{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T17:39:08Z","timestamp":1791999548984,"version":"4.4.0"},"reference-count":177,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2020,10,31]],"date-time":"2020-10-31T00:00:00Z","timestamp":1604102400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Bee venom (BV) is usually associated with pain since, when humans are stung by bees, local inflammation and even an allergic reaction can be produced. BV has been traditionally used in ancient medicine and in acupuncture. It consists of a mixture of substances, principally of proteins and peptides, including enzymes as well as other types of molecules in a very low concentration. Melittin and phospholipase A2 (PLA2) are the most abundant and studied compounds of BV. Literature of the main biological activities exerted by BV shows that most studies focuses on the comprehension and test of anti-inflammatory effects and its mechanisms of action. Other properties such as antioxidant, antimicrobial, neuroprotective or antitumor effects have also been assessed, both in vitro and in vivo. Moreover, human trials are necessary to confirm those clinical applications. However, notwithstanding the therapeutic potential of BV, there are certain problems regarding its safety and the possible appearance of adverse effects. On this perspective, new approaches have been developed to avoid these complications. This manuscript is aimed at reviewing the actual knowledge on BV components and its associated biological activities as well as the latest advances on this subject.<\/jats:p>","DOI":"10.3390\/nu12113360","type":"journal-article","created":{"date-parts":[[2020,10,31]],"date-time":"2020-10-31T21:39:56Z","timestamp":1604180396000},"page":"3360","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":172,"title":["Bee Venom: An Updating Review of Its Bioactive Molecules and Its Health Applications"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4819-7856","authenticated-orcid":false,"given":"Maria","family":"Carpena","sequence":"first","affiliation":[{"name":"Nutrition and Bromatology Group, Analytical and Food Chemistry Department, Faculty of Food Science and Technology, University of Vigo, Ourense Campus, E-32004 Ourense, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6435-7952","authenticated-orcid":false,"given":"Bernabe","family":"Nu\u00f1ez-Estevez","sequence":"additional","affiliation":[{"name":"Nutrition and Bromatology Group, Analytical and Food Chemistry Department, Faculty of Food Science and Technology, University of Vigo, Ourense Campus, E-32004 Ourense, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anton","family":"Soria-Lopez","sequence":"additional","affiliation":[{"name":"Nutrition and Bromatology Group, Analytical and Food Chemistry Department, Faculty of Food Science and Technology, University of Vigo, Ourense Campus, E-32004 Ourense, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9215-9737","authenticated-orcid":false,"given":"Jesus","family":"Simal-Gandara","sequence":"additional","affiliation":[{"name":"Nutrition and Bromatology Group, Analytical and Food Chemistry Department, Faculty of Food Science and Technology, University of Vigo, Ourense Campus, E-32004 Ourense, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,10,31]]},"reference":[{"key":"ref_1","first-page":"459","article-title":"Bee Venom Composition: From Chemistry to Biological Activity","volume":"60","author":"Khalifa","year":"2018","journal-title":"Stud. Nat. Prod. Chem."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1093\/ecam\/nem052","article-title":"Apitherapy: Usage and experience in German beekeepers","volume":"5","author":"Hellner","year":"2008","journal-title":"Evidence-Based Complement. Altern. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.toxicon.2018.04.012","article-title":"Bee venom therapy: Potential mechanisms and therapeutic applications","volume":"148","author":"Zhang","year":"2018","journal-title":"Toxicon"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Grassberger, M., Sherman, R.A., Gileva, O.S., and Kim, C.M.H. (2013). Biotherapy\u2014History, Principles and Practice, Springer.","DOI":"10.1007\/978-94-007-6585-6"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1126\/science.142.3589.228","article-title":"Venom collection from honey bees","volume":"142","author":"Benton","year":"1963","journal-title":"Science"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/00218839.2020.1738135","article-title":"Standard methods for Apis mellifera honey research","volume":"59","author":"Dietemann","year":"2020","journal-title":"J. Apic. Res."},{"key":"ref_7","unstructured":"Krell, R. (1996). Value-added products from beekeeping. FAO Agriculture Server Bulletin, Food and Agriculture Organization of the United Nations. No. 124."},{"key":"ref_8","first-page":"1","article-title":"Studies on Bee Venom and Its Medical Uses","volume":"1","author":"Ali","year":"2012","journal-title":"Int. J. Adv. Res."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fimmu.2019.02090","article-title":"Bee Updated: Current Knowledge on Bee Venom and Bee Envenoming Therapy","volume":"10","author":"Pucca","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/0021-9673(94)01170-J","article-title":"Comparison of high-performance liquid chromatography and capillary electrophoresis for the determination of some bee venom components","volume":"700","year":"1995","journal-title":"J. Chromatogr. A"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s10540-006-9030-z","article-title":"Melittin: A membrane-active peptide with diverse functions","volume":"27","author":"Raghuraman","year":"2007","journal-title":"Biosci. Rep."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s15007-017-1315-y","article-title":"Diagnostik der Hymenopteren-giftallergie: Aktuelle Konzepte und Entwicklungen mit besonderem Fokus auf die molekulare Allergiediagnostik","volume":"26","author":"Jakob","year":"2017","journal-title":"Allergo J."