{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T13:44:51Z","timestamp":1784036691472,"version":"3.55.0"},"reference-count":81,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2020,10,23]],"date-time":"2020-10-23T00:00:00Z","timestamp":1603411200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003693","name":"Korea Institute of Science and Technology","doi-asserted-by":"publisher","award":["2Z05310"],"award-info":[{"award-number":["2Z05310"]}],"id":[{"id":"10.13039\/501100003693","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003566","name":"Ministry of Oceans and Fisheries","doi-asserted-by":"publisher","award":["20190015"],"award-info":[{"award-number":["20190015"]}],"id":[{"id":"10.13039\/501100003566","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Dry eye syndrome (DES) is a corneal disease often characterized by an irritating, itching feeling in the eyes and light sensitivity. Inflammation and endoplasmic reticulum (ER) stress may play a crucial role in the pathogenesis of DES, although the underlying mechanism remains elusive. Aster koraiensis has been used traditionally as an edible herb in Korea. It has been reported to have wound-healing and inhibitory effects against insulin resistance and inflammation. Here, we examined the inhibitory effects of inflammation and ER stress by A. koraiensis extract (AKE) in animal model and human retinal pigmented epithelial (ARPE-19) cells. Oral administration of AKE mitigated DE symptoms, including reduced corneal epithelial thickness, increased the gap between lacrimal gland tissues in experimental animals and decreased tear production. It also inhibited inflammatory responses in the corneal epithelium and lacrimal gland. Consequently, the activation of NF-\u03baB was attenuated by the suppression of cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2). Moreover, AKE treatment ameliorated TNF-\u03b1-inducible ocular inflammation and thapsigargin (Tg)-inducible ER stress in animal model and human retinal pigmented epithelial (ARPE-19) cells. These results prove that AKE prevents detrimental functional and histological remodeling on the ocular surface and in the lacrimal gland through inhibition of inflammation and ER stress, suggesting its potential as functional food material for improvement of DES.<\/jats:p>","DOI":"10.3390\/nu12113245","type":"journal-article","created":{"date-parts":[[2020,10,23]],"date-time":"2020-10-23T08:59:28Z","timestamp":1603443568000},"page":"3245","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["In Vivo Anti-Inflammation Potential of Aster koraiensis Extract for Dry Eye Syndrome by the Protection of Ocular Surface"],"prefix":"10.3390","volume":"12","author":[{"given":"Sung-Chul","family":"Hong","sequence":"first","affiliation":[{"name":"Natural Informatics Research Center, Korea Institute of Science and Technology (KIST), Gangneung 25451, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5282-531X","authenticated-orcid":false,"given":"Jung-Heun","family":"Ha","sequence":"additional","affiliation":[{"name":"Research Center for Industrialization of Natural Neutralization, Dankook University, Cheonan 31116, Korea"},{"name":"Department of Food Science and Nutrition, Dankook University, Cheonan 31116, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer K.","family":"Lee","sequence":"additional","affiliation":[{"name":"Food Science &amp; Human Nutrition Department, University of Florida, Gainesville, FL 32611, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Hoon","family":"Jung","sequence":"additional","affiliation":[{"name":"Natural Product Research Center, Korea Institute of Science and Technology (KIST), Gangneung 25451, Korea"},{"name":"Division of Bio-Medical Science and Technology, KIST School, Korea University of Science and Technology (UST), Daejeon 34113, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Chul","family":"Kim","sequence":"additional","affiliation":[{"name":"Natural Informatics Research Center, Korea Institute of Science and Technology (KIST), Gangneung 25451, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,10,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Phadatare, S.P., Momin, M., Nighojkar, P., Askarkar, S., and Singh, K.K. (2015). A comprehensive review on dry eye disease: Diagnosis, medical management, recent developments, and future challenges. Adv. Pharm., 2015.","DOI":"10.1155\/2015\/704946"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/j.ajo.2013.12.023","article-title":"Dry eye in the beaver dam offspring study: Prevalence, risk factors, and health-related quality of life","volume":"157","author":"Paulsen","year":"2014","journal-title":"Am. J. Ophthalmol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1444-0938.2011.00634.x","article-title":"Osmolality and tear film dynamics","volume":"95","author":"Stahl","year":"2012","journal-title":"Clin. Exp. Optom."