{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T09:36:09Z","timestamp":1790501769103,"version":"4.1.0"},"reference-count":50,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2020,9,28]],"date-time":"2020-09-28T00:00:00Z","timestamp":1601251200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background: The current study aimed to test whether food addiction (FA) might mediate the relationship between the presence of a history of childhood maltreatment and eating disorder (ED) symptom severity. Methods: Participants were 231 patients with ED presenting between May 2017 and January 2020 to a daycare treatment facility for assessment and management with mainly the Eating Disorder Inventory-2 (EDI-2), the Child Trauma Questionnaire (CTQ), and the Yale Food Addiction Scale (YFAS 2.0). Results: Participants had a median age of 24 (interquartile range (IQR) 20\u201333) years and manifested anorexia nervosa (61.47%), bulimia nervosa (16.88%), binge-eating disorders (9.09%), and other types of ED (12.55%). They were grouped into those likely presenting FA (N = 154) and those without FA (N = 77). The group with FA reported higher scores on all five CTQ subscales, as well as the total score of the EDI-2 (p &lt; 0.001). Using mediation analysis; significant indirect pathways between all CTQ subscales and the EDI-2 total score emerged via FA, with the largest indirect effect emerging for physical neglect (standardized effect = 0.208; 95% confidence interval (CI) 0.127\u20130.29) followed by emotional abuse (standardized effect = 0.183; 95% CI 0.109\u20130.262). Conclusion: These results are compatible with a model in which certain types of childhood maltreatment, especially physical neglect, may induce, maintain, and\/or exacerbate ED symptoms via FA which may guide future treatments.<\/jats:p>","DOI":"10.3390\/nu12102969","type":"journal-article","created":{"date-parts":[[2020,9,28]],"date-time":"2020-09-28T10:39:58Z","timestamp":1601289598000},"page":"2969","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["The Impact of Retrospective Childhood Maltreatment on Eating Disorders as Mediated by Food Addiction: A Cross-Sectional Study"],"prefix":"10.3390","volume":"12","author":[{"given":"Rami","family":"Bou Khalil","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Saint Joseph University-H\u00f4tel Dieu de France Hospital, Beirut BP 166830, Lebanon"},{"name":"PSNREC, University of Montpellier, INSERM, CHU de Montpellier, 34295 Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8490-6958","authenticated-orcid":false,"given":"Ghassan","family":"Sleilaty","sequence":"additional","affiliation":[{"name":"Clincal Research Center and Department of Cardiac and Thoracic Surgery, Saint Joseph University-H\u00f4tel Dieu de France Hospital, Beirut BP 166830, Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sami","family":"Richa","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Saint Joseph University-H\u00f4tel Dieu de France Hospital, Beirut BP 166830, Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maude","family":"Seneque","sequence":"additional","affiliation":[{"name":"PSNREC, University of Montpellier, INSERM, CHU de Montpellier, 34295 Montpellier, France"},{"name":"Department of Psychiatric Emergency and Acute Care, Lapeyronie Hospital, CHRU, 34295 Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0054-1865","authenticated-orcid":false,"given":"Sylvain","family":"Iceta","sequence":"additional","affiliation":[{"name":"Quebec Heart and Lung Institute (IUCPQ), Qu\u00e9bec, QC G1V 4G5, Canada"},{"name":"School of Nutrition, Laval University, Qu\u00e9bec, QC G1V 0A6, Canada"},{"name":"Referral Center for Eating Disorder, Hospices Civils de Lyon, F-69677 Bron, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Rodgers","sequence":"additional","affiliation":[{"name":"Department of Psychiatric Emergency and Acute Care, Lapeyronie Hospital, CHRU, 34295 Montpellier, France"},{"name":"APPEAR, Department of Applied Psychology, Northeastern University, Boston, MA 02115, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0633-2810","authenticated-orcid":false,"given":"Adrian","family":"Alacreu-Crespo","sequence":"additional","affiliation":[{"name":"PSNREC, University of Montpellier, INSERM, CHU de Montpellier, 34295 Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Maimoun","sequence":"additional","affiliation":[{"name":"PhyMedExp, University of Montpellier, INSERM, CNRS, 34295 Montpellier, France"},{"name":"D\u00e9partement de M\u00e9decine Nucl\u00e9aire, H\u00f4pital Lapeyronie, Centre Hospitalier R\u00e9gional Universitaire (CHRU) Montpellier, 34295 Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Lefebvre","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Diabetes, and Nutrition, CHRU, 34295 Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3407-7263","authenticated-orcid":false,"given":"Eric","family":"Renard","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Diabetes, and