{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T23:46:20Z","timestamp":1790207180324,"version":"4.1.0"},"reference-count":154,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2021,2,26]],"date-time":"2021-02-26T00:00:00Z","timestamp":1614297600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>High-dose intravenously administered vitamin C (IVC) is widely used in cancer patients by complementary and alternative medicine practitioners. The most frequent indications for IVC therapy result from the belief in its effectiveness as a potent anti-cancer agent which additionally enhances chemosensitivity of cancer cells and reduces chemotherapy-related toxicities and fatigue intensity. In this narrative review, we decided to deal with this issue, trying to answer the question whether there is any scientific evidence supporting the rationale for application of high-dose IVC therapy in advanced-stage cancer patients. Although results obtained from preclinical studies demonstrated that millimolar ascorbate plasma concentrations achievable only after IVC administration were cytotoxic to fast-growing malignant cells and inhibited tumor growth as well as prolonged the survival of laboratory animals, such positive effects were not found in human studies with advanced-stage cancer patients. We also have not found the rationale for the use of IVC to increase the effectiveness of chemotherapy and to reduce the chemotherapy-induced toxicity in the above mentioned group. Nevertheless, in palliative care, high-dose IVC might be considered as a therapy improving the quality of life and reducing cancer-related symptoms, such as fatigue and bone pain. However, because of the absence of placebo-controlled randomized trials on IVC efficacy in advanced-stage cancer patients, the placebo effect cannot be excluded.<\/jats:p>","DOI":"10.3390\/nu13030735","type":"journal-article","created":{"date-parts":[[2021,2,26]],"date-time":"2021-02-26T04:36:24Z","timestamp":1614314184000},"page":"735","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["High-Dose Vitamin C in Advanced-Stage Cancer Patients"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4501-736X","authenticated-orcid":false,"given":"Anna","family":"Zasowska-Nowak","sequence":"first","affiliation":[{"name":"Department of Palliative Medicine, Chair of Oncology, Medical University of Lodz, Ul. Zeromskiego 113, 90-549 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8876-0682","authenticated-orcid":false,"given":"Piotr Jan","family":"Nowak","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Hypertension and Kidney Transplantation, Medical University of Lodz, Ul. Pomorska 251, 92-213 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Cia\u0142kowska-Rysz","sequence":"additional","affiliation":[{"name":"Department of Palliative Medicine, Chair of Oncology, Medical University of Lodz, Ul. Zeromskiego 113, 90-549 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,2,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"533","DOI":"10.7326\/0003-4819-140-7-200404060-00010","article-title":"Vitamin C Pharmacokinetics: Implications for Oral and Intravenous Use","volume":"140","author":"Padayatty","year":"2004","journal-title":"Ann. Intern. Med."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Padayatty, S.J., Sun, A.Y., Chen, Q., Espey, M.G., Drisko, J., and Levine, M. (2010). Vitamin C: Intravenous Use by Complementary and Alternative Medicine Practitioners and Adverse Effects. PLoS ONE, 5.","DOI":"10.1371\/journal.pone.0011414"},{"key":"ref_3","first-page":"313","article-title":"Cancer: The preconditioning factor in pathogenesis; a new etiologic approach","volume":"71","author":"McCormick","year":"1954","journal-title":"Arch. Pediatr."},{"key":"ref_4","first-page":"166","article-title":"Cancer: A collagen disease, secondary to a nutritional deficiency","volume":"76","author":"McCormick","year":"1959","journal-title":"Arch. Pediatr."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1159\/000224733","article-title":"Ascorbic Acid and the Glycosaminoglycans","volume":"27","author":"Cameron","year":"1973","journal-title":"Oncology"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/0009-2797(74)90018-0","article-title":"The orthomolecular treatment of cancer I. The role of ascorbic acid in host resistance","volume":"9","author":"Cameron","year":"1974","journal-title":"Chem. Biol. Interact."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/0009-2797(74)90019-2","article-title":"The orthomolecular treatment of cancer II. Clinical trial of high-dose ascorbic acid supplements in advanced human cancer","volume":"9","author":"Cameron","year":"1974","journal-title":"Chem. Biol. Interact."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"3685","DOI":"10.1073\/pnas.73.10.3685","article-title":"Supplemental ascorbate in the supportive treatment of cancer: Prolongation of survival times in terminal human cancer","volume":"73","author":"Cameron","year":"1976","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_9","first-page":"103","article-title":"Prolongation of survival times of terminal cancer patients by administration of large doses of ascorbate","volume":"23","author":"Murata","year":"1982","journal-title":"Int. J. Vitam. Nutr. Res. Suppl."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1056\/NEJM197909273011303","article-title":"Failure of High-Dose Vitamin C (Ascorbic Acid) Therapy to Benefit Patients with Advanced Cancer","volume":"301","author":"Creagan","year":"1979","journal-title":"N. Engl. J. Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1056\/NEJM198501173120301","article-title":"High-Dose Vitamin C versus Placebo in the Treatment of Patients with Advanced Cancer Who Have Had No Prior Chemotherapy","volume":"312","author":"Moertel","year":"1985","journal-title":"N. Engl. J. Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1023\/A:1012186203165","article-title":"Pharmacokinetic model of ascorbic acid in healthy male volunteers during depletion and repletion","volume":"14","author":"Graumlich","year":"1997","journal-title":"Pharm. Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1080\/07315724.2000.10718941","article-title":"Reevaluation of Ascorbate in Cancer Treatment: Emerging Evidence, Open Minds and Serendipity","volume":"19","author":"Padayatty","year":"2000","journal-title":"J. Am. Coll. Nutr."},{"key":"ref_14","first-page":"475","article-title":"Cytotoxic effect of ascorbate and its derivatives on cultured malignant and nonmalignant cell lines","volume":"13","author":"Leung","year":"1993","journal-title":"Anticancer Res."},{"key":"ref_15","first-page":"629","article-title":"Vitamin C preferential toxicity for malignant melanoma cells","volume":"11","author":"Bram","year":"1980","journal-title":"Chem. Informationsd."},{"key":"ref_16","first-page":"3125","article-title":"Induction of cell death by ascorbic acid derivatives in human renal carcinoma and glioblastoma cell lines","volume":"19","author":"Makino","year":"1999","journal-title":"Anticancer Res."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1002\/(SICI)1097-0045(19970801)32:3<188::AID-PROS5>3.0.CO;2-H","article-title":"Effect of vitamin C on prostate cancer cells in vitro: Effect on cell number, viability, and DNA synthesis","volume":"32","author":"Maramag","year":"1997","journal-title":"Prostate"},{"key":"ref_18","first-page":"2635","article-title":"Relationship between ascorbyl radical intensity and apoptosis-inducing activity","volume":"16","author":"Sakagami","year":"1996","journal-title":"Anticancer Res."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1503\/cmaj.050346","article-title":"Intravenously administered vitamin C as cancer therapy: Three cases","volume":"174","author":"Padayatty","year":"2006","journal-title":"Can. Med. Assoc. J."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1177\/1534735414534463","article-title":"Intravenous Vitamin C and Cancer","volume":"13","author":"Fritz","year":"2014","journal-title":"Integr. Cancer Ther."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/0009-2797(75)90007-1","article-title":"The orthomolecular treatment of cancer. III. Reticulum cell sarcoma: Double complete regression induced by high-dose ascorbic acid therapy","volume":"11","author":"Cameron","year":"1975","journal-title":"Chem. Biol. Interactico-Biol. Interact."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"4538","DOI":"10.1073\/pnas.75.9.4538","article-title":"Supplemental ascorbate in the supportive treatment of cancer: Reevaluation of prolongation of survival times in terminal human cancer","volume":"75","author":"Cameron","year":"1978","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"78","DOI":"10.3945\/an.110.000109","article-title":"Vitamin C: A Concentration-Function Approach Yields Pharmacology and Therapeutic Discoveries","volume":"2","author":"Levine","year":"2011","journal-title":"Adv. Nutr."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"3704","DOI":"10.1073\/pnas.93.8.3704","article-title":"Vitamin C pharmacokinetics in healthy volunteers: Evidence for a recommended dietary allowance","volume":"93","author":"Levine","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Carr, A.C., and Cook, J. (2018). Intravenous Vitamin C for Cancer Therapy\u2014Identifying the Current Gaps in Our Knowledge. Front. Physiol., 9.","DOI":"10.3389\/fphys.2018.01182"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Hoffer, L.J., Robitaille, L., Zakarian, R., Melnychuk, D., Kavan, P., Agulnik, J., Cohen, V., Small, D., and Miller, W.H. (2015). High-Dose Intravenous Vitamin C Combined with Cytotoxic Chemotherapy in Patients with Advanced Cancer: A Phase I-II Clinical Trial. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0120228"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"517","DOI":"10.21037\/tau.2017.04.42","article-title":"Weekly ascorbic acid infusion in castration-resistant prostate cancer patients: A single-arm phase II trial","volume":"6","author":"Nielsen","year":"2017","journal-title":"Transl. Androl. Urol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s00280-013-2179-9","article-title":"Phase I clinical trial to evaluate the safety, tolerability, and pharmacokinetics of high-dose intravenous ascorbic acid in patients with advanced cancer","volume":"72","author":"Stephenson","year":"2013","journal-title":"Cancer Chemother. Pharmacol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1093\/annonc\/mdn377","article-title":"Phase I clinical trial of i.v. ascorbic acid in advanced malignancy","volume":"19","author":"Hoffer","year":"2008","journal-title":"Ann. Oncol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1007\/s00280-013-2070-8","article-title":"Pharmacological ascorbate with gemcitabine for the control of metastatic and node-positive pancreatic cancer (PACMAN): Results from a phase I clinical trial","volume":"71","author":"Welsh","year":"2013","journal-title":"Cancer Chemother. Pharmacol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"222ra18","DOI":"10.1126\/scitranslmed.3007154","article-title":"High-Dose Parenteral Ascorbate Enhanced Chemosensitivity of Ovarian Cancer and Reduced Toxicity of Chemotherapy","volume":"6","author":"Ma","year":"2014","journal-title":"Sci. Transl. Med."