{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T21:16:11Z","timestamp":1779311771510,"version":"3.51.4"},"reference-count":56,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2020,12,31]],"date-time":"2020-12-31T00:00:00Z","timestamp":1609372800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004252","name":"Qatar University","doi-asserted-by":"publisher","award":["QUST-2-CMED-2019-6"],"award-info":[{"award-number":["QUST-2-CMED-2019-6"]}],"id":[{"id":"10.13039\/501100004252","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Low serum 25-hydroxyvitamin D [25(OH)D] is linked to an altered lipid profile. Monocytes play an important role in inflammation and lipid metabolism. Recently, monocyte percentage to HDL-cholesterol ratio (MHR) has emerged as a novel marker of inflammation. We investigated the association between serum 25(OH)D concentrations and MHR and serum lipids in young healthy adults. Data from the Qatar Biobank were utilized to investigate the relation between serum 25(OH)D and inflammation and serum lipid concentrations in healthy Qatari adults using multivariate regression analysis. Prevalence of serum 25(OH)D concentrations &lt;12 ng\/mL (deficiency), 12\u201320 ng\/mL (insufficiency), and \u226520 ng\/mL (sufficiency) were 55.8%, 29.9%, and 14.3%, respectively. Serum 25(OH)D was significantly inversely associated with monocyte percentage, MHR, total cholesterol, LDL-cholesterol, and triacylglycerol in multivariable adjusted analysis. MHR could be a potential biomarker to predict cardiometabolic diseases among young healthy Qataris.<\/jats:p>","DOI":"10.3390\/nu13010127","type":"journal-article","created":{"date-parts":[[2020,12,31]],"date-time":"2020-12-31T10:10:37Z","timestamp":1609409437000},"page":"127","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Serum 25-Hydroxyvitamin D Is Inversely Associated with Monocyte Percentage to HDL Cholesterol Ratio among Young Healthy Adults in Qatar"],"prefix":"10.3390","volume":"13","author":[{"given":"Hanaa","family":"Mousa","sequence":"first","affiliation":[{"name":"College of Medicine, QU Health, Qatar University, Doha P.O. Box 2731, Qatar"},{"name":"#2Biomedical and Pharmaceutical research Unit, QU Health, Qatar University, Doha P.O. Box 2731, Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nazmul","family":"Islam","sequence":"additional","affiliation":[{"name":"Public Health Department, College of Health Sciences, QU Health, Qatar University, Doha P.O. Box 2731, Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6314-7734","authenticated-orcid":false,"given":"Vijay","family":"Ganji","sequence":"additional","affiliation":[{"name":"Human Nutrition Department, College of Health Sciences, QU Health, Qatar University, Doha P.O. Box 2731, Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7487-8770","authenticated-orcid":false,"given":"Susu M.","family":"Zughaier","sequence":"additional","affiliation":[{"name":"College of Medicine, QU Health, Qatar University, Doha P.O. Box 2731, Qatar"},{"name":"#2Biomedical and Pharmaceutical research Unit, QU Health, Qatar University, Doha P.O. Box 2731, Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,12,31]]},"reference":[{"key":"ref_1","unstructured":"Feingold, K.R., Anawalt, B., Boyce, A., Chrousos, G., Dungan, K., Grossman, A., Hershman, J.M., Kaltsas, G., Koch, C., and Kopp, P. (2000). Vitamin D: Production, Metabolism, and Mechanisms of Action. Endotext, MDText.com, Inc."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"229","DOI":"10.4081\/jphr.2012.e36","article-title":"Prevalence of vitamin d insufficiency in qatar: A systematic review","volume":"1","author":"Badawi","year":"2012","journal-title":"J. Public Health Res."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"e263","DOI":"10.1038\/nutd.2017.14","article-title":"Prevalence of vitamin D deficiency and association with metabolic syndrome in a Qatari population","volume":"7","author":"Tsilidis","year":"2017","journal-title":"Nutr. Diabetes"},{"key":"ref_4","first-page":"75","article-title":"Clinical implications of vitamin D deficiency","volume":"14","year":"2015","journal-title":"Prz. Menopauzalny"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2385","DOI":"10.3389\/fimmu.2020.596611","article-title":"Editorial: Immune-Modulatory Effects of Vitamin D","volume":"11","author":"Zughaier","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"346","DOI":"10.14336\/AD.2016.1021","article-title":"Vitamin D and Chronic Diseases","volume":"8","author":"Wang","year":"2017","journal-title":"Aging Dis."