{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T07:06:51Z","timestamp":1793171211182,"version":"4.5.0"},"reference-count":38,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2021,1,9]],"date-time":"2021-01-09T00:00:00Z","timestamp":1610150400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Education, Science and Technology","award":["NRF-2018M3A9F3020956, NRF-2019R1I1A3A01060447, NRF-2020R1I1A3073530 and NRF-2020R1A6A1A03043026"],"award-info":[{"award-number":["NRF-2018M3A9F3020956, NRF-2019R1I1A3A01060447, NRF-2020R1I1A3073530 and NRF-2020R1A6A1A03043026"]}]},{"name":"Hallym University Research Fund","award":["Hallym University Research Fund"],"award-info":[{"award-number":["Hallym University Research Fund"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Malnutrition and cognitive dysfunction are typical features of alcoholic liver disease (ALD) and are correlated with the development of complications. The aim of this study is to explore the effect of nutritional state and diet on cognitive function in ALD. A total of 43 patients with compensated alcoholic cirrhosis were enrolled, and a neuropsychological test was assessed according to body mass index (BMI, &lt;22 and \u226522). In the ALD animal study, mice were divided into five groups (n = 9\/group; normal liquid, 5% EtOH + regular liquid, 5% EtOH + high-carbohydrate liquid, 5% EtOH + high-fat liquid, and 5% EtOH + high-protein liquid diet) and fed the same calories for eight weeks. To assess cognitive function, we performed T-maze studies weekly before\/after alcohol binging. In cognitive function (BMI &lt; 22\/\u226522), language score of Korea mini-mental state (7.4 \u00b1 1.4\/7.9 \u00b1 0.4), Boston naming (11.7 \u00b1 2.7\/13.0 \u00b1 1.8), forward digit span (6.7 \u00b1 1.8\/7.5 \u00b1 1.6), Korean color word stroop (24.2 \u00b1 26.5\/43.6 \u00b1 32.4), and interference score (33.9 \u00b1 31.9\/52.3 \u00b1 33.9) revealed significant differences. In the T-maze test, alcohol significantly delayed the time to reach food, and binge drinking provided a temporary recovery in cognition. The alcohol-induced delay was significantly reduced in the high-carbohydrate and high-fat diet groups. Synaptic function exhibited no changes in all groups. Cognitive dysfunction is affected by nutritional status and diet in ALD.<\/jats:p>","DOI":"10.3390\/nu13010185","type":"journal-article","created":{"date-parts":[[2021,1,10]],"date-time":"2021-01-10T21:21:45Z","timestamp":1610313705000},"page":"185","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Nutritional Status and Diet Style Affect Cognitive Function in Alcoholic Liver Disease"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9731-4510","authenticated-orcid":false,"given":"Ye Rin","family":"Choi","sequence":"first","affiliation":[{"name":"Institute for Liver and Digestive Diseases, Hallym University College of Medicine, Chuncheon 24252, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyeong Seop","family":"Kim","sequence":"additional","affiliation":[{"name":"Institute for Liver and Digestive Diseases, Hallym University College of Medicine, Chuncheon 24252, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4712-6359","authenticated-orcid":false,"given":"Sang Jun","family":"Yoon","sequence":"additional","affiliation":[{"name":"Institute for Liver and Digestive Diseases, Hallym University College of Medicine, Chuncheon 24252, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7922-4634","authenticated-orcid":false,"given":"Na Young","family":"Lee","sequence":"additional","affiliation":[{"name":"Institute for Liver and Digestive Diseases, Hallym University College of Medicine, Chuncheon 24252, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6008-1143","authenticated-orcid":false,"given":"Haripriya","family":"Gupta","sequence":"additional","affiliation":[{"name":"Institute for Liver and Digestive Diseases, Hallym University College of Medicine, Chuncheon 24252, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3060-6217","authenticated-orcid":false,"given":"Ganesan","family":"Raja","sequence":"additional","affiliation":[{"name":"Institute for Liver and Digestive Diseases, Hallym University College of Medicine, Chuncheon 24252, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5133-3620","authenticated-orcid":false,"given":"Yoseph Asmelash","family":"Gebru","sequence":"additional","affiliation":[{"name":"Institute for Liver and Digestive Diseases, Hallym University College of Medicine, Chuncheon 24252, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gi Soo","family":"Youn","sequence":"additional","affiliation":[{"name":"Institute for Liver and Digestive Diseases, Hallym University College of Medicine, Chuncheon 24252, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5792-1500","authenticated-orcid":false,"given":"Dong Joon","family":"Kim","sequence":"additional","affiliation":[{"name":"Institute for Liver and Digestive Diseases, Hallym University College of Medicine, Chuncheon 24252, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Lim","family":"Ham","sequence":"additional","affiliation":[{"name":"Department of Nursing, Daewon University College, Jaecheon 27135, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9206-9245","authenticated-orcid":false,"given":"Ki Tae","family":"Suk","sequence":"additional","affiliation":[{"name":"Institute for Liver and Digestive Diseases, Hallym University College of Medicine, Chuncheon 24252, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,1,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.jhep.2013.03.007","article-title":"Global burden of alcoholic liver diseases","volume":"59","author":"Rehm","year":"2013","journal-title":"J. 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