{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T23:54:54Z","timestamp":1779148494364,"version":"3.51.4"},"reference-count":71,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2020,12,14]],"date-time":"2020-12-14T00:00:00Z","timestamp":1607904000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010609","name":"Gda\u0144ski Uniwersytet Medyczny","doi-asserted-by":"publisher","award":["02-0039\/07\/221"],"award-info":[{"award-number":["02-0039\/07\/221"]}],"id":[{"id":"10.13039\/501100010609","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Anxiety disorders comprise persistent, disabling conditions that are distributed across the globe, and are associated with the high medical and socioeconomic burden of the disease. Within the array of biopsychosocial treatment modalities\u2014including monoaminergic antidepressants, benzodiazepines, and CBT\u2014there is an unmet need for the effective treatment of anxiety disorders resulting in full remission and recovery. Nutritional intervention may be hypothesized as a promising treatment strategy; in particular, it facilitates relapse prevention. Low-carbohydrate high-fat diets (LCHF) may provide a rewarding outcome for some anxiety disorders; more research is needed before this regimen can be recommended to patients on a daily basis, but the evidence mentioned in this paper should encourage researchers and clinicians to consider LCHF as a piece of advice somewhere between psychotherapy and pharmacology, or as an add-on to those two.<\/jats:p>","DOI":"10.3390\/nu12123822","type":"journal-article","created":{"date-parts":[[2020,12,14]],"date-time":"2020-12-14T21:25:08Z","timestamp":1607981108000},"page":"3822","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Ketogenic Diet: A Dietary Modification as an Anxiolytic Approach?"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8549-254X","authenticated-orcid":false,"given":"Adam","family":"W\u0142odarczyk","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Faculty of Medicine, Medical University of Gda\u0144sk, 80-952 Gda\u0144sk, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6343-8454","authenticated-orcid":false,"given":"Wies\u0142aw Jerzy","family":"Cuba\u0142a","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Faculty of Medicine, Medical University of Gda\u0144sk, 80-952 Gda\u0144sk, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleksandra","family":"Wielewicka","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Faculty of Medicine, Medical University of Gda\u0144sk, 80-952 Gda\u0144sk, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,12,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"327","DOI":"10.31887\/DCNS.2015.17.3\/bbandelow","article-title":"Epidemiology of anxiety disorders in the 21st century","volume":"17","author":"Bandelow","year":"2015","journal-title":"Dialogues Clin. Neurosci."},{"key":"ref_2","unstructured":"World Health Organization (2004). ICD-10: International Statistical Classification of Diseases and Related Health Problems: Tenth Revision, World Health Organization. [2nd ed.]. Available online: https:\/\/apps.who.int\/iris\/handle\/10665\/42980."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1002\/mpr.1359","article-title":"Twelve-month and lifetime prevalence and lifetime morbid risk of anxiety and mood disorders in the United States","volume":"21","author":"Kessler","year":"2012","journal-title":"Int. J. Methods Psychiatry Res."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Leon, A.C., Portera, L., and Weissman, M.M. (1995). The social costs of anxiety disorders. Br. J. Psychiatry Suppl., 19\u201322.","DOI":"10.1192\/S0007125000293355"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1017\/S0033291713003243","article-title":"The global burden of anxiety disorders in 2010","volume":"44","author":"Baxter","year":"2014","journal-title":"Psychol. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"127","DOI":"10.31887\/DCNS.2017.19.2\/dstein","article-title":"Epidemiology of anxiety disorders: From surveys to nosology and back","volume":"19","author":"Stein","year":"2017","journal-title":"Dialogues Clin. Neurosci."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1111\/j.1468-1331.2005.01196.x","article-title":"Cost of anxiety disorders in Europe","volume":"12","author":"Wittchen","year":"2005","journal-title":"Eur. J. Neurol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"147","DOI":"10.31887\/DCNS.2017.19.2\/dnutt","article-title":"Biological markers of generalized anxiety disorder","volume":"19","author":"Maron","year":"2017","journal-title":"Dialogues Clin. Neurosci."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"541","DOI":"10.2147\/NDT.S91311","article-title":"The noradrenergic paradox: Implications in the management of depression and anxiety","volume":"12","author":"Montoya","year":"2016","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1097\/01.jcp.0000138764.31106.60","article-title":"A double-blind, placebo-controlled study of a flexible dose of venlafaxine ER in adult outpatients with generalized social anxiety disorder","volume":"24","author":"Rickels","year":"2004","journal-title":"J. Clin. Psychopharmacol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1176\/appi.ajp.160.4.749","article-title":"Paroxetine treatment of generalized anxiety disorder: A double-blind, placebo-controlled study","volume":"160","author":"Rickels","year":"2003","journal-title":"Am. J. Psychiatry"},{"key":"ref_12","first-page":"S445","article-title":"Cortisol as an indicator of hypothalmic-pitituary-adrenal axis dysregulation in patients with panic disorder: A literature review","volume":"27","author":"Landowski","year":"2015","journal-title":"Psychiatr. Danub."