Nutrition, CHRU, 34295 Montpellier, France"},{"name":"UMR CNRS 5203, INSERM U1191, Institute of Functional Genomics, University of Montpellier, 34295 Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Courtet","sequence":"additional","affiliation":[{"name":"PSNREC, University of Montpellier, INSERM, CHU de Montpellier, 34295 Montpellier, France"},{"name":"Department of Psychiatric Emergency and Acute Care, Lapeyronie Hospital, CHRU, 34295 Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6769-9982","authenticated-orcid":false,"given":"Sebastien","family":"Guillaume","sequence":"additional","affiliation":[{"name":"PSNREC, University of Montpellier, INSERM, CHU de Montpellier, 34295 Montpellier, France"},{"name":"Department of Psychiatric Emergency and Acute Care, Lapeyronie Hospital, CHRU, 34295 Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,9,28]]},"reference":[{"key":"ref_1","unstructured":"(2020, September 16). Child Maltreatment. Available online: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/child-maltreatment#:~:text=Child%20maltreatment%20is%20the%20abuse,under%2018%20years%20of%20age."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/S0140-6736(09)61748-7","article-title":"Eating disorders","volume":"375","author":"Treasure","year":"2010","journal-title":"Lancet"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1097\/PSY.0000000000000233","article-title":"Disentangling the association between child abuse and eating disorders: A systematic review and meta-analysis","volume":"78","author":"Caslini","year":"2016","journal-title":"Psychosom. Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/S0033291716003561","article-title":"Childhood maltreatment and eating disorder pathology: A systematic review and dose-response meta-analysis","volume":"47","author":"Molendijk","year":"2017","journal-title":"Psychol. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"3576","DOI":"10.1038\/srep35761","article-title":"Associations between adverse childhood experiences and clinical characteristics of eating disorders","volume":"6","author":"Guillaume","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1097\/YCO.0000000000000545","article-title":"Eating disorders and posttraumatic stress disorder","volume":"32","author":"Rijkers","year":"2019","journal-title":"Curr. Opin. Psychiatry"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1002\/eat.22364","article-title":"Emotion dysregulation and anorexia nervosa: An exploration of the role of childhood abuse","volume":"48","author":"Racine","year":"2015","journal-title":"Intern. J. Eat. Dis."},{"key":"ref_8","first-page":"e5318","article-title":"Exploring the link between emotional child abuse and anorexia nervosa: A psychopathological correlation","volume":"11","author":"Rai","year":"2019","journal-title":"Cureus"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1111\/j.1365-2702.2008.02740.x","article-title":"Childhood trauma as a predictor of eating psychopathology and its mediating variables in patients with eating disorders","volume":"18","author":"Kong","year":"2009","journal-title":"J. Clin. Nurs."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/s40519-016-0355-8","article-title":"Food addiction as a proxy for eating disorder and obesity severity, trauma history, PTSD symptoms, and comorbidity","volume":"22","author":"Brewerton","year":"2017","journal-title":"Eat. Weight Disord."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Gordon, E.L., Ariel-Donges, A.H., Bauman, V., and Merlo, L.J. (2018). What is the evidence for \u2018food addiction?\u2019 A systematic review. Nutrients, 10.","DOI":"10.3390\/nu10040477"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Fauconnier, M., Rousselet, M., Brunault, P., Thiabaud, E., Lambert, S., Rocher, B., Challet-Bouju, G., and Grall-Bronnec, M. (2020). Food addiction among female patients seeking treatment for an eating disorder: Prevalence and associated factors. Nutrients, 12.","DOI":"10.3390\/nu12061897"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1001\/jamapsychiatry.2014.1208","article-title":"Posttraumatic stress disorder symptoms and food addiction in women by timing and type of trauma exposure","volume":"71","author":"Mason","year":"2014","journal-title":"JAMA Psychiatry"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1002\/erv.2646","article-title":"Associations of food addiction and nonsuicidal self-injury among women with an eating disorder: A common strategy for regulating emotions?","volume":"26","author":"Carlson","year":"2018","journal-title":"Eur. Eat. Disord. Rev."