{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T21:27:17Z","timestamp":1790285237094,"version":"4.1.0"},"reference-count":186,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2020,12,23]],"date-time":"2020-12-23T00:00:00Z","timestamp":1608681600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002850","name":"Fondo Nacional de Desarrollo Cient\u00edfico y Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["1181798"],"award-info":[{"award-number":["1181798"]}],"id":[{"id":"10.13039\/501100002850","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Prenatal and postnatal development are closely related to healthy maternal conditions that allow for the provision of all nutritional requirements to the offspring. In this regard, an appropriate supply of fatty acids (FA), mainly n-3 and n-6 long-chain polyunsaturated fatty acids (LCPUFA), is crucial to ensure a normal development, because they are an integral part of cell membranes and participate in the synthesis of bioactive molecules that regulate multiple signaling pathways. On the other hand, maternal obesity and excessive gestational weight gain affect FA supply to the fetus and neonate, altering placental nutrient transfer, as well as the production and composition of breast milk during lactation. In this regard, maternal obesity modifies FA profile, resulting in low n-3 and elevated n-6 PUFA levels in maternal and fetal circulation during pregnancy, as well as in breast milk during lactation. These modifications are associated with a pro-inflammatory state and oxidative stress with short and long-term consequences in different organs of the fetus and neonate, including in the liver, brain, skeletal muscle, and adipose tissue. Altogether, these changes confer to the offspring a higher risk of developing obesity and its complications, as well as neuropsychiatric disorders, asthma, and cancer. Considering the consequences of an abnormal FA supply to offspring induced by maternal obesity, we aimed to review the effects of obesity on the metabolism and bioavailability of FA during pregnancy and breastfeeding, with an emphasis on LCPUFA homeostasis.<\/jats:p>","DOI":"10.3390\/nu13010019","type":"journal-article","created":{"date-parts":[[2020,12,23]],"date-time":"2020-12-23T08:38:43Z","timestamp":1608712723000},"page":"19","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":66,"title":["Impact of Maternal Obesity on the Metabolism and Bioavailability of Polyunsaturated Fatty Acids during Pregnancy and Breastfeeding"],"prefix":"10.3390","volume":"13","author":[{"given":"Daniela","family":"\u00c1lvarez","sequence":"first","affiliation":[{"name":"Endocrinology and Metabolism Laboratory, West Division, Faculty of Medicine, University of Chile, Santiago 8380000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasna","family":"Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Endocrinology and Metabolism Laboratory, West Division, Faculty of Medicine, University of Chile, Santiago 8380000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Macarena","family":"Ortiz","sequence":"additional","affiliation":[{"name":"Endocrinology and Metabolism Laboratory, West Division, Faculty of Medicine, University of Chile, Santiago 8380000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Maliqueo","sequence":"additional","affiliation":[{"name":"Endocrinology and Metabolism Laboratory, West Division, Faculty of Medicine, University of Chile, Santiago 8380000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rapha\u00ebl","family":"Chouinard-Watkins","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, ON M5S1A8, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9298-6142","authenticated-orcid":false,"given":"Rodrigo","family":"Valenzuela","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, ON M5S1A8, Canada"},{"name":"Nutrition Department, Faculty of Medicine, University of Chile, Santiago 8380000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,12,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.pop.2015.09.003","article-title":"Obesity in Special Populations: Pregnancy","volume":"43","author":"Downs","year":"2016","journal-title":"Prim Care"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.ogc.2015.01.008","article-title":"Pregnancy risks associated with obesity","volume":"42","author":"Mission","year":"2015","journal-title":"Obstet. Gynecol. Clin. N. Am."},{"key":"ref_3","first-page":"345","article-title":"Effect of maternal obesity on pregnancy outcomes and long-term metabolic consequences","volume":"14","author":"Valsamakis","year":"2015","journal-title":"Hormones (Athens)"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1097\/MED.0000000000000305","article-title":"Maternal epigenetics and fetal and neonatal growth","volume":"24","author":"Tzetis","year":"2017","journal-title":"Curr. Opin. Endocrinol. Diabetes Obes."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1515\/hmbci-2015-0025","article-title":"Maternal and fetal lipid metabolism under normal and gestational diabetic conditions","volume":"26","author":"Herrera","year":"2016","journal-title":"Horm. Mol. Biol. Clin. Investig."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1080\/14767058.2018.1446207","article-title":"Interactions among insulin resistance, inflammation factors, obesity-related gene polymorphisms, environmental risk factors, and diet in the development of gestational diabetes mellitus","volume":"32","author":"Feng","year":"2019","journal-title":"J. Matern. Fetal Neonatal Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"25168","DOI":"10.3390\/ijms161025168","article-title":"Relevant Aspects of Nutritional and Dietary Interventions in Non-Alcoholic Fatty Liver Disease","volume":"16","author":"Valenzuela","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1159\/000496471","article-title":"Nutrition During Pregnancy, Lactation and Early Childhood and its Implications for Maternal and Long-Term Child Health: The Early Nutrition Project Recommendations","volume":"74","author":"Koletzko","year":"2019","journal-title":"Ann. Nutr. Metab."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1387\/ijdb.082765md","article-title":"Placental nutrient supply and fetal growth","volume":"54","author":"Desforges","year":"2010","journal-title":"Int. J. Dev. Biol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1016\/j.clnu.2017.10.007","article-title":"Maternal nutritional determinants of colostrum fatty acids in the EDEN mother-child cohort","volume":"37","author":"Armand","year":"2018","journal-title":"Clin. Nutr."