{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:11:20Z","timestamp":1790709080939,"version":"4.1.0"},"reference-count":46,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2020,11,20]],"date-time":"2020-11-20T00:00:00Z","timestamp":1605830400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100015766","name":"Danone Nutricia Research","doi-asserted-by":"publisher","award":["na"],"award-info":[{"award-number":["na"]}],"id":[{"id":"10.13039\/100015766","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>This study investigated growth, safety, and tolerance in healthy infants consuming a partly fermented infant formula (IF) with postbiotics, 2\u2032-linked fucosyllactose (2\u2032-FL), a specific prebiotic mixture of short-chain galacto-oligosaccharides (scGOS) and long-chain fructo-oligosaccharides (lcFOS), and milk fat. This double-blind, controlled trial randomised 215 fully IF-fed infants \u2264 14 days of age to either: Test Group (IF) containing 26% fermented formula with postbiotics derived from Lactofidus fermentation process (including 3\u2032-Galactosyllactose; 3\u2032-GL), 0.8 g\/100 mL scGOS\/lcFOS (9:1), 0.1 g\/100 mL 2\u2032-FL, and milk fat), or Control group (IF with 0.8 g\/100 mL scGOS\/lcFOS (9:1)) until 17 weeks of age. Fully breastfed infants were included as a reference. Anthropometric measures, gastrointestinal symptoms, and safety were assessed monthly. Equivalence in weight gain (primary outcome) between the Test and Control groups was confirmed (difference in means \u22120.08 g\/day; 90% CI (\u22121.47;1.31)) with estimated mean weight gain (SE) of 31.00 (0.59) g\/day and 31.08 (0.60) g\/day, respectively, (PP population, n = 196). Equivalence in length and head circumference gain between the randomised groups was also confirmed. No statistically significant differences were observed in adverse events or gastrointestinal tolerance between randomised IF groups. A partly fermented IF with postbiotics, specific oligosaccharides, 2\u2032-FL, and milk fat supports adequate infant growth and is safe and well-tolerated in healthy term infants.<\/jats:p>","DOI":"10.3390\/nu12113560","type":"journal-article","created":{"date-parts":[[2020,11,20]],"date-time":"2020-11-20T09:46:18Z","timestamp":1605865578000},"page":"3560","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":54,"title":["A Partly Fermented Infant Formula with Postbiotics Including 3\u2032-GL, Specific Oligosaccharides, 2\u2032-FL, and Milk Fat Supports Adequate Growth, Is Safe and Well-Tolerated in Healthy Term Infants: A Double-Blind, Randomised, Controlled, Multi-Country Trial"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1862-8651","authenticated-orcid":false,"given":"Yvan","family":"Vandenplas","sequence":"first","affiliation":[{"name":"KidZ Health Castle, UZ Brussel, Vrije Universiteit Brussel, 1090 Jette, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginie","family":"de Halleux","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire of Li\u00e8ge (CHU), Centre Hospitalier R\u00e9gional of Li\u00e8ge (CHR), 4000 Li\u00e8ge, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma\u0142gorzata","family":"Arciszewska","sequence":"additional","affiliation":[{"name":"Poliklinika Ginekologiczno-Po\u0142o\u017cnicza Sp. z o.o. Sp. k., 15-435 Bialystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"Lach","sequence":"additional","affiliation":[{"name":"Centrum Medyczne Promed, 31-411 Krak\u00f3w, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeriy","family":"Pokhylko","sequence":"additional","affiliation":[{"name":"Ukrainian Medical Stomatological Academy, Poltava Regional Children Clinical Hospital, 36011 Poltava, Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viktoriia","family":"Klymenko","sequence":"additional","affiliation":[{"name":"Kharkiv National Medical University, City Children\u2019s Clinical Hospital No. 19, 61051 Kharkiv, Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4054-1026","authenticated-orcid":false,"given":"Stefanie","family":"Schoen","sequence":"additional","affiliation":[{"name":"Danone Nutricia Research, 3584 CT Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1899-2824","authenticated-orcid":false,"given":"Marieke","family":"Abrahamse-Berkeveld","sequence":"additional","affiliation":[{"name":"Danone Nutricia Research, 3584 CT Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4060-6918","authenticated-orcid":false,"given":"Kelly","family":"Mulder","sequence":"additional","affiliation":[{"name":"Danone Nutricia Research, 3584 CT Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rocio","family":"Porcel Rubio","sequence":"additional","affiliation":[{"name":"Hospital Quironsalud, 08023 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the VOYAGE Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,11,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Anderson, C.E., Whaley, S.E., Crespi, C.M., Wang, M.C., and Chaparro, M.P. 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