{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:20:05Z","timestamp":1790698805008,"version":"4.1.0"},"reference-count":129,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2020,12,15]],"date-time":"2020-12-15T00:00:00Z","timestamp":1607990400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Immune-globulin E (IgE)-mediated food allergy is characterized by a variety of clinical entities within the gastrointestinal tract, skin and lungs, and systemically as anaphylaxis. The default response to food antigens, which is antigen specific immune tolerance, requires exposure to the antigen and is already initiated during pregnancy. After birth, tolerance is mostly acquired in the gut after oral ingestion of dietary proteins, whilst exposure to these same proteins via the skin, especially when it is inflamed and has a disrupted barrier, can lead to allergic sensitization. The crosstalk between the skin and the gut, which is involved in the induction of food allergy, is still incompletely understood. In this review, we will focus on mechanisms underlying allergic sensitization (to food antigens) via the skin, leading to gastrointestinal inflammation, and the development of IgE-mediated food allergy. Better understanding of these processes will eventually help to develop new preventive and therapeutic strategies in children.<\/jats:p>","DOI":"10.3390\/nu12123830","type":"journal-article","created":{"date-parts":[[2020,12,15]],"date-time":"2020-12-15T09:12:57Z","timestamp":1608023577000},"page":"3830","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Mechanisms Underlying the Skin-Gut Cross Talk in the Development of IgE-Mediated Food Allergy"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8695-9030","authenticated-orcid":false,"given":"Marloes","family":"van Splunter","sequence":"first","affiliation":[{"name":"Internal Medicine, Allergology &amp; Clinical Immunology, Erasmus Medical Centre, 3000 CA Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liu","family":"Liu","sequence":"additional","affiliation":[{"name":"Internal Medicine, Allergology &amp; Clinical Immunology, Erasmus Medical Centre, 3000 CA Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3991-5297","authenticated-orcid":false,"given":"R.J. Joost","family":"van Neerven","sequence":"additional","affiliation":[{"name":"Cell Biology and Immunology, Wageningen University &amp; Research Centre, 6708 WD Wageningen, The Netherlands"},{"name":"FrieslandCampina, 3818 LE Amersfoort, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8030-7090","authenticated-orcid":false,"given":"Harry J.","family":"Wichers","sequence":"additional","affiliation":[{"name":"Wageningen Food &amp; Biobased Research, Wageningen University &amp; Research Centre, 6708 WG Wageningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9017-4447","authenticated-orcid":false,"given":"Kasper A.","family":"Hettinga","sequence":"additional","affiliation":[{"name":"Food Quality &amp; Design Group, Wageningen University &amp; Research Centre, 6708 WG Wageningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolette W.","family":"de Jong","sequence":"additional","affiliation":[{"name":"Internal Medicine, Allergology &amp; Clinical Immunology, Erasmus Medical Centre, 3000 CA Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,12,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"5442","DOI":"10.1172\/JCI77798","article-title":"Thymic stromal lymphopoietin-mediated epicutaneous inflammation promotes acute diarrhea and anaphylaxis","volume":"124","author":"Han","year":"2014","journal-title":"J. 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