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Monti, D.A., Mitchell, E., Bazzan, A.J., Littman, S., Zabrecky, G., Yeo, C.J., Pillai, M.V., Newberg, A.B., Deshmukh, S., and Levine, M. (2012). Phase I Evaluation of Intravenous Ascorbic Acid in Combination with Gemcitabine and Erlotinib in Patients with Metastatic Pancreatic Cancer. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0029794"},{"key":"ref_33","unstructured":"Food and Nutrition Board, Institute of Medicine (US): Panel on Dietary Antioxidants and Related Compounds (2000). Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium and Carotenoids, National Academies Press (US)."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Me\u0161\u010di\u0107, M., Gazivoda, K., and Therapeutic, R.-M. (2019). Perspective of Vitamin C and Its Derivatives. Antioxidants, 8.","DOI":"10.3390\/antiox8080247"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fphys.2018.00809","article-title":"Potential Mechanisms of Action for Vitamin C in Cancer: Reviewing the Evidence","volume":"9","author":"Vissers","year":"2018","journal-title":"Front. Physiol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"27986","DOI":"10.1039\/C4RA13315C","article-title":"Free radicals, natural antioxidants, and their reaction mechanisms","volume":"5","author":"Nimse","year":"2015","journal-title":"RSC Adv."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0167-4889(03)00043-0","article-title":"Recycling of vitamin C from its oxidized forms by human endothelial cells","volume":"1640","author":"May","year":"2003","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1161\/01.CIR.94.1.6","article-title":"Antioxidant Vitamin C Improves Endothelial Dysfunction in Chronic Smokers","volume":"94","author":"Heitzer","year":"1996","journal-title":"Circulation"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.atherosclerosis.2014.04.004","article-title":"Effect of vitamin C on endothelial function in health and disease: A systematic review and meta-analysis of randomised controlled trials","volume":"235","author":"Ashor","year":"2014","journal-title":"Atherosclerosis"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1080\/07315724.2001.10719159","article-title":"Plasma-Saturating Intakes of Vitamin C Confer Maximal Antioxidant Protection to Plasma","volume":"20","author":"Johnston","year":"2001","journal-title":"J. Am. Coll. Nutr."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1080\/07315724.2003.10719330","article-title":"Orange Juice Ingestion and Supplemental Vitamin C Are Equally Effective at Reducing Plasma Lipid Peroxidation in Healthy Adult Women","volume":"22","author":"Johnston","year":"2003","journal-title":"J. Am. Coll. Nutr."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.jnutbio.2004.04.007","article-title":"Pulsed electric fields\u2013processed orange juice consumption increases plasma vitamin C and decreases F2-isoprostanes in healthy humans","volume":"15","author":"Cano","year":"2004","journal-title":"J. Nutr. Biochem."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"S\u00e1nchez-Moreno, C., Cano, M.P., De Ancos, B., Plaza, L., Olmedilla, B., Granado, F., and Mart\u00edn, A. (2003). High-pressurized orange juice consumption affects plasma vitamin C, Antioxidative status and inflammatory markers in healthy humans. J. Nutr.","DOI":"10.1093\/jn\/133.7.2204"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Kuiper, H.C., Bruno, R.S., Traber, M.G., and Stevens, J.F. (2011). Vitamin C supplementation lowers urinary levels of 4-hydroperoxy-2-nonenal metabolites in humans. Free Radic. Biol. Med.","DOI":"10.1016\/j.freeradbiomed.2011.01.004"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/S0006-291X(03)01383-4","article-title":"Vitamin C supplementation in normal subjects reduces constitutive ICAM-1 expression","volume":"308","author":"Rayment","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Galasko, D.R., Peskind, E., Clark, C.M., Quinn, J.F., Ringman, J.M., Jicha, G.A., Cotman, C., Cottrell, B., Montine, T.J., and Thomas, R.G. (2012). Antioxidants for Alzheimer Disease. Arch. Neurol., 69.","DOI":"10.1001\/archneurol.2012.85"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1007\/s00394-004-0470-6","article-title":"Vitamin C supplementation decreases oxidative DNA damage in mononuclear blood cells of smokers","volume":"43","author":"Viscovich","year":"2004","journal-title":"Eur. J. Nutr."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1556\/2060.104.2017.2.5","article-title":"Vitamin C attenuates methotrexate-induced oxidative stress in kidney and liver of rats","volume":"104","author":"Savran","year":"2017","journal-title":"Physiol. Int."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1186\/s13148-018-0527-7","article-title":"Vitamin C increases 5-hydroxymethylcytosine level and inhibits the growth of bladder cancer","volume":"10","author":"Peng","year":"2018","journal-title":"Clin. Epigenetics"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1146\/annurev-nutr-071714-034228","article-title":"Regulation of the Epigenome by Vitamin C","volume":"35","author":"Young","year":"2015","journal-title":"Annu. Rev. Nutr."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"139","DOI":"10.3747\/co.25.3790","article-title":"Intravenous vitamin C in the supportive care of cancer patients: A review and rational approach","volume":"25","author":"Klimant","year":"2018","journal-title":"Curr. Oncol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1186\/1479-5876-10-189","article-title":"Effect of high-dose intravenous vitamin C on inflammation in cancer patients","volume":"10","author":"Mikirova","year":"2012","journal-title":"J. Transl. Med."