043 Kemerovo, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4012-7570","authenticated-orcid":false,"given":"Kseniya","family":"Starovoytova","sequence":"additional","affiliation":[{"name":"Vegetable Food Technology Department, Kemerovo State University, Krasnaya Street 6, 650043 Kemerovo, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4921-8997","authenticated-orcid":false,"given":"Olga","family":"Babich","sequence":"additional","affiliation":[{"name":"Institute of Living Systems, Immanuel Kant Baltic Federal University, A. Nevskogo Street 14, 236016 Kaliningrad, Russia"},{"name":"Single Center of Collective Use, Innovation Park, Immanuel Kant Baltic Federal University, A. Nevskogo Street 14, 236016 Kaliningrad, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lyubov","family":"Dyshlyuk","sequence":"additional","affiliation":[{"name":"Natural Nutraceutical Biotesting Laboratory, Kemerovo State University, Krasnaya Street 6, 650043 Kemerovo, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1686-0131","authenticated-orcid":false,"given":"Irina","family":"Sergeeva","sequence":"additional","affiliation":[{"name":"Vegetable Food Technology Department, Kemerovo State University, Krasnaya Street 6, 650043 Kemerovo, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9460-7126","authenticated-orcid":false,"given":"Valery","family":"Pavsky","sequence":"additional","affiliation":[{"name":"Department of General Mathematics and Informatics, Kemerovo State University, Krasnaya Street, 6, 650043 Kemerovo, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1252-9572","authenticated-orcid":false,"given":"Svetlana","family":"Ivanova","sequence":"additional","affiliation":[{"name":"Natural Nutraceutical Biotesting Laboratory, Kemerovo State University, Krasnaya Street 6, 650043 Kemerovo, Russia"},{"name":"Department of General Mathematics and Informatics, Kemerovo State University, Krasnaya Street, 6, 650043 Kemerovo, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5630-3196","authenticated-orcid":false,"given":"Alexander","family":"Prosekov","sequence":"additional","affiliation":[{"name":"Laboratory of Biocatalysis, Kemerovo State University, Krasnaya Street 6, 650043 Kemerovo, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,9,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.nut.2018.11.015","article-title":"Trimethylamine N-oxide, Mediterranean diet, and nutrition in healthy, normal-weight adults: Also a matter of sex?","volume":"62","author":"Barrea","year":"2019","journal-title":"Nutrition"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2795","DOI":"10.1016\/j.dsx.2019.07.019","article-title":"Adherence to a healthy plant diet may reduce inflammatory factors in obese and overweight women-a cross-sectional study","volume":"13","author":"Bolori","year":"2019","journal-title":"Diabetes Metab. Syndr."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.ijcard.2019.07.102","article-title":"Healthy diet reduces markers of cardiac injury and inflammation regardless of macronutrients: Results from the OmniHeart trial","volume":"299","author":"Kovell","year":"2020","journal-title":"Int. J. Cardiol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/S0955-2863(02)00179-1","article-title":"Effects of an antioxidant-rich juice (sea buckthorn) on risk factors for coronary heart disease in humans","volume":"13","author":"Eccleston","year":"2002","journal-title":"J. Nutr. Biochem."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/j.jff.2015.06.018","article-title":"Phenolics and polyphenolics in foods, beverages and spices: Antioxidant activity and health effects\u2014A review","volume":"18","author":"Shahidi","year":"2015","journal-title":"J. Funct. Foods"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.jff.2019.04.008","article-title":"Sustainable production of natural phenolics for functional food applications","volume":"57","author":"Mark","year":"2019","journal-title":"J. Funct. Food"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1016\/j.jff.2013.04.014","article-title":"Functional food ingredients for the management of obesity and associated co-morbidities\u2014A review","volume":"5","author":"Baboota","year":"2013","journal-title":"J. Funct. Foods"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"162750","DOI":"10.1155\/2013\/162750","article-title":"Chemistry and biological activities of flavonoids: An overview","volume":"2013","author":"Kumar","year":"2013","journal-title":"Sci. World J."