{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T01:47:13Z","timestamp":1760233633223,"version":"build-2065373602"},"reference-count":37,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2021,1,25]],"date-time":"2021-01-25T00:00:00Z","timestamp":1611532800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>The assessment of compliance of gluten-free diet (GFD) is a keystone in the supervision of celiac disease (CD) patients. Few data are available documenting evidence-based follow-up frequency for CD patients. In this work we aim at creating a criterion for timing of clinical follow-up for CD patients using data mining. We have applied data mining to a dataset with 188 CD patients on GFD (75% of them are children below 14 years old), evaluating the presence of gluten immunogenic peptides (GIP) in stools as an adherence to diet marker. The variables considered are gender, age, years following GFD and adherence to the GFD by fecal GIP. The results identify patients on GFD for more than two years (41.5% of the patients) as more prone to poor compliance and so needing more frequent follow-up than patients with less than 2 years on GFD. This is against the usual clinical practice of following less patients on long term GFD, as they are supposed to perform better. Our results support different timing follow-up frequency taking into consideration the number of years on GFD, age and gender. Patients on long term GFD should have a more frequent monitoring as they show a higher level of gluten exposure. A gender perspective should also be considered as non-compliance is partially linked to gender in our results: Males tend to get more gluten exposure, at least in the cultural context where our study was carried out. Children tend to perform better than teenagers or adults.<\/jats:p>","DOI":"10.3390\/nu13020357","type":"journal-article","created":{"date-parts":[[2021,1,25]],"date-time":"2021-01-25T09:59:40Z","timestamp":1611568780000},"page":"357","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Rationale for Timing of Follow-Up Visits to Assess Gluten-Free Diet in Celiac Disease Patients Based on Data Mining"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1155-280X","authenticated-orcid":false,"given":"Alfonso","family":"Rodr\u00edguez-Herrera","sequence":"first","affiliation":[{"name":"Pediatrics, Saint Luke\u2019s Hospital, University College Dublin, Kilkenny R95 FY71, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0594-8813","authenticated-orcid":false,"given":"Joaqu\u00edn","family":"Reyes-Andrade","sequence":"additional","affiliation":[{"name":"Unidad de Gastroenterolog\u00eda y Nutrici\u00f3n, Instituto Hispalense de Pediatr\u00eda, 41013 Seville, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5732-9139","authenticated-orcid":false,"given":"Cristina","family":"Rubio-Escudero","sequence":"additional","affiliation":[{"name":"Department of Computer Languages and Systems, University of Seville, 41013 Seville, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,1,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1038\/ajg.2016.439","article-title":"Fecal gluten peptides reveal limitations of serological tests and food questionnaires for monitoring gluten-free diet in celiac disease patients","volume":"111","author":"Comino","year":"2016","journal-title":"Am. J. Gastroenterol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"S7","DOI":"10.1097\/01.mpg.0000450393.23156.59","article-title":"The New Epidemiology of Celiac Disease","volume":"59","author":"Catassi","year":"2014","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"708","DOI":"10.3109\/00365521.2015.1030766","article-title":"Coeliac disease\u2014From genetic and immunological studies to clinical applications","volume":"50","author":"Lundin","year":"2015","journal-title":"Scand. J. Gastroenterol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1038\/nri3407","article-title":"Triggers and drivers of autoimmunity: Lessons from coeliac disease","volume":"13","author":"Sollid","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1038\/nrgastro.2015.98","article-title":"Coeliac disease and gluten-related disorders in childhood","volume":"12","author":"Vriezinga","year":"2015","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1136\/gutjnl-2013-306578","article-title":"Diagnosis and management of adult coeliac disease: Guidelines from the British Society of