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"14","DOI":"10.12659\/MSM.895368","article-title":"Modulation of cytokines in cancer patients by intravenous ascorbate therapy","volume":"22","author":"Mikirova","year":"2016","journal-title":"Med. Sci. Monit."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Carr, A.C., and Rowe, S. (2020). Factors Affecting Vitamin C Status and Prevalence of Deficiency: A Global Health Perspective. Nutrients, 12.","DOI":"10.3390\/nu12071963"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Rowe, S., and Carr, A.C. (2020). Global vitamin c status and prevalence of deficiency: A cause for concern?. Nutrients, 12.","DOI":"10.3390\/nu12072008"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1191\/0269216305pm970oa","article-title":"Vitamin C deficiency in cancer patients","volume":"19","author":"Mayland","year":"2005","journal-title":"Palliat. Med."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"e587","DOI":"10.1038\/bcj.2017.65","article-title":"Upregulation of TET activity with ascorbic acid induces epigenetic modulation of lymphoma cells","volume":"7","author":"Shenoy","year":"2017","journal-title":"Blood Cancer J."},{"key":"ref_58","first-page":"269","article-title":"A pilot clinical study of continuous intravenous ascorbate in terminal cancer patients","volume":"24","author":"Riordan","year":"2005","journal-title":"P. R. Health Sci. J."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1186\/s13148-019-0739-5","article-title":"Oral vitamin C supplementation to patients with myeloid cancer on azacitidine treatment: Normalization of plasma vitamin C induces epigenetic changes","volume":"11","author":"Gillberg","year":"2019","journal-title":"Clin. Epigenetics"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12011-008-8309-2","article-title":"Evaluation of Oxidative Stress, Antioxidant Status and Serum Vitamin C Levels in Cancer Patients","volume":"130","author":"Mahdavi","year":"2009","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1111\/j.1365-2710.1995.tb00660.x","article-title":"Serum \u03b2\u2013carotene, vitamin E, vitamin C and malondialdehyde levels in several types of cancer","volume":"20","author":"Torun","year":"1995","journal-title":"J. Clin. Pharm. Ther."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1080\/10428190902802323","article-title":"Study of antioxidant levels in patients with multiple myeloma","volume":"50","author":"Sharma","year":"2009","journal-title":"Leuk. Lymphoma"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"3663","DOI":"10.7314\/APJCP.2013.14.6.3663","article-title":"Investigation of the Antioxidant Status in Multiple Myeloma Patients: Effects of Therapy","volume":"14","author":"Mehdi","year":"2013","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"3025","DOI":"10.7314\/APJCP.2012.13.7.3025","article-title":"Serum Levels of Alpha-Tocopherol, Vitamin C, Beta-Carotene, and Retinol in Malignant Pleural Mesothelioma","volume":"13","author":"Emri","year":"2012","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.rinim.2016.01.001","article-title":"Ascorbic acid serum levels are reduced in patients with hematological malignancies","volume":"6","author":"Huijskens","year":"2016","journal-title":"Results Immunol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.1089\/ars.2013.5372","article-title":"Parenteral Ascorbate As a Cancer Therapeutic: A Reassessment Based on Pharmacokinetics","volume":"19","author":"Parrow","year":"2013","journal-title":"Antioxid. Redox Signal."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1292S","DOI":"10.1093\/ajcn\/54.6.1292s","article-title":"Hypovitaminosis C in patients treated with high-dose interleukin 2 and lymphokine-activated killer cells","volume":"54","author":"Marcus","year":"1991","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1023\/A:1008407014084","article-title":"Cisplatin combination chemotherapy induces a fall in plasma antioxidants of cancer patients","volume":"9","author":"Weijl","year":"1998","journal-title":"Ann. Oncol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1093\/ajcn\/72.1.181","article-title":"Plasma antioxidant status after high-dose chemotherapy: A randomized trial of parenteral nutrition in bone marrow transplantation patients","volume":"72","author":"Jonas","year":"2000","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Carr, A.C., Spencer, E., Das, A., Meijer, N., Lauren, C., MacPherson, S., and Chambers, S.T. (2020). Patients Undergoing Myeloablative Chemotherapy and Hematopoietic Stem Cell Transplantation Exhibit Depleted Vitamin C Status in Association with Febrile Neutropenia. Nutrients, 12.","DOI":"10.3390\/nu12061879"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/BF02790109","article-title":"Lipoperoxides as an index of free radical activity in bone marrow transplant recipients","volume":"47","author":"Hunnisett","year":"1995","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.bbmt.2013.12.554","article-title":"Serial Profile of Vitamins and Trace Elements during the Acute Phase of Allogeneic Stem Cell Transplantation","volume":"20","author":"Nannya","year":"2014","journal-title":"Biol. Blood Marrow Transplant."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1017\/S0007114509993229","article-title":"Is vitamin C supplementation beneficial? Lessons learned from randomised controlled trials","volume":"103","author":"Lykkesfeldt","year":"2010","journal-title":"Br. J. Nutr."