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Soto-Hernandez, M., Palma-Tenango, M., and Garcia-Mateos, R. (2017). Health benefits of phenolic compounds against cancers. Phenolic Compounds\u2014Biological Activity, InTech. Chapter 10.","DOI":"10.5772\/63693"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.plefa.2018.05.003","article-title":"Dietary n-6 polyunsaturated fatty acids and cardiovascular disease: Epidemiologic evidence","volume":"135","author":"Wang","year":"2015","journal-title":"Prostaglandins Leukot. Essent. Fatty Acids"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.niox.2018.03.016","article-title":"Nitrated fatty acids in cardiovascular diseases","volume":"78","author":"Mollenhauer","year":"2018","journal-title":"Nitric Oxide"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"3545","DOI":"10.1002\/jsfa.6243","article-title":"Carotenoids, vitamins (A, B2, C and E) and total folate of traditional foods from Black Sea Area countries","volume":"93","author":"Albuquerque","year":"2013","journal-title":"J. Sci. Food Agric."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.tifs.2019.02.010","article-title":"Pomegranate and grape by-products and their active compounds: Are they a valuable source for food applications?","volume":"86","author":"Andrade","year":"2019","journal-title":"Trends Food Sci. Technol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"e03288","DOI":"10.1016\/j.heliyon.2020.e03288","article-title":"The effect of postharvest ultraviolet irradiation on the content of antioxidant compounds and the activity of antioxidant enzymes in tomato","volume":"6","author":"Babich","year":"2020","journal-title":"Heliyon"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.fitote.2017.09.015","article-title":"Marine OMEGA-3 fatty acids in the prevention of cardiovascular disease","volume":"123","author":"Mori","year":"2017","journal-title":"Fitoterapia"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3233\/CH-2009-1148","article-title":"Effects of a herbal medicine, Hippophae rhamnoides, on cardiovascular functions and coronary microvessels in the spontaneously hypertensive stroke-prone rat","volume":"41","author":"Koyama","year":"2009","journal-title":"Clin. Hemorheol. Microcirc."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s00394-009-0011-4","article-title":"Effect of a low dose of sea buckthorn berries on circulating concentrations of cholesterol, triacylglycerols, and flavonoids in healthy adults","volume":"48","author":"Larmo","year":"2009","journal-title":"Eur. J. Nutr."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.jep.2017.11.022","article-title":"The beneficial health aspects of sea buckthorn (Elaeagnus rhamnoides (L.) A. Nelson) oil","volume":"213","author":"Olas","year":"2018","journal-title":"J. Ethnopharmacol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.fct.2006.10.008","article-title":"Adaptogenic and safety evaluation of sea buckthorn (Hippophae rhamnoides) leaf extract: A dose dependent study","volume":"45","author":"Saggu","year":"2007","journal-title":"Food Chem. Toxicol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1016\/j.fct.2009.02.002","article-title":"Safety and healing efficacy of sea buckthorn (Hippophae rhamnoides L.) seed oil on burn wounds in rats","volume":"47","author":"Upadhyay","year":"2009","journal-title":"Food Chem. Toxicol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2483","DOI":"10.1016\/j.fct.2010.06.018","article-title":"Ninety day repeated gavage administration of Hippophae rhamnoides extract in rats","volume":"48","author":"Tulsawani","year":"2010","journal-title":"Food Chem. Toxicol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.jff.2011.01.001","article-title":"Health benefits of sea buckthorn for the prevention of cardiovascular diseases","volume":"3","author":"Xu","year":"2011","journal-title":"J. Funct. Foods"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"gmr.15038278","DOI":"10.4238\/gmr.15038278","article-title":"Characterization and identification of ISSR markers associated with oil content in sea buckthorn berries","volume":"15","author":"Ding","year":"2016","journal-title":"Genet. Mol. Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"69","DOI":"10.5923\/j.fph.20120203.02","article-title":"Hippophae rhamnoides L. (Sea buckthorn): A potential source of nutraceuticals","volume":"2","author":"Christaki","year":"2012","journal-title":"Food Public Health"},{"key":"ref_25","first-page":"32","article-title":"Anticarcinogenic potential of lipids from hippophae\u2014Evidence from the recent literature","volume":"7","author":"Zeb","year":"2006","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"491","DOI":"10.3923\/rjmp.2011.491.499","article-title":"Phytochemical and pharmacological profile of seabuckthorn oil: A review","volume":"5","author":"Kumar","year":"2011","journal-title":"Res. J. Med. Plant"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/S0955-2863(00)00088-7","article-title":"Effect of dietary supplementation with sea buckthorn (Hippopha\u00eb rhamnoides) seed and pulp oils on the fatty acid composition of skin glycerophospholipids of patients with atopic dermatitis","volume":"11","author":"Yang","year":"2000","journal-title":"J. Nutr. Biochem."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"4120","DOI":"10.1021\/acs.jafc.5b00564","article-title":"Analysis of lipophilic and hydrophilic bioactive compounds content in sea buckthorn (Hippophae rhamnoids L.) berries","volume":"63","author":"Teleszko","year":"2015","journal-title":"J. Agric. Food Chem."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Wang, Y., Zhao, L., Huo, Y., Zhou, F., Wu, W., Lu, F., Yang, X., Guo, X., Chen, P., and Deng, Q. (2016). Protective effect of proanthocyanidins from sea buckthorn (Hippophae rhamnoides L.) seed against visible light-induced retinal degeneration in vivo. Nutrients, 8.","DOI":"10.3390\/nu8050245"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.fct.2016.09.008","article-title":"Sea buckthorn as a source of important bioactive compounds in cardiovascular diseases","volume":"97","author":"Olas","year":"2016","journal-title":"Food Chem. Toxicol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.foodchem.2009.10.016","article-title":"Strawberry tree, blackthorn and rose fruits: Detailed characterization in nutrients and phytochemicals with antioxidant properties","volume":"120","author":"Barros","year":"2010","journal-title":"Food Chem."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.lwt.2013.12.038","article-title":"Evaluation of volatiles, phenolic compounds and antioxidant activities of rosehip (Rosa L.) fruits in Turkey","volume":"57","author":"Demir","year":"2014","journal-title":"LWT-Food Sci. Technol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.supflu.2016.08.011","article-title":"Oil recovery in rosehip seeds from food plant waste products using supercritical CO2 extraction","volume":"118","author":"Ekici","year":"2016","journal-title":"J. Supercrit. Fluids"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.foodchem.2015.05.034","article-title":"Characteristics of rose hip (Rosa canina L.) cold pressed oil and its oxidative stability studied by the differential scanning calorimetry method","volume":"188","author":"Grajer","year":"2015","journal-title":"Food Chem."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/j.foodchem.2015.07.089","article-title":"Comparative study of biological activities and phytochemical composition of two rose hips and their preserves: Rosa canina L. and Rosa arvensis Huds","volume":"192","author":"Nadpal","year":"2016","journal-title":"Food Chem."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.1016\/S1063-4584(08)60003-5","article-title":"Laboratory and preclinical studies on the anti-inflammatory and anti-oxidant properties of rosehip powder-identification and characterization of the active component GOPO\u00ae","volume":"16","author":"Kharazmi","year":"2008","journal-title":"Osteoarthr. Cartil."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.jfda.2016.12.019","article-title":"Assessment of rosehips based on the content of their biologically active compounds","volume":"25","author":"Bhave","year":"2017","journal-title":"J. Food Drug Anal."