{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T19:43:24Z","timestamp":1789847004938,"version":"4.0.1"},"reference-count":115,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2021,1,29]],"date-time":"2021-01-29T00:00:00Z","timestamp":1611878400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["EH 367\/5-1, EH 367\/7-1, SFB 940\/1, SM 80\/7-2"],"award-info":[{"award-number":["EH 367\/5-1, EH 367\/7-1, SFB 940\/1, SM 80\/7-2"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Brain-derived neurotrophic factor (BDNF), a neurotrophin involved in the regulation of food intake and body weight, has been implicated in the development and maintenance of Anorexia nervosa (AN). The majority of previous studies reported lower BDNF levels in acutely underweight AN patients (acAN) and increasing levels after weight rehabilitation. Here, we investigated serum BDNF concentrations in the largest known AN sample to date, both before and after weight restoration therapy. Serum BDNF was measured in 259 female volunteers: 77 in-patient acAN participants of the restrictive type (47 reassessed after short-term weight rehabilitation), 62 individuals long-term recovered from AN, and 120 healthy controls. We validated our findings in a post-hoc mega-analysis in which we reanalyzed combined data from the current sample and those from our previous study on BDNF in AN (combined sample: 389 participants). All analyses carefully accounted for known determinants of BDNF (age, sex, storage time of blood samples). We further assessed relationships with relevant clinical variables (body-mass-index, physical activity, symptoms). Contrary to our hypotheses, we found zero significant differences in either cross-sectional or longitudinal comparisons and no significant relationships with clinical variables. Together, our study suggests that BDNF may not be a reliable state- or trait-marker in AN after all.<\/jats:p>","DOI":"10.3390\/nu13020432","type":"journal-article","created":{"date-parts":[[2021,1,28]],"date-time":"2021-01-28T22:54:41Z","timestamp":1611874481000},"page":"432","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Is Serum BDNF Altered in Acute, Short- and Long-Term Recovered Restrictive Type Anorexia Nervosa?"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5726-0928","authenticated-orcid":false,"given":"Jonas L.","family":"Steinh\u00e4user","sequence":"first","affiliation":[{"name":"Division of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, Technische Universit\u00e4t Dresden, 01307 Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2864-5578","authenticated-orcid":false,"given":"Joseph A.","family":"King","sequence":"additional","affiliation":[{"name":"Division of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, Technische Universit\u00e4t Dresden, 01307 Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8333-867X","authenticated-orcid":false,"given":"Friederike I.","family":"Tam","sequence":"additional","affiliation":[{"name":"Division of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, Technische Universit\u00e4t Dresden, 01307 Dresden, Germany"},{"name":"Eating Disorder Treatment and Research Center, Department of Child and Adolescent Psychiatry, Faculty of Medicine, Technische Universit\u00e4t Dresden, 01307 Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Seidel","sequence":"additional","affiliation":[{"name":"Division of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, Technische Universit\u00e4t Dresden, 01307 Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0820-8231","authenticated-orcid":false,"given":"Ronald","family":"Biemann","sequence":"additional","affiliation":[{"name":"Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University of Leipzig, 04103 Leipzig, Germany"},{"name":"Institute for Clinical Chemistry and Pathobiochemistry, Otto-Von-Guericke University Magdeburg, 39120 Magdeburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Louis","family":"Wronski","sequence":"additional","affiliation":[{"name":"Division of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, Technische Universit\u00e4t Dresden, 01307 Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2076-5329","authenticated-orcid":false,"given":"Daniel","family":"Geisler","sequence":"additional","affiliation":[{"name":"Division of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, Technische Universit\u00e4t Dresden, 01307 Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1873-7081","authenticated-orcid":false,"given":"Veit","family":"Roessner","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Psychiatry, Faculty of Medicine, Technische Universit\u00e4t Dresden, 01307 Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Ehrlich","sequence":"additional","affiliation":[{"name":"Division of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, Technische Universit\u00e4t Dresden, 01307 Dresden, Germany"},{"name":"Eating Disorder Treatment and Research Center, Department of Child and Adolescent Psychiatry, Faculty of Medicine, Technische Universit\u00e4t Dresden, 01307 Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,1,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"15074","DOI":"10.1038\/nrdp.2015.74","article-title":"Anorexia Nervosa","volume":"1","author":"Treasure","year":"2015","journal-title":"Nat. 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