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1126\/science.345.6198.747","article-title":"Nature\u2019s first functional food","volume":"345","author":"Gura","year":"2014","journal-title":"Science"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1053\/j.semperi.2015.06.009","article-title":"Nutrition and maternal, neonatal, and child health","volume":"39","author":"Christian","year":"2015","journal-title":"Semin. Perinatol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1038\/nrn3820","article-title":"Polyunsaturated fatty acids and their metabolites in brain function and disease","volume":"15","author":"Bazinet","year":"2014","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"94","DOI":"10.33594\/000000007","article-title":"Linoleic Acid Increases Prostaglandin E2 Release and Reduces Mitochondrial Respiration and Cell Viability in Human Trophoblast-Like Cells","volume":"52","author":"Shrestha","year":"2019","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1111\/j.1471-0528.1998.tb10002.x","article-title":"Essential fatty acids in relation to pregnancy complications and fetal development","volume":"105","author":"Sattar","year":"1998","journal-title":"BJOG Int. J. Obstet. Gynaecol."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Guillou, H., Martin, P.G., and Pineau, T. (2008). Transcriptional regulation of hepatic fatty acid metabolism. Lipids in Health and Disease, Springer.","DOI":"10.1007\/978-1-4020-8831-5_1"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Renault, K.M., Carlsen, E.M., N\u00f8rgaard, K., Nilas, L., Pryds, O., Secher, N.J., Olsen, S.F., and Halldorsson, T.I. (2015). Intake of Sweets, Snacks and Soft Drinks Predicts Weight Gain in Obese Pregnant Women: Detailed Analysis of the Results of a Randomised Controlled Trial. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0133041"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"938","DOI":"10.3389\/fendo.2019.00938","article-title":"Nutrition, Behavior Change and Physical Activity Outcomes From the PEARS RCT-An mHealth-Supported, Lifestyle Intervention Among Pregnant Women With Overweight and Obesity","volume":"10","author":"Ainscough","year":"2019","journal-title":"Front. Endocrinol."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Barrera, C., Valenzuela, R., Chamorro, R., Bascunan, K., Sandoval, J., Sabag, N., Valenzuela, F., Valencia, M.P., Puigrredon, C., and Valenzuela, A. (2018). The Impact of Maternal Diet during Pregnancy and Lactation on the Fatty Acid Composition of Erythrocytes and Breast Milk of Chilean Women. Nutrients, 10.","DOI":"10.3390\/nu10070839"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"3441","DOI":"10.1113\/jphysiol.2009.173062","article-title":"Long chain fatty acids and dietary fats in fetal nutrition","volume":"587","author":"Cetin","year":"2009","journal-title":"J. Physiol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1016\/j.clnu.2019.04.014","article-title":"Altered materno-fetal transfer of 13C-polyunsaturated fatty acids in obese pregnant women","volume":"39","author":"Gazquez","year":"2019","journal-title":"Clin. Nutr."},{"key":"ref_22","first-page":"49","article-title":"Human Milk Composition: Nutrients and Bioactive Factors","volume":"60","author":"Ballard","year":"2013","journal-title":"Pediatr. Clin."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"640291","DOI":"10.1155\/2014\/640291","article-title":"Maternal Obesity and Occurrence of Fetal Macrosomia: A Systematic Review and Meta-Analysis","volume":"2014","author":"Gaudet","year":"2014","journal-title":"Biomed. Res. Int."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1016\/j.ajog.2004.05.052","article-title":"The influence of obesity and diabetes on the prevalence of macrosomia","volume":"191","author":"Ehrenberg","year":"2004","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Ratnasiri, A.W.G., Lee, H.C., Lakshminrusimha, S., Parry, S.S., Arief, V.N., DeLacy, I.H., Yang, J.-S., DiLibero, R.J., Logan, J., and Basford, K.E. (2019). Trends in maternal prepregnancy body mass index (BMI) and its association with birth and maternal outcomes in California, 2007\u20132016: A retrospective cohort study. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0222458"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1136\/bmj.1.6016.985","article-title":"Influence of maternal obesity on subcutaneous fat in the newborn","volume":"1","author":"Whitelaw","year":"1976","journal-title":"Br. Med. J."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"416.e1","DOI":"10.1016\/j.ajog.2007.10.796","article-title":"Impact of maternal body mass index on neonate birthweight and body composition","volume":"198","author":"Hull","year":"2008","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1111\/apa.12713","article-title":"Newborn regional body composition is influenced by maternal obesity, gestational weight gain and the birthweight standard score","volume":"103","author":"Carlsen","year":"2014","journal-title":"Acta Paediatr."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2286","DOI":"10.1007\/s10995-015-1747-5","article-title":"The Pattern of Gestational Weight Gain is Associated with Changes in Maternal Body Composition and Neonatal Size","volume":"19","author":"Widen","year":"2015","journal-title":"Matern. Child Health J."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.jogc.2015.12.014","article-title":"Timing of Excessive Weight Gain During Pregnancy Modulates Newborn Anthropometry","volume":"38","author":"Ruchat","year":"2016","journal-title":"J. Obstet. Gynaecol. Can."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1080\/01443615.2017.1328670","article-title":"Gestational weight gain in obese pregnancy: Impact on maternal and foetal metabolic parameters and birthweight","volume":"38","author":"Lindsay","year":"2018","journal-title":"J. Obstet. Gynaecol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.2337\/dc08-2077","article-title":"Fetuses of Obese Mothers Develop Insulin Resistance in Utero","volume":"32","author":"Catalano","year":"2009","journal-title":"Diabetes Care"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1203\/PDR.0b013e318225f9b1","article-title":"The Influence of Maternal Body Mass Index on Infant Adiposity and Hepatic Lipid Content","volume":"70","author":"Modi","year":"2011","journal-title":"Pediatr. Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1016\/j.jpeds.2012.11.017","article-title":"Intrahepatic fat is increased in the neonatal offspring of obese women with gestational diabetes","volume":"162","author":"Brumbaugh","year":"2013","journal-title":"J. Pediatr."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.3945\/ajcn.117.158683","article-title":"Trajectories of maternal weight from before pregnancy through postpartum and associations with childhood obesity","volume":"106","author":"Leonard","year":"2017","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1111\/1471-0528.13700","article-title":"Associations of maternal prepregnancy body mass index and gestational weight gain with cardio-metabolic risk factors in adolescent offspring: A prospective cohort study","volume":"123","author":"Gaillard","year":"2016","journal-title":"BJOG"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/S2213-8587(20)30151-0","article-title":"Maternal obesity and risk of cardiovascular diseases in offspring: A population-based cohort and sibling-controlled study","volume":"8","author":"Razaz","year":"2020","journal-title":"Lancet Diabetes Endocrinol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1161\/HYPERTENSIONAHA.107.101477","article-title":"Diet-Induced Obesity in Female Mice Leads to Offspring Hyperphagia, Adiposity, Hypertension, and Insulin Resistance","volume":"51","author":"Samuelsson","year":"2008","journal-title":"Hypertension"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1038\/ijo.2014.175","article-title":"Maternal weight gain in different periods of pregnancy and childhood cardio-metabolic outcomes. The Generation R Study","volume":"39","author":"Gaillard","year":"2015","journal-title":"Int. J. Obes."