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.appet.2017.09.026","article-title":"Food addiction and substance addiction in women: Common clinical characteristics","volume":"120","author":"Hardy","year":"2018","journal-title":"Appetite"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1111\/adb.12162","article-title":"Effects of childhood maltreatment on the neural correlates of stress- and drug cue-induced cocaine craving","volume":"20","author":"Elton","year":"2015","journal-title":"Addict. Biol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1001\/jamapsychiatry.2014.680","article-title":"Childhood maltreatment, altered limbic neurobiology, and substance use relapse severity via trauma-specific reductions in limbic gray matter volume","volume":"71","author":"Rando","year":"2014","journal-title":"JAMA Psychiatry"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1002\/1098-108X(198321)2:2<15::AID-EAT2260020203>3.0.CO;2-6","article-title":"Development and validation of a multidimensional eating disorder inventory for anorexia nervosa and bulimia","volume":"2","author":"Garner","year":"1983","journal-title":"Intern. J. Eat. Disord."},{"key":"ref_19","unstructured":"Guelfi, J.D., Gaillac, V., and Dardennes, R. (1995). Le \u2018Eating Disorder Inventory\u2019 (EDI), Psychopathologie Quantitative."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1002\/erv.2472","article-title":"Enduring changes in decision making in patients with full remission from anorexia nervosa","volume":"24","author":"Steward","year":"2016","journal-title":"Eur. Eat. Disord. Rev."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1037\/adb0000136","article-title":"Development of the yale food addiction scale Version 2.0","volume":"30","author":"Gearhardt","year":"2016","journal-title":"Psychol. Addict. Behav."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1177\/070674371405900507","article-title":"Validation of the French version of the yale food addiction scale: An examination of its factor structure, reliability, and construct validity in a nonclinical sample","volume":"59","author":"Brunault","year":"2014","journal-title":"Can. J. Psychiatry"},{"key":"ref_23","unstructured":"Bernstein, D.P., and Fink, L. (1998). Childhood Trauma Questionnaire: A Retrospective Self-Report, Psychological Corporation."},{"key":"ref_24","unstructured":"Hayes, A.F. (2013). Introduction to Mediation, Moderation, and Conditional Process Analysis, Guildford Press."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.chiabu.2016.06.023","article-title":"Childhood trauma in obese and overweight women with food addiction and clinical-level of binge eating","volume":"58","author":"Imperatori","year":"2016","journal-title":"Child. Abuse. Negl."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"104317","DOI":"10.1016\/j.appet.2019.104317","article-title":"Associations of childhood trauma with food addiction and insulin resistance in African-American women with diabetes mellitus","volume":"141","author":"Stojek","year":"2019","journal-title":"Appetite"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.biopsycho.2017.05.001","article-title":"Role of addiction and stress neurobiology on food intake and obesity","volume":"131","author":"Sinha","year":"2018","journal-title":"Biol. Psychol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"4552","DOI":"10.3390\/nu6104552","article-title":"The prevalence of food addiction as assessed by the Yale Food Addiction Scale: A systematic review","volume":"6","author":"Pursey","year":"2014","journal-title":"Nutrients"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/s40519-016-0344-y","article-title":"Incorporating food addiction into disordered eating: The disordered eating food addiction nutrition guide (DEFANG)","volume":"22","author":"Wiss","year":"2017","journal-title":"Eat. Weight Disord."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1002\/erv.2306","article-title":"Food addiction and bulimia nervosa","volume":"22","author":"Meule","year":"2014","journal-title":"Eur. Eat. Disord. Rev."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1002\/erv.2470","article-title":"Food addiction and bulimia nervosa: New data based on the yale food addiction scale 2.0","volume":"24","author":"Meule","year":"2016","journal-title":"Eur. Eat. Disord. Rev."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Jim\u00e9nez-Murcia, S., Ag\u00fcera, Z., Paslakis, G., Munguia, L., Granero, R., S\u00e1nchez-Gonz\u00e1lez, J., S\u00e1nchez, I., Riesco, N., Gearhardt, A.N., and Dieguez, C. (2019). Food addiction in eating disorders and obesity: Analysis of clusters and implications for treatment. Nutrients, 11.","DOI":"10.3390\/nu11112633"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.appet.2016.10.022","article-title":"Reward sensitivity and food addiction in women","volume":"115","author":"Loxton","year":"2017","journal-title":"Appetite"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"2747","DOI":"10.1002\/hbm.24557","article-title":"Neuroanatomical correlates of food addiction symptoms and body mass index in the general population","volume":"40","author":"Beyer","year":"2019","journal-title":"Hum. Brain. Mapp."