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1016\/j.neuropharm.2004.08.010","article-title":"Magnesium deficient diet alter depression-and anxiety-related behavior in mice\u2014Influence of desipramine and Hypericum perforatum extract","volume":"47","author":"Singewald","year":"2004","journal-title":"Neuropharmacology"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"459","DOI":"10.12740\/PP\/92392","article-title":"Probiotics supplementation in prophylaxis and treatment of depressive and anxiety disorders - a review of current research","volume":"53","author":"Hermann","year":"2019","journal-title":"Psychiatr. Pol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1080\/00048670802534408","article-title":"Association between magnesium intake and depression and anxiety in community-dwelling adults: The Hordaland Health Study","volume":"43","author":"Jacka","year":"2009","journal-title":"Aust. N. Z. J. Psychiatry"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1159\/000067810","article-title":"Antioxidant enzyme and malondialdehyde levels in patients with panic disorder","volume":"46","author":"Kuloglu","year":"2002","journal-title":"Neuropsychobiology"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1159\/000063573","article-title":"Antioxidant enzyme activities and malondialdehyde levels in patients with obsessive-compulsive disorder","volume":"46","author":"Kuloglu","year":"2002","journal-title":"Neuropsychobiology"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"120","DOI":"10.2174\/1570159X11666131120232135","article-title":"Association of oxidative stress to the genesis of anxiety: Implications for possible therapeutic interventions","volume":"12","author":"Hassan","year":"2014","journal-title":"Curr. Neuropharmacol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.cpr.2007.04.009","article-title":"Cognitive processes during fear acquisition and extinction in animals and humans: Implications for exposure therapy of anxiety disorders","volume":"28","author":"Hofmann","year":"2008","journal-title":"Clin. Psychol. Rev."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"5659","DOI":"10.2174\/138161212803530916","article-title":"d-cycloserine as an augmentation strategy for cognitive behavioral therapy of anxiety disorders: An update","volume":"18","author":"Hofmann","year":"2012","journal-title":"Curr. Pharm. Des."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.neuropharm.2011.08.040","article-title":"The GABA system in anxiety and depression and its therapeutic potential","volume":"62","year":"2012","journal-title":"Neuropharmacology"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"603","DOI":"10.2147\/DDDT.S62912","article-title":"Altered \u03b3-aminobutyric acid neurotransmission in major depressive disorder: A critical review of the supporting evidence and the influence of serotonergic antidepressants","volume":"9","author":"Pehrson","year":"2015","journal-title":"Drug Des. Dev. Ther."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1002\/da.20262","article-title":"Role of GABA in anxiety and depression","volume":"24","author":"Kalueff","year":"2007","journal-title":"Depress. Anxiety"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1038\/nrn1429","article-title":"The developmental origins of anxiety","volume":"5","author":"Gross","year":"2004","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.schres.2014.10.010","article-title":"GABA receptor subunit distribution and FMRP-mGluR5 signaling abnormalities in the cerebellum of subjects with schizophrenia, mood disorders, and autism","volume":"167","author":"Fatemi","year":"2015","journal-title":"Schizophr. Res."},{"key":"ref_26","first-page":"165","article-title":"Anxiety disorders and GABA neurotransmission: A disturbance of modulation","volume":"11","author":"Nuss","year":"2015","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"ref_27","first-page":"21","article-title":"The role of GABA in anxiety disorders","volume":"64","author":"Lydiard","year":"2003","journal-title":"J. Clin. Psychiatry"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1016\/j.neuroscience.2010.08.005","article-title":"Effects of the probiotic Bifidobacterium infantis in the maternal separation model of depression","volume":"170","author":"Desbonnet","year":"2010","journal-title":"Neuroscience"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1002\/j.1550-8528.1993.tb00605.x","article-title":"Letter on Corpulence Addressed to the Public","volume":"1","author":"Banting","year":"1993","journal-title":"Obes. Res."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1093\/ajcn\/87.1.44","article-title":"Effects of a high-protein ketogenic diet on hunger, appetite, and weight loss in obese men feeding ad libitum","volume":"87","author":"Johnstone","year":"2008","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_31","first-page":"27","article-title":"Ketosis, ketogenic diet and food intake control: A complex relationship","volume":"2","author":"Paoli","year":"2015","journal-title":"Front. Psychol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1093\/jn\/nxz308","article-title":"The Ketogenic Diet: Evidence for Optimism but High-Quality Research Needed","volume":"150","author":"Ludwig","year":"2020","journal-title":"J. Nutr."