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Certain substances such as antioxidants may protect bones; other substances may increase bone resorption. Nevertheless, the influence of coffee and tea on the development and course of inflammatory bowel diseases is contradictory.<\/jats:p>","DOI":"10.3390\/nu13010216","type":"journal-article","created":{"date-parts":[[2021,1,13]],"date-time":"2021-01-13T21:50:54Z","timestamp":1610574654000},"page":"216","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Does Drinking Coffee and Tea Affect Bone Metabolism in Patients with Inflammatory Bowel Diseases?"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7731-6965","authenticated-orcid":false,"given":"Alicja Ewa","family":"Ratajczak","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Dietetics and Internal Diseases, Poznan University of Medical Sciences, 61-701 Pozna\u0144, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6439-8420","authenticated-orcid":false,"given":"Aleksandra","family":"Szymczak-Tomczak","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Dietetics and Internal Diseases, Poznan University of Medical Sciences, 61-701 Pozna\u0144, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agnieszka","family":"Zawada","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Dietetics and Internal Diseases, Poznan University of Medical Sciences, 61-701 Pozna\u0144, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6586-3611","authenticated-orcid":false,"given":"Anna Maria","family":"Rychter","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Dietetics and Internal Diseases, Poznan University of Medical Sciences, 61-701 Pozna\u0144, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3647-5070","authenticated-orcid":false,"given":"Agnieszka","family":"Dobrowolska","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Dietetics and Internal Diseases, Poznan University of Medical Sciences, 61-701 Pozna\u0144, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5122-8003","authenticated-orcid":false,"given":"Iwona","family":"Krela-Ka\u017amierczak","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Dietetics and Internal Diseases, Poznan University of Medical Sciences, 61-701 Pozna\u0144, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,1,13]]},"reference":[{"key":"ref_1","first-page":"1017","article-title":"Epidemiology and Management of Osteoporosis in the People\u2019s Republic of China: Current Perspectives","volume":"10","author":"Lin","year":"2015","journal-title":"Clin. Interv. Aging"},{"key":"ref_2","first-page":"177","article-title":"Nutritional Procedure in Osteoporosis Prevention in Older People","volume":"13","author":"Kwiatkowska","year":"2019","journal-title":"Geriatria"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1007\/s00198-015-3440-3","article-title":"The National Osteoporosis Foundation\u2019s Position Statement on Peak Bone Mass Development and Lifestyle Factors: A Systematic Review and Implementation Recommendations","volume":"27","author":"Weaver","year":"2016","journal-title":"Osteoporos. Int."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.jocd.2016.08.005","article-title":"The Relationship of Knowledge of Osteoporosis and Bone Health in Postmenopausal Women in Silesia Osteo Active Study","volume":"21","author":"Tabor","year":"2018","journal-title":"J. Clin. Densitom."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.pop.2017.07.010","article-title":"An Update on Inflammatory Bowel Disease","volume":"44","author":"Sairenji","year":"2017","journal-title":"Prim. Care"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2769","DOI":"10.1016\/S0140-6736(17)32448-0","article-title":"Worldwide Incidence and Prevalence of Inflammatory Bowel Disease in the 21st Century: A Systematic Review of Population-Based Studies","volume":"390","author":"Ng","year":"2018","journal-title":"Lancet"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/s00535-018-1439-1","article-title":"Evidence-Based Clinical Practice Guidelines for Inflammatory Bowel Disease","volume":"53","author":"Matsuoka","year":"2018","journal-title":"J. Gastroenterol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.bpg.2017.10.004","article-title":"The Role of Smoking and Alcohol Behaviour in the Management of Inflammatory Bowel Disease","volume":"31","author":"Khasawneh","year":"2017","journal-title":"Best Pract. Res. Clin. Gastroenterol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"397","DOI":"10.32394\/rpzh.2018.0046","article-title":"Selected Anti-Health Behaviours among Women with Osteoporosis","volume":"69","author":"Szymura","year":"2018","journal-title":"Rocz. Panstw. Zakl. Hig."