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1002\/osp4.362","article-title":"History of early life adversity is associated with increased food addiction and sex-specific alterations in reward network connectivity in obesity","volume":"5","author":"Osadchiy","year":"2019","journal-title":"Obes. Sci. Pract."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.psychres.2016.06.013","article-title":"PTSD, food addiction, and disordered eating in a sample of primarily older veterans: The mediating role of emotion regulation","volume":"243","author":"Mitchell","year":"2016","journal-title":"Psychiatry Res."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Wenzel, K.R., Weinstock, J., and McGrath, A.B. (2020). The clinical significance of food addiction. J. Addict. Med.","DOI":"10.1097\/ADM.0000000000000626"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/bs.irn.2016.06.003","article-title":"Psychological and neurobiological correlates of food addiction","volume":"129","author":"Kalon","year":"2016","journal-title":"Int. Rev. Neurobiol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"104586","DOI":"10.1016\/j.appet.2020.104586","article-title":"Overeating and food addiction in Major Depressive Disorder: Links to peripheral dopamine","volume":"148","author":"Mills","year":"2020","journal-title":"Appetite"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.eurpsy.2019.08.002","article-title":"The association between childhood maltreatment and eating disorder psychopathology: A mixed-model investigation","volume":"61","author":"Monteleone","year":"2019","journal-title":"Eur. Psychiatry"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"104171","DOI":"10.1016\/j.chiabu.2019.104171","article-title":"Associations between childhood maltreatment latent classes and eating disorder symptoms in a nationally representative sample of young adults in the United States","volume":"98","author":"Hazzard","year":"2019","journal-title":"Child Abuse. Negl."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.chiabu.2011.08.005","article-title":"Deficits in emotion regulation mediate the relationship between childhood abuse and later eating disorder symptoms","volume":"36","author":"Burns","year":"2012","journal-title":"Child Abuse. Negl."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1034\/j.1600-0447.2002.02303.x","article-title":"Childhood maltreatment and personality disorders in adult patients with binge eating disorder","volume":"106","author":"Grilo","year":"2002","journal-title":"Acta. Psychiatr. Scand."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.jaac.2018.06.007","article-title":"Child abuse and neglect","volume":"57","author":"Zeanah","year":"2018","journal-title":"J. Am. Acad. Child Adolesc. Psychiatry"},{"key":"ref_45","first-page":"449","article-title":"Maturation of the adolescent brain","volume":"9","author":"Arain","year":"2013","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Rodenburg, G., Kremers, S.P., Oenema, A., and van de Mheen, D. (2012). Associations of children\u2019s appetitive traits with weight and dietary behaviours in the context of general parenting. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0050642"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.appet.2018.06.034","article-title":"The relationship between trauma and weight status among adolescents in eating disorder treatment","volume":"129","author":"Pratt","year":"2018","journal-title":"Appetite"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1037\/abn0000470","article-title":"Structural differences in eating disorder psychopathology after history of childhood abuse: Insights from a Bayesian network analysis","volume":"128","author":"Rodgers","year":"2019","journal-title":"J. Abnorm. Psychol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1521\/ijgp.2015.65.3.386","article-title":"A substance called food: Long-term psychodynamic group treatment for compulsive overeating","volume":"65","author":"Schwartz","year":"2015","journal-title":"Int. J. Group Psychother."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"41","DOI":"10.14740\/jocmr4066","article-title":"The opioid system and food intake: Use of opiate antagonists in treatment of binge eating disorder and abnormal eating behavior","volume":"12","author":"Valbrun","year":"2020","journal-title":"J. Clin. Med. Res."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/12\/10\/2969\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T10:14:35Z","timestamp":1760177675000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/12\/10\/2969"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,28]]},"references-count":50,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2020,10]]}},"alternative-id":["nu12102969"],"URL":"https:\/\/doi.org\/10.3390\/nu12102969","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,28]]}}}