{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T10:12:12Z","timestamp":1770891132797,"version":"3.50.1"},"reference-count":58,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2021,3,2]],"date-time":"2021-03-02T00:00:00Z","timestamp":1614643200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003524","name":"Ministry of Business, Innovation and Employment","doi-asserted-by":"publisher","award":["UOAX1611"],"award-info":[{"award-number":["UOAX1611"]}],"id":[{"id":"10.13039\/501100003524","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Health and Medical Research Council (NHMRC) of Australia","award":["1041352, 1109355"],"award-info":[{"award-number":["1041352, 1109355"]}]},{"name":"The Royal Children\u2019s Hospital Foundation","award":["(2014-241)"],"award-info":[{"award-number":["(2014-241)"]}]},{"name":"The Murdoch Children\u2019s Research Institute","award":["1"],"award-info":[{"award-number":["1"]}]},{"DOI":"10.13039\/501100001782","name":"The University of Melbourne","doi-asserted-by":"publisher","award":["1"],"award-info":[{"award-number":["1"]}],"id":[{"id":"10.13039\/501100001782","id-type":"DOI","asserted-by":"publisher"}]},{"name":"The National Heart Foundation of Australia","award":["(100660)"],"award-info":[{"award-number":["(100660)"]}]},{"name":"Financial Markets Foundation for Children","award":["(2014-055, 2016-310)"],"award-info":[{"award-number":["(2014-055, 2016-310)"]}]},{"name":"The Victorian Deaf Education Institute","award":["1"],"award-info":[{"award-number":["1"]}]},{"name":"The Victorian Government\u2019s Operational Infrastructure Support Program","award":["1"],"award-info":[{"award-number":["1"]}]},{"name":"New Zealand International Doctoral Research Scholarship 2017","award":["1"],"award-info":[{"award-number":["1"]}]},{"name":"National Health and Medical Research Council (NHMRC) Research Fellowships","award":["(1046518, 1160906, 1064629, GTN1175744)"],"award-info":[{"award-number":["(1046518, 1160906, 1064629, GTN1175744)"]}]},{"name":"National Heart Foundation of Australia: Honorary Future Leader Fellowship","award":["(100369)."],"award-info":[{"award-number":["(100369)."]}]},{"name":"Cure Kids New Zealand","award":["1"],"award-info":[{"award-number":["1"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Scope: B vitamers are co-enzymes involved in key physiological processes including energy production, one-carbon, and macronutrient metabolism. Studies profiling B vitamers simultaneously in parent\u2013child dyads are scarce. Profiling B vitamers in parent\u2013child dyads enables an insightful determination of gene\u2013environment contributions to their circulating concentrations. We aimed to characterise: (a) parent\u2013child dyad concordance, (b) generation (children versus adults), (c) age (within the adult subgroup (age range 28\u201371 years)) and (d) sex differences in plasma B vitamer concentrations in the CheckPoint study of Australian children. Methods and Results: 1166 children (11 \u00b1 0.5 years, 51% female) and 1324 parents (44 \u00b1 5.1 years, 87% female) took part in a biomedical assessment of a population-derived longitudinal cohort study: The Growing Up in Australia\u2019s Child Health CheckPoint. B vitamer levels were quantified by UHPLC\/MS-MS. B vitamer levels were weakly concordant between parent\u2013child pairs (10\u201331% of variability explained). All B vitamer concentrations exhibited generation-specificity, except for flavin mononucleotide (FMN). The levels of thiamine, pantothenic acid, and 4-pyridoxic acid were higher in male children, and those of pantothenic acid were higher in male adults compared to their female counterparts. Conclusion: Family, age, and sex contribute to variations in the concentrations of plasma B vitamers in Australian children and adults.<\/jats:p>","DOI":"10.3390\/nu13030821","type":"journal-article","created":{"date-parts":[[2021,3,2]],"date-time":"2021-03-02T10:36:37Z","timestamp":1614681397000},"page":"821","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Plasma B Vitamers: Population Epidemiology and Parent-Child Concordance in Children and Adults"],"prefix":"10.3390","volume":"13","author":[{"given":"Stephanie","family":"Andraos","sequence":"first","affiliation":[{"name":"The Liggins Institute, The University of Auckland, Auckland 1023, New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatrix","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Statistics, Faculty of Science, The University of Auckland, Auckland 1010, New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1062-3909","authenticated-orcid":false,"given":"Clare","family":"Wall","sequence":"additional","affiliation":[{"name":"Faculty of Medical and Health Sciences, The University of Auckland, Auckland 1023, New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Thorstensen","sequence":"additional","affiliation":[{"name":"The Liggins Institute, The University of Auckland, Auckland 1023, New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Kussmann","sequence":"additional","affiliation":[{"name":"The Liggins Institute, The University of Auckland, Auckland 1023, New Zealand"},{"name":"New Zealand National Science Challenge High-Value Nutrition, The University of Auckland, Auckland 1010, New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0144-5816","authenticated-orcid":false,"given":"David","family":"Cameron-Smith","sequence":"additional","affiliation":[{"name":"The Liggins Institute, The University of Auckland, Auckland 1023, New Zealand"},{"name":"Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research (A*STAR), 30 Medical Drive, Singapore 117609, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8175-6285","authenticated-orcid":false,"given":"Katherine","family":"Lange","sequence":"additional","affiliation":[{"name":"The Murdoch Children\u2019s Research Institute, Parkville, VIC 3052, Australia"},{"name":"Department of Paediatrics, University of Melbourne, Parkville, VIC 3010, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2678-9439","authenticated-orcid":false,"given":"Susan","family":"Clifford","sequence":"additional","affiliation":[{"name":"The Murdoch Children\u2019s Research Institute, Parkville, VIC 3052, Australia"},{"name":"Department of Paediatrics, University of Melbourne, Parkville, VIC 3010, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Saffery","sequence":"additional","affiliation":[{"name":"The Murdoch Children\u2019s Research Institute, Parkville, VIC 3052, Australia"},{"name":"Department of Paediatrics, University of Melbourne, Parkville, VIC 3010, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Burgner","sequence":"additional","affiliation":[{"name":"The Murdoch Children\u2019s Research Institute, Parkville, VIC 3052, Australia"},{"name":"Department of Paediatrics, University of Melbourne, Parkville, VIC 3010, Australia"},{"name":"Department of Paediatrics, Monash University, Clayton, VIC 3800, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa","family":"Wake","sequence":"additional","affiliation":[{"name":"The Murdoch Children\u2019s Research Institute, Parkville, VIC 3052, Australia"},{"name":"Department of Paediatrics, University of Melbourne, Parkville, VIC 3010, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2927-450X","authenticated-orcid":false,"given":"Justin","family":"O\u2019Sullivan","sequence":"additional","affiliation":[{"name":"The Liggins Institute, The University of Auckland, Auckland 1023, New Zealand"},{"name":"New Zealand National Science Challenge High-Value Nutrition, The University of Auckland, Auckland 1010, New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,3,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/B978-0-7020-4087-0.00059-0","article-title":"Hydrosoluble vitamins","volume":"120","author":"Chawla","year":"2014","journal-title":"Handb. 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