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Chan, C.Y., Subramaniam, S., Chin, K.-Y., Ima-Nirwana, S., Muhammad, N., Fairus, A., Mohd Rizal, A.M., Ng, P.Y., Nor Aini, J., and Aziz, N.A. (2019). Knowledge, Beliefs, Dietary, and Lifestyle Practices Related to Bone Health among Middle-Aged and Elderly Chinese in Klang Valley, Malaysia. Int. J. Environ. Res. Public Health, 16.","DOI":"10.3390\/ijerph16101787"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"702","DOI":"10.3111\/13696998.2016.1159567","article-title":"The Association between Osteoporosis and Patient Outcomes in Japan","volume":"19","author":"Yamamoto","year":"2016","journal-title":"J. Med. Econ."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"5580","DOI":"10.12659\/MSM.914182","article-title":"Associated Factors for Osteoporosis and Fracture in Chinese Elderly","volume":"25","author":"Wang","year":"2019","journal-title":"Med. Sci. Monit."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/s00198-015-3290-z","article-title":"Smoking, Smoking Cessation, and Fracture Risk in Elderly Women Followed for 10 Years","volume":"27","author":"Thorin","year":"2016","journal-title":"Osteoporos. Int."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1046\/j.1365-2265.1999.00776.x","article-title":"Postmenopausal Osteoporosis Is More Related to Hormonal Aberrations than to Lifestyle Factors","volume":"51","author":"Wilhelmsen","year":"1999","journal-title":"Clin. Endocrinol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"25","DOI":"10.5455\/medarh.2017.71.25-28","article-title":"Risk Factors for Osteoporosis in Postmenopausal Women","volume":"71","author":"Bijelic","year":"2017","journal-title":"Med. Arch."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.12998\/wjcc.v7.i15.1908","article-title":"Bone Alterations in Inflammatory Bowel Diseases","volume":"7","author":"Sgambato","year":"2019","journal-title":"World J. Clin. Cases"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"213","DOI":"10.11005\/jbm.2018.25.4.213","article-title":"Osteoporosis and Osteoporotic Fractures in Gastrointestinal Disease","volume":"25","author":"Oh","year":"2018","journal-title":"J. Bone Metab."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.amjmed.2009.01.022","article-title":"Osteoporosis in Inflammatory Bowel Disease","volume":"122","author":"Ali","year":"2009","journal-title":"Am. J. Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/j.archoralbio.2009.05.001","article-title":"The Effects of Caffeine Administration on the Early Stage of Bone Healing and Bone Density A Histometric Study in Rats","volume":"54","author":"Duarte","year":"2009","journal-title":"Arch. Oral Biol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1159\/000063078","article-title":"A Caffeine Diet Can Alter the Mechanical Properties of the Bones of Young Ovariectomized Rats","volume":"46","author":"Ohta","year":"2002","journal-title":"Ann. Nutr. Metab."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1093\/ajcn\/54.1.157","article-title":"Caffeine, Moderate Alcohol Intake, and Risk of Fractures of the Hip and Forearm in Middle-Aged Women","volume":"54","author":"Colditz","year":"1991","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1002\/jat.910","article-title":"Apoptosis Induced by Different Doses of Caffeine on Chinese Hamster Ovary Cells","volume":"23","year":"2003","journal-title":"J. Appl. Toxicol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"698","DOI":"10.3390\/ijms9050698","article-title":"Caffeine Induces Cell Death via Activation of Apoptotic Signal and Inactivation of Survival Signal in Human Osteoblasts","volume":"9","author":"Lu","year":"2008","journal-title":"Int. J. Mol. Sci."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1749-799X-1-7","article-title":"Direct Effects of Caffeine on Osteoblastic Cells Metabolism: The Possible Causal Effect of Caffeine on the Formation of Osteoporosis","volume":"1","author":"Tsuang","year":"2006","journal-title":"J. Orthop. Surg."