{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T22:18:19Z","timestamp":1791238699581,"version":"4.1.0"},"reference-count":36,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2021,1,5]],"date-time":"2021-01-05T00:00:00Z","timestamp":1609804800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004916","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado do Amazonas","doi-asserted-by":"publisher","award":["#062.03159.2014"],"award-info":[{"award-number":["#062.03159.2014"]}],"id":[{"id":"10.13039\/501100004916","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004612","name":"Funda\u00e7\u00e3o Arauc\u00e1ria","doi-asserted-by":"publisher","award":["#002\/2017"],"award-info":[{"award-number":["#002\/2017"]}],"id":[{"id":"10.13039\/501100004612","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["#001"],"award-info":[{"award-number":["#001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>The aim of the study was to verify the effects of creatine (Cr) supplementation on functional capacity (walking capacity; primary outcome) and calf muscle oxygen saturation (StO2) (secondary outcome) in symptomatic peripheral arterial disease (PAD) patients. Twenty-nine patients, of both sexes, were randomized (1:1) in a double-blind manner for administration of placebo (PLA, n = 15) or creatine monohydrate (Cr, n = 14). The supplementation protocol consisted of 20 g\/day for 1 week divided into four equal doses (loading phase), followed by single daily doses of 5 g in the subsequent 7 weeks (maintenance phase). Functional capacity (total walking distance) was assessed by the 6 min walk test, and calf muscle StO2 was assessed through near infrared spectroscopy. The measurements were collected before and after loading and after the maintenance phase. The level of significance was p &lt; 0.05. No significant differences were found for function capacity (total walking distance (PLA: pre 389 \u00b1 123 m vs. post loading 413 \u00b1 131 m vs. post maintenance 382 \u00b1 99 m; Cr: pre 373 \u00b1 149 m vs. post loading 390 \u00b1 115 m vs. post maintenance 369 \u00b1 115 m, p = 0.170) and the calf muscle StO2 parameters (p &gt; 0.05). Short- and long-term Cr supplementation does not influence functional capacity and calf muscle StO2 parameters in patients with symptomatic PAD.<\/jats:p>","DOI":"10.3390\/nu13010149","type":"journal-article","created":{"date-parts":[[2021,1,5]],"date-time":"2021-01-05T10:35:12Z","timestamp":1609842912000},"page":"149","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Effect of Creatine Supplementation on Functional Capacity and Muscle Oxygen Saturation in Patients with Symptomatic Peripheral Arterial Disease: A Pilot Study of a Randomized, Double-Blind Placebo-Controlled Clinical Trial"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1638-6465","authenticated-orcid":false,"given":"Wagner Jorge Ribeiro","family":"Domingues","sequence":"first","affiliation":[{"name":"Institute of Social Sciences Education and Zootechnics, Federal University of Amazonas, Parintins 69152-240, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7883-6746","authenticated-orcid":false,"given":"Raphael Mendes","family":"Ritti-Dias","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Rehabilitation Sciences, Nove de Julho University, Sao Paulo 03155-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel Grizzo","family":"Cucato","sequence":"additional","affiliation":[{"name":"Department of Sport, Exercise and Rehabilitation, Northumbria University, Newcastle upon Tyne NE1 8PP, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1991-3507","authenticated-orcid":false,"given":"Nelson","family":"Wolosker","sequence":"additional","affiliation":[{"name":"Hospital Israelita Albert Einstein, Sao Paulo 05652-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ant\u00f4nio Eduardo","family":"Zerati","sequence":"additional","affiliation":[{"name":"Cancer Institute of Sao Paulo, Sao Paulo 01246-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Puech-Le\u00e3o","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Sao Paulo University, Sao Paulo 04021-001, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8758-6507","authenticated-orcid":false,"given":"Daniel Boari","family":"Coelho","sequence":"additional","affiliation":[{"name":"Center for Engineering, Modeling and Applied Social Sciences (CECS), Federal University of ABC, S\u00e3o Bernardo do Campo 09606-070, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pollyana Mayara","family":"Nunhes","sequence":"additional","affiliation":[{"name":"Department of Physical Education, State University of Maringa, Maringa 87020-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9 Alberto","family":"Moliterno","sequence":"additional","affiliation":[{"name":"Department of Physical Education, State University of Maringa, Maringa 87020-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ademar","family":"Avelar","sequence":"additional","affiliation":[{"name":"Department of Physical Education, State University of Maringa, Maringa 87020-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,1,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1007\/s12529-014-9408-4","article-title":"Barriers to Physical Activity in Patients with Intermittent Claudication","volume":"22","author":"Barbosa","year":"2015","journal-title":"Int. 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