{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T15:44:04Z","timestamp":1792597444430,"version":"4.5.0"},"reference-count":27,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2020,11,16]],"date-time":"2020-11-16T00:00:00Z","timestamp":1605484800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>We have previously described increased fasting plasma glucose levels in patients with normocalcemic primary hyperparathyroidism (NPHPT) and co-existing prediabetes, compared to prediabetes per se. This study evaluated the effect of parathyroidectomy (PTx) (Group A), versus conservative follow-up (Group B), in a small cohort of patients with co-existing NPHPT and prediabetes. Sixteen patients were categorized in each group. Glycemic parameters (levels of fasting glucose (fGlu), glycosylated hemoglobin (HbA1c), and fasting insulin (fIns)), the homeostasis model assessment for estimating insulin secretion (HOMA-B) and resistance (HOMA-IR), and a 75-g oral glucose tolerance test were evaluated at baseline and after 32 weeks for both groups. Measurements at baseline were not significantly different between Groups A and B, respectively: fGlu (119.4 \u00b1 2.8 vs. 118.2 \u00b1 1.8 mg\/dL, p = 0.451), HbA1c (5.84 \u00b1 0.3 %vs. 5.86 \u00b1 0.4%, p = 0.411), HOMA-IR (3.1 \u00b1 1.2 vs. 2.9 \u00b1 0.2, p = 0.213), HOMA-B (112.9 \u00b1 31.8 vs. 116.9 \u00b1 21.0%, p = 0.312), fIns (11.0 \u00b1 2.3 vs. 12.8 \u00b1 1.4 \u03bcIU\/mL, p = 0.731), and 2-h post-load glucose concentrations (163.2 \u00b1 3.2 vs. 167.2 \u00b1 3.2 mg\/dL, p = 0.371). fGlu levels demonstrated a positive correlation with PTH concentrations for both groups (Group A, rho = 0.374, p = 0.005, and Group B, rho = 0.359, p = 0.008). At the end of follow-up, Group A demonstrated significant improvements after PTx compared to the baseline: fGlu ((119.4 \u00b1 2.8 vs. 111.2 \u00b1 1.9 mg\/dL, p = 0.021) (\u22128.2 \u00b1 0.6 mg\/dL)), and 2-h post-load glucose concentrations ((163.2 \u00b1 3.2 vs. 144.4 \u00b1 3.2 mg\/dL, p = 0.041), (\u221218.8 \u00b1 0.3 mg\/dL)). For Group B, results demonstrated non-significant differences: fGlu ((118.2 \u00b1 1.8 vs. 117.6 \u00b1 2.3 mg\/dL, p = 0.031), (\u22120.6 \u00b1 0.2 mg\/dL)), and 2-h post-load glucose concentrations ((167.2 \u00b1 2.7 vs. 176.2 \u00b1 3.2 mg\/dL, p = 0.781), (+9.0 \u00b1 0.8 mg\/dL)). We conclude that PTx for individuals with NPHPT and prediabetes may improve their glucose homeostasis when compared with conservative follow-up, after 8 months of follow-up.<\/jats:p>","DOI":"10.3390\/nu12113522","type":"journal-article","created":{"date-parts":[[2020,11,16]],"date-time":"2020-11-16T11:04:20Z","timestamp":1605524660000},"page":"3522","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Improving Glucose Homeostasis after Parathyroidectomy for Normocalcemic Primary Hyperparathyroidism with Co-Existing Prediabetes"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4225-2746","authenticated-orcid":false,"given":"Spyridon","family":"Karras","sequence":"first","affiliation":[{"name":"Division of Endocrinology and Metabolism, First Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, AHEPA University Hospital, 54621 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cedric","family":"Annweiler","sequence":"additional","affiliation":[{"name":"Division of Geriatric Medicine, Department of Neuroscience, Angers University Hospital, 49035 Angers, France"},{"name":"Robarts Research Institute, Department of Medical Biophysics, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, ON N6A 3K7, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitris","family":"Kiortsis","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, University of Ioannina, 45110 Ioannina, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis","family":"Koutelidakis","sequence":"additional","affiliation":[{"name":"Second Department of Surgery, Gennimatas General Hospital, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kalliopi","family":"Kotsa","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, First Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, AHEPA University Hospital, 54621 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,11,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.beem.2018.09.004","article-title":"Primary hyperparathyroidism","volume":"32","author":"Silva","year":"2018","journal-title":"Best Pract. 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