{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T05:32:52Z","timestamp":1790141572414,"version":"4.0.1"},"reference-count":94,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2021,1,28]],"date-time":"2021-01-28T00:00:00Z","timestamp":1611792000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Long-chain polyunsaturated fatty acids n-3 series and especially docosahexaenoic acid are known to exert preventive effects on metabolic disturbances associated with obesity and decrease cardiovascular disease risk. n-3 LC-PUFAs are mainly consumed in the form of fish oil, while other sources, such as certain microalgae, may contain a high content of these fatty acids. The aim of this study was to evaluate the effects of Tisochrysis lutea (Tiso), a microalga rich in DHA, on metabolic disorders associated with obesity. Three male Wistar rat groups were submitted for eight weeks to a standard diet or high-fat and high fructose diet (HF), supplemented or not with 12% of T. lutea (HF-Tiso). The supplementation did not affect plasma alanine aminotransferase (ALAT). Bodyweight, glycemia and insulinemia decreased in HF-Tiso rats (ANOVA, p &lt; 0.001), while total plasma cholesterol, high-density lipoprotein-cholesterol (HDL-C) increased (ANOVA, p &lt; 0.001) without change of low-density lipoprotein-cholesterol (LDL-C) and triacylglycerol (TAG) levels. Tiso supplementation decreased fat mass and leptinemia as well as liver TAG, cholesterol and plasma tumor necrosis factor-alpha levels (ANOVA, p &lt; 0.001) while it did not affect interleukin 6 (IL-6), IL-4 and lipopolysaccharides levels. HF-Tiso rats showed an increase of IL-10 level in abdominal adipose tissue (ANOVA, p &lt; 0.001). In conclusion, these results indicated that DHA-rich T. lutea might be beneficial for the prevention of obesity and improvement of lipid and glucose metabolism.<\/jats:p>","DOI":"10.3390\/nu13020430","type":"journal-article","created":{"date-parts":[[2021,1,28]],"date-time":"2021-01-28T11:54:53Z","timestamp":1611834893000},"page":"430","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["The Marine Microalga, Tisochrysis lutea, Protects against Metabolic Disorders Associated with Metabolic Syndrome and Obesity"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3035-294X","authenticated-orcid":false,"given":"Claire","family":"Mayer","sequence":"first","affiliation":[{"name":"EA 2160 MMS, Mer Mol\u00e9cules Sant\u00e9, IUML FR 3473 CNRS, Institut Universitaire Technologique, D\u00e9partement G\u00e9nie Biologique, Le Mans Universit\u00e9, CEDEX 9, 53020 Laval, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e9o","family":"Richard","sequence":"additional","affiliation":[{"name":"GP Solutions, 98000 Monaco, Monaco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martine","family":"C\u00f4me","sequence":"additional","affiliation":[{"name":"EA 2160 MMS, Mer Mol\u00e9cules Sant\u00e9, IUML FR 3473 CNRS, Institut Universitaire Technologique, D\u00e9partement G\u00e9nie Biologique, Le Mans Universit\u00e9, CEDEX 9, 53020 Laval, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9009-2791","authenticated-orcid":false,"given":"Lionel","family":"Ulmann","sequence":"additional","affiliation":[{"name":"EA 2160 MMS, Mer Mol\u00e9cules Sant\u00e9, IUML FR 3473 CNRS, Institut Universitaire Technologique, D\u00e9partement G\u00e9nie Biologique, Le Mans Universit\u00e9, CEDEX 9, 53020 Laval, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3607-295X","authenticated-orcid":false,"given":"Hassan","family":"Nazih","sequence":"additional","affiliation":[{"name":"EA 2160 MMS, Mer Mol\u00e9cules Sant\u00e9, IUML FR 3473 CNRS, UFR Pharmacie, Universit\u00e9 de Nantes, CEDEX 1, 44035 Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2441-1966","authenticated-orcid":false,"given":"Beno\u00eet","family":"Ch\u00e9nais","sequence":"additional","affiliation":[{"name":"EA 2160 MMS, Mer Mol\u00e9cules Sant\u00e9, IUML FR 3473 CNRS, UFR Sciences et Techniques, Le Mans Universit\u00e9, CEDEX 9, 72085 Le Mans, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khadija","family":"Ouguerram","sequence":"additional","affiliation":[{"name":"UMR1280 PhAN, Physiopathology of Nutritional Adaptations, INRAe, University of Nantes, CHU H\u00f4tel Dieu, IMAD, CRNH Ouest, 44000 Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2468-0659","authenticated-orcid":false,"given":"Virginie","family":"Mimouni","sequence":"additional","affiliation":[{"name":"EA 2160 MMS, Mer Mol\u00e9cules Sant\u00e9, IUML FR 3473 CNRS, Institut Universitaire Technologique, D\u00e9partement G\u00e9nie Biologique, Le Mans Universit\u00e9, CEDEX 9, 53020 Laval, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,1,28]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (WHO) (2018). 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