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/S0006-8993(97)01165-7","article-title":"Apamin, a blocker of the calcium-activated potassium channel, induces neurodegeneration of Purkinje cells exclusively","volume":"778","author":"Mourre","year":"1997","journal-title":"Brain Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1111\/j.1476-5381.1990.tb14707.x","article-title":"Anti-inflammatory activity of bee venom peptide 401 (mast cell degranulating peptide) and compound 48\/80 results from mast cell degranulation in vivo","volume":"99","author":"Banks","year":"1990","journal-title":"Br. J. Pharmacol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.dci.2016.05.011","article-title":"Secapin, a bee venom peptide, exhibits anti-fibrinolytic, anti-elastolytic, and anti-microbial activities","volume":"63","author":"Lee","year":"2016","journal-title":"Dev. Comp. Immunol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/0041-0101(82)90234-3","article-title":"Adolapin\u2014A newly isolated analgetic and anti-inflammatory polypeptide from bee venom","volume":"20","author":"Shkenderov","year":"1982","journal-title":"Toxicon"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1038\/337413a0","article-title":"Lethality of \u2018killer\u2019 bee stings","volume":"337","author":"Schumacher","year":"1989","journal-title":"Nature"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"104011","DOI":"10.1016\/j.micpath.2020.104011","article-title":"Influence of apitoxin and melittin from Apis mellifera bee on Staphylococcus aureus strains","volume":"141","author":"Albano","year":"2020","journal-title":"Microb. Pathog."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.tox.2019.03.003","article-title":"Involvement of the anti-inflammatory, anti-apoptotic, and anti-secretory activity of bee venom in its therapeutic effects on acetylsalicylic acid-induced gastric ulceration in rats","volume":"419","author":"Mohamed","year":"2019","journal-title":"Toxicology"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.plefa.2009.10.001","article-title":"Cardiovascular effect of peripheral injected melittin in normotensive conscious rats: Mediation of the central cholinergic system","volume":"81","author":"Yalcin","year":"2009","journal-title":"Prostaglandins Leukot. Essent. Fat. Acids"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Lim, H.N., Baek, S.B., and Jung, H.J. (2019). Bee venom and its peptide component melittin suppress growth and migration of melanoma cells via inhibition of PI3K\/Akt\/mTOR and MAPK pathways. Molecules, 24.","DOI":"10.3390\/molecules24050929"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.intimp.2015.02.021","article-title":"Melittin has a chondroprotective effect by inhibiting MMP-1 and MMP-8 expressions via blocking NF-\u03baB and AP-1 signaling pathway in chondrocytes","volume":"25","author":"Jeong","year":"2015","journal-title":"Int. Immunopharmacol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.5551\/jat.8474","article-title":"Melittin inhibits atherosclerosis in LPS\/high-fat treated mice through atheroprotective actions","volume":"18","author":"Kim","year":"2011","journal-title":"J. Atheroscler. Thromb."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s10096-019-03674-0","article-title":"Melittin: A venom-derived peptide with promising anti-viral properties","volume":"39","author":"Memariani","year":"2020","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"3186","DOI":"10.3748\/wjg.v22.i11.3186","article-title":"Melittin induces human gastric cancer cell apoptosis via activation of mitochondrial pathway","volume":"22","author":"Kong","year":"2016","journal-title":"World J. Gastroenterol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.taap.2011.08.012","article-title":"Protective effects of melittin on transforming growth factor-\u03b21 injury to hepatocytes via anti-apoptotic mechanism","volume":"256","author":"Lee","year":"2011","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Choi, S., Chae, H.K., Heo, H., Hahm, D.H., Kim, W., and Kim, S.K. (2019). Analgesic effect of melittin on oxaliplatin-induced peripheral neuropathy in rats. Toxins, 11.","DOI":"10.3390\/toxins11070396"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Li, L., Zhang, S., Wei, L., Wang, Z., Ma, W., Liu, F., Shen, Y., Zhang, S., Zhang, X., and Hang, Y. (2020). Anti-fibrotic effect of melittin on TRIM47 expression in human embryonic lung fibroblast through regulating TRIM47 pathway. Life Sci., 256.","DOI":"10.1016\/j.lfs.2020.117893"},{"key":"ref_29","first-page":"3","article-title":"Effect of Honey Bee Venom (Apis mellifera) on Hyperglycemia and Hyperlipidemia in Alloxan Induced Diabetic Rabbits","volume":"6","author":"Khulan","year":"2016","journal-title":"J. Diabetes Metab."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/S0005-2736(96)00122-8","article-title":"The lytic activity of the bee venom peptide melittin is strongly reduced by the presence of negatively charged phospholipids or chloroplast galactolipids in the membranes of phosphatidylcholine large unilamellar vesicles","volume":"1284","author":"Hincha","year":"1996","journal-title":"Biochim. Biophys. Acta Biomembr."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Shin, J.M., Jeong, Y.J., Cho, H.J., Park, K.K., Chung, I.K., Lee, I.K., Kwak, J.Y., Chang, H.W., Kim, C.H., and Moon, S.K. (2013). Melittin Suppresses HIF-1\u03b1\/VEGF Expression through Inhibition of ERK and mTOR\/p70S6K Pathway in Human Cervical Carcinoma Cells. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0069380"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s10059-010-0028-9","article-title":"Melittin suppresses PMA-induced tumor cell invasion by inhibiting NF-\u03baB and AP-1-dependent MMP-9 expression","volume":"29","author":"Park","year":"2010","journal-title":"Mol. Cells"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"6513","DOI":"10.1007\/s00253-020-10701-0","article-title":"Anti-fungal properties and mechanisms of melittin","volume":"104","author":"Memariani","year":"2020","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Shin, S.H., Ye, M.K., Choi, S.Y., and Park, K.K. (2017). The effects of melittin and apamin on airborne fungi-induced chemical mediator and extracellular matrix production from nasal polyp fibroblasts. Toxins, 9.","DOI":"10.3390\/toxins9110348"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.3892\/ijmm.2017.2922","article-title":"Apamin suppresses biliary fibrosis and activation of hepatic stellate cells","volume":"39","author":"Kim","year":"2017","journal-title":"Int. J. Mol. Med."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s10555-011-9339-3","article-title":"Bee venom in cancer therapy","volume":"31","year":"2012","journal-title":"Cancer Metastasis Rev."