{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T03:28:36Z","timestamp":1760239716487,"version":"build-2065373602"},"reference-count":26,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2020,12,8]],"date-time":"2020-12-08T00:00:00Z","timestamp":1607385600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>To evaluate the effects of 25-hydroxyvitamin D3 (25OHD) on symptoms at the onset of the upper respiratory tract infection (URTI) in subjects with insufficient or deficient serum 25-hydroxyvitamin D levels, we conducted a post hoc analysis of data from a randomized, placebo-controlled study; the subjects received 10 \u03bcg of 25OHD per day or a placebo for 16 weeks. The Wisconsin Upper Respiratory Symptom Survey-21 was used to determine URTI. The study endpoints included WURSS-21 scores, number of URTI events, and proportion of medication (antibiotics, antipyretic analgesics) usage. We found that the physical symptom scores for \u201cRunny nose,\u201d \u201cSneezing,\u201d and \u201cHead congestion\u201d were significantly lower in the 25OHD group than in the placebo group; for all items except \u201cBreathe easily, \u201cthe quality of life\u201d scores were significantly improved in the 25OHD group. There was no significant difference in the number of URTI events or the proportion of medication use between the groups. Collectively, the findings of this study indicate that a sufficient 25OHD intake can reduce physical symptoms at the onset of upper respiratory tract infection, particularly nasal symptoms, and may improve the quality of life at the time of onset.<\/jats:p>","DOI":"10.3390\/nu12123769","type":"journal-article","created":{"date-parts":[[2020,12,8]],"date-time":"2020-12-08T20:27:15Z","timestamp":1607459235000},"page":"3769","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Intake of 25-Hydroxyvitamin D3 May Reduce the Severity of Upper Respiratory Tract Infection: Post hoc Analysis of a Randomized, Double-Blind, Placebo-Controlled, Parallel Group Comparison Study"],"prefix":"10.3390","volume":"12","author":[{"given":"Yoshiki","family":"Shimizu","sequence":"first","affiliation":[{"name":"FANCL Research Institute, FANCL Corporation, 12-13 Kamishinano, Totuka-ku, Yokohama 244-0806, Kanagawa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukihiko","family":"Ito","sequence":"additional","affiliation":[{"name":"FANCL Research Institute, FANCL Corporation, 12-13 Kamishinano, Totuka-ku, Yokohama 244-0806, Kanagawa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuo","family":"Uotsu","sequence":"additional","affiliation":[{"name":"FANCL Research Institute, FANCL Corporation, 12-13 Kamishinano, Totuka-ku, Yokohama 244-0806, Kanagawa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kei","family":"Yui","sequence":"additional","affiliation":[{"name":"FANCL Research Institute, FANCL Corporation, 12-13 Kamishinano, Totuka-ku, Yokohama 244-0806, Kanagawa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,12,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0140-6736(03)12162-9","article-title":"The common cold","volume":"361","author":"Heikkinen","year":"2003","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1097\/00043764-200209000-00004","article-title":"Productivity losses related to the common cold","volume":"44","author":"Bramley","year":"2002","journal-title":"J. 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