{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T03:18:20Z","timestamp":1783653500259,"version":"3.55.0"},"reference-count":65,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2021,1,27]],"date-time":"2021-01-27T00:00:00Z","timestamp":1611705600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background: Prevalence of iron deficiency is commonly reported among athletic population groups. It impairs physical performance due to insufficient oxygen delivery to target organs and low energy production. This is due to the high demand of exercise on oxygen delivery for systemic metabolism by the erythrocytes in the blood. Hepcidin, the key regulator of iron homeostasis, decreases to facilitate iron efflux into the circulation during enhanced erythropoiesis. However, acute anaemia of exercise is caused by increased hepcidin expression that is induced by stress and inflammatory signal. The study aimed to systematically review changes in serum hepcidin levels during resistance and aerobic exercise programmes. Methods: A systemic literature search from 2010 to April 2020 across seven databases comprised of Cochrane library, PubMed, Web of Science, Scopus, Embase, MEDLINE, and OpenGrey. The primary outcome was increased or decreased serum hepcidin from baseline after the exercise activity. Risks of bias were evaluated by using the National Institutes of Health (NIH) for quality assessment of before and after different exercise programmes. Results: Overall, twenty-three studies met the inclusion criteria. Out of the 23 studies, 16 studies reported significantly exercise-induced serum hepcidin elevation. Of the 17 studies that evaluated serum interleukin (IL)-6 levels, 14 studies showed significant exercise-induced serum IL-6 elevation. Changes in exercise-induced serum hepcidin and IL-6 levels were similar in both resistance and endurance exercise. Significant correlations were observed between post-exercise hepcidin and baseline ferritin levels (r = 0.69, p &lt; 0.05) and between post-exercise hepcidin and post-exercise IL-6 (r = 0.625, p &lt; 0.05). Conclusion: Resistance and endurance training showed significant increase in serum hepcidin and IL-6 levels in response to exercise. Baseline ferritin and post-exercise IL-6 elevation are key determining factors in the augmentation of hepcidin response to exercise.<\/jats:p>","DOI":"10.3390\/nu13020393","type":"journal-article","created":{"date-parts":[[2021,1,27]],"date-time":"2021-01-27T12:20:26Z","timestamp":1611750026000},"page":"393","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Association of Serum Hepcidin Levels with Aerobic and Resistance Exercise: A Systematic Review"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5022-1790","authenticated-orcid":false,"given":"Phureephat","family":"Larsuphrom","sequence":"first","affiliation":[{"name":"Department of Nutritional Sciences, School of Life Course Sciences, King\u2019s College London, Franklin-Wilkins-Building, 150 Stamford Street, London SE1 9NH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0607-6909","authenticated-orcid":false,"given":"Gladys Oluyemisi","family":"Latunde-Dada","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences, School of Life Course Sciences, King\u2019s College London, Franklin-Wilkins-Building, 150 Stamford Street, London SE1 9NH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,1,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1139\/apnm-2014-0147","article-title":"Iron and the endurance athlete","volume":"39","author":"Hinton","year":"2014","journal-title":"Appl. Physiol. Nutr. Metab."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1249\/JSR.0b013e31829a6f6b","article-title":"Iron supplementation for female athletes: Effects on iron status and performance outcomes","volume":"12","author":"DellaValle","year":"2013","journal-title":"Curr. Sports Med. Rep."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1249\/MSS.0000000000000208","article-title":"Iron supplementation improves energetic efficiency in iron-depleted female rowers","volume":"46","author":"DellaValle","year":"2014","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1097\/00005768-200205000-00022","article-title":"Hematological indices and iron status in athletes of various sports and performances","volume":"34","author":"Schumacher","year":"2002","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"375","DOI":"10.3389\/fphys.2018.00375","article-title":"The Effects of Altitude Training on Erythropoietic Response and Hematological Variables in Adult Athletes: A Narrative Review","volume":"9","author":"Langfort","year":"2018","journal-title":"Front. Physiol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1007\/s00421-011-2002-4","article-title":"Iron status in elite young athletes: Gender-dependent influences of diet and exercise","volume":"112","author":"Koehler","year":"2012","journal-title":"Eur. J. Appl. Physiol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1249\/MSS.0000000000001259","article-title":"Iron Deficiency and Anemia among Collegiate Athletes: A Retrospective Chart Review","volume":"49","author":"Parks","year":"2017","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1007\/s00421-008-0726-6","article-title":"Athletic induced iron deficiency: New insights into the role of inflammation, cytokines and hormones","volume":"103","author":"Peeling","year":"2008","journal-title":"Eur. J. Appl. Physiol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s12970-015-0099-2","article-title":"Iron and the female athlete: A review of dietary treatment methods for improving iron status and exercise performance","volume":"12","author":"Alaunyte","year":"2015","journal-title":"J. Int. Soc. Sports Nutr."