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1111\/j.1476-5381.2010.00998.x","article-title":"Caffeine Inhibits the Viability and Osteogenic Differentiation of Rat Bone Marrow-Derived Mesenchymal Stromal Cells","volume":"161","author":"Zhou","year":"2010","journal-title":"Br. J. Pharmacol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1016\/S0278-6915(02)00094-7","article-title":"Effects of Caffeine on Bone and the Calcium Economy","volume":"40","author":"Heaney","year":"2002","journal-title":"Food Chem. Toxicol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1093\/jn\/123.9.1611","article-title":"Caffeine, Urinary Calcium, Calcium Metabolism and Bone","volume":"123","author":"Massey","year":"1993","journal-title":"J. Nutr."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/0265203021000007840","article-title":"Effects of Caffeine on Human Health","volume":"20","author":"Nawrot","year":"2003","journal-title":"Food Addit. Contam."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Samoggia, A., and Riedel, B. (2019). Consumers\u2019 Perceptions of Coffee Health Benefits and Motives for Coffee Consumption and Purchasing. Nutrients, 11.","DOI":"10.3390\/nu11030653"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/S0271-5317(05)80030-2","article-title":"Impact of Gender and Age on Urinary Water and Mineral Excretion Responses to Acute Caffeine Doses","volume":"12","author":"Massey","year":"1992","journal-title":"Nutr. Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1093\/ajcn\/74.3.343","article-title":"Carbonated Beverages and Urinary Calcium Excretion","volume":"74","author":"Heaney","year":"2001","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1093\/jn\/117.7.1224","article-title":"Effect of Dietary Caffeine and Theophylline on Urinary Calcium Excretion in the Adult Rat","volume":"117","author":"Whiting","year":"1987","journal-title":"J. Nutr."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1002\/mnfr.201300936","article-title":"Unfavorable Effect of Trigonelline, an Alkaloid Present in Coffee and Fenugreek, on Bone Mechanical Properties in Estrogen-Deficient Rats","volume":"58","author":"Folwarczna","year":"2014","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Kiyama, R. (2019). Estrogenic Activity of Coffee Constituents. Nutrients, 11.","DOI":"10.3390\/nu11061401"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1080\/10408390500400009","article-title":"Coffee and Health: A Review of Recent Human Research","volume":"46","author":"Higdon","year":"2006","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_36","first-page":"1","article-title":"Review on Health Benefit and Risk of Coffee Consumption","volume":"6","year":"2017","journal-title":"Med. Aromat. Plants"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1055\/s-0043-115007","article-title":"The Impact of Coffee on Health","volume":"83","author":"Nieber","year":"2017","journal-title":"Planta Med."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Reyes, C.M., and Cornelis, M.C. (2018). Caffeine in the Diet: Country-Level Consumption and Guidelines. Nutrients, 10.","DOI":"10.3390\/nu10111772"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1080\/10408398.2016.1247252","article-title":"Caffeine Intake and Its Sources: A Review of National Representative Studies","volume":"58","author":"Verster","year":"2018","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s00216-007-1437-2","article-title":"The Caffeine Contents of Dietary Supplements Commonly Purchased in the US: Analysis of 53 Products with Caffeine-Containing Ingredients","volume":"389","author":"Andrews","year":"2007","journal-title":"Anal. Bioanal. Chem."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"102","DOI":"10.3945\/an.114.007401","article-title":"Caffeine Intake from Food and Beverage Sources and Trends among Children and Adolescents in the United States: Review of National Quantitative Studies from 1999 to 2011","volume":"6","author":"Ahluwalia","year":"2015","journal-title":"Adv. Nutr."