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"225","DOI":"10.3945\/ajcn.111.013516","article-title":"Serum 25-hydroxyvitamin D concentrations are associated with prevalence of metabolic syndrome and various cardiometabolic risk factors in US children and adolescents based on assay-adjusted serum 25-hydroxyvitamin D data from NHANES 2001\u20132006","volume":"94","author":"Ganji","year":"2011","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_8","first-page":"69","article-title":"Vitamin D and inflammatory diseases","volume":"7","author":"Yin","year":"2014","journal-title":"J. Inflamm. Res."},{"key":"ref_9","first-page":"19","article-title":"The role of vitamin D in regulating the iron-hepcidin-ferroportin axis in monocytes","volume":"1","author":"Zughaier","year":"2014","journal-title":"J. Clin. Transl. Endocrinol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1159\/000136335","article-title":"The role of neutrophils and monocytes in innate immunity","volume":"15","author":"Kantari","year":"2008","journal-title":"Contrib. Microbiol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1161\/01.STR.0000130857.19423.ad","article-title":"Monocyte Count, But Not C-Reactive Protein or Interleukin-6, Is an Independent Risk Marker for Subclinical Carotid Atherosclerosis","volume":"35","author":"Hung","year":"2004","journal-title":"Stroke"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/nri3793","article-title":"Cholesterol, inflammation and innate immunity","volume":"15","author":"Tall","year":"2015","journal-title":"Nat. Rev. Immunol."},{"key":"ref_13","first-page":"9638317","article-title":"Relationship between Serum Vitamin D Levels and HDL Cholesterol in Postmenopausal Women from Colombian Caribbean","volume":"2018","author":"Becerra","year":"2018","journal-title":"J. Nutr. Metab."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s12199-019-0841-5","article-title":"Association between standardized vitamin 25(OH)D and dyslipidemia: A community-based study in Riyadh, Saudi Arabia","volume":"25","author":"AlQuaiz","year":"2020","journal-title":"Environ. Health Prev. Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1080\/03007995.2018.1552849","article-title":"Vitamin D deficiency is associated with dyslipidemia: A cross-sectional study in 3788 subjects","volume":"35","author":"Jiang","year":"2019","journal-title":"Curr. Med. Res. Opin."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.maturitas.2017.10.011","article-title":"Vitamin D deficiency is associated with metabolic syndrome in postmenopausal women","volume":"107","author":"Schmitt","year":"2018","journal-title":"Maturitas"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"213","DOI":"10.3177\/jnsv.62.213","article-title":"Vitamin D Deficiency in Relation to the Risk of Metabolic Syndrome in Middle-Aged and Elderly Patients with Type 2 Diabetes Mellitus","volume":"62","author":"Pan","year":"2016","journal-title":"J. Nutr. Sci. Vitam. (Tokyo)"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1080\/09273948.2019.1611876","article-title":"May Monocyte\/HDL Cholesterol Ratio (MHR) and Neutrophil\/Lymphocyte Ratio (NLR) Be an Indicator of Inflammation and Oxidative Stress in Patients with Keratoconus?","volume":"28","author":"Katipoglu","year":"2020","journal-title":"Ocul. Immunol. Inflamm."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"135","DOI":"10.5603\/EP.a2019.0002","article-title":"Novel inflammatory biomarkers may reflect subclinical inflammation in young healthy adults with obesity","volume":"70","author":"Osadnik","year":"2019","journal-title":"Endokrynol. Pol."},{"key":"ref_20","first-page":"190","article-title":"Monocyte to High-Density Lipoprotein Ratio: A Novel Inflammation Marker Related to Diabetic Retinopathy","volume":"42","author":"Pangal","year":"2020","journal-title":"Erc\u00fdyes Med. J."},{"key":"ref_21","first-page":"41","article-title":"A Novel Marker of Impaired Aortic Elasticity in Never Treated Hypertensive Patients: Monocyte\/High-Density Lipoprotein Cholesterol Ratio","volume":"33","author":"Yayla","year":"2017","journal-title":"Acta Cardiol. Sin."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/s00380-011-0130-8","article-title":"Development of a model for prediction of coronary atherosclerotic regression: Evaluation of high-density lipoprotein cholesterol level and peripheral blood monocyte count","volume":"27","author":"Tani","year":"2012","journal-title":"Heart Vessel."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"953","DOI":"10.2217\/bmm-2018-0048","article-title":"Monocyte to high-density lipoprotein cholesterol ratio in patients with diabetes mellitus and diabetic nephropathy","volume":"12","author":"Karatas","year":"2018","journal-title":"Biomark. Med."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.ijcac.2017.05.008","article-title":"Monocyte-to-high density lipoprotein ratio (MHR) can predict the significance of angiographically intermediate coronary lesions","volume":"3","author":"Korkmaz","year":"2017","journal-title":"Int. J. Cardiovasc. Acad."