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"112860","DOI":"10.1016\/j.jep.2020.112860","article-title":"Apamin from bee venom suppresses inflammation in a murine model of gouty arthritis","volume":"257","author":"Lee","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"ref_38","first-page":"1","article-title":"The protective effect of apamin on LPS\/fat-induced atherosclerotic mice","volume":"2012","author":"Kim","year":"2012","journal-title":"Evidence-Based Complement. Altern. Med."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1590\/0001-3765201520130511","article-title":"Antimicrobial activity of apitoxin, melittin and phospholipase A2 of honey bee (Apis mellifera) venom against oral pathogens","volume":"87","author":"Leandro","year":"2015","journal-title":"An. Acad. Bras. Cienc."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"424","DOI":"10.4103\/1735-5362.268203","article-title":"Evaluation of apamin effects on myelination process in C57BL\/6 mice model of multiple sclerosis","volume":"14","author":"Ghasemi","year":"2019","journal-title":"Res. Pharm. Sci."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1016\/S0196-9781(01)00542-3","article-title":"Mast cell degranulating peptide binds to RBL-2H3 mast cell receptors and inhibits IgE binding","volume":"22","author":"Buku","year":"2001","journal-title":"Peptides"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Wehbe, R., Frangieh, J., Rima, M., Obeid, D.E., Sabatier, J.M., and Fajloun, Z. (2019). Bee venom: Overview of main compounds and bioactivities for therapeutic interests. Molecules, 24.","DOI":"10.3390\/molecules24162997"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"106340","DOI":"10.1016\/j.prostaglandins.2019.106340","article-title":"Respective contribution of cytosolic phospholipase A2\u03b1 and secreted phospholipase A2 IIA to inflammation and eicosanoid production in arthritis","volume":"143","author":"Duchez","year":"2019","journal-title":"Prostaglandins Other Lipid Mediat."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/IAI.00556-19","article-title":"Antimalarial activity of human group IIA secreted phospholipase A2 in relation to enzymatic hydrolysis of oxidized lipoproteins","volume":"87","author":"Dacheux","year":"2019","journal-title":"Infect. Immun."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.exppara.2008.02.002","article-title":"The effects of bee (Apis mellifera) venom phospholipase A2 on Trypanosoma brucei brucei and enterobacteria","volume":"119","author":"Boutrin","year":"2008","journal-title":"Exp. Parasitol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fnagi.2019.00287","article-title":"Bee Venom Soluble Phospholipase A2 Exerts Neuroprotective Effects in a Lipopolysaccharide-Induced Mouse Model of Alzheimer\u2019s Disease via Inhibition of Nuclear Factor-Kappa B","volume":"11","author":"Ham","year":"2019","journal-title":"Front. Aging Neurosci."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1158\/1535-7163.MCT-09-0904","article-title":"Phospholipase A2 activity of peroxiredoxin 6 promotes invasion and metastasis of lung cancer cells","volume":"9","author":"Ho","year":"2010","journal-title":"Mol. Cancer Ther."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1124\/mol.60.2.341","article-title":"A peptide derived from bee venom-secreted phospholipase A2 inhibits replication of T-cell tropic HIV-1 strains via interaction with the CXCR4 chemokine receptor","volume":"60","author":"Fenard","year":"2001","journal-title":"Mol. Pharmacol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fnagi.2019.00080","article-title":"Dose-dependent neuroprotective effect of standardized bee venom phospholipase A2 against MPTP-induced Parkinson\u2019s disease in mice","volume":"11","author":"Kim","year":"2019","journal-title":"Front. Aging Neurosci."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0041-0101(99)00143-9","article-title":"Effect of crotapotin and heparin on the rat paw oedema induced by different secretory phospholipases A2","volume":"38","author":"Landucci","year":"2000","journal-title":"Toxicon"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1111\/all.12859","article-title":"Efficacy of a therapeutic treatment using gas-filled microbubble-associated phospholipase A2 in a mouse model of honeybee venom allergy","volume":"71","author":"Lassus","year":"2016","journal-title":"Allergy Eur. J. Allergy Clin. Immunol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fnagi.2018.00179","article-title":"Comparison of administration routes on the protective effects of Bee Venom Phospholipase A2 in a mouse model of Parkinson\u2019s disease","volume":"10","author":"Baek","year":"2018","journal-title":"Front. Aging Neurosci."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"e244","DOI":"10.1038\/emm.2016.49","article-title":"Bee venom phospholipase A2 ameliorates motor dysfunction and modulates microglia activation in Parkinson\u2019s disease alpha-synuclein transgenic mice","volume":"48","author":"Ye","year":"2016","journal-title":"Exp. Mol. Med."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/S0945-053X(01)00172-X","article-title":"The six hyaluronidase-like genes in the human and mouse genomes","volume":"20","author":"Csoka","year":"2001","journal-title":"Matrix Biol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1016\/S0969-2126(00)00511-6","article-title":"Crystal structure of hyaluronidase, a major allergen of bee venom","volume":"8","author":"Miglierini","year":"2000","journal-title":"Structure"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.jprot.2013.04.039","article-title":"Exploring the hidden honeybee (Apis mellifera) venom proteome by integrating a combinatorial peptide ligand library approach with FTMS","volume":"99","author":"Debyser","year":"2014","journal-title":"J. Proteom."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"110864","DOI":"10.1016\/j.fct.2019.110864","article-title":"An overview of the bioactive compounds, therapeutic properties and toxic effects of apitoxin","volume":"134","author":"Pascoal","year":"2019","journal-title":"Food Chem. Toxicol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.pneurobio.2010.06.006","article-title":"The nociceptive and anti-nociceptive effects of bee venom injection and therapy: A double-edged sword","volume":"92","author":"Chen","year":"2010","journal-title":"Prog. Neurobiol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.pharmthera.2007.04.004","article-title":"Therapeutic application of anti-arthritis, pain-releasing, and anti-cancer effects of bee venom and its constituent compounds","volume":"115","author":"Son","year":"2007","journal-title":"Pharmacol. Ther."