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Zhang, X., Qu, Y., He, X., Ou, S., Bu, J., Jia, C., Wang, J., Wu, H., Liu, Z., and Li, W. (2017). Dry eye management: Targeting the ocular surface microenvironment. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18071398"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.jtos.2018.03.003","article-title":"Genetic factors and molecular mechanisms in dry eye disease","volume":"16","author":"Lee","year":"2018","journal-title":"Ocul. Surf."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Liu, K.C., Huynh, K., Grubbs, J., and Davis, R.M. (2014). Autoimmunity in the pathogenesis and treatment of keratoconjunctivitis sicca. Curr. Allergy Asthma Rep., 14.","DOI":"10.1007\/s11882-013-0403-7"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/aos.13436","article-title":"Clinical impact of inflammation in dry eye disease: Proceedings of the ODISSEY group meeting","volume":"96","author":"Baudouin","year":"2018","journal-title":"Acta Ophthalmol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.3892\/mmr.2014.2041","article-title":"Decreased PPAR-\u03b3 expression in the conjunctiva and increased expression of TNF-\u03b1 and IL-1\u03b2 in the conjunctiva and tear fluid of dry eye mice","volume":"9","author":"Chen","year":"2014","journal-title":"Mol. Med. Rep."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1167\/iovs.11-7627","article-title":"Correlation of tear inflammatory cytokines and matrix metalloproteinases with four dry eye diagnostic tests","volume":"53","author":"VanDerMeid","year":"2012","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1001\/archopht.118.11.1489","article-title":"Analysis of topical cyclosporine treatment of patients with dry eye syndrome: Effect on conjunctival lymphocytes","volume":"118","author":"Kunert","year":"2000","journal-title":"Arch. Ophthalmol."},{"key":"ref_11","first-page":"2","article-title":"Modern perspectives on dry eye disease","volume":"11","author":"Rolando","year":"2017","journal-title":"Eur. Ophthalmic Rev."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"19","DOI":"10.3109\/08830185.2012.748052","article-title":"Dry eye as a mucosal autoimmune disease","volume":"32","author":"Stern","year":"2013","journal-title":"Int. Rev. Immunol."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Wei, Y., and Asbell, P.A. (2014). The core mechanism of dry eye disease (DED) is inflammation. Eye Contact Lens, 40.","DOI":"10.1097\/ICL.0000000000000042"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2656","DOI":"10.1172\/JCI26373","article-title":"Endoplasmic reticulum stress: Cell life and death decisions","volume":"115","author":"Xu","year":"2005","journal-title":"J. Clin. Investig."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Bahar, E., Kim, H., and Yoon, H. (2016). ER stress-mediated signaling: Action potential and Ca2+ as key players. Int. J. Mol. Sci., 17.","DOI":"10.3390\/ijms17091558"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1016\/j.cell.2010.02.034","article-title":"Endoplasmic reticulum stress and the inflammatory basis of metabolic disease","volume":"140","author":"Hotamisligil","year":"2010","journal-title":"Cell"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Seo, Y., Ji, Y., Lee, S., Shim, J., Noh, H., Yeo, A., Park, C., Park, M., Chang, E., and Lee, H. (2014). Activation of HIF-1 \u03b1 (hypoxia inducible factor-1 \u03b1) prevents dry eye-induced acinar cell death in the lacrimal gland. Cell Death Dis., 5.","DOI":"10.1038\/cddis.2014.382"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.preteyeres.2012.02.003","article-title":"Ocular surface immunity: Homeostatic mechanisms and their disruption in dry eye disease","volume":"31","author":"Barabino","year":"2012","journal-title":"Prog. Retin. Eye Res."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.sjopt.2014.06.002","article-title":"Dry eye disease: A review of diagnostic approaches and treatments","volume":"28","author":"Lin","year":"2014","journal-title":"Saudi J. Ophthalmol."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Messmer, E.M. (2015). The pathophysiology, diagnosis, and treatment of dry eye disease. Dtsch. \u00c4rztebl. Int., 112.","DOI":"10.3238\/arztebl.2015.0071"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1097\/OPX.0000000000000653","article-title":"A pragmatic approach to the management of dry eye disease: Evidence into practice","volume":"92","author":"Downie","year":"2015","journal-title":"Optom. Vis. Sci."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Sun, N.-N., Wu, T.-Y., and Chau, C.-F. (2016). Natural dietary and herbal products in anti-obesity treatment. Molecules, 21.","DOI":"10.3390\/molecules21101351"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1146\/annurev-food-032519-051708","article-title":"Functional foods: Product development, technological trends, efficacy testing, and safety","volume":"11","author":"Granato","year":"2020","journal-title":"Annu. Rev. Food Sci. Technol."