{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T04:15:33Z","timestamp":1793852133073,"version":"4.6.1"},"reference-count":93,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2021,2,8]],"date-time":"2021-02-08T00:00:00Z","timestamp":1612742400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Osteonecrosis of the jaw (ONJ) is a severe clinical condition characterized mostly but not exclusively by an area of exposed bone in the mandible and\/or maxilla that typically does not heal over a period of 6\u20138 weeks. The diagnosis is first of all clinical, but an imaging feedback such as Magnetic Resonance is essential to confirm clinical suspicions. In the last few decades, medication-related osteonecrosis of the jaw (MRONJ) has been widely discussed. From the first case reported in 2003, many case series and reviews have appeared in the scientific literature. Almost all papers concerning this topic conclude that bisphosphonates (BPs) can induce this severe clinical condition, particularly in cancer patients. Nevertheless, the exact mechanism by which amino-BPs would be responsible for ONJ is still debatable. Recent findings suggest a possible alternative explanation for BPs role in this pattern. In the present work we discuss how a condition of osteomalacia and low vitamin D levels might be determinant factors.<\/jats:p>","DOI":"10.3390\/nu13020561","type":"journal-article","created":{"date-parts":[[2021,2,14]],"date-time":"2021-02-14T02:08:12Z","timestamp":1613268492000},"page":"561","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Medication-Related Osteonecrosis of the Jaw (MRONJ): Are Antiresorptive Drugs the Main Culprits or Only Accomplices? The Triggering Role of Vitamin D Deficiency"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3263-6671","authenticated-orcid":false,"given":"Luca","family":"Dalle Carbonare","sequence":"first","affiliation":[{"name":"Department of Medicine, Section of Internal Medicine, University of Verona, 37134 Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7390-2246","authenticated-orcid":false,"given":"Monica","family":"Mottes","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Biomedicine and Movement Sciences, Section of Biology and Genetics, University of Verona, 37134 Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1166-8033","authenticated-orcid":false,"given":"Maria Teresa","family":"Valenti","sequence":"additional","affiliation":[{"name":"Department of Medicine, Section of Internal Medicine, University of Verona, 37134 Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,2,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1016\/j.joms.2014.04.031","article-title":"American Association of Oral and Maxillofacial Surgeons position paper on medication-related osteonecrosis of the jaw\u20142014 update","volume":"72","author":"Ruggiero","year":"2014","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2698","DOI":"10.1016\/j.joms.2009.07.097","article-title":"American Association of Oral and Maxillofacial Surgeons position paper: Bisphosphonate-Related Osteonecrosis of the Jaws-2009 update: The need to refine the BRONJ definition","volume":"67","author":"Colella","year":"2009","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1002\/jbmr.2525","article-title":"Comments on \u201cdiagnosis and management of osteonecrosis of the jaw: A systematic review and international consensus\u201d","volume":"30","author":"Otto","year":"2015","journal-title":"J. Bone Miner. Res."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1111\/odi.13160","article-title":"Workshop of European task force on medication-related osteonecrosis of the jaw\u2014Current challenges","volume":"10","author":"Schiodt","year":"2019","journal-title":"Oral Dis."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1200\/JOP.19.00716","article-title":"Reply to Fusco et al","volume":"16","author":"Yarom","year":"2020","journal-title":"JCO Oncol. Pract."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1007\/s00520-018-4501-x","article-title":"Osteonecrosis of the jaw related to non-antiresorptive medications: A systematic review","volume":"27","author":"Kouri","year":"2019","journal-title":"Support. Care Cancer"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/jbmr.2405","article-title":"Diagnosis and management of osteonecrosis of the jaw: A systematic review and international consensus","volume":"30","author":"Khan","year":"2015","journal-title":"J. Bone Miner. Res."