{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T18:23:49Z","timestamp":1791483829272,"version":"4.3.4"},"reference-count":99,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2020,10,27]],"date-time":"2020-10-27T00:00:00Z","timestamp":1603756800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Our sense of taste arises from the sensory information generated after compounds in the oral cavity and oropharynx activate taste receptor cells situated on taste buds. This produces the perception of sweet, bitter, salty, sour, or umami stimuli, depending on the chemical nature of the tastant. Taste impairments (dysgeusia) are alterations of this normal gustatory functioning that may result in complete taste losses (ageusia), partial reductions (hypogeusia), or over-acuteness of the sense of taste (hypergeusia). Taste impairments are not life-threatening conditions, but they can cause sufficient discomfort and lead to appetite loss and changes in eating habits, with possible effects on health. Determinants of such alterations are multiple and consist of both genetic and environmental factors, including aging, exposure to chemicals, drugs, trauma, high alcohol consumption, cigarette smoking, poor oral health, malnutrition, and viral upper respiratory infections including influenza. Disturbances or loss of smell, taste, and chemesthesis have also emerged as predominant neurological symptoms of infection by the recent Coronavirus disease 2019 (COVID-19), caused by Severe Acute Respiratory Syndrome Coronavirus strain 2 (SARS-CoV-2), as well as by previous both endemic and pandemic coronaviruses such as Middle East Respiratory Syndrome Coronavirus (MERS-CoV) and SARS-CoV. This review is focused on the main causes of alteration, reduction, and loss of taste and their potential repercussion on dietary habits and health, with a special focus on the recently developed hypotheses regarding the mechanisms through which SARS-CoV-2 might alter taste perception.<\/jats:p>","DOI":"10.3390\/nu12113284","type":"journal-article","created":{"date-parts":[[2020,10,27]],"date-time":"2020-10-27T09:22:45Z","timestamp":1603790565000},"page":"3284","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":134,"title":["Alteration, Reduction and Taste Loss: Main Causes and Potential Implications on Dietary Habits"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9848-8996","authenticated-orcid":false,"given":"Davide","family":"Risso","sequence":"first","affiliation":[{"name":"Ferrero Group, Soremartec Italia Srl, 12051 Alba, CN, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis","family":"Drayna","sequence":"additional","affiliation":[{"name":"National Institute on Deafness and Other Communication Disorders, NIH, Bethesda, MD 20892, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella","family":"Morini","sequence":"additional","affiliation":[{"name":"University of Gastronomic Sciences, Piazza Vittorio Emanuele 9, Bra, 12042 Pollenzo, CN, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,10,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"McDonald, S.T., Bolliet, D.A., and Hayes, J.E. (2016). Introduction: What is chemesthesis. Chemestesis, Chemical Touch in Food and Eating, Wiley-Blackwell Editor.","DOI":"10.1002\/9781118951620"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"R409","DOI":"10.1016\/j.cub.2013.04.010","article-title":"An Evolutionary Perspective on Food and Human Taste","volume":"23","author":"Breslin","year":"2013","journal-title":"Curr. Biol."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Stokes, D., Matthen, M., and Briggs, S. (2015). Confusing tastes with flavours. Perception and Its Modalities, Oxford University Press.","DOI":"10.1093\/acprof:oso\/9780199832798.001.0001"},{"key":"ref_4","unstructured":"ISO (2008). Standard 5492: Terms Relating to Sensory Analysis, International Organization for Standardization."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/B978-0-444-63855-7.00012-5","article-title":"Central taste anatomy and physiology","volume":"Volume 164","author":"Vincis","year":"2019","journal-title":"Handbook of Clinical Neurology"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"S34","DOI":"10.1038\/ijo.2009.70","article-title":"The gustatory cortex and multisensory integration","volume":"33","author":"Simon","year":"2009","journal-title":"Int. J. Obes."},{"key":"ref_7","first-page":"316","article-title":"Smell images and the flavour system in the human brain","volume":"444","author":"Shepherd","year":"2006","journal-title":"Nat. Cell Biol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"704S","DOI":"10.3945\/ajcn.113.067694","article-title":"Ontogeny of taste preferences: Basic biology and implications for health","volume":"99","author":"Mennella","year":"2014","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"13860","DOI":"10.1021\/acs.jafc.9b03542","article-title":"Basic Taste: A Perceptual Concept","volume":"67","author":"Beauchamp","year":"2019","journal-title":"J. Agric. Food Chem."