{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T06:45:51Z","timestamp":1773297951249,"version":"3.50.1"},"reference-count":57,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2020,11,28]],"date-time":"2020-11-28T00:00:00Z","timestamp":1606521600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Nucleus of Excellence Support Program","award":["249\/2013"],"award-info":[{"award-number":["249\/2013"]}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["88882.448882\/2019-01"],"award-info":[{"award-number":["88882.448882\/2019-01"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Funda&amp;#x00E7;&amp;#x00E3;o de Amparo &amp;#x00E0; Pesquisa do Estado de S&amp;#x00E3;o Paulo","award":["2018\/09868-7"],"award-info":[{"award-number":["2018\/09868-7"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>A high-carbohydrate diet (HCD) is a well-established experimental model of accelerated liver fatty acid (FA) deposition and inflammation. In this study, we evaluated whether canola oil can prevent these physiopathological changes. We evaluated hepatic FA accumulation and inflammation in mice fed with a HCD (72.1% carbohydrates) and either canola oil (C group) or soybean oil (S group) as a lipid source for 0, 7, 14, 28, or 56 days. Liver FA compositions were analyzed by gas chromatography. The mRNA expression of acetyl-CoA carboxylase 1 (ACC1) was measured as an indicator of lipogenesis. The mRNA expression of F4\/80, tumor necrosis factor-\u03b1 (TNF-\u03b1), interleukin (IL)-1\u03b2, IL-6, and IL-10, as mediators of liver inflammation, were also measured. The C group stored less n-6 polyunsaturated FAs (n-6 PUFAs) and had more intense lipid deposition of monounsaturated FAs (MUFAs), n-3 PUFAs, and total FAs. The C group also showed higher ACC1 expression. Moreover, on day 56, the C group showed higher expressions of the inflammatory genes F4\/80, TNF-\u03b1, IL-1\u03b2, and IL-6, as well as the anti-inflammatory IL-10. In conclusion, a diet containing canola oil as a lipid source does not prevent the fatty acid accumulation and inflammation induced by a HCD.<\/jats:p>","DOI":"10.3390\/nu12123667","type":"journal-article","created":{"date-parts":[[2020,11,29]],"date-time":"2020-11-29T21:00:57Z","timestamp":1606683657000},"page":"3667","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The Dietary Replacement of Soybean Oil by Canola Oil Does Not Prevent Liver Fatty Acid Accumulation and Liver Inflammation in Mice"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4728-8518","authenticated-orcid":false,"given":"Marina Masetto","family":"Antunes","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Therapeutics, State University of Maring\u00e1, Maring\u00e1 87020-900, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3339-0853","authenticated-orcid":false,"given":"Guilherme","family":"Godoy","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutics, State University of Maring\u00e1, Maring\u00e1 87020-900, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingrid de Lima","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Department of Chemistry, State University of Maring\u00e1, Maring\u00e1 87020-900, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5429-5743","authenticated-orcid":false,"given":"Luciana Pelissari","family":"Manin","sequence":"additional","affiliation":[{"name":"Department of Chemistry, State University of Maring\u00e1, Maring\u00e1 87020-900, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline","family":"Zappielo","sequence":"additional","affiliation":[{"name":"Department of Chemistry, State University of Maring\u00e1, Maring\u00e1 87020-900, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9472-7304","authenticated-orcid":false,"given":"Laureane Nunes","family":"Masi","sequence":"additional","affiliation":[{"name":"Interdisciplinary Post-Graduate Program in Health Sciences, Cruzeiro do Sul University, S\u00e3o Paulo 03342-000, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vivian Ara\u00fajo Barbosa de","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Interdisciplinary Post-Graduate Program in Health Sciences, Cruzeiro do Sul University, S\u00e3o Paulo 03342-000, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jesu\u00ed Verg\u00edlio","family":"Visentainer","sequence":"additional","affiliation":[{"name":"Department of Chemistry, State University of Maring\u00e1, Maring\u00e1 87020-900, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Curi","sequence":"additional","affiliation":[{"name":"Interdisciplinary Post-Graduate Program in Health Sciences, Cruzeiro do Sul University, S\u00e3o Paulo 03342-000, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8563-7913","authenticated-orcid":false,"given":"Roberto Barbosa","family":"Bazotte","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutics, State University of Maring\u00e1, Maring\u00e1 87020-900, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,11,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1126\/science.1204265","article-title":"Human fatty liver disease: Old questions and new insights","volume":"332","author":"Cohen","year":"2011","journal-title":"Science"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1053\/j.gastro.2020.01.052","article-title":"Nonalcoholic Fatty Liver Disease 2020: The state of the disease","volume":"158","author":"Cotter","year":"2020","journal-title":"Gastroenterology"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1097\/MOL.0b013e3282ff5e55","article-title":"Hepatic triglyceride synthesis and nonalcoholic fatty liver disease","volume":"19","author":"Choi","year":"2008","journal-title":"Curr. 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