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Aguilar-Toal\u00e1, J., Hern\u00e1ndez-Mendoza, A., Gonz\u00e1lez-C\u00f3rdova, A., Vallejo-Cordoba, B., and Liceaga, A. (2019). Potential role of natural bioactive peptides for development of cosmeceutical skin products. Peptides, 122.","DOI":"10.1016\/j.peptides.2019.170170"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.arr.2009.01.002","article-title":"Dried plum, an emerging functional food that may effectively improve bone health","volume":"8","author":"Hooshmand","year":"2009","journal-title":"Ageing Res. Rev."},{"key":"ref_26","first-page":"6267","article-title":"Antinociceptive profiles and mechanisms of orally administered Aster Koraiensis extract in the mouse","volume":"5","author":"Park","year":"2011","journal-title":"J. Med. Plants Res."},{"key":"ref_27","unstructured":"Ahn, D. (1998). Illustrated Book of Korean Medicinal Herbs, Kyohaksa."},{"key":"ref_28","first-page":"627","article-title":"Effect of plant growth regulators on growth and flowering of potted Lychnis cognata, Aster koraiensis and Campanula takesimana","volume":"38","author":"Ko","year":"1996","journal-title":"RDA J. Agric. Sci. Korea Repub."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1021\/np200646e","article-title":"Chemical constituents from the aerial parts of Aster koraiensis with protein glycation and aldose reductase inhibitory activities","volume":"75","author":"Lee","year":"2012","journal-title":"J. Nat. Prod."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.bbrc.2009.11.129","article-title":"Extract of the aerial parts of Aster koraiensis reduced development of diabetic nephropathy via anti-apoptosis of podocytes in streptozotocin-induced diabetic rats","volume":"391","author":"Sohn","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.imr.2018.09.001","article-title":"Aster koraiensis extract improves impaired skin wound healing during hyperglycemia","volume":"7","author":"Hyun","year":"2018","journal-title":"Integr. Med. Res."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Kim, J., Jo, K., Lee, I.-S., Kim, C.-S., and Kim, J.S. (2016). The extract of Aster Koraiensis prevents retinal Pericyte apoptosis in diabetic rats and its active compound, chlorogenic acid inhibits AGE formation and AGE\/RAGE interaction. Nutrients, 8.","DOI":"10.3390\/nu8090585"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Kim, J., Lee, Y.M., Jung, W., Park, S.-B., Kim, C.-S., and Kim, J.S. (2018). Aster koraiensis extract and chlorogenic acid inhibit retinal angiogenesis in a mouse model of oxygen-induced retinopathy. Evid. Based Complementary Altern. Med., 2018.","DOI":"10.1155\/2018\/6402650"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.meatsci.2011.05.027","article-title":"Total antioxidant capacities of raw and cooked meats","volume":"90","author":"Serpen","year":"2012","journal-title":"Meat Sci."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.jfca.2006.01.003","article-title":"Comparison of ABTS, DPPH, FRAP, and ORAC assays for estimating antioxidant activity from guava fruit extracts","volume":"19","author":"Thaipong","year":"2006","journal-title":"J. Food Compos. Anal."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0076-6879(99)99005-5","article-title":"[2] Ferric reducing\/antioxidant power assay: Direct measure of total antioxidant activity of biological fluids and modified version for simultaneous measurement of total antioxidant power and ascorbic acid concentration","volume":"Volume 299","author":"Benzie","year":"1999","journal-title":"Methods in Enzymology"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"156","DOI":"10.3136\/fstr.12.156","article-title":"Contribution of \u03b2-carotene to radical scavenging capacity varies among orange-fleshed sweet potato cultivars","volume":"12","author":"Oki","year":"2006","journal-title":"Food Sci. Technol. Res."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1016\/S0891-5849(98)00315-3","article-title":"Antioxidant activity applying an improved ABTS radical cation decolorization assay","volume":"26","author":"Re","year":"1999","journal-title":"Free Radic. Biol. Med."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"12221","DOI":"10.1021\/jf1031229","article-title":"Antiradical activity, phenolics profile, and hydroxymethylfurfural in espresso coffee: Influence of technological factors","volume":"58","author":"Alves","year":"2010","journal-title":"J. Agric. Food Chem."},{"key":"ref_40","first-page":"1142","article-title":"Antioxidant activity, phenol and flavonoid contents of some selected Iranian medicinal plants","volume":"5","author":"Pourmorad","year":"2006","journal-title":"Afr. J. Biotechnol."