Gastroenterology","volume":"63","author":"Ludvigsson","year":"2014","journal-title":"Gut"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1053\/j.gastro.2017.05.015","article-title":"Tests for serum transglutaminase and endomysial antibodies do not detect most patients with celiac disease and persistent villous atrophy on gluten-free diets: A meta-analysis","volume":"1533","author":"Silvester","year":"2017","journal-title":"Gastroenterology"},{"key":"ref_8","first-page":"250","article-title":"Detection of gluten immunogenic peptides in the urine of patients with coeliac disease reveals transgressions in the gluten-free diet and incomplete mucosal healing","volume":"662","author":"Cebolla","year":"2017","journal-title":"Gut"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1093\/ajcn\/87.2.405","article-title":"Sensitive detection of cereal fractions that are toxic to celiac disease patients by using monoclonal antibodies to a main immunogenic wheat peptide","volume":"87","author":"Cebolla","year":"2008","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Mor\u00f3n, B., Bethune, M.T., Comino, I., Manyani, H., Ferragud, M., L\u00f3pez, M.C., Cebolla, \u00c1., Khosla, C., and Sousa, C. (2008). Toward the Assessment of Food Toxicity for Celiac Patients: Characterization of Monoclonal Antibodies to a Main Immunogenic Gluten Peptide. PLoS ONE, 3.","DOI":"10.1371\/journal.pone.0002294"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"670","DOI":"10.3945\/ajcn.111.026708","article-title":"Monitoring of gluten-free diet compliance in celiac patients by assessment of gliadin 33-mer equivalent epitopes in feces","volume":"95","author":"Comino","year":"2012","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1155\/2007\/342685","article-title":"Long-term Follow-Up of Individuals with Celiac Disease: An Evaluation of Current Practice Guidelines","volume":"21","author":"Rashid","year":"2007","journal-title":"Can. J. Gastroenterol."},{"key":"ref_13","first-page":"17","article-title":"Evidence-based guidelines to determine follow-up intervals: A call for action","volume":"201","author":"Javorsky","year":"2014","journal-title":"Am. J. Manag. Care"},{"key":"ref_14","unstructured":"Han, J., Pei, J., and Kamber, M. (2011). Data Mining: Concepts and Techniques, Elsevier."},{"key":"ref_15","first-page":"121","article-title":"Clinical data mining: A review","volume":"1801","author":"Iavindrasana","year":"2009","journal-title":"Yearb. Med. Inform."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"S163","DOI":"10.1016\/S0016-5085(17)30865-X","article-title":"Oral Latiglutenase Improves Chronic Symptoms in Seropositive Celiac Disease Patients","volume":"152","author":"Syage","year":"2017","journal-title":"Gastroenterology"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"T135","DOI":"10.1111\/j.1750-3841.2008.00925.x","article-title":"Sandwich Enzyme-Linked Immunosorbent Assay (ELISA) for the Detection of Lupine Residues in Foods","volume":"73","author":"Kaw","year":"2008","journal-title":"J. Food Sci."},{"key":"ref_18","first-page":"37","article-title":"From data mining to knowledge discovery in databases","volume":"173","author":"Fayyad","year":"1996","journal-title":"AI Mag."},{"key":"ref_19","unstructured":"Phyu, T.N. (2009, January 18\u201320). Survey of classification techniques in data mining. Proceedings of the International MultiConference of Engineers and Computer Scientists, Hong Kong, China."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1145\/846170.846172","article-title":"A survey of data mining and knowledge discovery software tools","volume":"11","author":"Goebel","year":"1999","journal-title":"ACM SIGKDD Explor. Newsl."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10115-007-0114-2","article-title":"Top 10 algorithms in data mining","volume":"141","author":"Wu","year":"2008","journal-title":"Knowl. Inf. Syst."},{"key":"ref_22","first-page":"725","article-title":"Bagging, boosting, and C4. 5","volume":"1","author":"Quinlan","year":"1996","journal-title":"AAAI Conf. Artif. Intell."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/BF00116251","article-title":"Induction of decision trees","volume":"11","author":"Quinlan","year":"1986","journal-title":"Mach. Learn."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/S0034-4257(97)00049-7","article-title":"Decision tree classification of land cover from remotely sensed data","volume":"61","author":"Friedl","year":"1997","journal-title":"Remote Sens. Environ."