{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T01:28:24Z","timestamp":1780450104000,"version":"3.54.1"},"reference-count":66,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2021,3,4]],"date-time":"2021-03-04T00:00:00Z","timestamp":1614816000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"SIDRA Medicine Internal Research Fund","award":["SDR200010"],"award-info":[{"award-number":["SDR200010"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>In Qatar, Type 1 Diabetes mellitus (T1DM) is one of the most prevalent disorders. This study aimed to explore the gut microbiome\u2019s relation to the continuous subcutaneous insulin infusion (CSII) therapy, dietary habits, and the HbA1c level in the pediatric T1DM subjects in Qatar. We recruited 28 T1DM subjects with an average age of 10.5 \u00b1 3.53 years. The stool sample was used to measure microbial composition by 16s rDNA sequencing method. The results have revealed that the subjects who had undergone CSII therapy had increased microbial diversity and genus Akkermansia was significantly enriched in the subjects without CSII therapy. Moreover, genus Akkermansia was higher in the subjects with poor glycemic control (HbA1c &gt; 7.5%). When we classified the subjects based on dietary patterns and nationality, Akkermansia was significantly enriched in Qataris subjects without the CSII therapy consuming Arabic diet than expatriates living in Qatar and eating a Western\/mixed diet. Thus, this pilot study showed that abundance of Akkermansia is dependent on the Arabic diet only in poorly controlled Qataris T1DM patients, opening new routes to personalized treatment for T1DM in Qataris pediatric subjects. Further comprehensive studies on the relation between the Arabic diet, ethnicity, and Akkermansia are warranted to confirm this preliminary finding.<\/jats:p>","DOI":"10.3390\/nu13030836","type":"journal-article","created":{"date-parts":[[2021,3,5]],"date-time":"2021-03-05T00:39:07Z","timestamp":1614904747000},"page":"836","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Akkermansia, a Possible Microbial Marker for Poor Glycemic Control in Qataris Children Consuming Arabic Diet\u2014A Pilot Study on Pediatric T1DM in Qatar"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9738-7667","authenticated-orcid":false,"given":"Arun Prasath","family":"Lakshmanan","sequence":"first","affiliation":[{"name":"Research Department, Sidra Medicine, Doha P.O. Box 26999, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amira","family":"Kohil","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, College of Health Sciences, QU Health, Qatar University, Doha P.O. Box 2713, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farah","family":"El Assadi","sequence":"additional","affiliation":[{"name":"College of Health and Life Sciences, Hamad Bin Khalifa University, Doha P.O. Box 34110, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Al Zaidan","sequence":"additional","affiliation":[{"name":"Research Department, Sidra Medicine, Doha P.O. Box 26999, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaikha","family":"Al Abduljabbar","sequence":"additional","affiliation":[{"name":"Research Department, Sidra Medicine, Doha P.O. Box 26999, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhinoth Kumar","family":"Bangarusamy","sequence":"additional","affiliation":[{"name":"Research Department, Sidra Medicine, Doha P.O. Box 26999, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fawziya","family":"Al Khalaf","sequence":"additional","affiliation":[{"name":"Endocrinology Clinic, Sidra Medicine, Doha P.O. Box 26999, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Goran","family":"Petrovski","sequence":"additional","affiliation":[{"name":"Endocrinology Clinic, Sidra Medicine, Doha P.O. Box 26999, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9274-5373","authenticated-orcid":false,"given":"Annalisa","family":"Terranegra","sequence":"additional","affiliation":[{"name":"Research Department, Sidra Medicine, Doha P.O. 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Diabetes"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0140-6736(13)60591-7","article-title":"Type 1 diabetes","volume":"383","author":"Atkinson","year":"2014","journal-title":"Lancet"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1007\/s11892-017-0919-7","article-title":"Management of Type 1 Diabetes in the Hospital Setting","volume":"17","author":"Mendez","year":"2017","journal-title":"Curr. Diabetes Rep."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"American Diabetes Association (2019). 