{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T06:29:31Z","timestamp":1792132171979,"version":"4.4.0"},"reference-count":281,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2020,12,25]],"date-time":"2020-12-25T00:00:00Z","timestamp":1608854400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Inflammasomes are intracellular protein complexes that form in response to a variety of stress signals and that serve to catalyze the proteolytic conversion of pro-interleukin-1\u03b2 and pro-interleukin-18 to active interleukin-1\u03b2 and interleukin-18, central mediators of the inflammatory response; inflammasomes can also promote a type of cell death known as pyroptosis. The NLRP3 inflammasome has received the most study and plays an important pathogenic role in a vast range of pathologies associated with inflammation\u2014including atherosclerosis, myocardial infarction, the complications of diabetes, neurological and autoimmune disorders, dry macular degeneration, gout, and the cytokine storm phase of COVID-19. A consideration of the molecular biology underlying inflammasome priming and activation enables the prediction that a range of nutraceuticals may have clinical potential for suppressing inflammasome activity\u2014antioxidants including phycocyanobilin, phase 2 inducers, melatonin, and N-acetylcysteine, the AMPK activator berberine, glucosamine, zinc, and various nutraceuticals that support generation of hydrogen sulfide. Complex nutraceuticals or functional foods featuring a number of these agents may find utility in the prevention and control of a wide range of medical disorders.<\/jats:p>","DOI":"10.3390\/nu13010047","type":"journal-article","created":{"date-parts":[[2020,12,25]],"date-time":"2020-12-25T09:30:19Z","timestamp":1608888619000},"page":"47","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Nutraceutical Strategies for Suppressing NLRP3 Inflammasome Activation: Pertinence to the Management of COVID-19 and Beyond"],"prefix":"10.3390","volume":"13","author":[{"given":"Mark F.","family":"McCarty","sequence":"first","affiliation":[{"name":"Catalytic Longevity Foundation, San Diego, CA 92109, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2058-5881","authenticated-orcid":false,"given":"Simon Bernard","family":"Iloki Assanga","sequence":"additional","affiliation":[{"name":"Department of Research and Postgraduate in Food, University of Sonora, Centro 83000, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lidianys","family":"Lewis Luj\u00e1n","sequence":"additional","affiliation":[{"name":"Department of Research and Postgraduate in Food, University of Sonora, Centro 83000, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James H.","family":"O\u2019Keefe","sequence":"additional","affiliation":[{"name":"Mid America Heart Institute, Kansas City, MO 64111, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7888-1528","authenticated-orcid":false,"given":"James J.","family":"DiNicolantonio","sequence":"additional","affiliation":[{"name":"Mid America Heart Institute, Kansas City, MO 64111, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,12,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1111\/j.1600-065X.2011.01046.x","article-title":"The inflammasome: an integrated view","volume":"243","author":"Gross","year":"2011","journal-title":"Immunol. 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