},{"key":"ref_25","unstructured":"Play Tennis (2021, January 16). Simple Dataset with Decisions about Playing Tennis. Available online: https:\/\/www.kaggle.com\/fredericobreno\/play-tennis."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.proeng.2012.01.849","article-title":"Network Anomaly Detection by Cascading K-Means Clustering and C4.5 Decision Tree algorithm","volume":"30","author":"Muniyandi","year":"2012","journal-title":"Procedia Eng."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.cageo.2017.10.011","article-title":"Earthquake prediction in California using regression algorithms and cloud-based big data infrastructure","volume":"115","author":"Shang","year":"2018","journal-title":"Comput. Geosci."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1097\/MPG.0b013e31821a23d0","article-title":"European Society for Pediatric Gastroenterology, Hepatology, and Nutrition Guidelines for the Diagnosis of Coeliac Disease","volume":"54","author":"Husby","year":"2012","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/j.1536-4801.2005.tb00917.x","article-title":"Guideline for the diagnosis and treatment of celiac disease in children: Recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition","volume":"40","author":"Hill","year":"2005","journal-title":"J. Pediatric Gastroenterol. Nutr."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1177\/2050640619844125","article-title":"European Society for the Study of Coeliac Disease (ESsCD) guideline for coeliac disease and other gluten-related disorders","volume":"7","author":"Volta","year":"2019","journal-title":"United Eur. Gastroenterol. J."},{"key":"ref_31","unstructured":"National Institute for Health and Clinical Excellence (2021, January 16). Coeliac Disease: Recognition, Assessment and Management. Available online: https:\/\/www.guidelines.co.uk\/gastrointestinal\/nice-coeliac-disease-guideline\/252667.article 2015."},{"key":"ref_32","first-page":"656","article-title":"American College of Gastroenterology clinical guideline: Diagnosis and management of celiac disease","volume":"1085","author":"Hill","year":"2013","journal-title":"Am. J. Gastroenterol."},{"key":"ref_33","unstructured":"SPAIN Ministry of Health (2019, August 20). Working Group of the Protocol for the Early Diagnosis of Celiac Disease. Protocol for the Early Diagnosis of Celiac Disease. Ministry of Health, Social Services and Equality. Canary Islands Health Service Evaluation Service SESCS. Available online: https:\/\/www.mscbs.gob.es\/profesionales\/prestacionesSanitarias\/publicaciones\/Celiaquia\/enfermedadCeliaca.pdf."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Cervino, G., Fiorillo, L., Laino, L., Herford, A.S., Lauritano, F., Giudice, G.L., Fam\u00e0, F., Santoro, R., Troiano, G., and Iannello, G. (2018). Oral health impact profile in celiac patients: Analysis of recent findings in a literature review. Gastroenterol. Res. Pract., 7848735.","DOI":"10.1155\/2018\/7848735"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.2337\/diacare.25.7.1159","article-title":"Self-management education for adults with type 2 diabetes: A meta-analysis of the effect on glycemic control","volume":"257","author":"Norris","year":"2002","journal-title":"Diabetes Care"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.2522\/ptj.20090245","article-title":"The influence of the therapist-patient relationship on treatment outcome in physical rehabilitation: A systematic review","volume":"908","author":"Hall","year":"2010","journal-title":"J. Phys. Ther."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1016\/j.jada.2003.08.027","article-title":"Celiac diet: Its impact on quality of life","volume":"103","author":"Lee","year":"2003","journal-title":"J. Am. Diet. Assoc."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/13\/2\/357\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T05:15:01Z","timestamp":1760159701000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/13\/2\/357"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,25]]},"references-count":37,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2021,2]]}},"alternative-id":["nu13020357"],"URL":"https:\/\/doi.org\/10.3390\/nu13020357","relation":{},"ISSN":["2072-6643"],"issn-type":[{"type":"electronic","value":"2072-6643"}],"subject":[],"published":{"date-parts":[[2021,1,25]]}}}