4. Comprehensive Medical Evaluation and Assessment of Comorbidities: Standards of Medical Care in Diabetes-2019. Diabetes Care, 42, S34\u2013S45.","DOI":"10.2337\/dc19-S004"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1007\/s13300-019-00743-7","article-title":"Insulin Therapy in Adults with Type 1 Diabetes Mellitus: A Narrative Review","volume":"11","author":"Janez","year":"2020","journal-title":"Diabetes Ther."},{"key":"ref_8","first-page":"159","article-title":"Effectiveness and safety of basal-bolus therapy (insulin glargine+insulin glulisine) in patients with type 1 diabetes previously uncontrolled on any insulin regimen: Multinational phase-IV study","volume":"7","author":"Boudiba","year":"2017","journal-title":"Diabetes Manag."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1177\/193229681200600502","article-title":"Transitioning insulin pump therapy from the outpatient to the inpatient setting: A review of 6 years\u2019 experience with 253 cases","volume":"6","author":"Cook","year":"2012","journal-title":"J. Diabetes Sci. Technol"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.2337\/diacare.26.4.1142","article-title":"Safety and effectiveness of insulin pump therapy in children and adolescents with type 1 diabetes","volume":"26","author":"Plotnick","year":"2003","journal-title":"Diabetes Care"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1007\/s11892-013-0409-5","article-title":"Human intestinal microbiota and type 1 diabetes","volume":"13","author":"Vaarala","year":"2013","journal-title":"Curr. Diabetes Rep."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"590","DOI":"10.4049\/jimmunol.1601519","article-title":"The Influence of the Microbiome on Type 1 Diabetes","volume":"198","author":"Paun","year":"2017","journal-title":"J. Immunol."},{"key":"ref_13","first-page":"574","article-title":"Gut microbiome dysbiosis and increased intestinal permeability in children with islet autoimmunity and type 1 diabetes: A prospective cohort study","volume":"20","author":"Harbison","year":"2019","journal-title":"Pediatr. Diabetes"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"BSR20182348","DOI":"10.1042\/BSR20182348","article-title":"Gut microbiota imbalances in Tunisian participants with type 1 and type 2 diabetes mellitus","volume":"39","author":"Fassatoui","year":"2019","journal-title":"Biosci. Rep."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Durazzo, M., Ferro, A., and Gruden, G. (2019). Gastrointestinal Microbiota and Type 1 Diabetes Mellitus: The State of Art. J. Clin. Med., 8.","DOI":"10.3390\/jcm8111843"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"3062","DOI":"10.12659\/MSM.897270","article-title":"Association of Bactericidal Dysfunction of Paneth Cells in Streptozocin-Induced Diabetic Mice with Insulin Deficiency","volume":"22","author":"Yu","year":"2016","journal-title":"Med. Sci. Monit."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"6500","DOI":"10.7150\/thno.44113","article-title":"Depletion of the diabetic gut microbiota resistance enhances stem cells therapy in type 1 diabetes mellitus","volume":"10","author":"Lv","year":"2020","journal-title":"Theranostics"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1530\/EJE-18-0826","article-title":"Metformin induces weight loss associated with gut microbiota alteration in non-diabetic obese women: A randomized double-blind clinical trial","volume":"180","author":"Ejtahed","year":"2019","journal-title":"Eur. J. Endocrinol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1080\/19490976.2020.1717719","article-title":"Considering gut microbiota in treatment of type 2 diabetes mellitus","volume":"11","author":"Adeshirlarijaney","year":"2020","journal-title":"Gut Microbes"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.humic.2018.01.001","article-title":"Gut microbiota diversity according to dietary habits and geographical provenance","volume":"7\u20138","author":"Senghor","year":"2018","journal-title":"Hum. Microbiome J."