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.joms.2006.10.061","article-title":"Nature and frequency of bisphosphonate-associated osteonecrosis of the jaws in Australia","volume":"65","author":"Mavrokokki","year":"2007","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.joms.2013.06.221","article-title":"Osteonecrosis of the jaw in Sweden associated with the oral use of bisphosphonate","volume":"72","author":"Ulmner","year":"2014","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Kizub, D.A., Miao, J., Schubert, M.M., Paterson, A.H.G., Clemons, M., Dees, E.C., Ingle, J.N., Falkson, C.I., Barlow, W.E., and Hortobagyi, G.N. (2020). Risk factors for bisphosphonate-associated osteonecrosis of the jaw in the prospective randomized trial of adjuvant bisphosphonates for early-stage breast cancer (SWOG 0307). Support Care Cancer.","DOI":"10.1007\/s00520-020-05748-8"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1007\/s00198-019-05002-w","article-title":"Fracture risk following intermission of osteoporosis therapy","volume":"30","author":"Dennison","year":"2019","journal-title":"Osteoporos. Int."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1002\/jbmr.3337","article-title":"Vertebral fractures after discontinuation of denosumab: A post hoc analysis of the randomized placebo-controlled FREEDOM trial and its extension","volume":"33","author":"Cummings","year":"2018","journal-title":"J. Bone Miner. Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"115287","DOI":"10.1016\/j.bone.2020.115287","article-title":"Favorable skeletal benefit\/risk of long-term denosumab therapy: A virtual-twin analysis of fractures prevented relative to skeletal safety events observed","volume":"134","author":"Ferrari","year":"2020","journal-title":"Bone"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"e03795","DOI":"10.1016\/j.heliyon.2020.e03795","article-title":"Efficacy of a high-dose antiresorptive drug holiday to reduce the risk of medication-related osteonecrosis of the jaw (MRONJ): A systematic review","volume":"6","author":"Ottesen","year":"2020","journal-title":"Heliyon"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00774-020-01089-y","article-title":"Incidence and risk of antiresorptive agent-related osteonecrosis of the jaw (ARONJ) after tooth extraction in patients with autoimmune disease","volume":"38","author":"Fujieda","year":"2020","journal-title":"J. Bone Miner. Metab."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1590\/1516-3180.2019.0352.r2.15052020","article-title":"Clinical profile of individuals with bisphosphonate-related osteonecrosis of the jaw: An integrative review","volume":"138","author":"Maciel","year":"2020","journal-title":"Sao Paulo Med. J."},{"key":"ref_17","first-page":"364","article-title":"Pharmacogenetics of bisphosphonate-associated osteonecrosis of the jaw","volume":"3","author":"Marini","year":"2011","journal-title":"Front. Biosci. (Elite Ed.)"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"2709","DOI":"10.1182\/blood-2008-04-147884","article-title":"Bisphosphonate-related osteonecrosis of the jaw is associated with polymorphisms of the cytochrome P450 CYP2C8 in multiple myeloma: A genome-wide single nucleotide polymorphism analysis","volume":"112","author":"Sarasquete","year":"2008","journal-title":"Blood"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1002\/jbmr.3285","article-title":"SIRT1\/HERC4 locus associated with bisphosphonate-induced osteonecrosis of the jaw: An exome-wide association analysis","volume":"33","author":"Yang","year":"2018","journal-title":"J. Bone Miner. Res."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Yang, G., Collins, J.M., Rafiee, R., Singh, S., Langaee, T., McDonough, C.W., Holliday, L.S., Wang, D., Lamba, J.K., and Kim, Y.S. (2020). SIRT1 Gene SNP rs932658 Is Associated With Medication-Related Osteonecrosis of the Jaw. J. Bone Miner. Res.","DOI":"10.1002\/jbmr.4185"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.joms.2009.01.007","article-title":"The pathogenesis of bisphosphonate-related osteonecrosis of the jaw: So many hypotheses, so few data","volume":"67","author":"Allen","year":"2009","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"20190132","DOI":"10.1259\/dmfr.20190132","article-title":"Antiresorptive drug-related changes of the mandibular bone densitiy in medication-related osteonecrosis of the jaw patients","volume":"48","author":"Heim","year":"2019","journal-title":"Dentomaxillofac. Radiol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"4925","DOI":"10.3390\/ijms20194925","article-title":"From osteoclast differentiation to osteonecrosis of the jaw: Molecular and clinical insights","volume":"20","author":"Anesi","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.3390\/ijms20061467","article-title":"Zoledronate enhances osteocyte-mediated osteoclast differentiation by IL-6\/RANKL axis","volume":"20","author":"Kim","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"ref_25","first-page":"115","article-title":"Bisphosphonate-related osteonecrosis of the jaw: Current clinical significance and treatment strategy review","volume":"33","author":"Kim","year":"2020","journal-title":"Am. J. Dent."