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1159\/000224465","article-title":"Synergistic Killing of Ehrlich Ascites Carcinoma Cells by Ascorbate and 3-Amino-1,2,4,-triazole","volume":"23","author":"Benade","year":"1969","journal-title":"Oncology"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1097\/01.mco.0000232892.43921.98","article-title":"Oxidative metabolism in cancer growth","volume":"9","author":"Ristow","year":"2006","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1038\/177576a0","article-title":"Differences between the Electrical Charge carried by Normal and Homologous Tumour Cells","volume":"177","author":"Ambrose","year":"1956","journal-title":"Nature"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1007\/BF00402472","article-title":"Effects of ascorbic and dehydroascorbic acid on the multiplication of tumor ascites cells in vitro","volume":"108","author":"Liotti","year":"1984","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"11105","DOI":"10.1073\/pnas.0804226105","article-title":"Pharmacologic doses of ascorbate act as a prooxidant and decrease growth of aggressive tumor xenografts in mice","volume":"105","author":"Chen","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_79","first-page":"145","article-title":"Effects of high dose ascorbate administration on L-10 tumor growth in guinea pigs","volume":"24","author":"Casciari","year":"2005","journal-title":"P. R. Health Sci. J."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1002\/mc.22654","article-title":"Vitamin C at high concentrations induces cytotoxicity in malignant melanoma but promotes tumor growth at low concentrations","volume":"56","author":"Yang","year":"2017","journal-title":"Mol. Carcinog."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.freeradbiomed.2009.02.016","article-title":"Pharmacologic concentrations of ascorbate are achieved by parenteral administration and exhibit antitumoral effects","volume":"47","author":"Verrax","year":"2009","journal-title":"Free Radic. Biol. Med."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1186\/1479-5876-7-70","article-title":"High dose concentration administration of ascorbic acid inhibits tumor growth in BALB\/C mice implanted with sarcoma 180 cancer cells via the restriction of angiogenesis","volume":"7","author":"Yeom","year":"2009","journal-title":"J. Transl. Med."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1158\/1078-0432.CCR-09-1713","article-title":"Mechanisms of Ascorbate-Induced Cytotoxicity in Pancreatic Cancer","volume":"16","author":"Du","year":"2010","journal-title":"Clin. Cancer Res."},{"key":"ref_84","first-page":"249","article-title":"Pharmacological ascorbic acid suppresses syngeneic tumor growth and metastases in hormone-refractory prostate cancer","volume":"24","author":"Pollard","year":"2010","journal-title":"In Vivo"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1080\/01635581.2012.713539","article-title":"Cytotoxicity of Ascorbic Acid in a Human Colorectal Adenocarcinoma Cell Line (WiDr): In Vitro and In Vivo Studies","volume":"64","author":"Mamede","year":"2012","journal-title":"Nutr. Cancer"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"13604","DOI":"10.1073\/pnas.0506390102","article-title":"Pharmacologic ascorbic acid concentrations selectively kill cancer cells: Action as a pro-drug to deliver hydrogen peroxide to tissues","volume":"102","author":"Chen","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.bcp.2003.08.040","article-title":"Cell cycle arrest and autoschizis in a human bladder carcinoma cell line following Vitamin C and Vitamin K3 treatment","volume":"67","author":"Jamison","year":"2004","journal-title":"Biochem. Pharmacol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.1016\/j.freeradbiomed.2006.02.003","article-title":"Ascorbate and H2O2 induced oxidative DNA damage in Jurkat cells","volume":"40","author":"Ravanat","year":"2006","journal-title":"Free Radic. Biol. Med."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"8749","DOI":"10.1073\/pnas.0702854104","article-title":"Ascorbate in pharmacologic concentrations selectively generates ascorbate radical and hydrogen peroxide in extracellular fluid in vivo","volume":"104","author":"Chen","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/s41580-020-0230-3","article-title":"Reactive oxygen species (ROS) as pleiotropic physiological signalling agents","volume":"21","author":"Sies","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1126\/science.aaa5004","article-title":"Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH","volume":"350","author":"Yun","year":"2015","journal-title":"Science"},{"key":"ref_92","first-page":"1764","article-title":"Effect of ascorbate on the activity of hypoxia-inducible factor in cancer cells","volume":"63","author":"Knowles","year":"2003","journal-title":"Cancer Res."},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Kawada, H., Kaneko, M., Sawanobori, M., Uno, T., Matsuzawa, H., Nakamura, Y., Matsushita, H., and Ando, K. (2013). High Concentrations of L-Ascorbic Acid Specifically Inhibit the Growth of Human Leukemic Cells via Downregulation of HIF-1\u03b1 Transcription. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0062717"},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Miles, S.L., Fischer, A.P., Joshi, S.J., and Niles, R.M. (2015). Ascorbic acid and ascorbate-2-phosphate decrease HIF activity and malignant properties of human melanoma cells. BMC Cancer, 15.","DOI":"10.1186\/s12885-015-1878-5"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.freeradbiomed.2014.01.033","article-title":"Intracellular ascorbate enhances hypoxia-inducible factor (HIF)-hydroxylase activity and preferentially suppresses the HIF-1 transcriptional response","volume":"69","author":"Kuiper","year":"2014","journal-title":"Free Radic. Biol. Med."