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.jpeds.2014.05.050","article-title":"Maternal obesity, gestational weight gain, and offspring adiposity: The exploring perinatal outcomes among children study","volume":"165","author":"Kaar","year":"2014","journal-title":"J. Pediatr."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.jpeds.2017.09.008","article-title":"Fetal Overnutrition and Adolescent Hepatic Fat Fraction: The Exploring Perinatal Outcomes in Children Study","volume":"192","author":"Bellatorre","year":"2018","journal-title":"J. Pediatr."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1111\/obr.12643","article-title":"Maternal pre-pregnancy obesity and child neurodevelopmental outcomes: A meta-analysis","volume":"19","author":"Sanchez","year":"2018","journal-title":"Obes. Rev."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1001\/jamaneurol.2016.6130","article-title":"Maternal Body Mass Index in Early Pregnancy and Risk of Epilepsy in Offspring","volume":"74","author":"Razaz","year":"2017","journal-title":"JAMA Neurol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1038\/oby.2005.48","article-title":"Additive interactions of maternal prepregnancy BMI and breast-feeding on childhood overweight","volume":"13","author":"Li","year":"2005","journal-title":"Obes. Res."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s12986-017-0168-4","article-title":"Lipid overload during gestation and lactation can independently alter lipid homeostasis in offspring and promote metabolic impairment after new challenge to high-fat diet","volume":"14","author":"Torsoni","year":"2017","journal-title":"Nutr. Metab."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Mitanchez, D., Jacqueminet, S., Nizard, J., Tanguy, M.L., Ciangura, C., Lacorte, J.M., De Carne, C., Foix L\u2019Helias, L., Chavatte-Palmer, P., and Charles, M.A. (2017). Effect of maternal obesity on birthweight and neonatal fat mass: A prospective clinical trial. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0181307"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1002\/oby.21078","article-title":"Longitudinal body composition of children born to mothers with normal weight, overweight, and obesity","volume":"23","author":"Andres","year":"2015","journal-title":"Obesity"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"434","DOI":"10.3109\/07853890.2014.919728","article-title":"Long-term consequences of maternal overweight in pregnancy on offspring later health: Findings from the Helsinki Birth Cohort Study","volume":"46","author":"Eriksson","year":"2014","journal-title":"Ann. Med."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1002\/hep.29347","article-title":"Sex differences between parental pregnancy characteristics and nonalcoholic fatty liver disease in adolescents","volume":"67","author":"Ayonrinde","year":"2018","journal-title":"Hepatology"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.amepre.2017.05.013","article-title":"Maternal Prepregnancy Weight and Children\u2019s Behavioral and Emotional Outcomes","volume":"53","author":"Deardorff","year":"2017","journal-title":"Am. J. Prev. Med."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/oby.2007.57","article-title":"Effects of Breastfeeding on Trajectories of Body Fat and BMI throughout Childhood","volume":"16","author":"Buyken","year":"2008","journal-title":"Obesity"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1161\/HYPERTENSIONAHA.113.02671","article-title":"Childhood Cardiometabolic Outcomes of Maternal Obesity During Pregnancy","volume":"63","author":"Gaillard","year":"2014","journal-title":"Hypertension"},{"key":"ref_53","first-page":"59","article-title":"Maternal lipid metabolism and placental lipid transfer","volume":"65","author":"Herrera","year":"2006","journal-title":"Horm. Res."},{"key":"ref_54","unstructured":"Casart Quintero, Y., Garrido Cisneros, D., Guevara Flores, C., Castillo Andrade, R., Salas Salas, H., and Hern\u00e1ndez Guerra, H. (2016). Perfil lip\u00eddico en embarazadas durante el tercer trimestre seg\u00fan \u00edndice de masa corporal y consumo de grasas. Rev. Cuba. De Obstet. Y Ginecol., 42, Available online: http:\/\/scielo.sld.cu\/scielo.php?pid=S0138-600X2016000100006&script=sci_arttext&tlng=en."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"24","DOI":"10.2174\/1389201015666140330192345","article-title":"Lipid metabolism during pregnancy and its implications for fetal growth","volume":"15","author":"Herrera","year":"2014","journal-title":"Curr. Pharm. Biotechnol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1097\/MCO.0000000000000443","article-title":"Placental fatty acid transfer","volume":"21","author":"Lewis","year":"2018","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1159\/000480162","article-title":"Maternal Metabolic Adaptation to Pregnancy","volume":"Volume 28","author":"Lapolla","year":"2020","journal-title":"Gestational Diabetes. A Decade after the HAPO Study"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.plefa.2012.03.007","article-title":"Changes in rat n-3 and n-6 fatty acid composition during pregnancy are associated with progesterone concentrations and hepatic FADS2 expression","volume":"86","author":"Childs","year":"2012","journal-title":"Prostaglandins Leukot. Essent. Fat. Acids"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/s11745-006-3005-5","article-title":"Longitudinal assessment of erythrocyte fatty acid composition throughout pregnancy and post partum","volume":"42","author":"Stewart","year":"2007","journal-title":"Lipids"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1002\/oby.20576","article-title":"The impact of maternal obesity and gestational weight gain on early and mid-pregnancy lipid profiles","volume":"22","author":"Scifres","year":"2014","journal-title":"Obesity."},{"key":"ref_61","first-page":"57","article-title":"Mechanisms involved in the selective transfer of long chain polyunsaturated Fatty acids to the fetus","volume":"2","author":"Demmelmair","year":"2011","journal-title":"Front. Genet."