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Liebermann, H.R., Kanarek, R.B., and Prasad, C. (2005). Caffeine. Nutritional Neuroscience, Taylor & Francis.","DOI":"10.1201\/9780367800260"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.crohns.2011.05.010","article-title":"Environmental Factors in Inflammatory Bowel Disease: A Case-Control Study Based on a Danish Inception Cohort","volume":"5","author":"Hansen","year":"2011","journal-title":"J. Crohn\u2019s Colitis"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1136\/gutjnl-2014-307410","article-title":"Environmental Risk Factors in Inflammatory Bowel Disease: A Population-Based Case-Control Study in Asia-Pacific","volume":"64","author":"Ng","year":"2015","journal-title":"Gut"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"e9070","DOI":"10.1097\/MD.0000000000009070","article-title":"Beverage Consumption and Risk of Ulcerative Colitis","volume":"96","author":"Nie","year":"2017","journal-title":"Medicine"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"e15795","DOI":"10.1097\/MD.0000000000015795","article-title":"Beverage Intake and Risk of Crohn Disease","volume":"98","author":"Yang","year":"2019","journal-title":"Medicine"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1186\/s12937-015-0070-8","article-title":"Patients\u2019 Perceptions on the Impact of Coffee Consumption in Inflammatory Bowel Disease: Friend or Foe?\u2014A Patient Survey","volume":"14","author":"Barthel","year":"2015","journal-title":"Nutr. J."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"G\u0142\u0105bska, D., Guzek, D., and Lech, G. (2019). Analysis of the Nutrients and Food Products Intake of Polish Males with Ulcerative Colitis in Remission. Nutrients, 11.","DOI":"10.3390\/nu11102333"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"20","DOI":"10.20883\/pielpol.2017.2","article-title":"The Level of Patients\u2019 Knowladge about the Inflammatory Bowel Disease and Healthy Lifestyle","volume":"63","author":"Gacek","year":"2017","journal-title":"Piel\u0119gniarstwo Polskie"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"108650","DOI":"10.1016\/j.biopha.2019.108650","article-title":"Effect of Caffeine on Ovariectomy-Induced Osteoporosis in Rats","volume":"112","author":"Xu","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"e619","DOI":"10.1210\/clinem\/dgz210","article-title":"Serum Metabolome of Coffee Consumption and Its Association with Bone Mineral Density: The Hong Kong Osteoporosis Study","volume":"105","author":"Chau","year":"2019","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1093\/jn\/122.5.1119","article-title":"Calcium Metabolism in Postmenopausal Osteoporotic Women Is Determined by Dietary Calcium and Coffee Intake","volume":"122","author":"Hasling","year":"1992","journal-title":"J. Nutr."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Chang, H.-C., Hsieh, C.-F., Lin, Y.-C., Tantoh, D.M., Ko, P.-C., Kung, Y.-Y., Wang, M.-C., Hsu, S.-Y., Liaw, Y.-C., and Liaw, Y.-P. (2018). Does Coffee Drinking Have Beneficial Effects on Bone Health of Taiwanese Adults? A Longitudinal Study. BMC Public Health, 18.","DOI":"10.1186\/s12889-018-6168-0"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1093\/aje\/kwt062","article-title":"Long-Term Coffee Consumption in Relation to Fracture Risk and Bone Mineral Density in Women","volume":"178","author":"Byberg","year":"2013","journal-title":"Am. J. Epidemiol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1001\/jama.1994.03510280042030","article-title":"Coffee-Associated Osteoporosis Offset by Daily Milk Consumption. The Rancho Bernardo Study","volume":"271","author":"Chang","year":"1994","journal-title":"JAMA"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Choi, E., Choi, K.-H., Park, S.M., Shin, D., Joh, H.-K., and Cho, E. (2016). The Benefit of Bone Health by Drinking Coffee among Korean Postmenopausal Women: A Cross-Sectional Analysis of the Fourth & Fifth Korea National Health and Nutrition Examination Surveys. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0147762"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s41043-016-0060-2","article-title":"Subjective Evaluation of the Frequency of Coffee Intake and Relationship to Osteoporosis in Chinese Men","volume":"35","author":"Yu","year":"2016","journal-title":"J. Health Popul. Nutr."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/1475-2891-11-56","article-title":"Tea and Coffee Consumption in Relation to Vitamin D and Calcium Levels in Saudi Adolescents","volume":"11","author":"Yakout","year":"2012","journal-title":"Nutr. J."