{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T20:53:51Z","timestamp":1788209631406,"version":"build-2803163510"},"reference-count":33,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2020,12,30]],"date-time":"2020-12-30T00:00:00Z","timestamp":1609286400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background: We aimed to provide a systematic review and meta-analysis of randomized controlled trials assessing the effect of oral vitamin supplementation on symptoms and disease activity in patients with rheumatoid arthritis (RA), spondyloarthritis (SpA) and psoriatic arthritis (PsA). Methods: A systematic literature review and meta-analysis of randomized controlled trials including patients with inflammatory rheumatic diseases were performed using MEDLINE, EMBASE and abstracts from recent international rheumatology congresses. Studies were reviewed in accordance with PRISMA guidelines. We analysed clinical outcomes according to each type of vitamin supplementation. Results. The initial search yielded 606 articles. Of these, 13 studies were included in the qualitative synthesis: eight studied vitamin D supplementation, two assessed vitamin E supplementation, two folic acid, and one vitamin K, all of them on RA patients. No studies on SpA or PsA were selected. Oral vitamin supplementations were not associated with a reduction in RA activity (DAS-28 or pain) or RA flares. Conclusions: Despite their beneficial effects, the effects of vitamin supplementation on RA activity, if any, seem to be limited. Evidence on their efficacy on SpA or PsA activity is lacking. However, folic acid supplementation should be suggested to prevent methotrexate-related side effects, and vitamin D should be given to patients with vitamin D deficiency to prevent musculo-skeletal complications.<\/jats:p>","DOI":"10.3390\/nu13010107","type":"journal-article","created":{"date-parts":[[2020,12,30]],"date-time":"2020-12-30T09:35:23Z","timestamp":1609320923000},"page":"107","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Efficacy of Oral Vitamin Supplementation in Inflammatory Rheumatic Disorders: A Systematic Review and Meta-Analysis of Randomized Controlled Trials"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0866-3824","authenticated-orcid":false,"given":"Yann","family":"Nguyen","sequence":"first","affiliation":[{"name":"Service de M\u00e9decine Interne, Assistance Publique-H\u00f4pitaux de Paris (AP-HP), Nord, H\u00f4pital Beaujon, Universit\u00e9 de Paris, F-92100 Clichy, France"},{"name":"Centre de Recherche en Epid\u00e9miologie et Sant\u00e9 des Populations, INSERM U1018, Universit\u00e9 Paris-Saclay, F-94800 Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna","family":"Sigaux","sequence":"additional","affiliation":[{"name":"Service de Rhumatologie, AP-HP, H\u00f4pital Avicenne, F-93017 Bobigny, France"},{"name":"INSERM U1125, Sorbonne Paris Cit\u00e9, Universit\u00e9 Paris 13, F-93017 Bobigny, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2793-6303","authenticated-orcid":false,"given":"Jean-Guillaume","family":"Letarouilly","sequence":"additional","affiliation":[{"name":"Service de Rhumatologie, Universit\u00e9 de Lille, CHU Lille, F-59000 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauline","family":"Sanchez","sequence":"additional","affiliation":[{"name":"Service de Rhumatologie, CHU de Montpellier, Universit\u00e9 de Montpellier, F-34000 Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien","family":"Czernichow","sequence":"additional","affiliation":[{"name":"Service de Nutrition, Centre Sp\u00e9cialis\u00e9 Ob\u00e9sit\u00e9, AP-HP, H\u00f4pital Europ\u00e9en Georges Pompidou, Universit\u00e9 de Paris, F-75015 Paris, France"},{"name":"Epidemiology and Biostatistics Sorbonne Paris City Center (CRESS), UMR1153, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, F-75004 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9-Marc","family":"Flipo","sequence":"additional","affiliation":[{"name":"Service de Rhumatologie, Universit\u00e9 de Lille, CHU Lille, F-59000 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Soubrier","sequence":"additional","affiliation":[{"name":"Service de Rhumatologie, CHU Gabriel-Montpied, F-63000 Clermont-Ferrand, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Semerano","sequence":"additional","affiliation":[{"name":"Service de Rhumatologie, AP-HP, H\u00f4pital Avicenne, F-93017 Bobigny, France"},{"name":"INSERM U1125, Sorbonne Paris Cit\u00e9, Universit\u00e9 Paris 13, F-93017 Bobigny, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rapha\u00e8le","family":"Seror","sequence":"additional","affiliation":[{"name":"Service de Rhumatologie, AP-HP, H\u00f4pitaux Universitaires Paris-Saclay\u2014H\u00f4pital Bic\u00eatre, F-94270 Le Kremlin Bic\u00eatre, France"},{"name":"INSERM U1184, Universit\u00e9 Paris-Saclay, F-94270 Le Kremlin Bic\u00eatre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00e9mie","family":"Sellam","sequence":"additional","affiliation":[{"name":"Service de Rhumatologie, Sorbonne Universit\u00e9, AP-HP, H\u00f4pital Saint-Antoine, Inserm UMRS_938, FHU PaCeMM, F-75012 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Da\u00efen","sequence":"additional","affiliation":[{"name":"Service de Rhumatologie, CHU de Montpellier, Universit\u00e9 de Montpellier, F-34000 Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,12,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1126\/science.6310748","article-title":"1,25-Dihydroxyvitamin D3 Receptors in Human Leukocytes","volume":"221","author":"Provvedini","year":"1983","journal-title":"Science"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1124\/jpet.107.127209","article-title":"Immune Modulatory Treatment of Trinitrobenzene Sulfonic Acid Colitis with Calcitriol Is Associated with a Change of a T Helper (Th) 1\/Th17 to a Th2 and Regulatory T Cell Profile","volume":"324","author":"Daniel","year":"2008","journal-title":"J. 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