{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T14:36:05Z","timestamp":1782484565274,"version":"3.54.5"},"reference-count":39,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2020,11,13]],"date-time":"2020-11-13T00:00:00Z","timestamp":1605225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>We aimed to examine the impact of a daily pro-inflammatory diet during pregnancy on intrapartum fetal acidemia using a large birth cohort study in Japan. We used data on singleton pregnancies in the Japan Environment and Children\u2019s Study (JECS) involving births from 2011 to 2014 through vaginal delivery to calculate the maternal dietary inflammatory index (DII). Participants were categorized according to DII quintiles. A multiple logistic regression model was used to estimate the risk of a pro-inflammatory diet on fetal umbilical artery pH. In total, 56,490 participants were eligible for this study. Multiple regression analysis showed that nulliparous women who had undergone vaginal delivery and were consuming a pro-inflammatory diet had an increased risk of pH &lt; 7.10 (adjusted odds ratio [aOR]: 1.64, 95% confidence interval [CI]: 1.12\u20132.39). Among these women, the risk of pH &lt; 7.10 was not affected by the duration of labor (aOR: 1.64, 95% CI: 1.11\u20132.42). In conclusion, following a pro-inflammatory diet during pregnancy is a risk factor for fetal acidosis among nulliparous women undergoing vaginal delivery. A high DII diet during pregnancy may modify the intrapartum fetal heart rate pattern via intrauterine inflammation.<\/jats:p>","DOI":"10.3390\/nu12113482","type":"journal-article","created":{"date-parts":[[2020,11,13]],"date-time":"2020-11-13T08:44:02Z","timestamp":1605257042000},"page":"3482","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Dietary Inflammatory Index during Pregnancy and the Risk of Intrapartum Fetal Asphyxia: The Japan Environment and Children\u2019s Study"],"prefix":"10.3390","volume":"12","author":[{"given":"Hyo","family":"Kyozuka","sequence":"first","affiliation":[{"name":"Fukushima Regional Center for the Japan Environmental and Children\u2019s Study, 1 Hikarigaoka, Fukushima 960-1295, Japan"},{"name":"Department of Obstetrics and Gynecology, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima 960-1295, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9506-117X","authenticated-orcid":false,"given":"Tsuyoshi","family":"Murata","sequence":"additional","affiliation":[{"name":"Fukushima Regional Center for the Japan Environmental and Children\u2019s Study, 1 Hikarigaoka, Fukushima 960-1295, Japan"},{"name":"Department of Obstetrics and Gynecology, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima 960-1295, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toma","family":"Fukuda","sequence":"additional","affiliation":[{"name":"Fukushima Regional Center for the Japan Environmental and Children\u2019s Study, 1 Hikarigaoka, Fukushima 960-1295, Japan"},{"name":"Department of Obstetrics and Gynecology, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima 960-1295, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiko","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Fukushima Regional Center for the Japan Environmental and Children\u2019s Study, 1 Hikarigaoka, Fukushima 960-1295, Japan"},{"name":"Department of Obstetrics and Gynecology, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima 960-1295, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aya","family":"Kanno","sequence":"additional","affiliation":[{"name":"Fukushima Regional Center for the Japan Environmental and Children\u2019s Study, 1 Hikarigaoka, Fukushima 960-1295, Japan"},{"name":"Department of Obstetrics and Gynecology, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima 960-1295, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shun","family":"Yasuda","sequence":"additional","affiliation":[{"name":"Fukushima Regional Center for the Japan Environmental and Children\u2019s Study, 1 Hikarigaoka, Fukushima 960-1295, Japan"},{"name":"Department of Obstetrics and Gynecology, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima 960-1295, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiko","family":"Sato","sequence":"additional","affiliation":[{"name":"Fukushima Regional Center for the Japan Environmental and Children\u2019s Study, 1 Hikarigaoka, Fukushima 960-1295, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuka","family":"Ogata","sequence":"additional","affiliation":[{"name":"Fukushima Regional Center for the Japan Environmental and Children\u2019s Study, 1 Hikarigaoka, Fukushima 960-1295, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahito","family":"Kuse","sequence":"additional","affiliation":[{"name":"Fukushima Regional Center for the Japan Environmental and Children\u2019s Study, 1 Hikarigaoka, Fukushima 960-1295, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1626-3625","authenticated-orcid":false,"given":"Mitsuaki","family":"Hosoya","sequence":"additional","affiliation":[{"name":"Fukushima Regional Center for the Japan Environmental and Children\u2019s Study, 1 Hikarigaoka, Fukushima 960-1295, Japan"},{"name":"Department of Pediatrics, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima 960-1295, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4715-2840","authenticated-orcid":false,"given":"Seiji","family":"Yasumura","sequence":"additional","affiliation":[{"name":"Fukushima Regional Center for the Japan Environmental and Children\u2019s Study, 1 Hikarigaoka, Fukushima 960-1295, Japan"},{"name":"Department of Public Health, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima 960-1295, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7186-7603","authenticated-orcid":false,"given":"Koichi","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Fukushima Regional Center for the Japan Environmental and Children\u2019s Study, 1 Hikarigaoka, Fukushima 960-1295, Japan"},{"name":"Department of Public Health, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima 960-1295, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidekazu","family":"Nishigori","sequence":"additional","affiliation":[{"name":"Fukushima Regional Center for the Japan Environmental and Children\u2019s Study, 1 Hikarigaoka, Fukushima 960-1295, Japan"},{"name":"Fukushima Medical Center for Children and Women, Fukushima Medical University, 1 Hikarigaoka, Fukushima 960-1295, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiya","family":"Fujimori","sequence":"additional","affiliation":[{"name":"Fukushima Regional Center for the Japan Environmental and Children\u2019s Study, 1 Hikarigaoka, Fukushima 960-1295, Japan"},{"name":"Department of Obstetrics and Gynecology, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima 960-1295, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the Japan Environment and Children\u2019s Study (JECS) Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,11,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1194\/jlr.M014738","article-title":"Effect of industrially produced trans fat on markers of systemic inflammation: Evidence from a randomized trial in 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