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.ctim.2019.01.015","article-title":"Green Tea: A Possibility in the Therapeutic Approach of Inflammatory Bowel Diseases? Green Tea and Inflammatory Bowel Diseases","volume":"43","author":"Barbalho","year":"2019","journal-title":"Complement. Ther. Med."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"e6437","DOI":"10.1097\/MD.0000000000006437","article-title":"Updated Association of Tea Consumption and Bone Mineral Density: A Meta-Analysis","volume":"96","author":"Zhang","year":"2017","journal-title":"Medicine"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.fshw.2015.10.002","article-title":"Chemistry and Health Beneficial Effects of Oolong Tea and Theasinensins","volume":"4","author":"Weerawatanakorn","year":"2015","journal-title":"Food Sci. Hum. Wellness"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1053\/j.gastro.2019.04.016","article-title":"Environmental Risk Factors for Inflammatory Bowel Diseases: An Umbrella Review of Meta-Analyses","volume":"157","author":"Piovani","year":"2019","journal-title":"Gastroenterology"},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Du, Y., Ding, H., Vanarsa, K., Soomro, S., Baig, S., Hicks, J., and Mohan, C. (2019). Low Dose Epigallocatechin Gallate Alleviates Experimental Colitis by Subduing Inflammatory Cells and Cytokines, and Improving Intestinal Permeability. Nutrients, 11.","DOI":"10.3390\/nu11081743"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"2267","DOI":"10.1002\/mnfr.201501042","article-title":"(\u2212)-Epigallocatechin-3-Gallate Decreases Colonic Inflammation and Permeability in a Mouse Model of Colitis, but Reduces Macronutrient Digestion and Exacerbates Weight Loss","volume":"60","author":"Bitzer","year":"2016","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Oz, H.S. (2017). Chronic Inflammatory Diseases and Green Tea Polyphenols. Nutrients, 9.","DOI":"10.3390\/nu9060561"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/s10787-018-0462-4","article-title":"Treatment of Inflammatory Bowel Disease via Green Tea Polyphenols: Possible Application and Protective Approaches","volume":"26","author":"Rahman","year":"2018","journal-title":"Inflammopharmacology"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1016\/j.biopha.2018.07.103","article-title":"Theabrownin Suppresses in Vitro Osteoclastogenesis and Prevents Bone Loss in Ovariectomized Rats","volume":"106","author":"Liu","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1694S","DOI":"10.3945\/ajcn.113.058255","article-title":"Tea and Bone Health: Steps Forward in Translational Nutrition12345","volume":"98","author":"Shen","year":"2013","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1007\/s00198-011-1731-x","article-title":"Effect of Green Tea and Tai Chi on Bone Health in Postmenopausal Osteopenic Women: A 6-Month Randomized Placebo-Controlled Trial","volume":"23","author":"Shen","year":"2012","journal-title":"Osteoporos. Int."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"e9034","DOI":"10.1097\/MD.0000000000009034","article-title":"Association between Tea Consumption and Osteoporosis: A Meta-Analysis","volume":"96","author":"Sun","year":"2017","journal-title":"Medicine"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1007\/s00198-018-4767-3","article-title":"Tea Consumption and Bone Health in Chinese Adults: A Population-Based Study","volume":"30","author":"Li","year":"2019","journal-title":"Osteoporos. Int."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1007\/s12603-017-0898-z","article-title":"Tea Consumption Is Associated with Increased Bone Strength in Middle-Aged and Elderly Chinese Women","volume":"22","author":"Huang","year":"2018","journal-title":"J. Nutr. Health Aging"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.nutres.2017.02.010","article-title":"Tea Consumption May Decrease the Risk of Osteoporosis: An Updated Meta-Analysis of Observational Studies","volume":"42","author":"Guo","year":"2017","journal-title":"Nutr. Res."