},{"key":"ref_33","unstructured":"Einhorn, M. (1922). Lectures on Dietetics, Saunders."},{"key":"ref_34","unstructured":"Morgan, W. (1877). Diabetes Mellitus: Its History, Chemistry, Anatomy, Pathology, Physiology, and Treatment. Illustrated with Woodcuts, and Cases Successfully Treated, Homoeopathic Publishing Company."},{"key":"ref_35","unstructured":"Smith, W.D. (1994). Epidemics 2, Harvard University Press."},{"key":"ref_36","unstructured":"Atkins, R.C. (2002). Dr. Atkins\u2019 New Diet Revolution, M. Evans & Company."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/s13760-018-0881-4","article-title":"Efficacy of low glycemic index treatment in epileptic patients: A systematic review","volume":"118","author":"Rezaei","year":"2018","journal-title":"Acta Neurol. Belg."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"9","DOI":"10.4103\/2319-4170.107154","article-title":"Medium-chain triglyceride ketogenic diet, an effective treatment for drug-resistant epilepsy and a comparison with other ketogenic diets","volume":"36","author":"Liu","year":"2013","journal-title":"Biomed. J."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/0065-2571(66)90027-6","article-title":"The regulation of the release of ketone bodies by the liver","volume":"4","author":"Krebs","year":"1966","journal-title":"Adv. Enzyme Regul."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1111\/obr.12405","article-title":"Impact of low-carbohydrate diet on body composition: Meta-analysis of randomized controlled studies","volume":"17","author":"Hashimoto","year":"2016","journal-title":"Obes. Rev."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"2050","DOI":"10.1016\/S0140-6736(17)32252-3","article-title":"Associations of fats and carbohydrate intake with cardiovascular disease and mortality in 18 countries from five continents (PURE): A prospective cohort study","volume":"390","author":"Dehghan","year":"2017","journal-title":"Lancet"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.mehy.2018.06.022","article-title":"Ketogenic diet for schizophrenia: Nutritional approach to antipsychotic treatment","volume":"118","author":"Wiglusz","year":"2018","journal-title":"Med. Hypotheses"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.cell.2018.06.051","article-title":"The gut microbiota mediates the anti-seizure effects of the ketogenic diet","volume":"174","author":"Olson","year":"2018","journal-title":"Cell"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"823","DOI":"10.3389\/fimmu.2017.00823","article-title":"Free Fatty Acids Profiles Are Related to Gut Microbiota Signatures and Short-Chain Fatty Acids","volume":"8","author":"Salazar","year":"2017","journal-title":"Front. Immunol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.neulet.2017.02.014","article-title":"A ketogenic diet modifies glutamate, gamma-aminobutyric acid and agmatine levels in the hippocampus of rats: A microdialysis study","volume":"642","author":"Betancourt","year":"2017","journal-title":"Neurosci. Lett."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Paoli, A., Mancin, L., Bianco, A., Thomas, E., Mota, J.F., and Piccini, F. (2019). Ketogenic Diet and Microbiota: Friends or Enemies?. Genes, 10.","DOI":"10.3390\/genes10070534"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1111\/epi.13578","article-title":"2-Deoxy-d-glucose enhances tonic inhibition through the neurosteroid-mediated activation of extrasynaptic GABAA receptors","volume":"57","author":"Forte","year":"2016","journal-title":"Epilepsia"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.pediatrneurol.2007.02.008","article-title":"The neuropharmacology of the ketogenic diet","volume":"36","author":"Hartman","year":"2007","journal-title":"Pediatr. Neurol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s00213-013-3276-5","article-title":"Neurosteroid interactions with synaptic and extrasynaptic GABAA receptors: Regulation of subunit plasticity, phasic and tonic inhibition, and neuronal network excitability","volume":"230","author":"Carver","year":"2013","journal-title":"Psychopharmacology"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Thompson, R.S., Vargas, F., Dorrestein, P.C., Chichlowski, M., Berg, B.M., and Fleshner, M. (2020). Dietary prebiotics alter novel microbial dependent fecal metabolites that improve sleep. Sci. Rep., 10.","DOI":"10.1038\/s41598-020-60679-y"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1542\/peds.2011-2199","article-title":"The diet factor in attention-deficit\/hyperactivity disorder","volume":"129","author":"Millichap","year":"2012","journal-title":"Pediatrics"},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Lindefeldt, M., Eng, A., Darban, H., Bjerkner, A., Zetterstrom, C.K., Allander, T., Andersson, B., Borenstein, E., Dahlin, M., and Prast-Nielsen, S. (2019). The ketogenic diet influences taxonomic and functional composition of the gut microbiota in children with severe epilepsy. NPJ Biofilms Microbiomes, 5.","DOI":"10.1038\/s41522-018-0073-2"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.eplepsyres.2018.06.015","article-title":"Altered gut microbiome composition in children with refractory epilepsy after ketogenic diet","volume":"145","author":"Zhang","year":"2018","journal-title":"Epilepsy Res."