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1126\/science.1057206","article-title":"An iron-regulated ferric reductase associated with the absorption of dietary iron","volume":"291","author":"McKie","year":"2001","journal-title":"Science"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S1097-2765(00)80425-6","article-title":"A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation","volume":"5","author":"McKie","year":"2000","journal-title":"Mol. Cell"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1123\/ijsnem.21.1.19","article-title":"Does hepatic hepcidin play an important role in exercise-associated anemia in rats?","volume":"21","author":"Liu","year":"2011","journal-title":"Int. J. Sport Nutr. Exerc. Metab."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/2045-3701-4-19","article-title":"Hepcidin and sports anemia","volume":"4","author":"Kong","year":"2014","journal-title":"Cell Biosci."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2090","DOI":"10.1126\/science.1104742","article-title":"Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization","volume":"306","author":"Nemeth","year":"2004","journal-title":"Science"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"8780","DOI":"10.1073\/pnas.151179498","article-title":"Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice","volume":"98","author":"Nicolas","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1172\/JCI0215686","article-title":"The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation","volume":"110","author":"Nicolas","year":"2002","journal-title":"J. Clin. Investig."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"50","DOI":"10.3357\/ASEM.3092.2012","article-title":"Erythropoietin, 2,3 DPG, oxygen transport capacity, and altitude training in adolescent Alpine skiers","volume":"83","author":"Son","year":"2012","journal-title":"Aviat. Space Environ. Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1038\/ng.2996","article-title":"Identification of erythroferrone as an erythroid regulator of iron metabolism","volume":"46","author":"Kautz","year":"2014","journal-title":"Nat. Genet."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1182\/blood.2019002620","article-title":"Erythroferrone lowers hepcidin by sequestering BMP2\/6 heterodimer from binding to the BMP type I receptor ALK3","volume":"135","author":"Wang","year":"2020","journal-title":"Blood"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"100866","DOI":"10.1016\/j.mam.2020.100866","article-title":"Basics and principles of cellular and systemic iron homeostasis","volume":"75","author":"Katsarou","year":"2020","journal-title":"Mol. Asp. Med."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1111\/ejh.12026","article-title":"Iron metabolism in athletes--achieving a gold standard","volume":"90","year":"2013","journal-title":"Eur. J. Haematol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.cyto.2012.01.006","article-title":"Interleukin-6 contributes to hepcidin mRNA increase in response to exercise","volume":"58","author":"Banzet","year":"2012","journal-title":"Cytokine"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1007\/s00421-005-0055-y","article-title":"Iron-regulatory protein hepcidin is increased in female athletes after a marathon","volume":"95","author":"Roecker","year":"2005","journal-title":"Eur. J. Appl. Physiol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1007\/s00421-011-2156-0","article-title":"The effects of carbohydrate ingestion during endurance running on post-exercise inflammation and hepcidin levels","volume":"112","author":"Sim","year":"2012","journal-title":"Eur. J. Appl. Physiol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1123\/ijsnem.23.2.178","article-title":"Effect of exercise modality and intensity on post-exercise interleukin-6 and hepcidin levels","volume":"23","author":"Sim","year":"2013","journal-title":"Int. J. Sport Nutr. Exerc. Metab."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1123\/ijsnem.22.2.79","article-title":"The effects of acute exercise bouts on hepcidin in women","volume":"22","author":"Newlin","year":"2012","journal-title":"Int. J. Sport Nutr. Exerc. Metab."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1249\/MSS.0b013e318192ce58","article-title":"Training surface and intensity: Inflammation, hemolysis, and hepcidin expression","volume":"41","author":"Peeling","year":"2009","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1123\/ijsnem.19.6.583","article-title":"Effects of exercise on hepcidin response and iron metabolism during recovery","volume":"19","author":"Peeling","year":"2009","journal-title":"Int. J. Sport Nutr. Exerc. Metab."