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"115","DOI":"10.3945\/ajcn.2010.29589","article-title":"Maternal-fetal in vivo transfer of [13C]docosahexaenoic and other fatty acids across the human placenta 12 h after maternal oral intake","volume":"92","author":"Larque","year":"2010","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1194\/jlr.M200067-JLR200","article-title":"In vivo investigation of the placental transfer of (13)C-labeled fatty acids in humans","volume":"44","author":"Larque","year":"2003","journal-title":"J. Lipid Res."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"418","DOI":"10.3945\/jn.110.128488","article-title":"Maternal DHA Equilibrium during Pregnancy and Lactation Is Reached at an Erythrocyte DHA Content of 8 g\/100 g Fatty Acids","volume":"141","author":"Kuipers","year":"2011","journal-title":"J. Nutr."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1908S","DOI":"10.3945\/ajcn.110.001230","article-title":"Placental transfer of fatty acids and fetal implications","volume":"94","author":"Larque","year":"2011","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_66","unstructured":"Food and Agriculture Organization of the United Nations (2010). Fats and fatty acids in human nutrition. Report of an expert consultation. FAO Food. Nutr. Pap., 91, 1\u2013166."},{"key":"ref_67","first-page":"163","article-title":"Omega-3 Fatty acids and pregnancy","volume":"3","author":"Coletta","year":"2010","journal-title":"Rev. Obstet. Gynecol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1515\/JPM.2008.001","article-title":"The roles of long-chain polyunsaturated fatty acids in pregnancy, lactation and infancy: Review of current knowledge and consensus recommendations","volume":"36","author":"Koletzko","year":"2008","journal-title":"J. Perinat. Med."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1016\/S0002-8223(02)90346-9","article-title":"Dietary reference intakes for energy, carbohydrate, fiber, fat, fatty acids, cholesterol, protein and amino acids","volume":"102","author":"Trumbo","year":"2002","journal-title":"J. Am. Diet Assoc."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"S8","DOI":"10.1017\/S0007114512001444","article-title":"Recommended dietary reference intakes, nutritional goals and dietary guidelines for fat and fatty acids: A systematic review","volume":"107","author":"Aranceta","year":"2012","journal-title":"Br. J. Nutr."},{"key":"ref_71","unstructured":"Rasmussen, K.M., and Yaktine, A.L. (2009). The National Academies Collection: Reports funded by National Institutes of Health. Weight Gain During Pregnancy: Reexamining the Guidelines, National Academies Press (US), National Academy of Sciences."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1017\/S0007114507764747","article-title":"Dietary fat intakes for pregnant and lactating women","volume":"98","author":"Koletzko","year":"2007","journal-title":"Br. J. Nutr."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1452S","DOI":"10.1093\/ajcn\/83.6.1452S","article-title":"Effects of n-3 fatty acids during pregnancy and lactation","volume":"83","author":"Jensen","year":"2006","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1038\/ejcn.2013.2","article-title":"Effect of dietary intervention to reduce the n-6\/n-3 fatty acid ratio on maternal and fetal fatty acid profile and its relation to offspring growth and body composition at 1 year of age","volume":"67","author":"Much","year":"2013","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_75","first-page":"295","article-title":"Does maternal docosahexaenoic acid supplementation during pregnancy and lactation lower BMI in late infancy?","volume":"35","author":"Bergmann","year":"2007","journal-title":"J. Perinat. Med."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1515\/jpm-2012-0080","article-title":"Does docosahexaenoic acid (DHA) status in pregnancy have any impact on postnatal growth? Six-year follow-up of a prospective randomized double-blind monocenter study on low-dose DHA supplements","volume":"40","author":"Bergmann","year":"2012","journal-title":"J. Perinat. Med."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"29971","DOI":"10.1038\/srep29971","article-title":"The impact of preconceptional obesity on trajectories of maternal lipids during gestation","volume":"6","author":"Bozkurt","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Roland, M.C.P., Lekva, T., Godang, K., Bollerslev, J., and Henriksen, T. (2020). Changes in maternal blood glucose and lipid concentrations during pregnancy differ by maternal body mass index and are related to birthweight: A prospective, longitudinal study of healthy pregnancies. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0232749"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1159\/000014190","article-title":"Impaired serum lipids and lipoproteins in fetal macrosomia related to maternal obesity","volume":"77","author":"Merzouk","year":"2000","journal-title":"Biol. Neonate"},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Geraghty, A.A., Alberdi, G., O\u2019Sullivan, E.J., O\u2019Brien, E.C., Crosbie, B., Twomey, P.J., and McAuliffe, F.M. (2017). Maternal and fetal blood lipid concentrations during pregnancy differ by maternal body mass index: Findings from the ROLO study. BMC Pregnancy Childbirth, 17.","DOI":"10.1186\/s12884-017-1543-x"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1007\/s10654-015-0106-6","article-title":"Body mass index, gestational weight gain and fatty acid concentrations during pregnancy: The Generation R Study","volume":"30","author":"Vidakovic","year":"2015","journal-title":"Eur. J. Epidemiol."},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Cinelli, G., Fabrizi, M., Rav\u00e0, L., Ciofi Degli Atti, M., Vernocchi, P., Vallone, C., Pietrantoni, E., Lanciotti, R., Signore, F., and Manco, M. (2016). Influence of Maternal Obesity and Gestational Weight Gain on Maternal and Foetal Lipid Profile. Nutrients, 8.","DOI":"10.3390\/nu8060368"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/ijo.2016.153","article-title":"Association of maternal prepregnancy BMI with metabolomic profile across gestation","volume":"41","author":"Hellmuth","year":"2017","journal-title":"Int. J. Obes."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1080\/17474124.2020.1715210","article-title":"Fatty liver in pregnancy: A narrative review of two distinct conditions","volume":"14","author":"Azzaroli","year":"2020","journal-title":"Expert Rev. Gastroenterol. Hepatol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1038\/oby.2009.379","article-title":"Decreased liver fatty acid delta-6 and delta-5 desaturase activity in obese patients","volume":"18","author":"Araya","year":"2010","journal-title":"Obesity"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/s12944-017-0450-5","article-title":"Hydroxytyrosol prevents reduction in liver activity of \u0394-5 and \u0394-6 desaturases, oxidative stress, and depletion in long chain polyunsaturated fatty acid content in different tissues of high-fat diet fed mice","volume":"16","author":"Valenzuela","year":"2017","journal-title":"Lipids Health Dis."