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"6164","DOI":"10.3748\/wjg.v23.i33.6164","article-title":"Ketogenic diet poses a significant effect on imbalanced gut microbiota in infants with refractory epilepsy","volume":"23","author":"Xie","year":"2017","journal-title":"World J. Gastroenterol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s13229-016-0099-3","article-title":"Ketogenic diet modifies the gut microbiota in a murine model of autism spectrum disorder","volume":"7","author":"Newell","year":"2016","journal-title":"Mol. Autism"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.3389\/fmicb.2017.01141","article-title":"Reduced mass and diversity of the colonic microbiome in patients with multiple sclerosis and their improvement with ketogenic diet","volume":"8","author":"Swidsinski","year":"2017","journal-title":"Front. Microbiol."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Murtaza, N., Burke, L.M., Vlahovich, N., Charlesson, B., O\u2019Neill, H., Ross, M.L., Campbell, K.L., Krause, L., and Morrison, M. (2019). The effects of dietary pattern during intensified training on stool microbiota of elite race walkers. Nutrients, 11.","DOI":"10.3390\/nu11020261"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"6670","DOI":"10.1038\/s41598-018-25190-5","article-title":"Ketogenic diet enhances neurovascular function with altered gut microbiome in young healthy mice","volume":"8","author":"Ma","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1002\/ana.20062","article-title":"The ketogenic diet increases mitochondrial uncoupling protein levels and activity","volume":"55","author":"Sullivan","year":"2004","journal-title":"Ann Neurol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.plefa.2003.09.007","article-title":"The therapeutic implications of ketone bodies: The effects of ketone bodies in pathological conditions: Ketosis, ketogenic diet, redox states, insulin resistance, and mitochondrial metabolism","volume":"70","author":"Veech","year":"2004","journal-title":"Prostaglandins Leukot. Essent. Fatty Acids"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1475-2891-7-2","article-title":"Nutritional therapies for mental disorders","volume":"7","author":"Lakhan","year":"2008","journal-title":"Nutr. J."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"143","DOI":"10.7762\/cnr.2016.5.3.143","article-title":"Nutritional factors affecting mental health","volume":"5","author":"Lim","year":"2016","journal-title":"Clin. Nutr. Res."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.4088\/JCP.v67n1217","article-title":"Omega-3 fatty acids: Evidence basis for treatment and future research in psychiatry","volume":"67","author":"Freeman","year":"2006","journal-title":"J. Clin. Psychiatry"},{"key":"ref_64","first-page":"8","article-title":"Nutritional supplements in depressive disorders","volume":"45","year":"2017","journal-title":"Actas Esp. Psiquiatr."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.biopsych.2005.05.009","article-title":"Nutrition and Depression: Implications for Improving Mental Health Among Childbearing-Aged Women","volume":"58","author":"Bodnar","year":"2005","journal-title":"Biol. Psychiatry"},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Schweren, L.J.S., Larsson, H., Vinke, P.C., Li, L., Kvalvik, L.G., Arias-Vasquez, A., Haavik, J., and Hartman, C.A. (2020). Diet quality, stress and common mental health problems: A cohort study of 121,008 adults. Clin. Nutr.","DOI":"10.1016\/j.clnu.2020.06.016"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"701967","DOI":"10.1155\/2013\/701967","article-title":"Diet-Regulated Anxiety","volume":"2013","author":"Murphy","year":"2013","journal-title":"Int. J. Endocrinol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1001\/jama.2019.0556","article-title":"Effect of Multinutrient Supplementation and Food-Related Behavioral Activation Therapy on Prevention of Major Depressive Disorder Among Overweight or Obese Adults with Subsyndromal Depressive Symptoms. The MooDFOOD Randomized Clinical Trial","volume":"321","author":"Bot","year":"2019","journal-title":"JAMA"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1176\/appi.ajp.2009.09060881","article-title":"Association of Western and traditional diets with depression and anxiety in women","volume":"167","author":"Jacka","year":"2010","journal-title":"Am. J. Psychiatry"},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Davison, K.M., and Kaplan, B.J. (2012). Food intake and blood cholesterol levels of community-based adults with mood disorders. Davison Kaplan BMC Psychiatry, 12.","DOI":"10.1186\/1471-244X-12-10"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1186\/s13256-015-0709-2","article-title":"Ketoacidosis associated with low-carbohydrate diet in a non-diabetic lactating woman: A case report","volume":"9","author":"Ekelund","year":"2015","journal-title":"J. Med. Case Rep."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/12\/12\/3822\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T10:44:53Z","timestamp":1760179493000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/12\/12\/3822"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,14]]},"references-count":71,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2020,12]]}},"alternative-id":["nu12123822"],"URL":"https:\/\/doi.org\/10.3390\/nu12123822","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,14]]}}}