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s13148-015-0087-z","article-title":"Epigenetic reprogramming of melanoma cells by vitamin C treatment","volume":"7","author":"Gustafson","year":"2015","journal-title":"Clin. Epigenetics"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"13669","DOI":"10.1074\/jbc.C113.464800","article-title":"Ascorbate Induces Ten-Eleven Translocation (Tet) Methylcytosine Dioxygenase-mediated Generation of 5-Hydroxymethylcytosine","volume":"288","author":"Minor","year":"2013","journal-title":"J. Biol. Chem."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/nature12362","article-title":"Vitamin C induces Tet-dependent DNA demethylation in ESCs to promote a blastocyst-like state","volume":"500","author":"Blaschke","year":"2013","journal-title":"Nature"},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Belin, S., Kaya, F., Duisit, G., Giacometti, S., Ciccolini, J., and Font\u00e9s, M. (2009). Antiproliferative Effect of Ascorbic Acid Is Associated with the Inhibition of Genes Necessary to Cell Cycle Progression. PLoS ONE, 4.","DOI":"10.1371\/journal.pone.0004409"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.freeradbiomed.2016.08.027","article-title":"Pharmacokinetic and anti-cancer properties of high dose ascorbate in solid tumours of ascorbate-dependent mice","volume":"99","author":"Campbell","year":"2016","journal-title":"Free Radic. Biol. Med."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s10585-018-9876-z","article-title":"Pharmacologic ascorbate (P-AscH\u2212) suppresses hypoxia-inducible Factor-1\u03b1 (HIF-1\u03b1) in pancreatic adenocarcinoma","volume":"35","author":"Wilkes","year":"2018","journal-title":"Clin. Exp. Metastasis"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.pmu.2012.05.008","article-title":"High-dose intravenous vitamin C improves quality of life in cancer patients","volume":"1","author":"Takahashi","year":"2012","journal-title":"Pers. Med. Universe"},{"key":"ref_103","first-page":"111","article-title":"Phase I Clinical Trial of Intravenous L-ascorbic Acid Following Salvage Chemotherapy for Relapsed B-cell non-Hodgkin\u2019s Lymphoma","volume":"39","author":"Kawada","year":"2014","journal-title":"Tokai J. Exp. Clin. Med."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"17188","DOI":"10.1038\/s41598-017-17568-8","article-title":"High Dose Parenteral Ascorbate Inhibited Pancreatic Cancer Growth and Metastasis: Mechanisms and a Phase I\/IIa study","volume":"7","author":"Polireddy","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_105","first-page":"983","article-title":"Intravenous vitamin C administration improves quality of life in breast cancer patients during chemo-\/radiotherapy and aftercare: Results of a retrospective, multicentre, epidemiological cohort study in Germany","volume":"25","author":"Vollbracht","year":"2011","journal-title":"In Vivo"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.ccell.2017.02.018","article-title":"O2\u00b7\u2212 and H2O2-Mediated Disruption of Fe Metabolism Causes the Differential Susceptibility of NSCLC and GBM Cancer Cells to Pharmacological Ascorbate","volume":"31","author":"Schoenfeld","year":"2017","journal-title":"Cancer Cell"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1177\/1534735415622010","article-title":"Effects of High Doses of Vitamin C on Cancer Patients in Singapore: Nine Cases","volume":"15","author":"Raymond","year":"2016","journal-title":"Integr. Cancer Ther."},{"key":"ref_108","first-page":"115","article-title":"Intravenous vitamin C as a chemotherapy agent: A report on clinical cases","volume":"23","author":"Riordan","year":"2004","journal-title":"P. R. Health Sci. J."},{"key":"ref_109","first-page":"3658","article-title":"Feasibility and correlates of arsenic trioxide combined with ascorbic acid-mediated depletion of intracellular glutathione for the treatment of relapsed\/refractory multiple myeloma","volume":"8","author":"Bahlis","year":"2002","journal-title":"Clin. Cancer Res."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1385\/MO:23:2:263","article-title":"Efficacy and Safety Results with the Combination Therapy of Arsenic Trioxide, Dexamethasone, and Ascorbic Acid in Multiple Myeloma Patients: A Phase 2 Trial","volume":"23","author":"Reed","year":"2006","journal-title":"Med. Oncol."},{"key":"ref_111","first-page":"1722","article-title":"Phase II multicenter study of arsenic trioxide, ascorbic acid and dexamethasone in patients with relapsed or refractory multiple myeloma","volume":"91","author":"Wu","year":"2006","journal-title":"Haematologica"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1158\/1078-0432.CCR-06-1812","article-title":"A Phase I\/II Study of Arsenic Trioxide\/Bortezomib\/Ascorbic Acid Combination Therapy for the Treatment of Relapsed or Refractory Multiple Myeloma","volume":"13","author":"Berenson","year":"2007","journal-title":"Clin. Cancer Res."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1191\/0269216306pm1152ed","article-title":"According to the 2002 WHO Definition of Palliative Care","volume":"20","author":"Ventafridda","year":"2006","journal-title":"Palliat. Med."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"622","DOI":"10.7326\/0003-4819-118-8-199304150-00009","article-title":"Measuring Health-Related Quality of Life","volume":"118","author":"Guyatt","year":"1993","journal-title":"Ann. Intern. Med."