{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T23:52:50Z","timestamp":1791503570543,"version":"4.3.4"},"reference-count":29,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2020,11,10]],"date-time":"2020-11-10T00:00:00Z","timestamp":1604966400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2017R1A5A2014768"],"award-info":[{"award-number":["2017R1A5A2014768"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014189","name":"Korea Institute of Planning and Evaluation for Technology in Food, Agriculture and Forestry","doi-asserted-by":"publisher","award":["MAFRA 318027-4"],"award-info":[{"award-number":["MAFRA 318027-4"]}],"id":[{"id":"10.13039\/501100014189","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Excessive expression of interleukin (IL)-1\u03b2 in the brain causes depression and cognitive dysfunction. Herein, we investigated the effect of Lactobacillus gasseri NK109, which suppressed IL-1\u03b2 expression in activated macrophages, on Escherichia coli K1-induced cognitive impairment and depression in mice. Germ-free and specific pathogen-free mice with neuropsychiatric disorders were prepared by oral gavage of K1. NK109 alleviated K1-induced cognition-impaired and depressive behaviors, decreased the expression of IL-1\u03b2 and populations of NF-\u03baB+\/Iba1+ and IL-1R+ cells, and increased the K1-suppressed population of BDNF+\/NeuN+ cells in the hippocampus. However, its effects were partially attenuated by celiac vagotomy. NK109 treatment mitigated K1-induced colitis and gut dysbiosis. Tyndallized NK109, even if lysed, alleviated cognitive impairment and depression. In conclusion, NK109 alleviated neuropsychiatric disorders and colitis by modulating IL-1\u03b2 expression, gut microbiota, and vagus nerve-mediated gut\u2013brain signaling.<\/jats:p>","DOI":"10.3390\/nu12113441","type":"journal-article","created":{"date-parts":[[2020,11,10]],"date-time":"2020-11-10T10:47:28Z","timestamp":1605005248000},"page":"3441","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":76,"title":["A Probiotic Lactobacillus gasseri Alleviates Escherichia coli-Induced Cognitive Impairment and Depression in Mice by Regulating IL-1\u03b2 Expression and Gut Microbiota"],"prefix":"10.3390","volume":"12","author":[{"given":"Soo-Won","family":"Yun","sequence":"first","affiliation":[{"name":"Department of Food and Nutrition, Kyung Hee University, Seoul 02447, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeon-Kyung","family":"Kim","sequence":"additional","affiliation":[{"name":"Neurobiota Research Center, College of Pharmacy, Kyung Hee University, Seoul 02447, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung-Eon","family":"Lee","sequence":"additional","affiliation":[{"name":"Neurobiota Research Center, College of Pharmacy, Kyung Hee University, Seoul 02447, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Joon","family":"Oh","sequence":"additional","affiliation":[{"name":"Division of Research and Development, World Institute of Kimchi, Gwangju 61755, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1185-0919","authenticated-orcid":false,"given":"Hak-Jong","family":"Choi","sequence":"additional","affiliation":[{"name":"Division of Research and Development, World Institute of Kimchi, Gwangju 61755, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myung Joo","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Food and Nutrition, Kyung Hee University, Seoul 02447, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-Hyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Neurobiota Research Center, College of Pharmacy, Kyung Hee University, Seoul 02447, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,11,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"5486","DOI":"10.3748\/wjg.v23.i30.5486","article-title":"Influence of gut microbiota on neuropsychiatric disorders","volume":"23","author":"Cenit","year":"2017","journal-title":"World J. 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