{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T14:34:58Z","timestamp":1790346898941,"version":"4.1.0"},"reference-count":52,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2020,10,12]],"date-time":"2020-10-12T00:00:00Z","timestamp":1602460800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Because the analgesic effect of vitamin C against acute pain remains poorly addressed, this meta-analysis aimed at investigating its effectiveness against acute postoperative pain. A total of seven randomized controlled trials with placebo\/normal controls were identified from PubMed, Cochrane Library, Medline, Google Scholar, and Embase databases. Pooled analysis showed a lower pain score (standardized mean difference (SMD) = \u22120.68, 95% CI: \u22121.01 to \u22120.36, p &lt; 0.0001; I2 = 57%) and a lower morphine consumption (weighted mean difference (WMD) = \u22122.44 mg, 95% CI: \u22124.03 to \u22120.86, p = 0.003; I2 = 52%) in the vitamin group than that in the placebo group within postoperative 1\u20132 h. At postoperative 24 h, a lower pain score (SMD = \u22120.65, 95% CI: \u22121.11 to \u22120.19, p = 0.005; I2 = 81%) and lower morphine consumption (WMD = \u22126.74 mg, 95% CI: \u22129.63 to \u22123.84, p &lt; 0.00001; I2 = 85%) were also noted in the vitamin group. Subgroup analyses demonstrated significant reductions in pain severity and morphine requirement immediately (1\u20132 h) and 24 h after surgery for patients receiving intravenous vitamin C but not in the oral subgroup. These findings showed significant reductions in pain score and opioid requirement up to postoperative 24 h, respectively, suggesting the effectiveness of perioperative vitamin C use. Further large-scale trials are warranted to elucidate its optimal intravenous dosage and effectiveness against chronic pain in the postoperative pain control setting.<\/jats:p>","DOI":"10.3390\/nu12103109","type":"journal-article","created":{"date-parts":[[2020,10,13]],"date-time":"2020-10-13T22:02:02Z","timestamp":1602626522000},"page":"3109","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["The Effect of Perioperative Vitamin C on Postoperative Analgesic Consumption: A Meta-Analysis of Randomized Controlled Trials"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4507-8085","authenticated-orcid":false,"given":"Kuo-Chuan","family":"Hung","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Chi Mei Medical Center, Tainan City 71004, Taiwan"},{"name":"Department of Health and Nutrition, Chia Nan University of Pharmacy and Science, Tainan City 71710, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao-Tsung","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Chi Mei Medical Center, Tainan City 71004, Taiwan"},{"name":"Center of General Education, Chia Nan University of Pharmacy and Science, Tainan City 71710, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9772-482X","authenticated-orcid":false,"given":"Kee-Hsin","family":"Chen","sequence":"additional","affiliation":[{"name":"Post-Baccalaureate Program in Nursing, College of Nursing, Taipei Medical University, Taipei City 11042, Taiwan"},{"name":"Cochrane Taiwan, Taipei Medical University, Taipei City 11042, Taiwan"},{"name":"Center for Nursing and Healthcare Research in Clinical Practice Application, Wan Fang Hospital, Taipei Medical University, Taipei City 11042, Taiwan"},{"name":"Evidence-Based Knowledge Translation Center, Wan Fang Hospital, Taipei Medical University, Taipei City 11042, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8640-8231","authenticated-orcid":false,"given":"Li-Kai","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Chi Mei Medical Center, Tainan City 71004, Taiwan"},{"name":"Department of Health and Nutrition, Chia Nan University of Pharmacy and Science, Tainan City 71710, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2313-5701","authenticated-orcid":false,"given":"Jen-Yin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Chi Mei Medical Center, Tainan City 71004, Taiwan"},{"name":"Department of the Senior Citizen Service Management, Chia Nan University of Pharmacy and Science, Tainan City 71710, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-Jen","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Chi Mei Medical Center, Tainan City 71004, Taiwan"},{"name":"College of Health Sciences, Chang Jung Christian University, Tainan City 71101, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0984-6921","authenticated-orcid":false,"given":"Shao-Chun","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung City 83301, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min-Hsien","family":"Chiang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung City 83301, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2524-9684","authenticated-orcid":false,"given":"Cheuk-Kwan","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, E-Da Hospital, Kaohsiung City 82445, Taiwan"},{"name":"College of Medicine, I-Shou University, Kaohsiung City 82445, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,10,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1213\/01.ANE.0000068822.10113.9E","article-title":"Postoperative pain experience: Results from a national survey suggest postoperative pain continues to be undermanaged","volume":"97","author":"Apfelbaum","year":"2003","journal-title":"Anesth. 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