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1093\/oxfordjournals.aje.a009327","article-title":"Lycopene and myocardial infraction risk in the EURAMIC study","volume":"146","author":"Kohlmeier","year":"1997","journal-title":"Am. J. Epidemiol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1093\/jnci\/91.4.317","article-title":"Tomatoes, tomato-based products, lycopene, and cancer: Review of the epidemiologic literature","volume":"91","author":"Giovannucci","year":"1999","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/S0098-2997(03)00034-7","article-title":"Rosehip\u2014A \u201cnew\u201d source of lycopene?","volume":"24","author":"Bitsch","year":"2003","journal-title":"Mol. Aspects Med."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"100235","DOI":"10.1016\/j.hermed.2018.09.006","article-title":"A clinical review of the effectiveness of tomato (Solanum lycopersicum) against cardiovascular dysfunction and related metabolic syndrome","volume":"16","author":"Alam","year":"2019","journal-title":"J. Herb. Med."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"110564","DOI":"10.31883\/pjfns\/110564","article-title":"Effects of Biopreservatives Combined with Modified Atmosphere Packaging on the Quality of Apples and Tomatoes","volume":"69","author":"Babich","year":"2019","journal-title":"Pol. J. Food Nutr. Sci."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1002\/ptr.2400","article-title":"A systematic review on the Rosa canina effect and efficacy profiles","volume":"22","author":"Chrubasik","year":"2008","journal-title":"Phytother. Res."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1016\/j.phymed.2008.06.012","article-title":"Phytochemical composition and in vivo pharmacological activity of two rose hip (Rosa canina L.) preparations","volume":"15","author":"Wenzig","year":"2008","journal-title":"Phytomedicine"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s11130-010-0159-3","article-title":"Six edible wild fruits as potential antioxidant additives or nutritional supplements","volume":"65","author":"Ege","year":"2010","journal-title":"Plant. Foods Hum. Nutr."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.1016\/j.foodres.2010.10.005","article-title":"Exotic fruits as a source of important phytochemicals: Improving the traditional use of Rosa canina fruits in Portugal","volume":"44","author":"Barros","year":"2011","journal-title":"Food Res. Int."},{"key":"ref_47","first-page":"1273","article-title":"Effect of rosehip (Rosa canina L.) phytochemicals on stable free radicals and human cancer cells","volume":"92","author":"Tumbas","year":"2012","journal-title":"J. Food Compost. Anal."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s11130-013-0394-5","article-title":"Bioactivity of different enriched phenolic extracts of wild fruits from northeastern Portugal: A comparative study","volume":"69","author":"Guimaraes","year":"2014","journal-title":"Plant Foods Hum. Nutr."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Oszmia\u0144ski, J., and Lachowicz, S. (2016). Effect of the production of dried fruits and juice from chokeberry (Aronia melanocarpa L.) on the content and antioxidative activity of bioactive compounds. Molecules, 21.","DOI":"10.3390\/molecules21081098"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1515\/pjfns-2016-0009","article-title":"Effects of weather conditions on phenolic content and antioxidant capacity in juice of chokeberries (Aronia melanocarpa L.)","volume":"67","year":"2017","journal-title":"Polish J. Food Nutr. Sci."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1002\/ptr.3226","article-title":"The clinical effectiveness of chokeberry: A systematic review","volume":"24","author":"Chrubasik","year":"2010","journal-title":"Phytother. Res."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.tifs.2019.05.006","article-title":"Black chokeberry (Aronia melanocarpa) and its products as potential health-promoting factors\u2014An overview","volume":"89","author":"Sidor","year":"2019","journal-title":"Trends Food Sci. Technol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"e02245","DOI":"10.1016\/j.heliyon.2019.e02245","article-title":"Identification and quantification of phenolic compounds of Western Siberia Astragalus danicus in different regions","volume":"5","author":"Babich","year":"2019","journal-title":"Heliyon"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.sajb.2019.07.043","article-title":"Genotoxic and antigenotoxic potential of herbal mixture and five medicinal plants used in ethnopharmacology","volume":"125","year":"2019","journal-title":"S. Afr. J. Bot."