},{"key":"ref_41","first-page":"255","article-title":"Total phenolics and total flavonoids in Bulgarian fruits and vegetables","volume":"40","author":"Marinova","year":"2005","journal-title":"J. Univ. Chem. Technol. Metallurgy"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Kasote, D.M., Katyare, S.S., Hegde, M.V., and Bae, H. (2015). Significance of antioxidant potential of plants and its relevance to therapeutic applications. Int. J. Biol. Sci., 11.","DOI":"10.7150\/ijbs.12096"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"El Jemli, M., Kamal, R., Marmouzi, I., Zerrouki, A., Cherrah, Y., and Alaoui, K. (2016). Radical-scavenging activity and ferric reducing ability of Juniperus thurifera (L.), J. oxycedrus (L.), J. phoenicea (L.) and Tetraclinis articulata (L.). Adv. Pharmacol. Sci., 2016.","DOI":"10.1155\/2016\/6392656"},{"key":"ref_44","unstructured":"Javadi, M.-A., and Feizi, S. (2011). Dry eye syndrome. J. Ophthalmic Vis. Res., 6."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Dienes, L., Kiss, H.J., Per\u00e9nyi, K., Nagy, Z.Z., Acosta, M.C., Gallar, J., and Kov\u00e1cs, I. (2015). Corneal sensitivity and dry eye symptoms in patients with keratoconus. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0141621"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Conrady, C.D., Joos, Z.P., and Patel, B.C. (2016). The lacrimal gland and its role in dry eye. J. Ophthalmol., 2016.","DOI":"10.1155\/2016\/7542929"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.sjopt.2013.09.004","article-title":"Human lacrimal gland regeneration: Perspectives and review of literature","volume":"28","author":"Tiwari","year":"2014","journal-title":"Saudi J. Ophthalmol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/43354","article-title":"Akt is more than just a Bad kinase","volume":"401","author":"Khwaja","year":"1999","journal-title":"Nature"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.tibs.2004.11.009","article-title":"Phosphorylation of NF-kappaB and IkappaB proteins: Implications in cancer and inflammation","volume":"30","author":"Viatour","year":"2005","journal-title":"Trends Biochem. Sci."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1007\/s11064-015-1798-4","article-title":"Potential role of endoplasmic reticulum stress in pathogenesis of diabetic retinopathy","volume":"41","author":"Salceda","year":"2016","journal-title":"Neurochem. Res."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1016\/j.autrev.2016.09.001","article-title":"Dry eye disease and uveitis: A closer look at immune mechanisms in animal models of two ocular autoimmune diseases","volume":"15","author":"Bose","year":"2016","journal-title":"Autoimmun. Rev."},{"key":"ref_52","unstructured":"An, E., Gordish-Dressman, H., and Hathout, Y. (2008). Effect of TNF-\u03b1 on human ARPE-19-secreted proteins. Mol. Vis., 14."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"535","DOI":"10.2119\/molmed.2010.00070","article-title":"Endoplasmic reticulum stress in age-related macular degeneration: Trigger for neovascularization","volume":"16","author":"Salminen","year":"2010","journal-title":"Mol. Med."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1016\/j.febslet.2009.04.007","article-title":"Endoplasmic reticulum stress is implicated in retinal inflammation and diabetic retinopathy","volume":"583","author":"Li","year":"2009","journal-title":"FEBS Lett."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1001\/archopht.120.3.338","article-title":"Prevention of experimental choroidal neovascularization with intravitreal anti\u2013vascular endothelial growth factor antibody fragment","volume":"120","author":"Krzystolik","year":"2002","journal-title":"Arch. Ophthalmol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.bbrc.2015.02.004","article-title":"Ca2+ homeostasis and endoplasmic reticulum (ER) stress: An integrated view of calcium signaling","volume":"460","author":"Krebs","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1016\/j.ophtha.2017.07.010","article-title":"The pathophysiology of dry eye disease: What we know and future directions for research","volume":"124","author":"Pflugfelder","year":"2017","journal-title":"Ophthalmology"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1056\/NEJMra1407936","article-title":"Dry eye","volume":"378","author":"Clayton","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Kang, W.S., Jung, E., and Kim, J. (2018). Aucuba japonica extract and aucubin prevent desiccating stress-induced corneal epithelial cell injury and improve tear secretion in a mouse model of dry eye disease. Molecules, 23.","DOI":"10.3390\/molecules23102599"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.cyto.2018.02.009","article-title":"Effect of tear supplements on signs, symptoms and inflammatory markers in dry eye","volume":"105","author":"Martin","year":"2018","journal-title":"Cytokine"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1007\/s10792-014-9901-4","article-title":"The efficacy of topical 0.05% cyclosporine A in patients with dry eye disease associated with Sj\u00f6gren\u2019s syndrome","volume":"34","author":"Kobak","year":"2014","journal-title":"Int. Ophthalmol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1080\/02713683.2017.1377261","article-title":"Conjunctival tear layer temperature, evaporation, hyperosmolarity, inflammation, hyperemia, tissue damage, and symptoms: A review of an amplifying cascade","volume":"42","author":"McMonnies","year":"2017","journal-title":"Curr. Eye Res."