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/B978-0-444-63855-7.00010-1","article-title":"Anatomy and development of the human taste system","volume":"Volume 164","author":"Witt","year":"2019","journal-title":"Handbook of Clinical Neurology"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s12078-014-9166-3","article-title":"Regional Differences in Suprathreshold Intensity for Bitter and Umami Stimuli","volume":"7","author":"Feeney","year":"2014","journal-title":"Chemosens. Percept."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1093\/chemse\/bjy055","article-title":"Regional Differences in Taste Responsiveness: Effect of Stimulus and Tasting Mode","volume":"43","author":"Colvin","year":"2018","journal-title":"Chem. Senses"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1093\/chemse\/bjz064","article-title":"Regional Variation of Bitter Taste and Aftertaste in Humans","volume":"44","author":"Higgins","year":"2019","journal-title":"Chem. Senses"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1038\/nrn.2017.68","article-title":"Taste buds: Cells, signals and synapses","volume":"18","author":"Roper","year":"2017","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2669","DOI":"10.2174\/13816128113199990566","article-title":"Genetics of Taste Receptors","volume":"20","author":"Bachmanov","year":"2014","journal-title":"Curr. Pharm. Des."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1126\/science.aao3264","article-title":"An evolutionarily conserved gene family encodes proton-selective ion channels","volume":"359","author":"Tu","year":"2018","journal-title":"Science"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/j.neuroscience.2005.12.020","article-title":"The role of the capsaicin receptor TRPV1 and acid-sensing ion channels (ASICS) in proton sensitivity of subpopulations of primary nociceptive neurons in rats and mice","volume":"139","author":"Leffler","year":"2006","journal-title":"Neuroscience"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0079-6123(08)61085-7","article-title":"Chapter 8. Tissue acidosis in nociception and pain","volume":"Volume 113","author":"Reeh","year":"1996","journal-title":"Progress in Brain Research"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Bigiani, A. (2020). Does ENaC Work as Sodium Taste Receptor in Humans?. Nutrients, 12.","DOI":"10.3390\/nu12041195"},{"key":"ref_20","first-page":"10","article-title":"Genetic Background of Taste Perception, Taste Preferences, and Its Nutritional Implications: A Systematic Review","volume":"10","author":"Llanaj","year":"2019","journal-title":"Front. Genet."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1007\/s00018-006-6077-8","article-title":"Natural sweet macromolecules: How sweet proteins work","volume":"63","author":"Temussi","year":"2006","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1146\/annurev-food-022811-101236","article-title":"Non-Caloric Sweeteners, Sweetness Modulators, and Sweetener Enhancers","volume":"3","author":"Dubois","year":"2012","journal-title":"Annu. Rev. Food Sci. Technol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.physbeh.2016.03.015","article-title":"Molecular mechanism of sweetness sensation","volume":"164","author":"Dubois","year":"2016","journal-title":"Physiol. Behav."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"5520","DOI":"10.1021\/jm0503345","article-title":"From Small Sweeteners to Sweet Proteins: Anatomy of the Binding Sites of the Human T1R2_T1R3 Receptor","volume":"48","author":"Morini","year":"2005","journal-title":"J. Med. Chem."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Hartley, I.E., Liem, D.G., and Keast, R.S.J. (2019). Umami as an \u2018Alimentary\u2019 Taste. A New Perspective on Taste Classification. Nutrients, 11.","DOI":"10.3390\/nu11010182"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"2204","DOI":"10.1021\/acs.jafc.6b04835","article-title":"Vertebrate Bitter Taste Receptors: Keys for Survival in Changing Environments","volume":"66","author":"Behrens","year":"2018","journal-title":"J. Agric. Food Chem."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"20","DOI":"10.3410\/B3-20","article-title":"Taste isn\u2019t just for taste buds anymore","volume":"3","author":"Finger","year":"2011","journal-title":"F1000 Biol. Rep."