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1007\/s00421-017-3611-3","article-title":"Factors influencing the post-exercise hepcidin-25 response in elite athletes","volume":"117","author":"Peeling","year":"2017","journal-title":"Eur. J. Appl. Physiol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1007\/s00421-009-1031-8","article-title":"Daily regulation of serum and urinary hepcidin is not influenced by submaximal cycling exercise in humans with normal iron metabolism","volume":"106","author":"Troadec","year":"2009","journal-title":"Eur. J. Appl. Physiol."},{"key":"ref_31","first-page":"141","article-title":"Effect of exercise intensity on the hepcidin response","volume":"40","author":"Renguea","year":"2020","journal-title":"Nutr. Clin. Diet. Hosp."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1371\/journal.pmed.1000100","article-title":"The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: Explanation and elaboration","volume":"6","author":"Liberati","year":"2009","journal-title":"PLoS Med."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Goto, K., Kojima, C., Kasai, N., Sumi, D., Hayashi, N., and Hwang, H. (2020). Resistance exercise causes greater serum hepcidin elevation than endurance (cycling) exercise. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0228766"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Tomczyk, M., Kortas, J., Flis, D., Kaczorowska-Hacm, B., Grzybkowska, A., Borkowska, A., Lewicka, E., D\u0105browska-Kugacka, A., and Antosiewicz, J. (2020). Marathon Run-induced Changes in the Erythropoietin-Erythroferrone-Hepcidin Axis are Iron Dependent. Int. J. Environ. Res. Public Health, 17.","DOI":"10.3390\/ijerph17082781"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.1249\/MSS.0000000000002026","article-title":"The Impact of Morning versus Afternoon Exercise on Iron Absorption in Athletes","volume":"51","author":"McCormick","year":"2019","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1080\/00913847.2018.1482187","article-title":"Acute effects of high-intensity exercise on hematological and iron metabolic parameters in elite male and female dragon boating athletes","volume":"46","author":"Bauer","year":"2018","journal-title":"Phys. Sportsmed."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1139\/apnm-2017-0418","article-title":"Postexercise serum hepcidin response to repeated sprInt. exercise under normoxic and hypoxic conditions","volume":"43","author":"Goto","year":"2018","journal-title":"Appl. Physiol. Nutr. Metab."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Goto, K., Sumi, D., Kojima, C., and Ishibashi, A. (2017). Post-exercise serum hepcidin levels were unaffected by hypoxic exposure during prolonged exercise sessions. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0183629"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.3389\/fphys.2019.01577","article-title":"Increased Hepcidin Levels During a Period of High Training Load Do Not Alter Iron Status in Male Elite Junior Rowers","volume":"10","author":"Treff","year":"2020","journal-title":"Front. Physiol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1093\/ajcn\/nqy247","article-title":"An intensified training schedule in recreational male runners is associated with increases in erythropoiesis and inflammation and a net reduction in plasma hepcidin","volume":"108","author":"Moretti","year":"2018","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1111\/sms.12685","article-title":"Live high, train low\u2014Influence on resting and post-exercise hepcidin levels","volume":"27","author":"Govus","year":"2017","journal-title":"Scand. J. Med. Sci. Sports"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/s00421-014-3018-3","article-title":"Effect of intense physical exercise on hepcidin levels and selected parameters of iron metabolism in rowing athletes","volume":"115","author":"Basta","year":"2015","journal-title":"Eur. J. Appl. Physiol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1007\/s00421-014-2938-2","article-title":"Acute hypoxic exercise does not alter post-exercise iron metabolism in moderately trained endurance athletes","volume":"114","author":"Govus","year":"2014","journal-title":"Eur. J. Appl. Physiol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/1550-2783-11-14","article-title":"A seven day running training period increases basal urinary hepcidin levels as compared to cycling","volume":"11","author":"Sim","year":"2014","journal-title":"J. Int. Soc. Sports Nutr."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Peeling, P., Sim, M., Badenhorst, C.E., Dawson, B., Govus, A.D., Abbiss, C.R., Swinkels, D.W., and Trinder, D. (2014). Iron status and the acute post-exercise hepcidin response in athletes. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0093002"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1007\/s00421-014-2829-6","article-title":"Influence of post-exercise hypoxic exposure on hepcidin response in athletes","volume":"114","author":"Badenhorst","year":"2014","journal-title":"Eur. J. Appl. Physiol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.cellimm.2013.06.006","article-title":"Repeated \u201call out\u201d interval exercise causes an increase in serum hepcidin concentration in both trained and untrained men","volume":"283","author":"Antosiewicz","year":"2013","journal-title":"Cell. Immunol."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Auersperger, I., \u0160kof, B., Lesko\u0161ek, B., Knap, B., Jerin, A., and Lainscak, M. (2013). Exercise-induced changes in iron status and hepcidin response in female runners. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0058090"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1123\/ijsnem.22.1.55","article-title":"The effects of 8 weeks of endurance running on hepcidin concentrations, inflammatory parameters, and iron status in female runners","volume":"22","author":"Auersperger","year":"2012","journal-title":"Int. J. Sport Nutr. Exerc. Metab."},{"key":"ref_50","first-page":"533","article-title":"Running a 100-km ultra-marathon induces an inflammatory response but does not raise the level of the plasma iron-regulatory protein hepcidin","volume":"53","author":"Kasprowicz","year":"2013","journal-title":"J. Sports Med. Phys. Fit."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.scispo.2018.08.012","article-title":"Effect of intense physical exercise on hepcidin levels and selected parameters of iron metabolism in two different trial of training","volume":"34","author":"Basta","year":"2019","journal-title":"Sci. Sports"},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Dom\u00ednguez, R., S\u00e1nchez-Oliver, A.J., Mata-Ordo\u00f1ez, F., Feria-Madue\u00f1o, A., Grimaldi-Puyana, M., L\u00f3pez-Samanes, \u00c1., and P\u00e9rez-L\u00f3pez, A. (2018). Effects of an Acute Exercise Bout on Serum Hepcidin Levels. Nutrients, 10.","DOI":"10.3390\/nu10020209"},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Williams, J.H., Batts, T.W., and Lees, S. (2013). Reduced Muscle Glycogen Differentially Affects Exercise Performance and Muscle Fatigue. ISRN Physiol., 2013.","DOI":"10.1155\/2013\/371235"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s12011-014-0075-8","article-title":"Effects of resistance exercise on iron absorption and balance in iron-deficient rats","volume":"161","author":"Fujii","year":"2014","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"e12820","DOI":"10.14814\/phy2.12820","article-title":"Effects of exercise mode, energy, and macronutrient interventions on inflammation during military training","volume":"4","author":"Pasiakos","year":"2016","journal-title":"Physiol. Rep."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1139\/h06-003","article-title":"Reduced glycogen availability is associated with increased AMPKalpha2 activity, nuclear AMPKalpha2 protein abundance, and GLUT4 mRNA expression in contracting human skeletal muscle","volume":"31","author":"Steinberg","year":"2006","journal-title":"Appl. Physiol. Nutr. Metab."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1113\/JP272881","article-title":"The effects of cold water immersion and active recovery on inflammation and cell stress responses in human skeletal muscle after resistance exercise","volume":"595","author":"Peake","year":"2017","journal-title":"J. Physiol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1152\/japplphysiol.00631.2001","article-title":"Footstrike is the major cause of hemolysis during running","volume":"94","author":"Telford","year":"2003","journal-title":"J. Appl. Physiol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"4425","DOI":"10.1182\/blood-2011-01-258467","article-title":"Hepcidin and iron regulation, 10 years later","volume":"117","author":"Ganz","year":"2011","journal-title":"Blood"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"2603","DOI":"10.1210\/jcem.84.8.5894","article-title":"Circadian interleukin-6 secretion and quantity and depth of sleep","volume":"84","author":"Vgontzas","year":"1999","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1249\/MSS.0000000000000568","article-title":"Effect of Intravenous Iron on Aerobic Capacity and Iron Metabolism in Elite Athletes","volume":"47","author":"Burden","year":"2015","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s00421-009-0988-7","article-title":"Cumulative effects of consecutive running sessions on hemolysis, inflammation and hepcidin activity","volume":"106","author":"Peeling","year":"2009","journal-title":"Eur. J. Appl. Physiol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"510304","DOI":"10.1155\/2011\/510304","article-title":"Hepcidin: A Critical Regulator of Iron Metabolism during Hypoxia","volume":"2011","author":"Hintze","year":"2011","journal-title":"Adv. Hematol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.1172\/JCI31370","article-title":"Regulation of iron homeostasis by the hypoxia-inducible transcription factors (HIFs)","volume":"117","author":"Peyssonnaux","year":"2007","journal-title":"J. Clin. Investig."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.ijcard.2010.10.139","article-title":"Absolute and functional iron deficiency in professional athletes during training and recovery","volume":"156","author":"Reinke","year":"2012","journal-title":"Int. J. Cardiol."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/13\/2\/393\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T05:16:09Z","timestamp":1760159769000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/13\/2\/393"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,27]]},"references-count":65,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2021,2]]}},"alternative-id":["nu13020393"],"URL":"https:\/\/doi.org\/10.3390\/nu13020393","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,27]]}}}