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1016\/j.nut.2016.04.006","article-title":"Supplementation with antioxidant-rich extra virgin olive oil prevents hepatic oxidative stress and reduction of desaturation capacity in mice fed a high-fat diet: Effects on fatty acid composition in liver and extrahepatic tissues","volume":"32","author":"Valenzuela","year":"2016","journal-title":"Nutrition"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"582748","DOI":"10.1155\/2012\/582748","article-title":"Impact of oxidative stress in fetal programming","volume":"2012","author":"Thompson","year":"2012","journal-title":"J. Pregnancy"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1093\/nutrit\/nuu001","article-title":"Impact of oxidative stress during pregnancy on fetal epigenetic patterns and early origin of vascular diseases","volume":"73","author":"Avila","year":"2015","journal-title":"Nutr. Rev."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1038\/ijo.2013.150","article-title":"Exercise in obese female rats has beneficial effects on maternal and male and female offspring metabolism","volume":"39","author":"Vega","year":"2015","journal-title":"Int. J. Obes."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.plefa.2016.08.010","article-title":"The effect of n-3 LCPUFA supplementation on oxidative stress and inflammation in the placenta and maternal plasma during pregnancy","volume":"113","author":"Leghi","year":"2016","journal-title":"Prostaglandins Leukot. Essent. Fat. Acids"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.placenta.2014.02.012","article-title":"The Human Placenta Project: Placental Structure, Development, and Function in Real Time","volume":"35","author":"Guttmacher","year":"2014","journal-title":"Placenta"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1097\/MCO.0b013e3283523b6e","article-title":"Current understanding of placental fatty acid transport","volume":"15","author":"Koletzko","year":"2012","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"179827","DOI":"10.1155\/2012\/179827","article-title":"Regulation of nutrient transport across the placenta","volume":"2012","author":"Lager","year":"2012","journal-title":"J. Pregnancy"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1194\/jlr.P072355","article-title":"The influence of placental metabolism on fatty acid transfer to the fetus","volume":"58","author":"Perazzolo","year":"2017","journal-title":"J. Lipid Res."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.plipres.2008.11.001","article-title":"Transport of fatty acids across the human placenta: A review","volume":"48","author":"Duttaroy","year":"2009","journal-title":"Prog. Lipid Res."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.clnu.2016.01.014","article-title":"Placental MFSD2a transporter is related to decreased DHA in cord blood of women with treated gestational diabetes","volume":"36","author":"Pagan","year":"2017","journal-title":"Clin. Nutr."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/nature13241","article-title":"Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid","volume":"509","author":"Nguyen","year":"2014","journal-title":"Nature"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.placenta.2010.12.023","article-title":"Placental structure and inflammation in pregnancies associated with obesity","volume":"32","author":"Roberts","year":"2011","journal-title":"Placenta"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.placenta.2010.10.012","article-title":"Effect of IL-6 and TNF-alpha on fatty acid uptake in cultured human primary trophoblast cells","volume":"32","author":"Lager","year":"2011","journal-title":"Placenta"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"3061","DOI":"10.1089\/ars.2010.3765","article-title":"The role of oxidative stress in the pathophysiology of gestational diabetes mellitus","volume":"15","author":"Lappas","year":"2011","journal-title":"Antioxid. Redox Signal."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1194\/jlr.M039842","article-title":"Maternal dietary omega-3 fatty acid intake increases resolvin and protectin levels in the rat placenta","volume":"54","author":"Jones","year":"2013","journal-title":"J. Lipid Res."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1530\/REP-14-0549","article-title":"Effects of maternal n-3 fatty acid supplementation on placental cytokines, pro-resolving lipid mediators and their precursors","volume":"149","author":"Keelan","year":"2015","journal-title":"Reproduction"},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Jones, M.L., Mark, P.J., Mori, T.A., Keelan, J.A., and Waddell, B.J. (2013). Maternal Dietary Omega-3 Fatty Acid Supplementation Reduces Placental Oxidative Stress and Increases Fetal and Placental Growth in the Rat1. Biol. Reprod., 88.","DOI":"10.1095\/biolreprod.112.103754"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"R143","DOI":"10.1530\/REP-13-0376","article-title":"Maternal dietary omega-3 fatty acids and placental function","volume":"147","author":"Jones","year":"2014","journal-title":"Reproduction"},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Shrestha, N., Holland, O.J., Kent, N.L., Perkins, A.V., McAinch, A.J., Cuffe, J.S.M., and Hryciw, D.H. (2020). Maternal High Linoleic Acid Alters Placental Fatty Acid Composition. Nutrients, 12.","DOI":"10.3390\/nu12082183"},{"key":"ref_107","doi-asserted-by":"crossref","unstructured":"Reyes-Hern\u00e1ndez, C.G., Ramiro-Cortijo, D., Rodr\u00edguez-Rodr\u00edguez, P., Giambelluca, S., Simonato, M., Gonz\u00e1lez, M.D.C., L\u00f3pez de Pablo, A.L., L\u00f3pez-Gim\u00e9nez, M.D.R., Cogo, P., and S\u00e1enz de Pipa\u00f3n, M. (2018). Effects of Arachidonic and Docosohexahenoic Acid Supplementation during Gestation in Rats. Implication of Placental Oxidative Stress. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19123863"},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Garcia-Contreras, C., Vazquez-Gomez, M., Astiz, S., Torres-Rovira, L., Sanchez-Sanchez, R., Gomez-Fidalgo, E., Gonzalez, J., Isabel, B., Rey, A., and Ovilo, C. (2017). Ontogeny of Sex-Related Differences in Foetal Developmental Features, Lipid Availability and Fatty Acid Composition. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18061171"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"R1224","DOI":"10.1152\/ajpregu.00309.2010","article-title":"Maternal obesity markedly increases placental fatty acid transporter expression and fetal blood triglycerides at midgestation in the ewe","volume":"299","author":"Zhu","year":"2010","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/ijo.2016.188","article-title":"Maternal obesity modulates intracellular lipid turnover in the human term placenta","volume":"41","author":"Hirschmugl","year":"2017","journal-title":"Int. J. Obes."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1095\/biolreprod.111.098095","article-title":"Modulation of fatty acid transport and metabolism by maternal obesity in the human full-term placenta","volume":"87","author":"Dube","year":"2012","journal-title":"Biol. Reprod."