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.exer.2016.07.004","article-title":"Mucosal tolerance disruption favors disease progression in an extraorbital lacrimal gland excision model of murine dry eye","volume":"151","author":"Keitelman","year":"2016","journal-title":"Exp. Eye Res."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.exer.2006.02.004","article-title":"Corticosteroid and doxycycline suppress MMP-9 and inflammatory cytokine expression, MAPK activation in the corneal epithelium in experimental dry eye","volume":"83","author":"Corrales","year":"2006","journal-title":"Exp. Eye Res."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.ophtha.2014.07.048","article-title":"Matrix metalloproteinase 9 and transglutaminase 2 expression at the ocular surface in patients with different forms of dry eye disease","volume":"122","author":"Aragona","year":"2015","journal-title":"Ophthalmology"},{"key":"ref_66","first-page":"1","article-title":"NF-\u03baB signaling in inflammation","volume":"2","author":"Liu","year":"2017","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.tcb.2012.08.001","article-title":"The nuclear factor kappa B signaling pathway: Integrating metabolism with inflammation","volume":"22","author":"Tornatore","year":"2012","journal-title":"Trends Cell Biol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1161\/ATVBAHA.110.207449","article-title":"Prostaglandins and inflammation","volume":"31","author":"Ricciotti","year":"2011","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Liang, N., and Kitts, D.D. (2016). Role of chlorogenic acids in controlling oxidative and inflammatory stress conditions. Nutrients, 8.","DOI":"10.3390\/nu8010016"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"2864","DOI":"10.1080\/13880209.2016.1190381","article-title":"In vivo anti-inflammatory activity of caffeoylquinic acid derivatives from Solidago virgaurea in rats","volume":"54","author":"Ezzat","year":"2016","journal-title":"Pharm. Biol."},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Newton, K., and Dixit, V.M. (2012). Signaling in innate immunity and inflammation. Cold Spring Harb. Perspect. Biol., 4.","DOI":"10.1101\/cshperspect.a006049"},{"key":"ref_72","first-page":"807","article-title":"Mammalian MAPK signal transduction pathways activated by stress and inflammation: A 10-year update","volume":"2","author":"Kyriakis","year":"2012","journal-title":"Physiol. Rev."},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Whitcup, S.M., Nussenblatt, R.B., Lightman, S.L., and Hollander, D.A. (2013). Inflammation in retinal disease. Int. J. Inflamm., 2013.","DOI":"10.1155\/2013\/724648"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13024-017-0183-y","article-title":"Endoplasmic reticulum stress and inflammation in the central nervous system","volume":"12","author":"Sprenkle","year":"2017","journal-title":"Mol. Neurodegener."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1111\/febs.14522","article-title":"ER stress and unfolded protein response in ocular health and disease","volume":"286","author":"Kroeger","year":"2019","journal-title":"FEBS J."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.exer.2014.04.015","article-title":"Endoplasmic reticulum stress and the unfolded protein responses in retinal degeneration","volume":"125","author":"Zhang","year":"2014","journal-title":"Exp. Eye Res."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1001\/archophthalmol.2010.124","article-title":"Evidence of corneal lymphangiogenesis in dry eye disease: A potential link to adaptive immunity?","volume":"128","author":"Goyal","year":"2010","journal-title":"Arch. Ophthalmol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1808","DOI":"10.2337\/db12-1744","article-title":"Using the past to inform the future: Anti-VEGF therapy as a road map to develop novel therapies for diabetic retinopathy","volume":"62","author":"Titchenell","year":"2013","journal-title":"Diabetes"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/j.amjmed.2009.12.004","article-title":"Glycemic control and complications in type 2 diabetes mellitus","volume":"123","author":"Stolar","year":"2010","journal-title":"Am. J. Med."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"74","DOI":"10.3746\/jkfn.2014.43.1.074","article-title":"Component analysis and antioxidant activity of Aster koraiensis Nakai","volume":"43","author":"Shin","year":"2014","journal-title":"J. Korean Soc. Food Sci. Nutr."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"799","DOI":"10.3945\/jn.113.186957","article-title":"Ocular inflammation and endoplasmic reticulum stress are attenuated by supplementation with grape polyphenols in human retinal pigmented epithelium cells and in C57BL\/6 mice","volume":"144","author":"Ha","year":"2014","journal-title":"J. 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