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"121","DOI":"10.2147\/DHPS.S6285","article-title":"Safety and tolerability of zoledronic acid and other bisphosphonates in osteoporosis management","volume":"2","author":"Carbonare","year":"2010","journal-title":"Drug Healthc. Patient Saf."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.3390\/ijms18061261","article-title":"Enhanced osteogenic differentiation in zoledronate-treated osteoporotic patients","volume":"18","author":"Carbonare","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.bone.2008.09.012","article-title":"Osteonecrosis of the jaw\u2014Who gets it, and why?","volume":"44","author":"Reid","year":"2009","journal-title":"Bone"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.4065\/83.9.1032","article-title":"Bisphosphonates: Mechanism of action and role in clinical practice","volume":"83","author":"Drake","year":"2008","journal-title":"Mayo Clin. Proc."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2013\/215034","article-title":"Oral bisphosphonate related osteonecrosis of the jaw: A challenging adverse effect","volume":"2013","author":"Benlidayi","year":"2013","journal-title":"ISRN Rheumatol."},{"key":"ref_31","first-page":"254","article-title":"Bisphosphonate-related osteonecrosis of the jaw: Specificities","volume":"8","author":"Paulo","year":"2014","journal-title":"Oncol. Rev."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1097\/BOR.0b013e32832ca41c","article-title":"Denosumab update","volume":"21","author":"Lewiecki","year":"2009","journal-title":"Curr. Opin. Rheumatol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1177\/1759720X09343221","article-title":"Denosumab in postmenopausal osteoporosis: What the clinician needs to know","volume":"1","author":"Lewiecki","year":"2009","journal-title":"Ther. Adv. Musculoskelet. Dis."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1200\/JCO.2008.19.2146","article-title":"Randomized phase II trial of denosumab in patients with bone metastases from prostate cancer, breast cancer, or other neoplasms after intravenous bisphosphonates","volume":"27","author":"Fizazi","year":"2009","journal-title":"J. Clin. Oncol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/j.joms.2009.10.010","article-title":"Osteonecrosis of the jaw in a patient on Denosumab","volume":"68","author":"Aghaloo","year":"2010","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_36","first-page":"e1","article-title":"Denosumab related osteonecrosis of jaw: A case report","volume":"9","author":"Lima","year":"2018","journal-title":"J. Oral Maxillofac. Res."},{"key":"ref_37","first-page":"358","article-title":"Animal models of osteonecrosis of the jaw","volume":"7","author":"Allen","year":"2007","journal-title":"J. Musculoskelet. Neuronal Interact."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1111\/j.1747-4477.2009.00213.x","article-title":"American Association of Oral and Maxillofacial Surgeons position paper on bisphosphonate-related osteonecrosis of the jaw\u20142009 update","volume":"35","author":"Ruggiero","year":"2009","journal-title":"Aust. Endod. J."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1359\/jbmr.0707onj","article-title":"Bisphosphonate-associated osteonecrosis of the jaw: Report of a task force of the American Society for Bone and Mineral Research","volume":"22","author":"Khosla","year":"2007","journal-title":"J. Bone Miner. Res."},{"key":"ref_40","unstructured":"Garetto, L.P., Turner, C.H., Duncan, R.L., and Burr, D.B. (1998, January 13\u201316). Remodeling of bone surrounding the implant interface. Bridging the Gap between Dental and Orthopaedic Implants, Proceedings of the 3rd Annual Indiana Conference, Indianapolis, IN, USA."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1002\/ar.a.20396","article-title":"Remodeling dynamics in the alveolar process in skeletally mature dogs","volume":"288","author":"Huja","year":"2006","journal-title":"Anat. Rec. A Discov. Mol. Cell. Evol. Biol."},{"key":"ref_42","first-page":"1053","article-title":"Osteonecrosis of the jaw in cancer patients receiving IV bisphosphonates","volume":"20","author":"Estilo","year":"2006","journal-title":"Oncology"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.tripleo.2006.06.004","article-title":"Bisphosphonate-related osteonecrosis of the jaw: Background and guidelines for diagnosis, staging and management","volume":"102","author":"Ruggiero","year":"2006","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"2150","DOI":"10.1359\/JBMR.050819","article-title":"Genetic background influences cortical bone response to ovariectomy","volume":"20","author":"Li","year":"2005","journal-title":"J. Bone Miner. Res."