{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T20:10:00Z","timestamp":1784923800351,"version":"3.55.0"},"reference-count":33,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background: non-autoimmune thyroid disorder is a common finding in celiac patients, more frequent than in the general population. An impairment of iodine absorption has been hypothesized, but it has never been investigated so far. We aimed to evaluate the iodine absorption in children and adolescents with newly diagnosed celiac disease. Methods: 36 consecutive celiac patients (age 7.4 years, range 2.4\u201314.5 years) before starting a gluten-free diet (GFD) were enrolled. We assayed the urinary iodine concentration (UIC) in a 24-h urine sample, at baseline (T0) after 3 (T1) and 12 months (T2) of GFD. Results: UIC at T0 was 64 \u03bcg\/L (IQR 45\u201393.25 \u03bcg\/L) with an iodine deficiency rate of 77.8%. UIC was not different according to histological damage, clinical presentation (typical vs atypical); we found no correlation with the thyroid function tests and auxological parameters. UIC was not statistically different at T1 (76 \u03bcg\/L) and T2 (89 \u03bcg\/L) vs T0. UIC at T2 was similar between patients with positive and negative anti-transglutaminase antibodies at T2. No patients presented overt hypothyroidism during the study. Conclusions: We found that iodine absorption in celiac children is impaired compared to the general population; it increases slightly, but not significantly, during the GFD. We should regularly reinforce the need for a proper iodine intake in celiac disease patients to reduce iodine deficiency risk.<\/jats:p>","DOI":"10.3390\/nu13030808","type":"journal-article","created":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T10:25:18Z","timestamp":1614594318000},"page":"808","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Iodine Absorption in Celiac Children: A Longitudinal Pilot Study"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1528-0012","authenticated-orcid":false,"given":"Maurizio","family":"Delvecchio","sequence":"first","affiliation":[{"name":"Metabolic Disorder and Diabetology Unit, \u201cGiovanni XXIII\u201d Children Hospital, 70126 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Bizzoco","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, \u201cGiovanni XXIII\u201d Children Hospital, \u201cAldo Moro\u201d University of Bari, 70126 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Lapolla","sequence":"additional","affiliation":[{"name":"Pediatrics Unit, \u201cSan Carlo\u201d Hospital, 85100 Potenza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonia","family":"Gentile","sequence":"additional","affiliation":[{"name":"Pediatrics Unit, \u201cAntonio Perrino\u201d Hospital, 72100 Brindisi, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cinzia","family":"Carrozza","sequence":"additional","affiliation":[{"name":"UOC Chimica, Biochimica e Biologia Molecolare Clinica, Fondazione Policlinico Universitario \u201cA. Gemelli\u201d, IRCCS, Universit\u00e0 Cattolica del Sacro Cuore, 00168 Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8284-5127","authenticated-orcid":false,"given":"Michele","family":"Barone","sequence":"additional","affiliation":[{"name":"Section of Gastroenterology, Department of Emergency and Organ Transplantation, \u201cAldo Moro\u201d University of Bari, 70125 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simonetta","family":"Simonetti","sequence":"additional","affiliation":[{"name":"Neonatal Screening Center and Clinical Pathology Unit, \u201cGiovanni XXIII\u201d Children Hospital, 70126 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Giordano","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, \u201cGiovanni XXIII\u201d Children Hospital, \u201cAldo Moro\u201d University of Bari, 70126 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa Nadia","family":"Dargenio","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, \u201cGiovanni XXIII\u201d Children Hospital, \u201cAldo Moro\u201d University of Bari, 70126 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda","family":"Cristofori","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, \u201cGiovanni XXIII\u201d Children Hospital, \u201cAldo Moro\u201d University of Bari, 70126 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4603-974X","authenticated-orcid":false,"given":"Ruggiero","family":"Francavilla","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, \u201cGiovanni XXIII\u201d Children Hospital, \u201cAldo Moro\u201d University of Bari, 70126 Bari, Italy"},{"name":"Interdisciplinary Department of Medicine-Pediatrics Section, \u201cAldo Moro\u201d University of Bari, 70121 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,3,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.bpg.2005.01.008","article-title":"Coeliac disease in children","volume":"19","author":"Fasano","year":"2005","journal-title":"Best Pract. 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