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.bcdf.2017.09.001","article-title":"In vivo study of medical and biological properties of functional bakery products with the addition of pumpkin flour","volume":"12","author":"Dyshlyuk","year":"2017","journal-title":"Bioact. Carbohydr. Diet. Fibre"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"100185","DOI":"10.1016\/j.bcdf.2019.100185","article-title":"In vivo study of the potential of the carbohydrate-mineral complex from pine nut shells as an ingredient of functional food products","volume":"18","author":"Babich","year":"2019","journal-title":"Bioact. Carbohydr. Diet. Fibre"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1093\/clinchem\/20.4.470","article-title":"Enzymatic determination of total serum cholesterol","volume":"20","author":"Allain","year":"1974","journal-title":"Clin. Chem."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","article-title":"Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction","volume":"95","author":"Ohkawa","year":"1979","journal-title":"Anal. Biochem."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/0009-3084(87)90071-5","article-title":"Lipid Peroxides and Human Diseases","volume":"45","author":"Yagi","year":"1987","journal-title":"Chem. Phys. Lipids"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/S0891-5849(96)00351-6","article-title":"Antioxidant and prooxidant behavior of flavonoids: Structure-activity relation ships","volume":"22","author":"Cao","year":"1997","journal-title":"Free Radic. Biol. Med."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"67","DOI":"10.12737\/2058","article-title":"Aspects of production of functional emulsion foods","volume":"1","author":"Tereshchuk","year":"2013","journal-title":"Foods Raw Mater."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1134\/S0040579514040198","article-title":"Stochastic modeling of protein solution foaming process","volume":"48","author":"Ivanova","year":"2014","journal-title":"Theor. Found. Chem. Eng."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"264","DOI":"10.21603\/2308-4057-2018-2-264-280","article-title":"Prospects for using pine nut products in the dairy industry","volume":"6","author":"Dyshlyuk","year":"2018","journal-title":"Food Raw Mater."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.fbio.2018.05.003","article-title":"Functional properties of the enzyme-modified protein from oat bran","volume":"24","author":"Prosekov","year":"2018","journal-title":"Food Biosci."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Terechuk, L., Starovoytova, K., Ivanova, S., and Sergeeva, I. (2019, January 20\u201321). Obtaining Functional Products from Sea Buckthorn Berries. Proceedings of the 2nd International Conference on Education Science and Social Development, 2019 (ESSD 2019), Changsha, China.","DOI":"10.2991\/essd-19.2019.90"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"170","DOI":"10.21603\/2308-4057-2017-2-170-177","article-title":"The potential of pine nut as a component of sport nutrition","volume":"5","author":"Babich","year":"2017","journal-title":"Foods Raw Mater."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"136","DOI":"10.21603\/2308-4057-2018-1-136-143","article-title":"Study of the biofunctional properties of cedar pine oil with the use of testing cultures","volume":"6","author":"Prosekov","year":"2018","journal-title":"Food Raw Mater."},{"key":"ref_68","unstructured":"(1981). OECD Guidelines for Testing of Chemicals, Organisation for Economic Co-operation and Development. Available online: http:\/\/www.oecd.org\/department\/0,3355,en_2649_34377_1_1_1_1_1,00.html."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.msec.2016.03.087","article-title":"Phyto-mediated nanostructured carriers based on dual vegetable actives involved in the prevention of cellular damage","volume":"64","author":"Istrati","year":"2016","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_70","first-page":"4606","article-title":"The effect of medicinal plants and plant extracted oils on broiler duodenum morphology and immunological profile","volume":"14","author":"Lavinia","year":"2009","journal-title":"Rom. Biotechnol. Let."