{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T03:17:00Z","timestamp":1792293420280,"version":"4.4.0"},"reference-count":34,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2020,12,11]],"date-time":"2020-12-11T00:00:00Z","timestamp":1607644800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background: Spices, i.e., curcumin, ginger, saffron, and cinnamon, have a thousand-year history of medicinal use in Asia. Modern medicine has begun to explore their therapeutic properties during the last few decades. We aimed to perform a systematic literature review (SLR) of randomized controlled trials (RCTs) assessing the effect of spice supplementation on symptoms and disease activity in patients with chronic inflammatory rheumatic diseases (rheumatoid arthritis (RA), spondylarthritis, or psoriatic arthritis). Methods: An SLR of RCTs, reviews, and meta-analyses was performed, searching for articles in MEDLINE\/PubMed. Abstracts from international rheumatology and nutrition congresses (2017\u20132020) were also scrutinized. The risk of bias of the selected studies was evaluated using the Cochrane Collaboration\u2019s tool and the Jadad scale. Results: Altogether, six studies, assessing the use of spice supplementation only in RA patients, were included: one on garlic supplementation, two on curcumin, one on ginger, one on cinnamon, and one on saffron supplementation. Garlic, ginger, cinnamon, or saffron supplementation was associated with a decrease in RA clinical activity. However, several points limit the external validity of these studies. No conclusion on the impact of curcumin supplementation on RA activity could be drawn due to low-quality studies. Conclusions: Garlic, ginger, cinnamon, and saffron supplementation could have a beneficial effect on RA activity, but the risk of bias of these studies is difficult to assess and data are too limited to recommend them in daily practice.<\/jats:p>","DOI":"10.3390\/nu12123800","type":"journal-article","created":{"date-parts":[[2020,12,13]],"date-time":"2020-12-13T20:56:57Z","timestamp":1607893017000},"page":"3800","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Efficacy of Spice Supplementation in Rheumatoid Arthritis: A Systematic Literature Review"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2793-6303","authenticated-orcid":false,"given":"Jean-Guillaume","family":"Letarouilly","sequence":"first","affiliation":[{"name":"Department of Rheumatology, CHU Lille, Universit\u00e9 de Lille, F-59000 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauline","family":"Sanchez","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, CHU de Montpellier, Montpellier University, 34295 Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0866-3824","authenticated-orcid":false,"given":"Yann","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, H\u00f4pital Beaujon, AP-HP Nord, Universit\u00e9 de Paris, F-92100 Clichy, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna","family":"Sigaux","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, H\u00f4pital Avicenne, AP-HP, INSERM U1125, Universit\u00e9 Paris 13, F-93017 Bobigny, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien","family":"Czernichow","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Specialized Obesity Center, H\u00f4pital Europ\u00e9en Georges Pompidou, Universit\u00e9 de Paris, AP-HP, F-75015 Paris, France"},{"name":"Epidemiology and Biostatistics Sorbonne Paris City Center, UMR1153, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, F-75004 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9-Marc","family":"Flipo","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, CHU Lille, Universit\u00e9 de Lille, F-59000 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00e9mie","family":"Sellam","sequence":"additional","affiliation":[{"name":"DMU 3ID, H\u00f4pital Saint Antoine, AP-HP, CRSA Inserm UMRS_938, Sorbonne Universit\u00e9, F-75012 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Da\u00efen","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, CHU de Montpellier, Montpellier University, 34295 Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,12,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s12263-019-0636-8","article-title":"Herbs and Spices-Biomarkers of Intake Based on Human Intervention Studies\u2013A Systematic Review","volume":"14","author":"Rosana","year":"2019","journal-title":"Genes Nutr."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"395","DOI":"10.5740\/jaoacint.18-0418","article-title":"Health Benefits of Culinary Herbs and Spices","volume":"102","author":"Jiang","year":"2019","journal-title":"J. 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