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.placenta.2016.02.010","article-title":"Protein expression of fatty acid transporter 2 is polarized to the trophoblast basal plasma membrane and increased in placentas from overweight\/obese women","volume":"40","author":"Lager","year":"2016","journal-title":"Placenta"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"2543","DOI":"10.1210\/en.2017-00152","article-title":"Effect of Maternal Obesity on Placental Lipid Metabolism","volume":"158","author":"Haghiac","year":"2017","journal-title":"Endocrinology"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12986-018-0330-7","article-title":"Maternal dietary ratio of linoleic acid to alpha-linolenic acid during pregnancy has sex-specific effects on placental and fetal weights in the rat","volume":"16","author":"Draycott","year":"2019","journal-title":"Nutr. Metab."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.placenta.2017.11.014","article-title":"Preliminary metabolomics analysis of placenta in maternal obesity","volume":"61","author":"Fattuoni","year":"2018","journal-title":"Placenta"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.placenta.2013.03.009","article-title":"Placental oleic acid uptake is lower in male offspring of obese women","volume":"34","author":"Brass","year":"2013","journal-title":"Placenta"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1002\/oby.21159","article-title":"Maternal obesity increases oxidative stress in the newborn","volume":"23","author":"Gallardo","year":"2015","journal-title":"Obesity"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.earlhumdev.2009.02.003","article-title":"Effect of docosahexaenoic acid on oxidative stress in placental trophoblast cells","volume":"85","author":"Shoji","year":"2009","journal-title":"Early Hum. Dev."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/CS20060339","article-title":"Role of the placenta in fetal programming: Underlying mechanisms and potential interventional approaches","volume":"113","author":"Jansson","year":"2007","journal-title":"Clin. Sci."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.tjog.2017.01.001","article-title":"Fetal programming of the metabolic syndrome","volume":"56","author":"Marciniak","year":"2017","journal-title":"Taiwan J. Obstet. Gynecol"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/S0022-2275(20)37440-X","article-title":"High polyunsaturated fatty acid, thromboxane A2, and alpha-fetoprotein concentrations at the human feto-maternal interface","volume":"38","author":"Benassayag","year":"1997","journal-title":"J. Lipid Res."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1016\/S0022-2275(20)33492-1","article-title":"Linoleic acid kinetics and conversion to arachidonic acid in the pregnant and fetal baboon","volume":"40","author":"Su","year":"1999","journal-title":"J. Lipid Res."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1159\/000242104","article-title":"Essential Fatty Acids Interconversion in the Human Fetal Liver","volume":"47","author":"Chambaz","year":"1985","journal-title":"Neonatology"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1016\/S0022-2275(20)32170-2","article-title":"\u03946- and \u03945-desaturase activities in the human fetal liver: Kinetic aspects","volume":"39","author":"Rodriguez","year":"1998","journal-title":"J. Lipid Res."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1146\/annurev.nutr.012809.104742","article-title":"Fatty Acid Supply to the Human Fetus","volume":"30","author":"Haggarty","year":"2010","journal-title":"Annu. Rev. Nutr."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/nrgastro.2016.160","article-title":"Developmental origins of NAFLD: A womb with a clue","volume":"14","author":"Wesolowski","year":"2017","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1152\/ajplegacy.1958.194.3.457","article-title":"Effect of oxygen deprivation on the metabolism of fetal and adult tissues","volume":"194","author":"Villee","year":"1958","journal-title":"Am. J. Physiol."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0014-5793(82)81329-X","article-title":"Regulation of hepatic carnitine palmitoyltransferase activity during the foetal-neonatal transition","volume":"150","author":"Saggerson","year":"1982","journal-title":"FEBS Lett."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s10545-006-0199-x","article-title":"Fatty acid oxidation in the human fetus: Implications for fetal and adult disease","volume":"29","author":"Oey","year":"2006","journal-title":"J. Inherit. Metab. Dis."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"R1569","DOI":"10.1152\/ajpregu.00385.2015","article-title":"Increased placental fatty acid transporter 6 and binding protein 3 expression and fetal liver lipid accumulation in a mouse model of obesity in pregnancy","volume":"309","author":"Diaz","year":"2015","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"ref_131","first-page":"323","article-title":"Maternal high-fat diet triggers lipotoxicity in the fetal livers of nonhuman primates","volume":"119","author":"McCurdy","year":"2009","journal-title":"J. Clin. Investig."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.jnutbio.2015.08.019","article-title":"Maternal saturated-fat-rich diet promotes leptin resistance in fetal liver lipid catabolism and programs lipid homeostasis impairments in the liver of rat offspring","volume":"27","author":"Mazzucco","year":"2016","journal-title":"J. Nutr. Biochem."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"7231","DOI":"10.3390\/nu7095337","article-title":"High Fat Diet Exposure during Fetal Life Enhances Plasma and Hepatic Omega-6 Fatty Acid Profiles in Fetal Wistar Rats","volume":"7","author":"Cerf","year":"2015","journal-title":"Nutrients"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1002\/lipd.12074","article-title":"Dietary Unsaturated Fatty Acids Modulate Maternal Dyslipidemia-Induced DNA Methylation and Histone Acetylation in Placenta and Fetal Liver in Rats","volume":"53","author":"Ramaiyan","year":"2018","journal-title":"Lipids"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"G250","DOI":"10.1152\/ajpgi.00189.2011","article-title":"Metabolic development in the liver and the implications of the n-3 fatty acid supply","volume":"302","author":"Novak","year":"2012","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"ref_136","doi-asserted-by":"crossref","unstructured":"Serafim, T.L., Cunha-Oliveira, T., Deus, C.M., Sardao, V.A., Cardoso, I.M., Yang, S., Odhiambo, J.F., Ghnenis, A.B., Smith, A.M., and Li, J. (2020). Maternal obesity in sheep impairs fetal hepatic respiratory chain capacity. Eur. J. Clin. Investig., e13375.","DOI":"10.1111\/eci.13375"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1097\/GRF.0b013e3182a09760","article-title":"Developmental programming of pediatric nonalcoholic fatty liver disease: Redefining the \u201cfirst hit\u201d","volume":"56","author":"Stewart","year":"2013","journal-title":"Clin. Obstet. Gynecol."