{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T07:02:24Z","timestamp":1763535744672,"version":"build-2065373602"},"reference-count":36,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2020,10,7]],"date-time":"2020-10-07T00:00:00Z","timestamp":1602028800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010661","name":"Horizon 2020","doi-asserted-by":"publisher","award":["733206","824989","874583","696295"],"award-info":[{"award-number":["733206","824989","874583","696295"]}],"id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","award":["529051014"],"award-info":[{"award-number":["529051014"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["ERC-2014-CoG-648916"],"award-info":[{"award-number":["ERC-2014-CoG-648916"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Fatty acids might play a role in asthma and allergy development as they can modulate immune responses. We examined among 4260 mother-child pairs participating in a population-based cohort the associations of maternal plasma fatty acid patterns during pregnancy with a child\u2019s respiratory and allergy outcomes at school-age. In mid-pregnancy, 22 individual fatty acids were measured from maternal blood. Three patterns were previously identified by principal component analysis: A \u2018high n-6 polyunsaturated fatty acid (PUFA)\u2019, a \u2018monounsaturated and saturated fatty acid\u2019, and a \u2018high n-3 PUFA\u2019 pattern. At the age of 10 years, a child\u2019s lung function was assessed by spirometry, current asthma and physician-diagnosed inhalant allergy by questionnaire, and inhalant allergic sensitization by skin prick tests. A higher \u2018high n-6 PUFA\u2019 pattern was associated with a higher forced expiratory volume in 1 s\/forced vital capacity and forced expiratory flow after exhaling 75% of forced vital capacity (Z-score difference (95% CI) 0.04 (0, 0.07) and 0.04 (0.01, 0.07), respectively, per SD increase in the fatty acid pattern). We observed no associations of maternal fatty acid patterns with a child\u2019s asthma or allergy outcomes. Our results showed limited associations of maternal patterns of high n-6 PUFA concentrations in pregnancy with a better lung function in school-aged children.<\/jats:p>","DOI":"10.3390\/nu12103057","type":"journal-article","created":{"date-parts":[[2020,10,7]],"date-time":"2020-10-07T09:12:58Z","timestamp":1602061978000},"page":"3057","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Associations of Plasma Fatty Acid Patterns during Pregnancy with Respiratory and Allergy Outcomes at School Age"],"prefix":"10.3390","volume":"12","author":[{"given":"Sara M.","family":"Mensink-Bout","sequence":"first","affiliation":[{"name":"The Generation R Study Group, Erasmus MC, University Medical Center, 3000 CA Rotterdam, The Netherlands"},{"name":"Department of Pediatrics, Division of Respiratory Medicine and Allergology, Erasmus MC, University Medical Center, 3000 CA Rotterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2830-6813","authenticated-orcid":false,"given":"Trudy","family":"Voortman","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Erasmus MC, University Medical Center, 3000 CA Rotterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marsela","family":"Dervishaj","sequence":"additional","affiliation":[{"name":"The Generation R Study Group, Erasmus MC, University Medical Center, 3000 CA Rotterdam, The Netherlands"},{"name":"Department of Pediatrics, Division of Respiratory Medicine and Allergology, Erasmus MC, University Medical Center, 3000 CA Rotterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irwin K. M.","family":"Reiss","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Neonatology, Erasmus MC, University Medical Center, 3000 CA Rotterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johan C.","family":"De Jongste","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Respiratory Medicine and Allergology, Erasmus MC, University Medical Center, 3000 CA Rotterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent W. V.","family":"Jaddoe","sequence":"additional","affiliation":[{"name":"The Generation R Study Group, Erasmus MC, University Medical Center, 3000 CA Rotterdam, The Netherlands"},{"name":"Department of Pediatrics, Erasmus MC, University Medical Center, 3000 CA Rotterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6731-9452","authenticated-orcid":false,"given":"Liesbeth","family":"Duijts","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Respiratory Medicine and Allergology, Erasmus MC, University Medical Center, 3000 CA Rotterdam, The Netherlands"},{"name":"Department of Pediatrics, Division of Neonatology, Erasmus MC, University Medical Center, 3000 CA Rotterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,10,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1111\/all.12729","article-title":"Maternal nutrition during pregnancy and risk of asthma, wheeze, and atopic diseases during childhood: A systematic review and meta-analysis","volume":"70","author":"Beckhaus","year":"2015","journal-title":"Allergy"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1183\/09031936.97.10010006","article-title":"Dietary fat and asthma: Is there a connection?","volume":"10","author":"Black","year":"1997","journal-title":"Eur. 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