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.tifs.2017.03.001","article-title":"Rose hip as an underutilized functional food: Evidence-based review","volume":"63","author":"Patel","year":"2017","journal-title":"Trends Food Sci. Technol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1016\/j.phymed.2007.03.018","article-title":"Anti-atherogenic effects of sea buckthorn (Hippophaea rhamnoides) seed oil","volume":"14","author":"Basu","year":"2007","journal-title":"Phytomedicine"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1016\/j.fct.2009.06.015","article-title":"Protective effects of seabuckthorn (Hippophae rhamnoides L.) seed oil against carbon tertrachloride-induced hepatotoxicity in mice","volume":"47","author":"Hsu","year":"2009","journal-title":"Food Chem. Toxicol."},{"key":"ref_74","first-page":"175","article-title":"The antioxidant activity and hypolipidemic activity of the total flavonoids from the fruit of Rosa laevigata Michx","volume":"2","author":"Liu","year":"2010","journal-title":"Nat. Sci."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"3133","DOI":"10.1016\/j.fct.2012.06.047","article-title":"Total flavonoids from Rosa Laevigata Michx fruit attenuates hydrogen peroxide induced injury in human umbilical vein endothelial cells","volume":"50","author":"Jia","year":"2012","journal-title":"Food Chem. Toxicol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.fct.2012.12.041","article-title":"Protection of the flavonoid fraction from Rosa laevigata Michx fruit against carbon tetrachloride-induced acute liver injury in mice","volume":"55","author":"Zhang","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.foodchem.2019.01.108","article-title":"Black chokeberry (Aronia melanocarpa) polyphenols reveal different antioxidant, antimicrobial and neutrophil-modulating activities","volume":"284","author":"Denev","year":"2019","journal-title":"Food Chem."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.etp.2004.04.012","article-title":"Hepatoprotective effect of the natural fruit juice from Aronia melanocarpa on carbon tetrachloride-induced acute liver damage in rats","volume":"56","author":"Borisova","year":"2004","journal-title":"Exp. Toxicol. Pathol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1016\/j.jnutbio.2011.06.004","article-title":"Prevention of liver ischemia reperfusion injury by a combined thyroid hormone and fish oil protocol","volume":"23","author":"Mardones","year":"2012","journal-title":"J. Nutr. Biochem."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1039\/C7FO00090A","article-title":"Molecular adaptations underlying the beneficial effects of hydroxytyrosol in the pathogenic alterations induced by a high-fat diet in mouse liver: PPAR-\u03b1 and Nrf2 activation, and NF-\u03baB down-regulation","volume":"8","author":"Valenzuela","year":"2017","journal-title":"Food Funct."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1700479","DOI":"10.1002\/mnfr.201700479","article-title":"Supplementation with Docosahexaenoic Acid and Extra Virgin Olive Oil Prevents Liver Steatosis Induced by a High-Fat Diet in Mice through PPAR-\u03b1 and Nrf2 Upregulation with Concomitant SREBP-1c and NF-kB Downregulation","volume":"61","author":"Valenzuela","year":"2017","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"2472","DOI":"10.1016\/j.biopha.2018.11.120","article-title":"Hydroxytyrosol supplementation ameliorates the metabolic disturbances in white adipose tissue from mice fed a high-fat diet through recovery of transcription factors Nrf2, SREBP-1c, PPAR-\u03b3 and NF-\u03baB","volume":"109","author":"Illesca","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1002\/biof.1556","article-title":"Docosahexaenoic acid and hydroxytyrosol co-administration fully prevents liver steatosis and related parameters in mice subjected to high-fat diet: A molecular approach","volume":"45","author":"Ortiz","year":"2019","journal-title":"BioFactors"}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/12\/10\/2941\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T10:13:35Z","timestamp":1760177615000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/12\/10\/2941"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,25]]},"references-count":83,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2020,10]]}},"alternative-id":["nu12102941"],"URL":"https:\/\/doi.org\/10.3390\/nu12102941","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,25]]}}}