{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,3]],"date-time":"2026-01-03T15:12:32Z","timestamp":1767453152162,"version":"build-2065373602"},"reference-count":59,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2020,10,26]],"date-time":"2020-10-26T00:00:00Z","timestamp":1603670400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI17\/02305"],"award-info":[{"award-number":["PI17\/02305"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Vitamin D deficiency during pregnancy has been linked to perinatal adverse outcomes. Studies conducted to date have recommended assessing interactions with other vitamin D-related metabolites to clarify this subject. We aimed to evaluate the association of vitamin D deficiency during early pregnancy with preterm birth. Secondary outcomes included low birth weight and small for gestational age. Additionally, we explored the role that parathyroid hormone, calcium and phosphorus could play in the associations. We conducted a prospective cohort study comprising 289 pregnant women in a hospital in Granada, Spain. Participants were followed-up from weeks 10\u201312 of gestation to postpartum. Serum 25-hydroxyvitamin D, parathyroid hormone, calcium, and phosphorus were measured within the first week after recruitment. Pearson\u2019s \u03c72 test, Mann\u2013Whitney U test, binary and multivariable logistic regression models were used to explore associations between variables and outcomes. 36.3% of the participants were vitamin D deficient (&lt;20 ng\/mL). 25-hydroxyvitamin D concentration was inversely correlated with parathyroid hormone (\u03c1 = \u22120.146, p = 0.013). Preterm birth was associated with vitamin D deficiency in the multivariable model, being this association stronger amongst women with parathyroid hormone serum levels above the 80th percentile (adjusted odds ratio (aOR) = 6.587, 95% CI (2.049, 21.176), p = 0.002). Calcium and phosphorus were not associated with any studied outcome. Combined measurement of 25-hydroxyvitamin D and parathyroid hormone could be a better estimator of preterm birth than vitamin D in isolation.<\/jats:p>","DOI":"10.3390\/nu12113279","type":"journal-article","created":{"date-parts":[[2020,10,26]],"date-time":"2020-10-26T10:38:35Z","timestamp":1603708715000},"page":"3279","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Associations of Vitamin D Deficiency, Parathyroid hormone, Calcium, and Phosphorus with Perinatal Adverse Outcomes. A Prospective Cohort Study"],"prefix":"10.3390","volume":"12","author":[{"given":"\u00cd\u00f1igo Mar\u00eda","family":"P\u00e9rez-Castillo","sequence":"first","affiliation":[{"name":"Andalusian Plan for Research, Development and Innovation, CTS 367, University of Granada, 18001 Granada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tania","family":"Rivero-Blanco","sequence":"additional","affiliation":[{"name":"Andalusian Plan for Research, Development and Innovation, CTS 367, University of Granada, 18001 Granada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ximena Alejandra","family":"Le\u00f3n-R\u00edos","sequence":"additional","affiliation":[{"name":"Andalusian Plan for Research, Development and Innovation, CTS 367, University of Granada, 18001 Granada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuela","family":"Exp\u00f3sito-Ruiz","sequence":"additional","affiliation":[{"name":"Foundation for Biomedical Research in Eastern Andalusia (FIBAO), 18014 Granada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Setefilla","family":"L\u00f3pez-Criado","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Service, Virgen de las Nieves University Hospital, 18014 Granada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6268-0975","authenticated-orcid":false,"given":"Mar\u00eda Jos\u00e9","family":"Aguilar-Cordero","sequence":"additional","affiliation":[{"name":"Andalusian Plan for Research, Development and Innovation, CTS 367, University of Granada, 18001 Granada, Spain"},{"name":"Department of Nursing, Faculty of Health Sciences, University of Granada, 18071 Granada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,10,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/s11154-017-9424-1","article-title":"The Vitamin D Deficiency Pandemic: Approaches for diagnosis, treatment and prevention","volume":"18","author":"Holick","year":"2017","journal-title":"Rev. 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