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1038\/s41573-018-0002-3","article-title":"Therapeutic potential of ectopic olfactory and taste receptors","volume":"18","author":"Lee","year":"2018","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1080\/10408398.2016.1152229","article-title":"Guelph Family Health Study. A review of the associations between single nucleotide polymorphisms in taste receptors, eating behaviors, and health","volume":"58","author":"Chamoun","year":"2017","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.foodres.2017.08.024","article-title":"Taste receptors in the gut\u2014A new target for health promoting properties in diet","volume":"100","author":"Ekstrand","year":"2017","journal-title":"Food Res. Int."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1093\/chemse\/bjv057","article-title":"Prevalence and Risk Factors of Self-Reported Smell and Taste Alterations: Results from the 2011\u20132012 US National Health and Nutrition Examination Survey (NHANES)","volume":"41","author":"Rawal","year":"2015","journal-title":"Chem. Senses"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1001\/archotol.1991.01870170065015","article-title":"Smell and Taste Disorders, A Study of 750 Patients From the University of Pennsylvania Smell and Taste Center","volume":"117","author":"Deems","year":"1991","journal-title":"Arch. Otolaryngol. Head Neck Surg."},{"key":"ref_33","first-page":"93","article-title":"Smell and taste disorders","volume":"20","author":"Hummel","year":"2012","journal-title":"GMS Curr. Top. Otorhinolaryngol. Head Neck Surg."},{"key":"ref_34","unstructured":"Davis, B., and Hoffman, H. (2020, June 08). What the Numbers Mean: An Epidemiological Perspective on Taste and Smell, Available online: https:\/\/www.nidcd.nih.gov\/health\/statistics\/what-numbersmean-epidemiological-perspective-taste-smell."},{"key":"ref_35","first-page":"386","article-title":"A study about the frequency of taste disorders","volume":"258","author":"Wolfensberger","year":"2010","journal-title":"J. Neurol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"753.e1","DOI":"10.1016\/j.amjmed.2016.02.003","article-title":"The Impact of Aging and Medical Status on Dysgeusia","volume":"129","author":"Syed","year":"2016","journal-title":"Am. J. Med."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1126\/science.147.3661.1040","article-title":"Absence of Taste-Bud Papillae in Familial Dysautonomia","volume":"147","author":"Smith","year":"1965","journal-title":"Science"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1126\/science.1080190","article-title":"Positional Cloning of the Human Quantitative Trait Locus Underlying Taste Sensitivity to Phenylthiocarbamide","volume":"299","author":"Kim","year":"2003","journal-title":"Science"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"25506","DOI":"10.1038\/srep25506","article-title":"Global diversity in the TAS2R38 bitter taste receptor: Revisiting a classic evolutionary PROPosal","volume":"6","author":"Risso","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1007\/s12263-014-0401-y","article-title":"Genetic signature of differential sensitivity to stevioside in the Italian population","volume":"9","author":"Risso","year":"2014","journal-title":"Genes Nutr."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/B978-0-444-63855-7.00022-8","article-title":"Toxic exposures and the senses of taste and smell","volume":"Volume 164","author":"Genter","year":"2019","journal-title":"Handbook of Clinical Neurology"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Nolden, A.A., Hwang, L.-D., Boltong, A., and Reed, D.R. (2019). Chemosensory Changes from Cancer Treatment and Their Effects on Patients\u2019 Food Behavior: A Scoping Review. Nutrients, 11.","DOI":"10.3390\/nu11102285"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1097\/SPC.0000000000000346","article-title":"Taste alterations and cancer treatment","volume":"12","author":"Kramer","year":"2018","journal-title":"Curr. Opin. Support. Palliat. Care"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/B978-0-444-63855-7.00023-X","article-title":"The influence of head injury on olfactory and gustatory function","volume":"Volume 164","author":"Schofield","year":"2019","journal-title":"Handbook of Clinical Neurology"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"e18527","DOI":"10.5812\/aapm.18527","article-title":"Postoperative Alterations in Taste and Smell","volume":"4","author":"Elterman","year":"2014","journal-title":"Anesthesiol. Pain Med."},{"key":"ref_46","first-page":"165","article-title":"Taste dysfunction and eating behaviors in survivors of head and neck cancer treatment","volume":"23","author":"McLaughlin","year":"2014","journal-title":"Medsurg Nurs."