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"4277","DOI":"10.1177\/0300060518788987","article-title":"Pathogenesis of medication-related osteonecrosis of the jaw: A comparative study of in vivo and in vitro trials","volume":"46","author":"Holtmann","year":"2018","journal-title":"J. Int. Med. Res."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1111\/j.1600-0714.2012.01140.x","article-title":"Comparison of effects of clodronate and zoledronic acid on the repair of maxilla surgical wounds\u2013histomorphometric, receptor activator of nuclear factor-kB ligand, osteoprotegerin, von Willebrand factor, and caspase-3 evaluation","volume":"41","author":"Vasconcelos","year":"2012","journal-title":"J. Oral Pathol. Med."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1007\/s00784-014-1347-6","article-title":"Periosteal microcirculatory reactions in a zoledronate-induced osteonecrosis model of the jaw in rats","volume":"19","author":"Janovszky","year":"2015","journal-title":"Clin. Oral Investig."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1177\/0022034512472335","article-title":"Effect of local vs. systemic bisphosphonate delivery on dental implant fixation in a model of osteonecrosis of the jaw","volume":"92","author":"Abtahi","year":"2013","journal-title":"J. Dent. Res."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.oraloncology.2008.04.013","article-title":"Bony changes in the jaws of rats treated with zoledronic acid and dexamethasone before dental extractions mimic bisphosphonate-related osteonecrosis in cancer patients","volume":"45","author":"Sonis","year":"2009","journal-title":"Oral Oncol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1016\/j.joen.2016.07.020","article-title":"Preexisting periapical inflammatory condition exacerbates tooth extraction\u2013induced bisphosphonate-related osteonecrosis of the jaw lesions in mice","volume":"42","author":"Song","year":"2016","journal-title":"J. Endod."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.bone.2013.05.013","article-title":"Chemotherapeutic and antiresorptive combination therapy suppressed lymphangiogenesis and induced osteonecrosis of the jaw-like lesions in mice","volume":"56","author":"Kuroshima","year":"2013","journal-title":"Bone"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1002\/jbmr.2097","article-title":"RANKL inhibitors induce osteonecrosis of the jaw in mice with periapical disease","volume":"29","author":"Aghaloo","year":"2014","journal-title":"J. Bone Miner. Res."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/j.bone.2012.04.020","article-title":"Bisphosphonate related osteonecrosis of the jaw: A minipig large animal model","volume":"51","author":"Pautke","year":"2012","journal-title":"Bone"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.1089\/scd.2012.0615","article-title":"Allogeneic mesenchymal stem cell therapy for bisphosphonate-related jaw osteonecrosis in swine","volume":"22","author":"Li","year":"2013","journal-title":"Stem Cells Dev."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s00784-015-1468-6","article-title":"Zoledronate induces bisphosphonate-related osteonecrosis of the jaw in osteopenic sheep","volume":"20","author":"Voss","year":"2016","journal-title":"Clin. Oral Investig."},{"key":"ref_56","first-page":"796","article-title":"Prevalence and clinical characteristics of X-linked hypophosphatemia in Paran\u00e1, southern Brazil","volume":"64","author":"Moreira","year":"2020","journal-title":"Arch. Endocrinol. Metab."},{"key":"ref_57","first-page":"399","article-title":"Hypophosphataemic rickets\/osteomalacia: A descriptive analysis","volume":"131","author":"Bhadada","year":"2010","journal-title":"Indian J. Med Res."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Laurent, M.R., Bravenboer, N., van Schoor, N.M., Bouillon, R., Pettifor, J.M., and Lips, P. (2018). Rickets and osteomalacia. Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, John Wiley & Sons.","DOI":"10.1002\/9781119266594.ch89"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.bone.2013.01.046","article-title":"Osteocyte regulation of phosphate homeostasis and bone mineralization underlies the pathophysiology of the heritable disorders of rickets and osteomalacia","volume":"54","author":"Feng","year":"2013","journal-title":"Bone"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"2798","DOI":"10.1002\/jbmr.487","article-title":"Mutations in SERPINF1 cause osteogenesis imperfecta type VI","volume":"26","author":"Homan","year":"2011","journal-title":"J. Bone Miner. Res."