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"e15340","DOI":"10.1097\/MD.0000000000015340","article-title":"Higher monocyte count with normal white blood cell count is positively associated with 10-year cardiovascular disease risk determined by Framingham risk score among community-dwelling Korean individuals","volume":"98","author":"Kim","year":"2019","journal-title":"Medicine"},{"key":"ref_26","first-page":"PA1007","article-title":"Could Monocyte \/HDL cholesterol ratio predict cardiovascular events in patients with Chronic Obstructive Pulmonary Disease?","volume":"50","author":"Yakar","year":"2017","journal-title":"Eur. Respir. J."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1253\/circj.CJ-17-0427","article-title":"Novel Risk Biomarker for Infective Endocarditis Patients With Normal Left Ventricular Ejection Fraction- Monocyte to High-Density Lipoprotein Cholesterol Ratio","volume":"82","author":"Wei","year":"2017","journal-title":"Circ. J."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"e710","DOI":"10.1016\/j.wneu.2020.05.272","article-title":"Prognostic Significance of Various Inflammation-Based Scores in Patients with Mechanical Thrombectomy for Acute Ischemic Stroke","volume":"141","author":"Oh","year":"2020","journal-title":"World Neurosurg."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1093\/aje\/kwz084","article-title":"Qatar Biobank Cohort Study: Study Design and First Results","volume":"188","author":"Fthenou","year":"2019","journal-title":"Am. J. Epidemiol."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Al Kuwari, H., Al Thani, A., Al Marri, A., Al Kaabi, A., Abderrahim, H., Afifi, N., Qafoud, F., Chan, Q., Tzoulaki, I., and Downey, P. (2015). The Qatar Biobank: Background and methods. BMC Public Health, 15.","DOI":"10.1186\/s12889-015-2522-7"},{"key":"ref_31","unstructured":"Ross, A.C., Taylor, C.L., Yaktine, A.L., and HB, D.V. (2011). Institute of Medicine (US) Committee to Review Dietary Reference Intakes for Vitamin D and Calcium. Dietary Reference Intakes for Calcium and Vitamin D, National Academies Press."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/BF00280883","article-title":"Homeostasis model assessment: Insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man","volume":"28","author":"Matthews","year":"1985","journal-title":"Diabetologia"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"9237","DOI":"10.1002\/jcp.27028","article-title":"Monocyte-to-HDL-cholesterol ratio as a prognostic marker in cardiovascular diseases","volume":"233","author":"Ganjali","year":"2018","journal-title":"J. Cell. Physiol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.pjnns.2017.08.011","article-title":"Monocyte\/high-density lipoprotein ratio predicts the mortality in ischemic stroke patients","volume":"52","author":"Bolayir","year":"2018","journal-title":"Neurol. Neurochir. Pol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.jns.2016.11.022","article-title":"Monocyte to HDL cholesterol ratio is associated with discharge and 3-month outcome in patients with acute intracerebral hemorrhage","volume":"372","author":"You","year":"2017","journal-title":"J. Neurol. Sci."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s12958-018-0351-0","article-title":"The monocyte counts to HDL cholesterol ratio in obese and lean patients with polycystic ovary syndrome","volume":"16","author":"Usta","year":"2018","journal-title":"Reprod. Biol. Endocrinol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"362","DOI":"10.21037\/cdt.2019.08.02","article-title":"Relationship between monocyte to HDL cholesterol ratio and concomitant cardiovascular disease in Chinese Han patients with obstructive sleep apnea","volume":"9","author":"Li","year":"2019","journal-title":"Cardiovasc. Diagn."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.repc.2017.06.021","article-title":"Increased monocyte to high-density lipoprotein cholesterol ratio is associated with TIMI risk score in patients with ST-segment elevation myocardial infarction","volume":"37","author":"Sercelik","year":"2018","journal-title":"Rev. Port. Cardiol. (Engl. Ed.)"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1556\/EuJMI.2.2012.2.1","article-title":"Monocytes in health and disease\u2014Minireview","volume":"2","author":"Karlmark","year":"2012","journal-title":"Eur. J. Microbiol. Immunol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.4049\/jimmunol.1102412","article-title":"Vitamin D Inhibits Monocyte\/Macrophage Proinflammatory Cytokine Production by Targeting MAPK Phosphatase-1","volume":"188","author":"Zhang","year":"2012","journal-title":"J. Immunol."