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.fct.2016.06.008","article-title":"Chemical characterization, antioxidant, anti-inflammatory and cytotoxic properties of bee venom collected in Northeast Portugal","volume":"94","author":"Sobral","year":"2016","journal-title":"Food Chem. Toxicol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.canlet.2017.05.010","article-title":"Melittin, a major peptide component of bee venom, and its conjugates in cancer therapy","volume":"402","author":"Rady","year":"2017","journal-title":"Cancer Lett."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.jphs.2019.03.009","article-title":"Melittin\u2014A bee venom component\u2014Enhances muscle regeneration factors expression in a mouse model of skeletal muscle contusion","volume":"140","author":"Lee","year":"2019","journal-title":"J. Pharmacol. Sci."},{"key":"ref_63","unstructured":"(2020, September 16). PubChem Compound Summary: Melittin, Available online: https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/16133648#section=UN-GHS-Classification."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.peptides.2004.10.004","article-title":"Deletion of two C-terminal Gln residues of 12\u201326-residue fragment of melittin improves its antimicrobial activity","volume":"26","author":"Sun","year":"2005","journal-title":"Peptides"},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Lee, G., and Bae, H. (2016). Anti-inflammatory applications of melittin, a major component of bee venom: Detailed mechanism of action and adverse effects. Molecules, 21.","DOI":"10.3390\/molecules21050616"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"2586","DOI":"10.1021\/bi802127h","article-title":"Thermodynamics of melittin binding to lipid bilayers. Aggregation and pore formation","volume":"48","author":"Klocek","year":"2009","journal-title":"Biochemistry"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"2234","DOI":"10.1016\/j.bbamem.2018.09.007","article-title":"Molecular details on the intermediate states of melittin action on a cell membrane","volume":"1860","author":"Liu","year":"2018","journal-title":"Biochim. Biophys. Acta Biomembr."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.etap.2013.06.009","article-title":"Melittin: A lytic peptide with anticancer properties","volume":"36","author":"Gajski","year":"2013","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"14243","DOI":"10.1073\/pnas.1307010110","article-title":"Process of inducing pores in membranes by melittin","volume":"110","author":"Lee","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"95","DOI":"10.3851\/IMP2346","article-title":"Cytolytic nanoparticles attenuate HIV-1 infectivity","volume":"18","author":"Hood","year":"2013","journal-title":"Antivir. Ther."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1007\/s12275-016-6376-1","article-title":"Inhibitory effects of bee venom and its components against viruses in vitro and in vivo","volume":"54","author":"Uddin","year":"2016","journal-title":"J. Microbiol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.taap.2011.10.009","article-title":"Anti-cancer effect of bee venom toxin and melittin in ovarian cancer cells through induction of death receptors and inhibition of JAK2\/STAT3 pathway","volume":"258","author":"Jo","year":"2012","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Zhang, H., Zhao, B., Huang, C., Meng, X.M., Bian, E.B., and Li, J. (2014). Melittin restores PTEN expression by down-regulating HDAC2 in human hepatocelluar carcinoma HepG2 cells. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0095520"},{"key":"ref_74","first-page":"1","article-title":"Immune modulation of liver sinusoidal endothelial cells by melittin nanoparticles suppresses liver metastasis","volume":"10","author":"Yu","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_75","unstructured":"(2020, September 17). PubChem Apamin, N-acetyl-4-(N6-acetyl-L-lysine)-78114-13-3, Available online: https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/91808948."},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Palma, M.S. (2013). Hymenoptera Insect Peptides. Handbook of Biologically Active Peptides: Venom Peptides, Elsevier Inc.","DOI":"10.1016\/B978-0-12-385095-9.00058-0"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"27067","DOI":"10.1074\/jbc.M110.110072","article-title":"Allosteric block of KCa2 channels by apamin","volume":"285","author":"Lamy","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.ejphar.2009.09.064","article-title":"Apamin reduces neuromuscular transmission by activating inhibitory muscarinic M2 receptors on motor nerve terminals","volume":"626","author":"Silva","year":"2010","journal-title":"Eur. J. Pharmacol."},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Gu, H., Han, S.M., and Park, K.K. (2020). Therapeutic effects of apamin as a bee venom component for non-neoplastic disease. Toxins, 12.","DOI":"10.3390\/toxins12030195"},{"key":"ref_80","first-page":"6632","article-title":"Anti-inflammatory effect of bee venom in an allergic chronic rhinosinusitis mouse model","volume":"17","author":"Shin","year":"2018","journal-title":"Mol. Med. Rep."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1016\/j.pharep.2017.04.006","article-title":"Apamin inhibits TNF-\u03b1-and IFN-\u03b3-induced inflammatory cytokines and chemokines via suppressions of NF-\u03baB signaling pathway and STAT in human keratinocytes","volume":"69","author":"Kim","year":"2017","journal-title":"Pharmacol. Rep."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.yexmp.2012.04.003","article-title":"Apamin inhibits THP-1-derived macrophage apoptosis via mitochondria-related apoptotic pathway","volume":"93","author":"Kim","year":"2012","journal-title":"Exp. Mol. Pathol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1111\/j.2042-7158.1990.tb06595.x","article-title":"Mast Cell Degranulating Peptide: A Multi-functional Neurotoxin","volume":"42","author":"Ziai","year":"1990","journal-title":"J. Pharm. Pharmacol."},{"key":"ref_84","unstructured":"(2020, September 17). PubChem Mast Cell Degranulating Peptide, Available online: https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/16132290."