{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:59:30Z","timestamp":1787029170030,"version":"build-2736575974"},"reference-count":44,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2020,12,31]],"date-time":"2020-12-31T00:00:00Z","timestamp":1609372800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009725","name":"Wishlist","doi-asserted-by":"publisher","award":["NA"],"award-info":[{"award-number":["NA"]}],"id":[{"id":"10.13039\/100009725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Abdominal aortic aneurysm (AAA) is a vascular disease involving permanent focal dilation of the abdominal aorta (\u226530 mm) that can lead to catastrophic rupture. Destructive remodeling of aortic connective tissue in AAA contributes to wall stiffening, a mechanical parameter of the arterial system linked to a heightened risk of cardiovascular morbidity and mortality. Since aortic stiffening is associated with AAA progression, treatment options that target vascular inflammation would appear prudent. Given this, and growing evidence indicating robust anti-inflammatory and vasoprotective properties for long chain omega-3 polyunsaturated fatty acids (LC n-3 PUFAs), this study evaluated the impact of these nutrients (1.8 g\/day for 12 weeks) on indices of vascular stiffness in patients with AAA. At baseline, pulse wave velocity (PWV) and augmentation index normalized to a heart rate of 75 bpm (AIx75) were significantly higher in patients with AAA compared to control participants (PWV: 14.2 \u00b1 0.4 m.s\u22121 vs. 12.6 \u00b1 0.4 m.s\u22121, p = 0.014; AIx75: 26.4 \u00b1 1.7% vs. 17.3 \u00b1 2.7%, p = 0.005). Twelve-week LC n-3 PUFA supplementation significantly decreased PWV (baseline: 14.2 \u00b1 0.6 m.s\u22121, week 12: 12.8 \u00b1 0.7 m.s\u22121, p = 0.014) and heart rate (baseline: 63 \u00b1 3 bpm, week 12: 58 \u00b1 3 bpm, p = 0.009) in patients with AAA. No change was observed for patients receiving placebo capsules. While this raises the possibility that LC n-3 PUFAs provide improvements in aortic stiffness in patients with AAA, the clinical implications remain to be fully elucidated.<\/jats:p>","DOI":"10.3390\/nu13010138","type":"journal-article","created":{"date-parts":[[2020,12,31]],"date-time":"2020-12-31T20:18:47Z","timestamp":1609445927000},"page":"138","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Long Chain Omega-3 Polyunsaturated Fatty Acids Improve Vascular Stiffness in Abdominal Aortic Aneurysm: A Randomized Controlled Trial"],"prefix":"10.3390","volume":"13","author":[{"given":"Lara T.","family":"Meital","sequence":"first","affiliation":[{"name":"Centre for Genetics, Ecology &amp; Physiology, University of the Sunshine Coast, Maroochydore, QLD 4556, Australia"},{"name":"School of Health and Behavioural Sciences, University of the Sunshine Coast, Maroochydore, QLD 4556, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl","family":"Schulze","sequence":"additional","affiliation":[{"name":"Sunshine Vascular, Buderim, QLD 4556, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Magee","sequence":"additional","affiliation":[{"name":"Department of Surgery, Sunshine Coast University Hospital, Birtinya, QLD 4575, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jill","family":"O\u2019Donnell","sequence":"additional","affiliation":[{"name":"Department of Surgery, Sunshine Coast University Hospital, Birtinya, QLD 4575, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pankaj","family":"Jha","sequence":"additional","affiliation":[{"name":"Department of Surgery, Sunshine Coast University Hospital, Birtinya, QLD 4575, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaim Y.","family":"Meital","sequence":"additional","affiliation":[{"name":"Moffat Beach Family Medical Practice, Moffat Beach, QLD 4551, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1869-4461","authenticated-orcid":false,"given":"Rebecca","family":"Donkin","sequence":"additional","affiliation":[{"name":"School of Health and Behavioural Sciences, University of the Sunshine Coast, Maroochydore, QLD 4556, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8531-2780","authenticated-orcid":false,"given":"Tom G.","family":"Bailey","sequence":"additional","affiliation":[{"name":"Physiology and Ultrasound Laboratory in Science and Exercise (PULSE), Centre for Research on Exercise, Physical Activity and Health, School of Human Movement and Nutrition Sciences, The University of Queensland, Queensland, QLD 4343, Australia"},{"name":"School of Nursing, Midwifery and Social Work, The University of Queensland, Queensland, QLD 4343, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8076-8789","authenticated-orcid":false,"given":"Christopher D.","family":"Askew","sequence":"additional","affiliation":[{"name":"School of Health and Behavioural Sciences, University of the Sunshine Coast, Maroochydore, QLD 4556, Australia"},{"name":"VasoActive Research Group, Sunshine Coast Health Institute, Sunshine Coast Hospital and Health Service, Birtinya, QLD 4575, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8396-4558","authenticated-orcid":false,"given":"Fraser D.","family":"Russell","sequence":"additional","affiliation":[{"name":"Centre for Genetics, Ecology &amp; Physiology, University of the Sunshine Coast, Maroochydore, QLD 4556, Australia"},{"name":"School of Health and Behavioural Sciences, University of the Sunshine Coast, Maroochydore, QLD 4556, Australia"},{"name":"VasoActive Research Group, Sunshine Coast Health Institute, Sunshine Coast Hospital and Health Service, Birtinya, QLD 4575, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,12,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/nrcardio.2017.52","article-title":"Monocytes and macrophages in abdominal aortic aneurysm","volume":"14","author":"Raffort","year":"2017","journal-title":"Nat. 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