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1634\/theoncologist.7-2-120","article-title":"The Cancer Patient and Quality of Life","volume":"7","author":"Bottomley","year":"2002","journal-title":"Oncologist"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"263s","DOI":"10.1016\/S0924-9338(97)89095-5","article-title":"Quality of life assessment: The World Health Organization perspective","volume":"12","author":"Saxena","year":"1997","journal-title":"Eur. Psychiatry"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1093\/jnci\/85.5.365","article-title":"The European Organization for Research and Treatment of Cancer QLQ-C30: A quality-of-life instrument for use in international clinical trials in oncology","volume":"85","author":"Aaronson","year":"1993","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"445","DOI":"10.4103\/IJPC.IJPC_82_17","article-title":"Quality of life among cancer patients","volume":"23","author":"Nayak","year":"2017","journal-title":"Indian J. Palliat. Care"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1111\/ecc.12360","article-title":"Spirituality, quality of life, psychological adjustment in terminal cancer patients in hospice","volume":"25","author":"Bovero","year":"2016","journal-title":"Eur. J. Cancer Care"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3346\/jkms.2007.22.1.7","article-title":"Changes of Terminal Cancer Patients\u2019 Health-related Quality of Life after High Dose Vitamin C Administration","volume":"22","author":"Yeom","year":"2007","journal-title":"J. Korean Med. Sci."},{"key":"ref_121","first-page":"66","article-title":"Relief from cancer chemotherapy side effects with pharmacologic vitamin C","volume":"127","author":"Carr","year":"2014","journal-title":"N. Z. Med. J."},{"key":"ref_122","first-page":"84","article-title":"Parenteral vitamin C for palliative care of terminal cancer patients","volume":"127","author":"Carr","year":"2014","journal-title":"N. Z. Med. J."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1080\/01635581.2015.1055366","article-title":"Palliative Vitamin C Application in Patients with Radiotherapy-Resistant Bone Metastases: A Retrospective Study","volume":"67","author":"Kiziltan","year":"2015","journal-title":"Nutr. Cancer"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.annonc.2020.02.016","article-title":"Cancer-related fatigue: ESMO Clinical Practice Guidelines for diagnosis and treatment","volume":"31","author":"Fabi","year":"2020","journal-title":"Ann. Oncol."},{"key":"ref_125","first-page":"161","article-title":"Cancer-related fatigue: Epidemiology, pathogenesis, diagnosis, and treatment","volume":"109","author":"Horneber","year":"2012","journal-title":"Dtsch. Arztebl. Int."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1093\/jncimonographs\/lgh027","article-title":"Evidence Report on the Occurrence, Assessment, and Treatment of Fatigue in Cancer Patients","volume":"32","author":"Lawrence","year":"2004","journal-title":"J. Natl. Cancer Inst. Monogr."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"448","DOI":"10.6004\/jnccn.2008.0036","article-title":"Fatigue is the most important symptom for advanced cancer patients who have had chemotherapy","volume":"6","author":"Butt","year":"2008","journal-title":"JNCCN J. Natl. Compr. Cancer Netw."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/nrclinonc.2014.127","article-title":"Cancer-related fatigue\u2014Mechanisms, risk factors, and treatments","volume":"11","author":"Bower","year":"2014","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1475-2891-11-7","article-title":"Intravenous Vitamin C administration reduces fatigue in office workers: A double-blind randomized controlled trial","volume":"11","author":"Suh","year":"2012","journal-title":"Nutr. J."},{"key":"ref_130","doi-asserted-by":"crossref","unstructured":"Gholami, M., Najafizadeh, H., Teimouri, H., Ardalan, A., Pooria, A., and Tarrahi, M.J. (2019). The combined effect of vitamin C and omega-3 polyunsaturated fatty acids on fatigue following coronary artery bypass graft surgery: A triple-blind clinical trial. J. Complement. Integr. Med., 16.","DOI":"10.1515\/jcim-2018-0113"},{"key":"ref_131","doi-asserted-by":"crossref","unstructured":"Tardy, A.-L., Pouteau, E., Marquez, D., Yilmaz, C., and Scholey, A. (2020). Vitamins and Minerals for Energy, Fatigue and Cognition: A Narrative Review of the Biochemical and Clinical Evidence. Nutrients, 12.","DOI":"10.3390\/nu12010228"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"2543","DOI":"10.1089\/ars.2011.3965","article-title":"Chemotherapy-Induced Weakness and Fatigue in Skeletal Muscle: The Role of Oxidative Stress","volume":"15","author":"Gilliam","year":"2011","journal-title":"Antioxid. Redox Signal."},{"key":"ref_133","doi-asserted-by":"crossref","unstructured":"Carr, A.C., Vissers, M.C.M., and Cook, J.S. (2014). The effect of intravenous vitamin C on cancer- and chemotherapy-related fatigue and quality of life. Front. Oncol., 4.","DOI":"10.3389\/fonc.2014.00283"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/978-94-007-2199-9_6","article-title":"Vitamin C Transport and Its Role in the Central Nervous System","volume":"Volume 56","author":"May","year":"2012","journal-title":"Subcellular Biochemistry"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1016\/j.jpainsymman.2015.12.340","article-title":"Update on Prevalence of Pain in Patients With Cancer: Systematic Review and Meta-Analysis","volume":"51","author":"Hochstenbach","year":"2016","journal-title":"J. Pain Symptom Manag."