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1016\/S0196-9781(01)00538-1","article-title":"Further studies on the structural requirements for mast cell degranulating (MCD) peptide-mediated histamine release","volume":"22","author":"Buku","year":"2001","journal-title":"Peptides"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/S0196-9781(98)00167-3","article-title":"Mast cell degranulating (MCD) peptide: A prototypic peptide in allergy and inflammation","volume":"20","author":"Buku","year":"1999","journal-title":"Peptides"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1007\/s12016-017-8597-4","article-title":"Immunology of Bee Venom","volume":"54","author":"Shafaghat","year":"2018","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1002\/psc.532","article-title":"Partial alanine scan of mast cell degranulating peptide (MCD): Importance of the histidine-and arinine residues","volume":"10","author":"Buku","year":"2004","journal-title":"J. Pept. Sci."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fphar.2017.00412","article-title":"Therapeutic properties of bioactive compounds from different honeybee products","volume":"8","author":"Cornara","year":"2017","journal-title":"Front. Pharmacol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1016\/j.cclet.2012.09.003","article-title":"A novel peptide from Apis mellifera and solid-phase synthesis of its analogue","volume":"23","author":"Meng","year":"2012","journal-title":"Chin. Chem. Lett."},{"key":"ref_91","unstructured":"(2020, September 18). PubChem Secapin, Available online: https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/Secapin."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1111\/j.1432-1033.1984.tb08549.x","article-title":"Nucleotide sequence of cloned cDNAs coding for preprosecapin, a major product of queen-bee venom glands","volume":"145","author":"Vlasak","year":"1984","journal-title":"Eur. J. Biochem."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"8081","DOI":"10.1007\/s11033-014-3706-4","article-title":"Production of antibacterial peptide from bee venom via a new strategy for heterologous expression","volume":"41","author":"Hou","year":"2014","journal-title":"Mol. Biol. Rep."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.peptides.2014.07.004","article-title":"Hyperalgesic and edematogenic effects of Secapin-2, a peptide isolated from Africanized honeybee (Apis mellifera) venom","volume":"59","author":"Mourelle","year":"2014","journal-title":"Peptides"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"3715","DOI":"10.3390\/toxins7093715","article-title":"Bee venom protects against rotenone-induced cell death in NSC34 motor neuron cells","volume":"7","author":"Jung","year":"2015","journal-title":"Toxins"},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Moga, M.A., Dimienescu, O.G., Arv\u01cetescu, C.A., Ifteni, P., and Ple\u015f, L. (2018). Anticancer activity of toxins from bee and snake venom-an overview on ovarian cancer. Molecules, 23.","DOI":"10.3390\/molecules23030692"},{"key":"ref_97","first-page":"196","article-title":"Tertiapin Potently and Selectively Blocks Muscarinic K+ Channels in Rabbit Cardiac Myocytes 1","volume":"293","author":"Kitamura","year":"2000","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_98","unstructured":"PubChem (2020, September 18). Tertiapin LQ, Available online: https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/90488935."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-020-66673-8","article-title":"Inhibition of G protein-gated K + channels by tertiapin-Q rescues sinus node dysfunction and atrioventricular conduction in mouse models of primary bradycardia","volume":"10","author":"Bidaud","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"14294","DOI":"10.1021\/bi991206j","article-title":"Mechanisms of inward-rectifier K+ channel inhibition by tertiapin-Q","volume":"38","author":"Jin","year":"1999","journal-title":"Biochemistry"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1021\/jf60191a002","article-title":"Procamine and Other Basic Peptides in the Venom of the Honeybee (Apis mellifera)","volume":"22","author":"Peck","year":"1974","journal-title":"J. Agric. Food Chem."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/0003-9861(71)90044-0","article-title":"Polypeptides minimine and melittin from bee venom: Effects on Drosophila","volume":"145","author":"Lowy","year":"1971","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/0041-0101(74)90237-2","article-title":"Beta adrenergic and anti-arrhythmic effects of cardiopep, a newly isolated substance from whole bee venom","volume":"12","author":"Vick","year":"1974","journal-title":"Toxicon"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1111\/imb.12013","article-title":"Extending the honey bee venome with the antimicrobial peptide apidaecin and a protein resembling wasp antigen 5","volume":"22","author":"Cardoen","year":"2013","journal-title":"Insect Mol. Biol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.biochi.2010.09.012","article-title":"Disulfide bonds of phospholipase A2 from bee venom yield discrete contributions to its conformational stability","volume":"93","author":"Welker","year":"2011","journal-title":"Biochimie"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"6130","DOI":"10.1021\/cr200085w","article-title":"Phospholipase A2 enzymes: Physical structure, biological function, disease implication, chemical inhibition, and therapeutic intervention","volume":"111","author":"Dennis","year":"2011","journal-title":"Chem. Rev."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1007\/s00262-006-0220-0","article-title":"Bee venom secretory phospholipase A2 and phosphatidylinositol-homologues cooperatively disrupt membrane integrity, abrogate signal transduction and inhibit proliferation of renal cancer cells","volume":"56","author":"Putz","year":"2007","journal-title":"Cancer Immunol. Immunother."},{"key":"ref_108","first-page":"3","article-title":"Phospholipase A2 Enzymes","volume":"68\u201369","author":"Kudo","year":"2020","journal-title":"Prostaglandins Other Lipids Mediat."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1111\/j.1365-2672.2006.03161.x","article-title":"Antibacterial activity of snake, scorpion and bee venoms: A comparison with purified venom phospholipase A2 enzymes","volume":"102","author":"Samy","year":"2007","journal-title":"J. Appl. Microbiol."