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1080\/00365521.2016.1216587","article-title":"The Association between the Gut Microbiota and the Inflammatory Bowel Disease Activity: A Systematic Review and Meta-Analysis","volume":"51","author":"Prosberg","year":"2016","journal-title":"Scand. J. Gastroenterol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1136\/gut.2003.037747","article-title":"Maintaining Remission of Ulcerative Colitis with the Probiotic Escherichia Coli Nissle 1917 Is as Effective as with Standard Mesalazine","volume":"53","author":"Kruis","year":"2004","journal-title":"Gut"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"16173","DOI":"10.1038\/s41598-018-34571-9","article-title":"Effect of Coffee or Coffee Components on Gut Microbiome and Short-Chain Fatty Acids in a Mouse Model of Metabolic Syndrome","volume":"8","author":"Nishitsuji","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1016\/j.cell.2016.05.041","article-title":"From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites","volume":"165","author":"Koh","year":"2016","journal-title":"Cell"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.cell.2013.12.016","article-title":"Microbiota-Generated Metabolites Promote Metabolic Benefits via Gut-Brain Neural Circuits","volume":"156","author":"Goncalves","year":"2014","journal-title":"Cell"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"418","DOI":"10.2334\/josnusd.18-0269","article-title":"Effect of Coffee on the Compositional Shift of Oral Indigenous Microbiota Cultured in Vitro","volume":"61","author":"Ogata","year":"2019","journal-title":"J. Oral Sci."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"2466","DOI":"10.1002\/ptr.6185","article-title":"Guarana (Paullinia Cupana Mart.) Alters Gut Microbiota and Modulates Redox Status, Partially via Caffeine in Wistar Rats","volume":"32","author":"Moresco","year":"2018","journal-title":"Phytother. Res."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1007\/s00535-013-0865-3","article-title":"Oral Caffeine Administration Ameliorates Acute Colitis by Suppressing Chitinase 3-like 1 Expression in Intestinal Epithelial Cells","volume":"49","author":"Lee","year":"2014","journal-title":"J. Gastroenterol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"e00601-17","DOI":"10.1128\/IAI.00601-17","article-title":"Polyphenol- and Caffeine-Rich Postfermented Pu-Erh Tea Improves Diet-Induced Metabolic Syndrome by Remodeling Intestinal Homeostasis in Mice","volume":"86","author":"Gao","year":"2017","journal-title":"Infect. Immun."},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Zhang, Z., Mocanu, V., Cai, C., Dang, J., Slater, L., Deehan, E.C., Walter, J., and Madsen, K.L. (2019). Impact of Fecal Microbiota Transplantation on Obesity and Metabolic Syndrome-A Systematic Review. Nutrients, 11.","DOI":"10.3390\/nu11102291"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1016\/j.foodres.2010.04.020","article-title":"Comparison of the Antioxidant Capacity and the Antimicrobial Activity of Black and Green Tea","volume":"43","author":"Bancirova","year":"2010","journal-title":"Food Res. Int."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1136\/gutjnl-2017-314508","article-title":"Akkermansia Muciniphila Induces Gut Microbiota Remodelling and Controls Islet Autoimmunity in NOD Mice","volume":"67","author":"Toivonen","year":"2018","journal-title":"Gut"},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Chen, W., Liu, F., Ling, Z., Tong, X., and Xiang, C. (2012). Human Intestinal Lumen and Mucosa-Associated Microbiota in Patients with Colorectal Cancer. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0039743"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/s40168-016-0218-6","article-title":"The Gut Microbiota in Conventional and Serrated Precursors of Colorectal Cancer","volume":"4","author":"Peters","year":"2016","journal-title":"Microbiome"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1136\/gutjnl-2017-314814","article-title":"The Oral Microbiota in Colorectal Cancer Is Distinctive and Predictive","volume":"67","author":"Flemer","year":"2018","journal-title":"Gut"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1080\/10715760500197177","article-title":"Green Tea Polyphenol Extract Attenuates Colon Injury Induced by Experimental Colitis","volume":"39","author":"Mazzon","year":"2005","journal-title":"Free Radic. Res."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.4158\/EP161435.ESGL","article-title":"American Association of Clinical Endocrinologists and American College of Endocrinology Clinical Practice Guidelines for the Diagnosis and Treatment of Postmenopausal Osteoporosis\u20142016\u2014Executive Summary","volume":"22","author":"Camacho","year":"2016","journal-title":"Endocr. 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