{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T11:30:12Z","timestamp":1787830212827,"version":"build-2784847793"},"reference-count":49,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2020,10,19]],"date-time":"2020-10-19T00:00:00Z","timestamp":1603065600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI12\/02777"],"award-info":[{"award-number":["PI12\/02777"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Vitamin D status during pregnancy is involved in numerous physiological processes, including brain development. In this study, we assess the association between vitamin D status during pregnancy and infant neurodevelopment (cognitive, language, and motor skills). From an initial sample of 793 women (mean age 30.6) recruited before the 12th week of pregnancy, 422 mother\u2013infant pairs were followed up to a postpartum visit. Vitamin D levels were assessed in the first and third trimesters of pregnancy, and socio-demographic, nutritional, and psychological variables were collected. At 40 days postpartum, the Bayley Scales of Infant Development-III were administered to the infants and several obstetrical data were recorded. Independently from several confounding factors, deficient vitamin D levels in the first trimester of pregnancy (&lt;30 nmol\/L) predicted a worse performance in cognitive and language skills. Language performance worsened with lower vitamin D levels (&lt;20 nmol\/L). In the third trimester, this highly deficient level was also associated with lower motor skills. Vitamin D deficiency was therefore associated with worse neurodevelopmental outcomes. More studies are needed to determine specific recommendations with regard to vitamin D supplementation during pregnancy in order to promote an optimal course for pregnancy and optimal infant neurodevelopment.<\/jats:p>","DOI":"10.3390\/nu12103196","type":"journal-article","created":{"date-parts":[[2020,10,19]],"date-time":"2020-10-19T09:36:28Z","timestamp":1603100188000},"page":"3196","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Effect of Vitamin D Status during Pregnancy on Infant Neurodevelopment: The ECLIPSES Study"],"prefix":"10.3390","volume":"12","author":[{"given":"N\u00faria","family":"Voltas","sequence":"first","affiliation":[{"name":"Research Group in Nutrition and Mental Health (NUTRISAM), Universitat Rovira i Virgili, 43204 Reus, Spain"},{"name":"Research Center for Behavior Assessment (CRAMC), Universitat Rovira i Virgili, 43002 Tarragona, Spain"},{"name":"Institut d\u2019Investigaci\u00f3 Sanit\u00e0ria Pere Virgili (IISPV), 43007 Reus, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6209-9558","authenticated-orcid":false,"given":"Josefa","family":"Canals","sequence":"additional","affiliation":[{"name":"Research Group in Nutrition and Mental Health (NUTRISAM), Universitat Rovira i Virgili, 43204 Reus, Spain"},{"name":"Research Center for Behavior Assessment (CRAMC), Universitat Rovira i Virgili, 43002 Tarragona, Spain"},{"name":"Institut d\u2019Investigaci\u00f3 Sanit\u00e0ria Pere Virgili (IISPV), 43007 Reus, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Hern\u00e1ndez-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Research Group in Nutrition and Mental Health (NUTRISAM), Universitat Rovira i Virgili, 43204 Reus, Spain"},{"name":"Research Center for Behavior Assessment (CRAMC), Universitat Rovira i Virgili, 43002 Tarragona, Spain"},{"name":"Institut d\u2019Investigaci\u00f3 Sanit\u00e0ria Pere Virgili (IISPV), 43007 Reus, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0064-2017","authenticated-orcid":false,"given":"N\u00faria","family":"Serrat","sequence":"additional","affiliation":[{"name":"Laboratory ICS Tarragona, University Hospital of Tarragona Joan XXIII, Catalan Institute of Health (ICS), 43005 Tarragona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josep","family":"Basora","sequence":"additional","affiliation":[{"name":"Collaborative Research Group on Lifestyles, Nutrition and Smoking (CENIT), Jordi Gol Primary Care Research Institute (IDIAPJGol), Cam\u00ed de Riudoms 53-55, 43202 Reus, Spain"},{"name":"Jordi Gol Primary Care Research Institute (IDIAPJGol), Cam\u00ed de Riudoms 53-55, 43202 Reus, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Arija","sequence":"additional","affiliation":[{"name":"Research Group in Nutrition and Mental Health (NUTRISAM), Universitat Rovira i Virgili, 43204 Reus, Spain"},{"name":"Research Center for Behavior Assessment (CRAMC), Universitat Rovira i Virgili, 43002 Tarragona, Spain"},{"name":"Institut d\u2019Investigaci\u00f3 Sanit\u00e0ria Pere Virgili (IISPV), 43007 Reus, Spain"},{"name":"Laboratory ICS Tarragona, University Hospital of Tarragona Joan XXIII, Catalan Institute of Health (ICS), 43005 Tarragona, Spain"},{"name":"Collaborative Research Group on Lifestyles, Nutrition and Smoking (CENIT), Jordi Gol Primary Care Research Institute (IDIAPJGol), Cam\u00ed de Riudoms 53-55, 43202 Reus, Spain"},{"name":"Jordi Gol Primary Care Research Institute (IDIAPJGol), Cam\u00ed de Riudoms 53-55, 43202 Reus, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,10,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.jsbmb.2017.12.011","article-title":"Vitamin D: Effects on human reproduction, pregnancy, and fetal well-being","volume":"180","author":"Heyden","year":"2018","journal-title":"J. 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