},{"key":"ref_110","first-page":"1","article-title":"Broad-spectrum antiviral agents: Secreted phospholipase A2 targets viral envelope lipid bilayers derived from the endoplasmic reticulum membrane","volume":"7","author":"Chen","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Lee, G., and Bae, H. (2016). Bee venom phospholipase A2: Yesterday\u2019s enemy becomes today\u2019s friend. Toxins, 8.","DOI":"10.3390\/toxins8020048"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"9526","DOI":"10.1016\/S0021-9258(19)38881-7","article-title":"Identification and purification of a very high affinity binding protein for toxic phospholipases A2 in skeletal muscle","volume":"265","author":"Lambeau","year":"1990","journal-title":"J. Biol. Chem."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"11503","DOI":"10.1016\/S0021-9258(18)60492-2","article-title":"Identification and properties of very high affinity brain membrane-binding sites for a neurotoxic phospholipase from the taipan venom","volume":"264","author":"Lambeau","year":"1989","journal-title":"J. Biol. Chem."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"7173","DOI":"10.1074\/jbc.272.11.7173","article-title":"Localization of structural elements of bee venom phospholipase A2 involved in N-type receptor binding and neurotoxicity","volume":"272","author":"Nicolas","year":"1997","journal-title":"J. Biol. Chem."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"4853","DOI":"10.4049\/jimmunol.1500386","article-title":"Bee Venom Phospholipase A 2, a Novel Foxp3 + Regulatory T Cell Inducer, Protects Dopaminergic Neurons by Modulating Neuroinflammatory Responses in a Mouse Model of Parkinson\u2019s Disease","volume":"195","author":"Chung","year":"2015","journal-title":"J. Immunol."},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"Baek, H., Park, S.Y., Ku, S.J., Ryu, K., Kim, Y., Bae, H., and Lee, Y.S. (2020). Bee venom phospholipase A2 induces regulatory T cell populations by suppressing apoptotic signaling pathway. Toxins, 12.","DOI":"10.3390\/toxins12030198"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1016\/j.immuni.2013.10.006","article-title":"Bee venom phospholipase A2 induces a primary type 2 response that is dependent on the receptor ST2 and confers protective immunity","volume":"39","author":"Palm","year":"2013","journal-title":"Immunity"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1038\/ni.2586","article-title":"Mast cell maturation is driven via a group III phospholipase A 2-prostaglandin D2-DP1 receptor paracrine axis","volume":"14","author":"Taketomi","year":"2013","journal-title":"Nat. Immunol."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.toxicon.2018.04.029","article-title":"Diversity of peptidic and proteinaceous toxins from social Hymenoptera venoms","volume":"148","author":"Lasa","year":"2018","journal-title":"Toxicon"},{"key":"ref_120","first-page":"1","article-title":"Impact of bee venom enzymes on diseases and immune responses","volume":"22","author":"Hossen","year":"2017","journal-title":"Molecules"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1016\/j.jaci.2005.12.1331","article-title":"Molecular cloning and expression in insect cells of honeybee venom allergen acid phosphatase (Api m 3)","volume":"117","author":"Grunwald","year":"2006","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"5403","DOI":"10.4049\/jimmunol.0803709","article-title":"Identification, Recombinant Expression, and Characterization of the 100 kDa High Molecular Weight Hymenoptera Venom Allergens Api m 5 and Ves v 3","volume":"184","author":"Blank","year":"2010","journal-title":"J. Immunol."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.dci.2018.04.001","article-title":"Honeybee (Apis cerana) vitellogenin acts as an antimicrobial and antioxidant agent in the body and venom","volume":"85","author":"Park","year":"2018","journal-title":"Dev. Comp. Immunol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.toxicon.2018.02.049","article-title":"Antioxidant activity and irritation property of venoms from Apis species","volume":"145","author":"Somwongin","year":"2018","journal-title":"Toxicon"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"112987","DOI":"10.1016\/j.physbeh.2020.112987","article-title":"Effect of bee venom on reproductive performance and immune response of male rabbits","volume":"223","author":"Abdella","year":"2020","journal-title":"Physiol. Behav."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.toxicon.2019.02.016","article-title":"Anti-inflammatory and antioxidative properties of honey bee venom on Freund\u2019s Complete Adjuvant-induced arthritis model in rats","volume":"161","author":"Kocyigit","year":"2019","journal-title":"Toxicon"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.phymed.2014.11.019","article-title":"Pharmacological synergism of bee venom and melittin with antibiotics and plant secondary metabolites against multi-drug resistant microbial pathogens","volume":"22","author":"Zimmermann","year":"2015","journal-title":"Phytomedicine"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"12466","DOI":"10.1073\/pnas.92.26.12466","article-title":"Inhibition of a plant virus infection by analogs of melittin","volume":"92","author":"Marcos","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/0014-5793(92)80780-K","article-title":"Influence of amphipathic peptides on the HIV-1 production in persistently infected T lymphoma cells","volume":"309","author":"Wachinger","year":"1992","journal-title":"FEBS Lett."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"1922","DOI":"10.1038\/jid.2014.75","article-title":"The protective effects of melittin on propionibacterium acnes-induced inflammatory responses in vitro and in vivo","volume":"134","author":"Lee","year":"2014","journal-title":"J. Invest. Dermatol."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1101\/gad.13.3.284","article-title":"Signal-induced ubiquitination of I\u03baB\u03b1 by the F-box protein Slimb\/\u03b2-TrCP","volume":"13","author":"Spencer","year":"1999","journal-title":"Genes Dev."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.jdermsci.2009.08.001","article-title":"Nicotinamide inhibits Propionibacterium acnes-induced IL-8 production in keratinocytes through the NF-\u03baB and MAPK pathways","volume":"56","author":"Grange","year":"2009","journal-title":"J. Dermatol. Sci."