},{"key":"ref_47","first-page":"427","article-title":"Smell and taste disorders: A primary care approach","volume":"61","author":"Bromley","year":"2000","journal-title":"Am. Fam. Physician"},{"key":"ref_48","first-page":"455","article-title":"Taste change associated with a dental procedure: Case report and review of the literature","volume":"74","author":"Klasser","year":"2008","journal-title":"J. Can. Dent. Assoc."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"43","DOI":"10.18332\/tid\/94202","article-title":"Tobacco use and chemosensory impairments among current adult tobacco users in the US: Data from NHANES 2013\u20132014","volume":"16","author":"Schneller","year":"2018","journal-title":"Tob. Induc. Dis."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1093\/alcalc\/agv116","article-title":"Effect of Heavy Consumption of Alcoholic Beverages on the Perception of Sweet and Salty Taste","volume":"51","author":"Silva","year":"2015","journal-title":"Alcohol Alcohol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11864-018-0580-7","article-title":"Radiation-Related Alterations of Taste Function in Patients With Head and Neck Cancer: A Systematic Review","volume":"19","author":"Deshpande","year":"2018","journal-title":"Curr. Treat. Options Oncol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"44","DOI":"10.2174\/2212798411305010007","article-title":"The Role of Zinc in the Treatment of Taste Disorders","volume":"5","author":"Yagi","year":"2013","journal-title":"Recent Patents Food Nutr. Agric."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1016\/j.nutres.2015.09.011","article-title":"A potential trigger for pine mouth: A case of a homozygous phenylthiocarbamide taster","volume":"35","author":"Risso","year":"2015","journal-title":"Nutr. Res."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1002\/jnr.23819","article-title":"Contributory role of sex differences in the variations of gustatory function","volume":"95","author":"Martin","year":"2016","journal-title":"J. Neurosci. Res."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"167","DOI":"10.2147\/CIA.S37477","article-title":"Taste loss in hospitalized multimorbid elderly subjects","volume":"8","author":"Toffanello","year":"2013","journal-title":"Clin. Interv. Aging"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.parkreldis.2008.05.008","article-title":"Abnormality of taste and smell in Parkinson\u2019s disease","volume":"15","author":"Shah","year":"2009","journal-title":"Park. Relat. Disord."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.jns.2006.05.020","article-title":"Taste in dementing diseases and Parkinsonism","volume":"248","author":"Lang","year":"2006","journal-title":"J. Neurol. Sci."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"88","DOI":"10.3109\/00016489509133353","article-title":"Olfactory Threshold and Nasal Mucosal Changes in Experimentally Induced Common Cold","volume":"115","author":"Akerlund","year":"1995","journal-title":"Acta Oto-Laryngol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1093\/chemse\/27.9.831","article-title":"Intranasal Volume and Olfactory Function","volume":"27","author":"Damm","year":"2002","journal-title":"Chem. Senses"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1111\/j.1749-6632.2009.04480.x","article-title":"Inflammation and Taste Disorders","volume":"1170","author":"Wang","year":"2009","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.neuron.2020.06.032","article-title":"COVID-19 and the Chemical Senses: Supporting Players Take Center Stage","volume":"107","author":"Cooper","year":"2020","journal-title":"Neuron"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1093\/chemse\/bjaa031","article-title":"Coronaviruses and the Chemical Senses: Past, Present, and Future","volume":"45","author":"Pellegrino","year":"2020","journal-title":"Chem. Senses"},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Huart, C., Philpott, C., Konstantinidis, I., Altundag, A., Trecca, E.M.C., Cassano, M., Rombaux, P., and Hummel, T. (2020). Comparison of COVID-19 and common cold chemosensory dysfunction. Rhinology, 58.","DOI":"10.4193\/Rhin20.251"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1053\/j.gastro.2020.05.003","article-title":"Taste Changes (Dysgeusia) in COVID-19: A Systematic Review and Meta-analysis","volume":"159","author":"Aziz","year":"2020","journal-title":"Gastroenterology"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.oooo.2020.06.016","article-title":"Dysgeusia in COVID-19: Possible Mechanisms and Implications","volume":"130","author":"Fortuna","year":"2020","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"10260","DOI":"10.1523\/JNEUROSCI.1225-04.2004","article-title":"Bitter Taste Receptors for Saccharin and Acesulfame K","volume":"24","author":"Kuhn","year":"2004","journal-title":"J. Neurosci."