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1056\/NEJM197109302851403","article-title":"Fibrogenesis imperfecta ossium: A collagen defect causing osteomalacia","volume":"285","author":"Frame","year":"1971","journal-title":"N. Engl. J. Med."},{"key":"ref_62","first-page":"8","article-title":"Osteomalacia in Hazara District, Pakistan","volume":"35","author":"Herm","year":"2005","journal-title":"Trop. Dr."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/S0140-6736(84)90553-1","article-title":"How common is osteomalacia in the elderly?","volume":"324","author":"Campbell","year":"1984","journal-title":"Lancet"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1210\/edrv.22.4.0437","article-title":"Vitamin D deficiency and secondary hyperparathyroidism in the elderly: Consequences for bone loss and fractures and therapeutic implications","volume":"22","author":"Lips","year":"2001","journal-title":"Endocr. Rev."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1359\/jbmr.090728","article-title":"Bone mineralization defects and vitamin D deficiency: Histomorphometric analysis of iliac crest bone biopsies and circulating 25-hydroxyvitamin D in 675 patients","volume":"25","author":"Priemel","year":"2010","journal-title":"J. Bone Miner. Res."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s11657-011-0059-7","article-title":"Bone pain and extremely low bone mineral density due to severe vitamin D deficiency in celiac disease","volume":"6","author":"Rabelink","year":"2011","journal-title":"Arch. Osteoporos."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/8756-3282(85)90003-1","article-title":"Metabolic bone disease with and without osteomalacia after intestinal bypass surgery: A bone histomorphometric study","volume":"6","author":"Parfitt","year":"1985","journal-title":"Bone"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1136\/gut.32.11.1303","article-title":"Osteopenia and osteomalacia after gastrectomy: Interrelations between biochemical markers of bone remodelling, vitamin D metabolites, and bone histomorphometry","volume":"32","author":"Bisballe","year":"1991","journal-title":"Gut"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"181","DOI":"10.3892\/etm.2011.205","article-title":"Prevalence of serum vitamin D deficiency and insufficiency in cancer: Review of the epidemiological literature","volume":"2","author":"Gupta","year":"2011","journal-title":"Exp. Ther. Med."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.maturitas.2010.03.012","article-title":"Vitamin D deficiency and bone mineral density in postmenopausal women receiving aromatase inhibitors for early breast cancer","volume":"66","author":"Servitja","year":"2010","journal-title":"Maturitas"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1158\/1055-9965.EPI-09-0774","article-title":"Serum vitamin D and breast density in breast cancer survivors","volume":"19","author":"Neuhouser","year":"2010","journal-title":"Cancer Epidemiol. Prev. Biomark."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"2151","DOI":"10.1200\/JCO.2008.19.6162","article-title":"High prevalence of vitamin D deficiency despite supplementation in premenopausal women with breast cancer undergoing adjuvant chemotherapy","volume":"27","author":"Crew","year":"2009","journal-title":"J. Clin. Oncol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4076\/1757-1626-2-8390","article-title":"Triple negative breast cancer patients presenting with low serum vitamin D levels: A case series","volume":"2","author":"Rainville","year":"2009","journal-title":"Cases J."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1093\/ajcn\/88.1.133","article-title":"Vitamin D insufficiency in a multiethnic cohort of breast cancer survivors","volume":"88","author":"Neuhouser","year":"2008","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/s00384-008-0593-y","article-title":"Chemotherapy is linked to severe vitamin D deficiency in patients with colorectal cancer","volume":"24","author":"Fakih","year":"2009","journal-title":"Int. J. Colorectal Dis."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1111\/j.1464-410X.2009.08531.x","article-title":"Vitamin D deficiency and insufficiency among patients with prostate cancer","volume":"104","author":"Trump","year":"2009","journal-title":"BJU Int."},{"key":"ref_77","first-page":"6281","article-title":"Prevalence of vitamin D deficiency in patients with bone metastases and multiple myeloma","volume":"35","author":"Maier","year":"2015","journal-title":"Anticancer Res."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"45","DOI":"10.3390\/medicina54030045","article-title":"The relationship between vitamin D and periodontal pathology","volume":"54","year":"2018","journal-title":"Medicina"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1177\/0022034513495239","article-title":"Vitamin D and periodontal health in older men","volume":"92","author":"Alshouibi","year":"2013","journal-title":"J. Dent. Res."