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/s12967-017-1179-7","article-title":"The role of vitamin C in the treatment of pain: New insights","volume":"15","author":"Carr","year":"2017","journal-title":"J. Transl. Med."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"2527","DOI":"10.1097\/j.pain.0000000000000671","article-title":"Serum vitamin C and spinal pain","volume":"157","author":"Dionne","year":"2016","journal-title":"Pain"},{"key":"ref_138","first-page":"16","article-title":"Ascorbic-acid Treatment for Progressive Bone Metastases After Radiotherapy: A Pilot Study","volume":"20","author":"Kiziltan","year":"2014","journal-title":"Altern. Ther. Health Med."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"442","DOI":"10.4097\/kjae.2013.65.5.442","article-title":"Antiallodynic effects of vitamin C and vitamin E in chronic post-ischemia pain rat model","volume":"65","author":"Park","year":"2013","journal-title":"Korean J. Anesthesiol."},{"key":"ref_140","first-page":"405","article-title":"Influence of vitamin C status on the urinary excretion of catecholamines in stress","volume":"37","author":"Kallner","year":"1983","journal-title":"Hum. Nutr. Clin. Nutr."},{"key":"ref_141","doi-asserted-by":"crossref","unstructured":"Obata, H. (2017). Analgesic Mechanisms of Antidepressants for Neuropathic Pain. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18112483"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1097\/AJP.0b013e318193cf32","article-title":"Plasma Vitamin C Is Lower in Postherpetic Neuralgia Patients and Administration of Vitamin C Reduces Spontaneous Pain but Not Brush-evoked Pain","volume":"25","author":"Chen","year":"2009","journal-title":"Clin. J. Pain"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"677","DOI":"10.5021\/ad.2016.28.6.677","article-title":"A Study of Intravenous Administration of Vitamin C in the Treatment of Acute Herpetic Pain and Postherpetic Neuralgia","volume":"28","author":"Kim","year":"2016","journal-title":"Ann. Dermatol."},{"key":"ref_144","doi-asserted-by":"crossref","unstructured":"Wang, L.-K., Lin, Y.-T., Hung, K.-C., Chang, C.-Y., Wu, Z.-F., Hu, M.-L., and Chen, J.-Y. (2020). Plasma Vitamin C Concentrations Were Negatively Associated with Tingling, Prickling or Pins and Needles Sensation in Patients with Postherpetic Neuralgia. Nutrients, 12.","DOI":"10.3390\/nu12082384"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.lfs.2016.05.035","article-title":"Vitamin C enhances the analgesic effect of gabapentin on rats with neuropathic pain","volume":"157","author":"Li","year":"2016","journal-title":"Life Sci."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.brainresbull.2016.02.004","article-title":"Systemic administration of vitamins C and E attenuates nociception induced by chronic constriction injury of the sciatic nerve in rats","volume":"121","author":"Riffel","year":"2016","journal-title":"Brain Res. Bull."},{"key":"ref_147","doi-asserted-by":"crossref","unstructured":"Lu, R., Kallenborn-Gerhardt, W., Geisslinger, G., and Schmidtko, A. (2011). Additive Antinociceptive Effects of a Combination of Vitamin C and Vitamin E after Peripheral Nerve Injury. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0029240"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1515\/jbcpp-2017-0015","article-title":"Functional interaction between N-methyl-D-aspartate receptor and ascorbic acid during neuropathic pain induced by chronic constriction injury of the sciatic nerve","volume":"28","author":"Saffarpour","year":"2017","journal-title":"J. Basic Clin. Physiol. Pharmacol."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1007\/s00520-016-3472-z","article-title":"An open-label pilot study of oral vitamin C as an opioid-sparing agent in patients with chronic pain secondary to cancer","volume":"25","author":"Pinkerton","year":"2017","journal-title":"Support. Care Cancer"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"810","DOI":"10.7326\/0003-4819-82-6-810_1","article-title":"Ascorbic Acid-Induced Hemolysis in G-6-PD Deficiency","volume":"82","author":"Campbell","year":"1975","journal-title":"Ann. Intern. Med."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1136\/bmj.306.6881.841","article-title":"Acute haemolysis induced by high dose ascorbic acid in glucose-6-phosphate dehydrogenase deficiency","volume":"306","author":"Rees","year":"1993","journal-title":"BMJ"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S0140-6736(94)91195-9","article-title":"Haemolysis induced by ascorbic acid in paroxysmal nocturnal haemoglobinuria","volume":"343","author":"Iwamoto","year":"1994","journal-title":"Lancet"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1001\/archinte.1985.00360050220044","article-title":"Acute Oxalate Nephropathy After Massive Ascorbic Acid Administration","volume":"145","author":"Lawton","year":"1985","journal-title":"Arch. Intern. Med."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1111\/j.1445-5994.1994.tb01477.x","article-title":"Acute oxalate nephropathy after a massive intravenous dose of vitamin C","volume":"24","author":"Wong","year":"1994","journal-title":"Aust. N. Z. J. Med."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/13\/3\/735\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T05:28:57Z","timestamp":1760160537000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/13\/3\/735"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,26]]},"references-count":154,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2021,3]]}},"alternative-id":["nu13030735"],"URL":"https:\/\/doi.org\/10.3390\/nu13030735","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,26]]}}}