},{"key":"ref_41","first-page":"244","article-title":"Vitamin D in inflammatory diseases","volume":"5","author":"Sorg","year":"2014","journal-title":"Front Physiol"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"38482","DOI":"10.1074\/jbc.M112.386912","article-title":"Vitamin D suppression of endoplasmic reticulum stress promotes an antiatherogenic monocyte\/macrophage phenotype in type 2 diabetic patients","volume":"287","author":"Riek","year":"2012","journal-title":"J. Biol. Chem."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1002\/eji.200425995","article-title":"Vitamin D3 down-regulates monocyte TLR expression and triggers hyporesponsiveness to pathogen-associated molecular patterns","volume":"36","author":"Sadeghi","year":"2006","journal-title":"Eur. J. Immunol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.ijid.2017.07.026","article-title":"Vitamin D deficiency is a risk factor for infections in patients affected by HCV-related liver cirrhosis","volume":"63","author":"Buonomo","year":"2017","journal-title":"Int. J. Infect. Dis."},{"key":"ref_45","first-page":"439","article-title":"Association of vitamin D deficiency with severity of acute respiratory infection: A case-control study in New Zealand children","volume":"44","author":"Ingham","year":"2014","journal-title":"Eur. Respir. J."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1093\/tropej\/fms042","article-title":"Cord blood 25-hydroxyvitamin D levels and the risk of acute lower respiratory tract infection in early childhood","volume":"59","author":"Mohamed","year":"2013","journal-title":"J. Trop. Pediatr."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"i6583","DOI":"10.1136\/bmj.i6583","article-title":"Vitamin D supplementation to prevent acute respiratory tract infections: Systematic review and meta-analysis of individual participant data","volume":"356","author":"Martineau","year":"2017","journal-title":"BMJ"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1007\/s10620-010-1544-3","article-title":"Vitamin D deficiency in children with inflammatory bowel disease","volume":"56","author":"Levin","year":"2011","journal-title":"Dig. Dis. Sci."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1177\/2042018812471070","article-title":"Vitamin D and rheumatoid arthritis","volume":"3","author":"Athanassiou","year":"2012","journal-title":"Adv. Endocrinol. Metab."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"R221","DOI":"10.1186\/ar4060","article-title":"Restoration of regulatory and effector T cell balance and B cell homeostasis in systemic lupus erythematosus patients through vitamin D supplementation","volume":"14","author":"Terrier","year":"2012","journal-title":"Arthritis Res."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"2327","DOI":"10.1210\/jc.2013-4320","article-title":"Review: The impacts of circulating 25-hydroxyvitamin D levels on cancer patient outcomes: A systematic review and meta-analysis","volume":"99","author":"Li","year":"2014","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Daneshkhah, A., Agrawal, V., Eshein, A., Subramanian, H., Roy, H.K., and Backman, V. (2020). The Possible Role of Vitamin D in Suppressing Cytokine Storm and Associated Mortality in COVID-19 Patients. medRxiv.","DOI":"10.1101\/2020.04.08.20058578"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s12944-019-0961-3","article-title":"Association of 25-hydroxyvitamin D with HDL-cholesterol and other cardiovascular risk biomarkers in subjects with non-cardiac chest pain","volume":"18","author":"Alkhatatbeh","year":"2019","journal-title":"Lipids Health Dis."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1161\/01.CIR.79.1.8","article-title":"High-density lipoprotein cholesterol and cardiovascular disease. Four prospective American studies","volume":"79","author":"Gordon","year":"1989","journal-title":"Circulation"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"597","DOI":"10.2147\/DMSO.S238990","article-title":"Comparison of the Value of Neutrophil to High-Density Lipoprotein Cholesterol Ratio and Lymphocyte to High-Density Lipoprotein Cholesterol Ratio for Predicting Metabolic Syndrome Among a Population in the Southern Coast of China","volume":"13","author":"Chen","year":"2020","journal-title":"Diabetes Metab. Syndr. Obes."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.2147\/DMSO.S219363","article-title":"Lymphocyte To High-Density Lipoprotein Ratio As A New Indicator Of Inflammation And Metabolic Syndrome","volume":"12","author":"Chen","year":"2019","journal-title":"Diabetes Metab. Syndr. Obes."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/13\/1\/127\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T10:48:27Z","timestamp":1760179707000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/13\/1\/127"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,31]]},"references-count":56,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,1]]}},"alternative-id":["nu13010127"],"URL":"https:\/\/doi.org\/10.3390\/nu13010127","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,31]]}}}