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"3692","DOI":"10.1172\/JCI120846","article-title":"Mitochondrial role in the neonatal predisposition to developing nonalcoholic fatty liver disease","volume":"128","author":"Baker","year":"2018","journal-title":"J. Clin. Investig."},{"key":"ref_139","doi-asserted-by":"crossref","unstructured":"Bobi\u0144ski, R., and Mikulska, M. (2015). The ins and outs of maternal-fetal fatty acid metabolism. Acta Biochim. Pol., 62.","DOI":"10.18388\/abp.2015_1067"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.plipres.2006.01.003","article-title":"Temporal changes in dietary fats: Role of n-6 polyunsaturated fatty acids in excessive adipose tissue development and relationship to obesity","volume":"45","author":"Ailhaud","year":"2006","journal-title":"Prog. Lipid Res."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1210\/en.2009-0849","article-title":"Up-regulation of Toll-like receptor 4\/nuclear factor-kappaB signaling is associated with enhanced adipogenesis and insulin resistance in fetal skeletal muscle of obese sheep at late gestation","volume":"151","author":"Yan","year":"2010","journal-title":"Endocrinology"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"2651","DOI":"10.1113\/jphysiol.2007.149633","article-title":"AMP-activated protein kinase signalling pathways are down regulated and skeletal muscle development impaired in fetuses of obese, over-nourished sheep","volume":"586","author":"Zhu","year":"2008","journal-title":"J. Physiol."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"15","DOI":"10.3389\/fnut.2018.00015","article-title":"Effect of Eicosapentaenoic Acid and Docosahexaenoic Acid on Myogenesis and Mitochondrial Biosynthesis during Murine Skeletal Muscle Cell Differentiation","volume":"5","author":"Hsueh","year":"2018","journal-title":"Front. Nutr."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1097\/MCO.0000000000000440","article-title":"Mechanisms regulating brain docosahexaenoic acid uptake: What is the recent evidence?","volume":"21","author":"Lacombe","year":"2018","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"ref_145","doi-asserted-by":"crossref","unstructured":"Hadley, K.B., Ryan, A.S., Forsyth, S., Gautier, S., and Salem, N. (2016). The Essentiality of Arachidonic Acid in Infant Development. Nutrients, 8.","DOI":"10.3390\/nu8040216"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1038\/ng.3311","article-title":"Inactivating mutations in MFSD2A, required for omega-3 fatty acid transport in brain, cause a lethal microcephaly syndrome","volume":"47","author":"Nguyen","year":"2015","journal-title":"Nat. Genet."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1007\/s12272-019-01138-9","article-title":"Hypothalamic inflammation and obesity: A mechanistic review","volume":"42","author":"Seong","year":"2019","journal-title":"Arch. Pharm. Res."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"a026591","DOI":"10.1101\/cshperspect.a026591","article-title":"Effects of Maternal Obesity on Fetal Programming: Molecular Approaches","volume":"6","author":"Neri","year":"2015","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1172\/JCI59660","article-title":"Obesity is associated with hypothalamic injury in rodents and humans","volume":"122","author":"Thaler","year":"2012","journal-title":"J. Clin. Investig."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1017\/S002966511200078X","article-title":"Hypothalamic dysfunction in obesity","volume":"71","author":"Williams","year":"2012","journal-title":"Proc. Nutr. Soc."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1172\/JCI88882","article-title":"The initiation of metabolic inflammation in childhood obesity","volume":"127","author":"Singer","year":"2017","journal-title":"J. Clin. Investig."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1210\/en.2011-1589","article-title":"Hypothalamic JNK1 and IKK\u03b2 Activation and Impaired Early Postnatal Glucose Metabolism after Maternal Perinatal High-Fat Feeding","volume":"153","author":"Rother","year":"2012","journal-title":"Endocrinology"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.plefa.2010.02.034","article-title":"Human milk fatty acids from lactating mothers of preterm infants: A study revealing wide intra- and inter-individual variation","volume":"83","author":"Smithers","year":"2010","journal-title":"Prostaglandins Leukot Essent Fat. Acids"},{"key":"ref_154","unstructured":"Kovacs, C.S., and Deal, C.L. (2020). Chapter 14-The Onset and Maintenance of Human Lactation and its Endocrine Regulation. Maternal-Fetal and Neonatal Endocrinology, Academic Press."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"E700","DOI":"10.1152\/ajpendo.00052.2013","article-title":"Regulation of lipid synthesis genes and milk fat production in human mammary epithelial cells during secretory activation","volume":"305","author":"Mohammad","year":"2013","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"E1059","DOI":"10.1152\/ajpendo.00083.2011","article-title":"Prolactin-mediated regulation of lipid biosynthesis genes in vivo in the lactating mammary epithelial cell","volume":"300","author":"Rudolph","year":"2011","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"6128","DOI":"10.12659\/MSM.915827","article-title":"Gestational Diabetes Mellitus Changes the Metabolomes of Human Colostrum, Transition Milk and Mature Milk","volume":"25","author":"Wen","year":"2019","journal-title":"Med. Sci. Monit."},{"key":"ref_158","doi-asserted-by":"crossref","unstructured":"Siziba, L.P., Lorenz, L., Stahl, B., Mank, M., Marosv\u00f6lgyi, T., Decsi, T., Rothenbacher, D., and Genuneit, J. (2019). Changes in Human Milk Fatty Acid Composition During Lactation: The Ulm SPATZ Health Study. Nutrients, 11.","DOI":"10.3390\/nu11122842"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/S0378-3782(01)00204-3","article-title":"Physiological aspects of human milk lipids","volume":"65","author":"Koletzko","year":"2001","journal-title":"Early Hum. Dev."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s40748-017-0061-1","article-title":"Docosahexaenoic acid and the preterm infant","volume":"3","author":"Smith","year":"2017","journal-title":"Matern. Health Neonatol. Perinatol."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.plefa.2015.01.005","article-title":"Docosahexaenoic acid supplementation in lactating women increases breast milk and plasma docosahexaenoic acid concentrations and alters infant omega 6:3 fatty acid ratio","volume":"95","author":"Sherry","year":"2015","journal-title":"Prostaglandins Leukot. Essent. Fat. Acids"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"e465","DOI":"10.1542\/peds.113.5.e465","article-title":"Prepregnant overweight and obesity diminish the prolactin response to suckling in the first week postpartum","volume":"113","author":"Rasmussen","year":"2004","journal-title":"Pediatrics"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"407","DOI":"10.3945\/an.115.011007","article-title":"Does Insulin Explain the Relation between Maternal Obesity and Poor Lactation Outcomes? An Overview of the Literature","volume":"7","year":"2016","journal-title":"Adv. Nutr."