{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T02:04:31Z","timestamp":1792029871047,"version":"4.4.0"},"reference-count":42,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2021,2,22]],"date-time":"2021-02-22T00:00:00Z","timestamp":1613952000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003549","name":"Hungarian Scientific Research Fund","doi-asserted-by":"publisher","award":["116954"],"award-info":[{"award-number":["116954"]}],"id":[{"id":"10.13039\/501100003549","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Semmelweis Science and Innovation Fund","award":["STIA-KF-17"],"award-info":[{"award-number":["STIA-KF-17"]}]},{"name":"Hungarian Hypertension Society","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]},{"DOI":"10.13039\/501100002332","name":"Semmelweis University","doi-asserted-by":"publisher","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}],"id":[{"id":"10.13039\/501100002332","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Vitamin D deficiency shows positive correlation to cardiovascular risk, which might be influenced by gender specific features. Our goal was to examine the effect of Vitamin D supplementation and Vitamin D deficiency in male and female rats on an important hypertension target organ, the renal artery. Female and male Wistar rats were fed with Vitamin D reduced chow for eight weeks to induce hypovitaminosis. Another group of animals received normal chow with further supplementation to reach optimal serum vitamin levels. Isolated renal arteries of Vitamin D deficient female rats showed increased phenylephrine-induced contraction. In all experimental groups, both indomethacin and selective cyclooxygenase-2 inhibition (NS398) decreased the phenylephrine-induced contraction. Angiotensin II-induced contraction was pronounced in Vitamin D supplemented males. In both Vitamin D deficient groups, acetylcholine-induced relaxation was impaired. In the female Vitamin D supplemented group NS398, in males the indomethacin caused reduced acetylcholine-induced relaxation. Increased elastic fiber density was observed in Vitamin D deficient females. The intensity of eNOS immunostaining was decreased in Vitamin D deficient females. The density of AT1R staining was the highest in the male Vitamin D deficient group. Although Vitamin D deficiency induced renal vascular dysfunction in both sexes, female rats developed more extensive impairment that was accompanied by enzymatic and structural changes.<\/jats:p>","DOI":"10.3390\/nu13020704","type":"journal-article","created":{"date-parts":[[2021,2,22]],"date-time":"2021-02-22T20:42:51Z","timestamp":1614026571000},"page":"704","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Vitamin D Deficiency Cause Gender Specific Alterations of Renal Arterial Function in a Rodent Model"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-0827-6689","authenticated-orcid":false,"given":"Mikl\u00f3s","family":"Sipos","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine, Semmelweis University, \u00dcll\u0151i Street 78\/a, 1083 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Borb\u00e1la","family":"P\u00e9terffy","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine, Semmelweis University, T\u0171zolt\u00f3 Street 37-47, 1094 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9170-4331","authenticated-orcid":false,"given":"R\u00e9ka Eszter","family":"Sziva","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine, Semmelweis University, \u00dcll\u0151i Street 78\/a, 1083 Budapest, Hungary"},{"name":"Department of Physiology, Faculty of Medicine, Semmelweis University, T\u0171zolt\u00f3 Street 37-47, 1094 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e9ter","family":"Magyar","sequence":"additional","affiliation":[{"name":"Medical Imaging Centre, Faculty of Medicine, Semmelweis University, \u00dcll\u0151i Street 78\/a, 1083 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leila","family":"Hadjadj","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine, Faculty of Medicine, Semmelweis University, T\u0171zolt\u00f3 Street 37-47, 1094 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5531-0661","authenticated-orcid":false,"given":"B\u00e1lint","family":"B\u00e1nyai","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine, Semmelweis University, T\u0171zolt\u00f3 Street 37-47, 1094 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"S\u00fcli","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine, Semmelweis University, \u00dcll\u0151i Street 78\/a, 1083 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eszter","family":"Solt\u00e9sz-Katona","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine, Semmelweis University, T\u0171zolt\u00f3 Street 37-47, 1094 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u00f3ra","family":"Gerszi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine, Semmelweis University, \u00dcll\u0151i Street 78\/a, 1083 Budapest, Hungary"},{"name":"Department of Physiology, Faculty of Medicine, Semmelweis University, T\u0171zolt\u00f3 Street 37-47, 1094 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judit","family":"Kiss","sequence":"additional","affiliation":[{"name":"Department of Morphology and Physiology, Faculty of Health Sciences, Semmelweis University, Vas Street 17, 1088 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6967-1158","authenticated-orcid":false,"given":"M\u00e1ria","family":"Szekeres","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine, Semmelweis University, T\u0171zolt\u00f3 Street 37-47, 1094 Budapest, Hungary"},{"name":"Department of Morphology and Physiology, Faculty of Health Sciences, Semmelweis University, Vas Street 17, 1088 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2057-2391","authenticated-orcid":false,"given":"Gy\u00f6rgy L.","family":"N\u00e1dasy","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine, Semmelweis University, T\u0171zolt\u00f3 Street 37-47, 1094 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eszter M\u00e1ria","family":"Horv\u00e1th","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine, Semmelweis University, T\u0171zolt\u00f3 Street 37-47, 1094 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7109-6906","authenticated-orcid":false,"given":"Szabolcs","family":"V\u00e1rb\u00edr\u00f3","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine, Semmelweis University, \u00dcll\u0151i Street 78\/a, 1083 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,2,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"g2035","DOI":"10.1136\/bmj.g2035","article-title":"Vitamin D and multiple health outcomes: Umbrella review of systematic reviews and meta-analyses of observational studies and randomised 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Tissue Int."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/13\/2\/704\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T05:28:11Z","timestamp":1760160491000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/13\/2\/704"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,22]]},"references-count":42,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2021,2]]}},"alternative-id":["nu13020704"],"URL":"https:\/\/doi.org\/10.3390\/nu13020704","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,22]]}}}