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"81","DOI":"10.3389\/fmolb.2017.00081","article-title":"A Matter of Taste: Lineage-Specific Loss of Function of Taste Receptor Genes in Vertebrates","volume":"4","author":"Antinucci","year":"2017","journal-title":"Front. Mol. Biosci."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"S90","DOI":"10.1093\/jhered\/esp015","article-title":"Analyses of Sweet Receptor Gene (Tas1r2) and Preference for Sweet Stimuli in Species of Carnivora","volume":"100","author":"Li","year":"2009","journal-title":"J. Hered."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Risso, D.S., Kozlitina, J., Sainz, E., Gutierrez, J., Wooding, S., Getachew, B., Luiselli, D., Berg, C.J., and Drayna, D. (2016). Genetic Variation in the TAS2R38 Bitter Taste Receptor and Smoking Behaviors. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0164157"},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Kozlitina, J., Risso, D., Lansu, K., Olsen, R.H.J., Sainz, E., Luiselli, D., Barik, A., Frigerio-Domingues, C., Pagani, L., and Wooding, S. (2019). An African-specific haplotype in MRGPRX4 is associated with menthol cigarette smoking. PLoS Genet., 15.","DOI":"10.1371\/journal.pgen.1007916"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"16819","DOI":"10.1073\/pnas.1016644108","article-title":"Human sweet taste receptor mediates acid-induced sweetness of miraculin","volume":"108","author":"Koizumi","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"25711","DOI":"10.1074\/jbc.M114.560409","article-title":"Molecular Mechanisms for Sweet-suppressing Effect of Gymnemic Acids","volume":"289","author":"Sanematsu","year":"2014","journal-title":"J. Biol. Chem."},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Barrag\u00e1n, R., Coltell, O., Portol\u00e9s, O., Asensio, E.M., Sorl\u00ed, J.V., Ortega-Azor\u00edn, C., Gonz\u00e1lez, J.I., Saiz, C., Fern\u00e1ndez-Carri\u00f3n, R., and Ordov\u00e1s, J.M. (2018). Bitter, Sweet, Salty, Sour and Umami Taste Perception Decreases with Age: Sex-Specific Analysis, Modulation by Genetic Variants and Taste-Preference Associations in 18 to 80 Year-Old Subjects. Nutrients, 10.","DOI":"10.3390\/nu10101539"},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Cowart, B.J., Young, I., Feldman, R.S., and Lowry, L.D. (1997). Clinical disorders of smell and taste. Tasting and Smelling, Academic Press.","DOI":"10.1016\/B978-012161958-9\/50006-3"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1007\/BF03654833","article-title":"Taste loss in the elderly: Epidemiology, causes and consequences","volume":"24","author":"Imoscopi","year":"2012","journal-title":"Aging Clin. Exp. Res."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1093\/chemse\/bjx005","article-title":"The Impact of Pregnancy on Taste Function","volume":"42","author":"Choo","year":"2017","journal-title":"Chem. Senses"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1177\/000348947508400519","article-title":"Hypogeusia, Dysgeusia, Hyposmia, and Dysosmia following Influenza-Like Infection","volume":"84","author":"Henkin","year":"1975","journal-title":"Ann. Otol. Rhinol. Laryngol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.amjoto.2013.04.006","article-title":"Taste and smell function in chronic disease: A Review of Clinical and Biochemical Evaluations of Taste and Smell Dysfunction in Over 5000 Patients at The Taste and Smell Clinic in Washington, DC","volume":"34","author":"Henkin","year":"2013","journal-title":"Am. J. Otolaryngol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1128\/JCM.36.2.539-542.1998","article-title":"Viruses and Bacteria in the Etiology of the Common Cold","volume":"36","author":"Puhakka","year":"1998","journal-title":"J. Clin. Microbiol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1093\/cid\/ciaa330","article-title":"Self-reported olfactory and taste disorders in SARS-CoV-2 patients: A cross-sectional study","volume":"71","author":"Giacomelli","year":"2020","journal-title":"Clin. Infect. Dis."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1093\/chemse\/bjaa041","article-title":"More Than Smell\u2014COVID-19 Is Associated With Severe Impairment of Smell, Taste, and Chemesthesis","volume":"45","author":"Parma","year":"2020","journal-title":"Chem. Senses"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1002\/hed.26204","article-title":"Objective evaluation of anosmia and ageusia in COVID -19 patients: Single-center experience on 72 cases","volume":"42","author":"Vaira","year":"2020","journal-title":"Head Neck"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"eabc3582","DOI":"10.1126\/sciimmunol.abc3582","article-title":"TMPRSS2 and TMPRSS4 promote SARS-CoV-2 infection of human small intestinal enterocytes","volume":"5","author":"Zang","year":"2020","journal-title":"Sci. Immunol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1002\/ddr.21674","article-title":"COVID -19 transmission through host cell directed network of GPCR","volume":"81","author":"Singh","year":"2020","journal-title":"Drug Dev. Res."