},{"key":"ref_164","doi-asserted-by":"crossref","unstructured":"Saben, J.L., Bales, E.S., Jackman, M.R., Orlicky, D., MacLean, P.S., and McManaman, J.L. (2014). Maternal obesity reduces milk lipid production in lactating mice by inhibiting acetyl-CoA carboxylase and impairing fatty acid synthesis. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0098066"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/ejcn.2013.229","article-title":"Maternal overweight impacts infant feeding patterns--the STEPS Study","volume":"68","author":"Makela","year":"2014","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1590\/1519-6984.166788","article-title":"Effects of maternal high fat intake during pregnancy and lactation on total cholesterol and adipose tissue in neonatal rats","volume":"78","author":"Lima","year":"2018","journal-title":"Braz. J. Biol."},{"key":"ref_167","doi-asserted-by":"crossref","unstructured":"Erliana, U.D., and Fly, A.D. (2019). The Function and Alteration of Immunological Properties in Human Milk of Obese Mothers. Nutrients, 11.","DOI":"10.3390\/nu11061284"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/cen.12055","article-title":"The risk of maternal obesity to the long-term health of the offspring","volume":"78","author":"Reynolds","year":"2013","journal-title":"Clin. Endocrinol."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1007\/s00394-012-0378-5","article-title":"Breast milk fatty acid composition differs between overweight and normal weight women: The STEPS Study","volume":"52","author":"Makela","year":"2013","journal-title":"Eur. J. Nutr."},{"key":"ref_170","doi-asserted-by":"crossref","unstructured":"De la Garza Puentes, A., Mart\u00ed Alemany, A., Chisaguano, A.M., Montes Goyanes, R., Castellote, A.I., Torres-Esp\u00ednola, F.J., Garc\u00eda-Vald\u00e9s, L., Escudero-Mar\u00edn, M., Segura, M.T., and Campoy, C. (2019). The Effect of Maternal Obesity on Breast Milk Fatty Acids and Its Association with Infant Growth and Cognition\u2014The PREOBE Follow-Up. Nutrients, 11.","DOI":"10.3390\/nu11092154"},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1007\/s00394-012-0403-8","article-title":"Breast milk fat concentration and fatty acid pattern during the first six months in exclusively breastfeeding Greek women","volume":"52","author":"Antonakou","year":"2013","journal-title":"Eur. J. Nutr."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"e12979","DOI":"10.1111\/mcn.12979","article-title":"Impact of maternal overweight and obesity on milk composition and infant growth","volume":"16","author":"Ellsworth","year":"2020","journal-title":"Matern. Child. Nutr."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1089\/bfm.2017.0214","article-title":"Fatty Acid Composition and Eicosanoid Levels (LTE(4) and PGE(2)) of Human Milk from Normal Weight and Overweight Mothers","volume":"13","author":"Murray","year":"2018","journal-title":"Breastfeed. Med. Off. J. Acad. Breastfeed. Med."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1038\/jp.2015.199","article-title":"Breastmilk from obese mothers has pro-inflammatory properties and decreased neuroprotective factors","volume":"36","author":"Panagos","year":"2016","journal-title":"J. Perinatol."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.plefa.2012.11.007","article-title":"Different fatty acid pattern in breast milk of obese compared to normal-weight mothers","volume":"88","author":"Strandvik","year":"2013","journal-title":"Prostaglandins Leukot Essent. Fat. Acids"},{"key":"ref_176","doi-asserted-by":"crossref","unstructured":"Grant, W.F., Gillingham, M.B., Batra, A.K., Fewkes, N.M., Comstock, S.M., Takahashi, D., Braun, T.P., Grove, K.L., Friedman, J.E., and Marks, D.L. (2011). Maternal high fat diet is associated with decreased plasma n-3 fatty acids and fetal hepatic apoptosis in nonhuman primates. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0017261"},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.bbalip.2017.11.004","article-title":"Levels of palmitic acid ester of hydroxystearic acid (PAHSA) are reduced in the breast milk of obese mothers","volume":"1863","author":"Brezinova","year":"2018","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids"},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.jnutbio.2014.10.001","article-title":"Type of fatty acids in maternal diets during pregnancy and\/or lactation and metabolic consequences of the offspring","volume":"26","author":"Mennitti","year":"2015","journal-title":"J. Nutr. Biochem."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1016\/j.bbalip.2018.09.008","article-title":"Maternal n-3 PUFA supplementation promotes fetal brown adipose tissue development through epigenetic modifications in C57BL\/6 mice","volume":"1863","author":"Fan","year":"2018","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids"},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1017\/S0007114518001629","article-title":"Programming mediated by fatty acids affects uncoupling protein 1 (UCP-1) in brown adipose tissue","volume":"120","author":"Argentato","year":"2018","journal-title":"Br. J. Nutr."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"48","DOI":"10.3389\/fgene.2011.00048","article-title":"Maternal omega-3 supplementation increases fat mass in male and female rat offspring","volume":"2","author":"Muhlhausler","year":"2011","journal-title":"Front. Genet."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1017\/S0007114508025038","article-title":"Maternal fatty acid intake and fetal growth: Evidence for an association in overweight women. The \u2018EDEN mother-child\u2019 cohort (study of pre- and early postnatal determinants of the child\u2019s development and health)","volume":"101","author":"Drouillet","year":"2009","journal-title":"Br. J. Nutr."},{"key":"ref_183","doi-asserted-by":"crossref","unstructured":"Monthe-Dreze, C., Penfield-Cyr, A., Smid, M.C., and Sen, S. (2018). Maternal Pre-Pregnancy Obesity Attenuates Response to Omega-3 Fatty Acids Supplementation During Pregnancy. Nutrients, 10.","DOI":"10.3390\/nu10121908"},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1038\/pr.2013.82","article-title":"Breast milk fatty acid profile in relation to infant growth and body composition: Results from the INFAT study","volume":"74","author":"Much","year":"2013","journal-title":"Pediatr. Res."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1017\/S0007114515000033","article-title":"The effects of Nordic school meals on concentration and school performance in 8- to 11-year-old children in the OPUS School Meal Study: A cluster-randomised, controlled, cross-over trial","volume":"113","author":"Sorensen","year":"2015","journal-title":"Br. J. 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