},{"key":"ref_133","first-page":"106","article-title":"Anti\u2014Inflammatory effect of bee venom in phthalic anhydride\u2014Induced atopic dermatitis animal model","volume":"56","author":"Jin","year":"2019","journal-title":"Inflammopharmacology"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.aller.2016.10.015","article-title":"Comparison of inflammatory cytokine release from nasal epithelial cells of non-atopic non-rhinitic, allergic rhinitic and polyp subjects and effects of diesel exhaust particles in vitro","volume":"45","author":"Ozturk","year":"2017","journal-title":"Allergol. Immunopathol."},{"key":"ref_135","first-page":"3","article-title":"The epidemiology of established rheumatoid arthritis","volume":"33","author":"Carmona","year":"2019","journal-title":"Best Pr. Res. Clin. Rheumatol."},{"key":"ref_136","first-page":"801","article-title":"Inhibitory effect of whole bee venom in adjuvant-induced arthritis","volume":"19","author":"Lee","year":"2005","journal-title":"In Vivo"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0304-3959(00)00412-7","article-title":"Bee venom injection into an acupuncture point reduces arthritis associated edema and nociceptive responses","volume":"90","author":"Kwon","year":"2001","journal-title":"Pain"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"1759720X1984442","DOI":"10.1177\/1759720X19844429","article-title":"Recent developments in advanced imaging in gout","volume":"11","author":"Davies","year":"2019","journal-title":"Ther. Adv. Musculoskelet. Dis."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1038\/nrn3880","article-title":"Immune attack: The role of inflammation in Alzheimer disease","volume":"16","author":"Heppner","year":"2015","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_140","first-page":"1","article-title":"A review: Inflammatory process in Alzheimer\u2019s disease, role of cytokines","volume":"2012","year":"2012","journal-title":"Sci. World J."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1007\/s00109-004-0555-y","article-title":"Nuclear factor-\u03baB: Its role in health and disease","volume":"82","author":"Kumar","year":"2004","journal-title":"J. Mol. Med."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1016\/j.bbi.2012.08.013","article-title":"Neuro-protective effects of bee venom by suppression of neuroinflammatory responses in a mouse model of Parkinson\u2019s disease: Role of regulatory T cells","volume":"26","author":"Chung","year":"2012","journal-title":"Brain. Behav. Immun."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1038\/ki.2015.147","article-title":"Phospholipase A2 inhibits cisplatin-induced acute kidney injury by modulating regulatory T cells by the CD206 mannose receptor","volume":"88","author":"Kim","year":"2015","journal-title":"Kidney Int."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12974-016-0476-z","article-title":"Neuroprotective effects of bee venom phospholipase A2 in the 3xTg AD mouse model of Alzheimer\u2019s disease","volume":"13","author":"Ye","year":"2016","journal-title":"J. Neuroinflammation"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/srep24493","article-title":"Osmotin attenuates LPS-induced neuroinflammation and memory impairments via the TLR4\/NF\u03baB signaling pathway","volume":"6","author":"Badshah","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1212\/01.WNL.0000140706.52798.BE","article-title":"Incidence of parkinsonism and Parkinson disease in a general population: The Rotterdam Study","volume":"63","author":"Giesbergen","year":"2004","journal-title":"Neurology"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40035-015-0042-0","article-title":"Neuroinflammation in Parkinson\u2019s disease and its potential as therapeutic target","volume":"4","author":"Wang","year":"2015","journal-title":"Transl. Neurodegener."},{"key":"ref_148","doi-asserted-by":"crossref","unstructured":"Jung, K., Baek, H., Kang, M., Kim, N., Lee, S.Y., and Bae, H. (2017). Dust Mite Extract Induced Atopic Dermatitis Like Skin Lesions in Mice. Toxins, 9.","DOI":"10.3390\/toxins9020068"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1002\/pros.21296","article-title":"Anti-cancer effect of bee venomin prostate cancer cells through activation of caspase pathway via inactivation of NF-\u03baB","volume":"71","author":"Park","year":"2011","journal-title":"Prostate"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"57","DOI":"10.3892\/mmr.2016.5215","article-title":"Melittin inhibits tumor angiogenesis modulated by endothelial progenitor cells associated with the SDF-1\u03b1\/CXCR4 signaling pathway in a UMR-106 osteosarcoma xenograft mouse model","volume":"14","author":"Qin","year":"2016","journal-title":"Mol. Med. Rep."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"10443","DOI":"10.1007\/s13277-014-2218-0","article-title":"Melittin enhances radiosensitivity of hypoxic head and neck squamous cell carcinoma by suppressing HIF-1\u03b1","volume":"35","author":"Yang","year":"2014","journal-title":"Tumor Biol."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1211\/jpp.58.1.0010","article-title":"Effect of polypeptides in bee venom on growth inhibition and apoptosis induction of the human hepatoma cell line SMMC-7721 in-vitro and Balb\/c nude mice in-vivo","volume":"58","author":"Hu","year":"2006","journal-title":"J. Pharm. Pharmacol."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1254\/jphs.91.95","article-title":"Bee venom induces apoptosis and inhibits expression of cyclooxygenase-2 mRNA in human lung cancer cell line NCI-H1299","volume":"91","author":"Jang","year":"2003","journal-title":"J. Pharmacol. Sci."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1007\/BF00258116","article-title":"Inhibition of growth of leukemic cells by inhibitors of calmodulin: Phenothiazines and melittin","volume":"14","author":"Hait","year":"1985","journal-title":"Cancer Chemother. Pharmacol."