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"2001948","DOI":"10.1183\/13993003.01948-2020","article-title":"Elevated ACE2 expression in the olfactory neuroepithelium: Implications for anosmia and upper respiratory SARS-CoV-2 entry and replication","volume":"56","author":"Chen","year":"2020","journal-title":"Eur. Respir. J."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1038\/s41591-020-0868-6","article-title":"SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes","volume":"26","author":"Sungnak","year":"2020","journal-title":"Nat. Med."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12916-020-01673-z","article-title":"New insights into genetic susceptibility of COVID-19: An ACE2 and TMPRSS2 polymorphism analysis","volume":"18","author":"Hou","year":"2020","journal-title":"BMC Med."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"329","DOI":"10.3949\/ccjm.69.4.329","article-title":"Management of smell and taste problems","volume":"69","author":"Mann","year":"2002","journal-title":"Clevel. Clin. J. Med."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s00784-002-0169-0","article-title":"Perceived taste disturbance in adults: Prevalence and association with oral and psychological factors and medication","volume":"6","author":"Bergdahl","year":"2002","journal-title":"Clin. Oral Investig."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1002\/lio2.142","article-title":"Association of alterations in smell and taste with depression in older adults","volume":"3","author":"Hur","year":"2018","journal-title":"Laryngoscope"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"3684","DOI":"10.1080\/10408398.2016.1160208","article-title":"Taste loss in the elderly: Possible implications for dietary habits","volume":"57","author":"Sergi","year":"2017","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Xue, Y., Wen, Q., Xu, C., Zhang, X., Zeng, J., Sha, A.M., Lan, C., Li, L., Wang, H., and Yang, X. (2020). Elevated Salt Taste Threshold Is Associated with Increased Risk of Coronary Heart Disease. J. Cardiovasc. Transl. Res., 1\u20138.","DOI":"10.1007\/s12265-020-10017-4"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1111\/1541-4337.12399","article-title":"New Food Products for Sensory-Compromised Situations","volume":"17","author":"Regenstein","year":"2018","journal-title":"Compr. Rev. Food Sci. Food Saf."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"m2237","DOI":"10.1136\/bmj.m2237","article-title":"Obesity and covid-19: The role of the food industry","volume":"369","author":"Tan","year":"2020","journal-title":"BMJ"},{"key":"ref_95","first-page":"1","article-title":"Eating habits and lifestyle changes during COVID-19 lockdown: An Italian survey","volume":"18","author":"Gualtieri","year":"2020","journal-title":"J. Transl. Med."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.crfs.2020.05.003","article-title":"Perspectives from CO+RE: How COVID-19 changed our food systems and food security paradigms","volume":"3","author":"Bakalis","year":"2020","journal-title":"Curr. Res. Food Sci."},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Ammar, A., Brach, M., Trabelsi, K., Chtourou, H., Boukhris, O., Masmoudi, L., Bouaziz, B., Bentlage, E., How, D., and Ahmed, M. (2020). Effects of COVID-19 Home Confinement on Eating Behaviour and Physical Activity: Results of the ECLB-COVID19 International Online Survey. Nutrients, 12.","DOI":"10.3390\/nu12061583"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.bbi.2020.04.040","article-title":"The impact of nutrition on COVID-19 susceptibility and long-term consequences","volume":"87","author":"Butler","year":"2020","journal-title":"Brain Behav. Immun."},{"key":"ref_99","unstructured":"WHO (2020, October 26). Nutrition Advice for Adults during the COVID-19 Outbreak. Available online: http:\/\/www.emro.who.int\/nutrition\/nutrition-infocus\/nutrition-advice-for-adults-during-the-covid-19-outbreak.html."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/12\/11\/3284\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T10:28:49Z","timestamp":1760178529000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/12\/11\/3284"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,27]]},"references-count":99,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2020,11]]}},"alternative-id":["nu12113284"],"URL":"https:\/\/doi.org\/10.3390\/nu12113284","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,27]]}}}