{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T22:25:04Z","timestamp":1793744704115,"version":"4.6.1"},"reference-count":156,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2020,11,28]],"date-time":"2020-11-28T00:00:00Z","timestamp":1606521600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004339","name":"Sanofi","doi-asserted-by":"publisher","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}],"id":[{"id":"10.13039\/100004339","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Magnesium deficiency and stress are both common conditions among the general population, which, over time, can increase the risk of health consequences. Numerous studies, both in pre-clinical and clinical settings, have investigated the interaction of magnesium with key mediators of the physiological stress response, and demonstrated that magnesium plays an inhibitory key role in the regulation and neurotransmission of the normal stress response. Furthermore, low magnesium status has been reported in several studies assessing nutritional aspects in subjects suffering from psychological stress or associated symptoms. This overlap in the results suggests that stress could increase magnesium loss, causing a deficiency; and in turn, magnesium deficiency could enhance the body\u2019s susceptibility to stress, resulting in a magnesium and stress vicious circle. This review revisits the magnesium and stress vicious circle concept, first introduced in the early 1990s, in light of recent available data.<\/jats:p>","DOI":"10.3390\/nu12123672","type":"journal-article","created":{"date-parts":[[2020,11,29]],"date-time":"2020-11-29T21:00:57Z","timestamp":1606683657000},"page":"3672","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":150,"title":["Magnesium Status and Stress: The Vicious Circle Concept Revisited"],"prefix":"10.3390","volume":"12","author":[{"given":"Gis\u00e8le","family":"Pickering","sequence":"first","affiliation":[{"name":"Plateforme d\u2019Investigation Clinique\/CIC Inserm 1405, University Hospital CHU, 63000 Clermont-Ferrand, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Mazur","sequence":"additional","affiliation":[{"name":"INRAE, UNH, Unit\u00e9 de Nutrition Humaine, Universit\u00e9 Clermont Auvergne, 63001 Clermont-Ferrand, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0592-4547","authenticated-orcid":false,"given":"Marion","family":"Trousselard","sequence":"additional","affiliation":[{"name":"Independent Regulatory Board for Auditors (IRBA), 91220 Bretigny-sur-Orge, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Przemyslaw","family":"Bienkowski","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Warsaw Medical University, 02-091 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Yaltsewa","sequence":"additional","affiliation":[{"name":"Department of General Medicine, The Yaroslavl State Medical University Institute of Postgraduate Education, 150000 Yaroslavl, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7706-4211","authenticated-orcid":false,"given":"Mohamed","family":"Amessou","sequence":"additional","affiliation":[{"name":"Medical Affairs Department, Consumer HealthCare, Sanofi, Gentilly, 94250 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lionel","family":"Noah","sequence":"additional","affiliation":[{"name":"Medical Affairs Department, Consumer HealthCare, Sanofi, Gentilly, 94250 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8254-1892","authenticated-orcid":false,"given":"Etienne","family":"Pouteau","sequence":"additional","affiliation":[{"name":"Medical Affairs Department, Consumer HealthCare, Sanofi, Gentilly, 94250 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,11,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1017\/S1121189X00001421","article-title":"The global burden of mental disorders: An update from the WHO World Mental Health (WMH) Surveys","volume":"18","author":"Kessler","year":"2009","journal-title":"Epidemiol. 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