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1111\/odi.13360","article-title":"The association between serum 25-hydroxyvitamin D levels and dental caries in US adults","volume":"26","author":"Zhou","year":"2020","journal-title":"Oral Dis."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12903-018-0505-7","article-title":"A cross-sectional study on the association between vitamin D levels and caries in the permanent dentition of Korean children","volume":"18","author":"Kim","year":"2018","journal-title":"BMC Oral Health"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"199","DOI":"10.5005\/jp-journals-10005-1511","article-title":"Comparison of vitamin D level of children with severe early childhood caries and children with no caries","volume":"11","author":"Chhonkar","year":"2018","journal-title":"Int. J. Clin. Pediatric Dent."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"e40","DOI":"10.1093\/pch\/pxx150","article-title":"Combined deficiencies of 25-hydroxyvitamin D and anemia in preschool children with severe early childhood caries: A case\u2013control study","volume":"23","author":"Deane","year":"2018","journal-title":"Paediatr. Child Health"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1002\/jbmr.3395","article-title":"Evaluation of a multimodal, direct-to-patient educational intervention targeting barriers to osteoporosis care: A randomized clinical trial","volume":"33","author":"Danila","year":"2018","journal-title":"J. Bone Miner. Res."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"2068","DOI":"10.1016\/j.jcms.2017.09.015","article-title":"Vitamin D (25-OHD) deficiency may increase the prevalence of medication-related osteonecrosis of the jaw","volume":"45","author":"Heim","year":"2017","journal-title":"J. Cranio-Maxillofac. Surg."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"154","DOI":"10.4103\/njcp.njcp_374_19","article-title":"Changes in serological bone turnover markers in bisphosphonate induced osteonecrosis of the jaws: A case control study","volume":"23","author":"Demircan","year":"2020","journal-title":"Niger. J. Clin. Pract."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1634\/theoncologist.2012-0141","article-title":"Osteomalacia: The missing link in the pathogenesis of bisphosphonate-related osteonecrosis of the jaws?","volume":"17","author":"Bedogni","year":"2012","journal-title":"Oncologist"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1016\/S0140-6736(94)92446-5","article-title":"Mineralisation defects after pamidronate for Paget\u2019s disease","volume":"343","author":"Boyce","year":"1994","journal-title":"Lancet"},{"key":"ref_89","first-page":"CD013020","article-title":"Bisphosphonates or RANK-ligand-inhibitors for men with prostate cancer and bone metastases: A network meta-analysis","volume":"12","author":"Jakob","year":"2020","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1248\/yakushi.19-00125","article-title":"Basic Studies on the Mechanism, Prevention, and Treatment of Osteonecrosis of the Jaw Induced by Bisphosphonates","volume":"140","author":"Endo","year":"2020","journal-title":"Yakugaku zasshi: J. Pharm. Soc. Japan"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"503","DOI":"10.3390\/antiox9060503","article-title":"Structure-Dependent Effects of Bisphosphonates on Inflammatory Responses in Cultured Neonatal Mouse Calvaria","volume":"9","author":"Suzuki","year":"2020","journal-title":"Antioxidants"},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"D\u2019Andrea, S., Martorella, A., Coccia, F., Castellini, C., Minaldi, E., Totaro, M., Parisi, A., Francavilla, F., and Barbonetti, A. (2020). Relationship of Vitamin D status with testosterone levels: A systematic review and meta-analysis. Endocrine.","DOI":"10.1007\/s12020-020-02482-3"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1681\/ASN.V1161093","article-title":"High prevalence of low bone turnover and occurrence of osteomalacia after kidney transplantation","volume":"11","author":"Mawad","year":"2000","journal-title":"J. Am. Soc. Nephrol."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/13\/2\/561\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T05:21:37Z","timestamp":1760160097000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/13\/2\/561"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,8]]},"references-count":93,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2021,2]]}},"alternative-id":["nu13020561"],"URL":"https:\/\/doi.org\/10.3390\/nu13020561","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,8]]}}}