{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T18:14:27Z","timestamp":1792174467220,"version":"4.4.0"},"reference-count":57,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2020,11,14]],"date-time":"2020-11-14T00:00:00Z","timestamp":1605312000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Sapienza University of Rome, Italy","award":["Ricerca di Ateneo 2017"],"award-info":[{"award-number":["Ricerca di Ateneo 2017"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Sirtuin 1 (SIRT1) is a sensor of cell energy availability, and with leptin and adiponectin, it regulates metabolic homeostasis. Widely studied in tissues, SIRT1 is under evaluation as a plasmatic marker. We aimed at assessing whether circulating SIRT1 behaves consistently with leptin and adiponectin in conditions of deficiency, excess or normal fat content. Eighty subjects were evaluated: 27 with anorexia nervosa (AN), 26 normal-weight and 27 with obesity. Bloodstream SIRT1, leptin and adiponectin (ELISA), total and trunk fat mass (FM) %, abdominal visceral adipose tissue, liver steatosis and epicardial fat thickness (EFT) were assessed. For each fat store, the coefficient of determination (R2) was used to evaluate the prediction capability of SIRT1, leptin and adiponectin. Plasma SIRT1 and adiponectin coherently decreased with the increase of FM, while the opposite occurred with leptin. Mean levels of each analyte were different between groups (p &lt; 0.005). A significant association between plasma variables and FM depots was observed. SIRT1 showed a good predictive strength for FM, particularly in the obesity group, where the best R2 was recorded for EFT (R2 = 0.7). Blood SIRT1, adiponectin and leptin behave coherently with FM and there is synchrony between them. The association of SIRT1 with FM is substantially superimposable to that of adiponectin and leptin. Given its homeostatic roles, SIRT1 may deserve to be considered as a plasma clinical\/biochemical parameter of adiposity and metabolic health.<\/jats:p>","DOI":"10.3390\/nu12113506","type":"journal-article","created":{"date-parts":[[2020,11,16]],"date-time":"2020-11-16T11:04:20Z","timestamp":1605524660000},"page":"3506","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Blood SIRT1 Shows a Coherent Association with Leptin and Adiponectin in Relation to the Degree and Distribution of Adiposity: A Study in Obesity, Normal Weight and Anorexia Nervosa"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1762-4701","authenticated-orcid":false,"given":"Stefania","family":"Mariani","sequence":"first","affiliation":[{"name":"Department of Experimental Medicine, Section of Medical Physiopathology, Food Science and Endocrinology, \u201cSapienza\u201d University of Rome, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Rosaria","family":"Di Giorgio","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine, Section of Medical Physiopathology, Food Science and Endocrinology, \u201cSapienza\u201d University of Rome, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica","family":"Rossi","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine, Section of Medical Physiopathology, Food Science and Endocrinology, \u201cSapienza\u201d University of Rome, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3358-4204","authenticated-orcid":false,"given":"Rossella","family":"Tozzi","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine, \u201cSapienza\u201d University of Rome, 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Savina","family":"Contini","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine, Section of Medical Physiopathology, Food Science and Endocrinology, \u201cSapienza\u201d University of Rome, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2738-6180","authenticated-orcid":false,"given":"Lisa","family":"Bauleo","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Lazio Regional Health Service, 00147 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiammetta","family":"Cipriani","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine, Section of Medical Physiopathology, Food Science and Endocrinology, \u201cSapienza\u201d University of Rome, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaella","family":"Toscano","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine, Section of Medical Physiopathology, Food Science and Endocrinology, \u201cSapienza\u201d University of Rome, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Basciani","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine, Section of Medical Physiopathology, Food Science and Endocrinology, \u201cSapienza\u201d University of Rome, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Barbaro","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine, Section of Medical Physiopathology, Food Science and Endocrinology, \u201cSapienza\u201d University of Rome, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2225-8814","authenticated-orcid":false,"given":"Mikiko","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine, Section of Medical Physiopathology, Food Science and Endocrinology, \u201cSapienza\u201d University of Rome, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agostino","family":"Valenti","sequence":"additional","affiliation":[{"name":"Internal Medicine, Santo Spirito in Sassia Hospital, 00193 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armando","family":"Cotugno","sequence":"additional","affiliation":[{"name":"Department of Mental Health, UOSD eating behavior disorders, Padiglione I, Comprensorio S. Maria della Piet\u00e0, 00135 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0081-0655","authenticated-orcid":false,"given":"Carla","family":"Ancona","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Lazio Regional Health Service, 00147 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Lubrano","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine, Section of Medical Physiopathology, Food Science and Endocrinology, \u201cSapienza\u201d University of Rome, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucio","family":"Gnessi","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine, Section of Medical Physiopathology, Food Science and Endocrinology, \u201cSapienza\u201d University of Rome, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,11,14]]},"reference":[{"key":"ref_1","first-page":"1027","article-title":"The role of leptin and adiponectin in obesity-associated cognitive decline and Alzheimer\u2019s disease","volume":"12","author":"Vieira","year":"2018","journal-title":"Front. 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