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"6853","DOI":"10.1038\/sj.onc.1203239","article-title":"Activators and target genes of Rel\/NF-\u03baB transcription factors","volume":"18","author":"Pahl","year":"1999","journal-title":"Oncogene"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"54951","DOI":"10.18632\/oncotarget.18627","article-title":"Melittin suppresses tumor progression by regulating tumorassociated macrophages in a Lewis lung carcinoma mouse model","volume":"8","author":"Lee","year":"2017","journal-title":"Oncotarget"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0224028","article-title":"The membrane effects of melittin on gastric and colorectal cancer","volume":"14","author":"Soliman","year":"2019","journal-title":"PLoS ONE"},{"key":"ref_158","first-page":"90","article-title":"Use of Selected Carbon Nanoparticles as Melittin","volume":"13","author":"Mcf","year":"1870","journal-title":"Materials"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1016\/j.parkreldis.2012.04.030","article-title":"Effectiveness of acupuncture and bee venom acupuncture in idiopathic Parkinson\u2019s disease","volume":"18","author":"Cho","year":"2012","journal-title":"Park. Relat. Disord."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/j.jns.2017.08.2040","article-title":"Efficacy of combined treatment with acupuncture and Bee venom acupuncture for Parkinson\u2019s disease: Double blind randomized controlled trial","volume":"381","author":"Park","year":"2017","journal-title":"J. Neurol. Sci."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.neuint.2014.11.008","article-title":"Neuroprotective effects of bee venom acupuncture therapy against rotenone-induced oxidative stress and apoptosis","volume":"80","author":"Khalil","year":"2015","journal-title":"Neurochem. Int."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.brainres.2005.12.086","article-title":"Antinociceptive effect and the mechanism of bee venom acupuncture (Apipuncture) on inflammatory pain in the rat model of collagen-induced arthritis: Mediation by \u03b12-Adrenoceptors","volume":"1073\u20131074","author":"Baek","year":"2006","journal-title":"Brain Res."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"846","DOI":"10.3390\/toxins7030846","article-title":"The effects of bee venom acupuncture on the central nervous system and muscle in an animal hsOD1G93A mutant","volume":"7","author":"Cai","year":"2015","journal-title":"Toxins"},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/j.biopha.2017.04.055","article-title":"Therapeutic effect of melittin on a rat model of chronic prostatitis induced by Complete Freund\u2019s Adjuvant","volume":"90","author":"Lin","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/j.hrthm.2018.01.016","article-title":"Role of apamin-sensitive small conductance calcium-activated potassium currents in long-term cardiac memory in rabbits","volume":"15","author":"Yin","year":"2018","journal-title":"Hear Rhythm"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.neuropharm.2018.10.029","article-title":"Apamin treatment accelerates equilibrium recovery and gaze stabilization in unilateral vestibular neurectomized cats: Cellular and behavioral aspects","volume":"144","author":"Tighilet","year":"2019","journal-title":"Neuropharmacology"},{"key":"ref_167","first-page":"1","article-title":"Bee venom for the treatment of Parkinson disease\u2014A randomized controlled clinical trial","volume":"11","author":"Hartmann","year":"2016","journal-title":"PLoS ONE"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.toxicon.2018.09.013","article-title":"To bee or not to bee: The potential efficacy and safety of bee venom acupuncture in humans","volume":"154","author":"Cherniack","year":"2018","journal-title":"Toxicon"},{"key":"ref_169","doi-asserted-by":"crossref","unstructured":"Park, J.H., Yim, B.K., Lee, J.H., Lee, S., and Kim, T.H. (2015). Risk associated with bee venom therapy: A systematic review and meta-analysis. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0126971"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"45","DOI":"10.18176\/jiaci.0202","article-title":"Death due to live bee acupuncture apitherapy","volume":"28","year":"2018","journal-title":"J. Investig. Allergol. Clin. Immunol."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.jep.2016.11.012","article-title":"Safety of essential bee venom pharmacopuncture as assessed in a randomized controlled double-blind trial","volume":"194","author":"Ahn","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.jpba.2010.08.020","article-title":"Characterization of honeybee venom by MALDI-TOF and nanoESI-QqTOF mass spectrometry","volume":"54","author":"Matysiak","year":"2011","journal-title":"J. Pharm. Biomed. Anal."},{"key":"ref_173","doi-asserted-by":"crossref","unstructured":"Bae, Y.H., and Park, K. (2020). Advanced drug delivery 2020 and beyond: Perspectives on the future. Adv. Drug Deliv. Rev., (in press).","DOI":"10.1016\/j.addr.2020.06.018"},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.jconrel.2003.08.019","article-title":"Oral colon-specific drug delivery for bee venom peptide: Development of a coated calcium alginate gel beads-entrapped liposome","volume":"93","author":"Xing","year":"2003","journal-title":"J. Control. Release"},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.ijpharm.2007.05.056","article-title":"Effect of bee venom peptide-copolymer interactions on thermosensitive hydrogel delivery systems","volume":"345","author":"Qiao","year":"2007","journal-title":"Int. J. Pharm."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.biomaterials.2018.11.004","article-title":"pH-sensitive polymer micelles provide selective and potentiated lytic capacity to venom peptides for effective intracellular delivery","volume":"192","author":"Peeler","year":"2019","journal-title":"Biomaterials"},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.vetimm.2018.04.006","article-title":"Nasal delivery of chitosan\/alginate nanoparticle encapsulated bee (Apis mellifera) venom promotes antibody production and viral clearance during porcine reproductive and respiratory syndrome virus infection by modulating T cell related responses","volume":"200","author":"Lee","year":"2018","journal-title":"Vet. Immunol. Immunopathol."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/12\/11\/3360\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T10:27:36Z","timestamp":1760178456000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/12\/11\/3360"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,31]]},"references-count":177,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2020,11]]}},"alternative-id":["nu12113360"],"URL":"https:\/\/doi.org\/10.3390\/nu12113360","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,31]]}}}