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1093\/bioinformatics\/btt593","article-title":"PEAR: A fast and accurate Illumina Paired-End reAd mergeR","volume":"30","author":"Zhang","year":"2014","journal-title":"Bioinformatics"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1093\/bioinformatics\/btu170","article-title":"Trimmomatic: A flexible trimmer for Illumina sequence data","volume":"30","author":"Bolger","year":"2014","journal-title":"Bioinformatics"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/nmeth.f.303","article-title":"QIIME allows analysis of high-throughput community sequencing data","volume":"7","author":"Caporaso","year":"2010","journal-title":"Nat. Methods"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"5069","DOI":"10.1128\/AEM.03006-05","article-title":"Greengenes, a chimera-checked 16S rRNA gene database and workbench compatible with ARB","volume":"72","author":"DeSantis","year":"2006","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Wickham, H. (2009). ggplot2, Springer.","DOI":"10.1007\/978-0-387-98141-3"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"McMurdie, P.J., and Holmes, S. (2013). phyloseq: An R package for reproducible interactive analysis and graphics of microbiome census data. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0061217"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1038\/s41596-019-0264-1","article-title":"Using MicrobiomeAnalyst for comprehensive statistical, functional, and meta-analysis of microbiome data","volume":"15","author":"Chong","year":"2020","journal-title":"Nat. Protoc."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"R60","DOI":"10.1186\/gb-2011-12-6-r60","article-title":"Metagenomic biomarker discovery and explanation","volume":"12","author":"Segata","year":"2011","journal-title":"Genome Biol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"e3043","DOI":"10.1002\/dmrr.3043","article-title":"Gut microbiome in type 1 diabetes: A comprehensive review","volume":"34","author":"Zheng","year":"2018","journal-title":"Diabetes Metab. Res. Rev."},{"key":"ref_30","first-page":"678","article-title":"Bacteroides dorei dominates gut microbiome prior to autoimmunity in Finnish children at high risk for type 1 diabetes","volume":"5","author":"Ardissone","year":"2014","journal-title":"Front. Microbiol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1007\/s00125-014-3274-0","article-title":"Aberrant gut microbiota composition at the onset of type 1 diabetes in young children","volume":"57","author":"Fuentes","year":"2014","journal-title":"Diabetologia"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1210\/er.2017-00192","article-title":"Evaluating Causality of Gut Microbiota in Obesity and Diabetes in Humans","volume":"39","author":"Meijnikman","year":"2018","journal-title":"Endocr. Rev."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s11892-017-0933-9","article-title":"Modulation of Type 1 Diabetes Risk by the Intestinal Microbiome","volume":"17","author":"Knip","year":"2017","journal-title":"Curr. Diabetes Rep."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1038\/ismej.2010.92","article-title":"Toward defining the autoimmune microbiome for type 1 diabetes","volume":"5","author":"Giongo","year":"2011","journal-title":"ISME J."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Tascini, G., Berioli, M.G., Cerquiglini, L., Santi, E., Mancini, G., Rogari, F., Toni, G., and Esposito, S. (2018). Carbohydrate Counting in Children and Adolescents with Type 1 Diabetes. Nutrients, 10.","DOI":"10.3390\/nu10010109"},{"key":"ref_36","first-page":"2343","article-title":"Type 1 diabetes mellitus and the use of flexible insulin regimens","volume":"60","author":"Hirsch","year":"1999","journal-title":"Am. Fam. Physician"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1111\/pedi.12416","article-title":"Insulin pump therapy in children with type 1 diabetes: Analysis of data from the SWEET registry","volume":"17","author":"Szypowska","year":"2016","journal-title":"Pediatr. Diabetes"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1210\/jcem-64-2-269","article-title":"The role of glucosylated serum albumin in monitoring glycemic control in stable insulin-requiring diabetic out-patients","volume":"64","author":"Ziel","year":"1987","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"166","DOI":"10.3389\/fmicb.2011.00166","article-title":"Modulation of Mucosal Immune Response, Tolerance, and Proliferation in Mice Colonized by the Mucin-Degrader Akkermansia muciniphila","volume":"2","author":"Derrien","year":"2011","journal-title":"Front. Microbiol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"e01438-14","DOI":"10.1128\/mBio.01438-14","article-title":"Differential modulation by Akkermansia muciniphila and Faecalibacterium prausnitzii of host peripheral lipid metabolism and histone acetylation in mouse gut organoids","volume":"5","author":"Lukovac","year":"2014","journal-title":"mBio"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1016\/j.cell.2016.10.043","article-title":"A Dietary Fiber-Deprived Gut Microbiota Degrades the Colonic Mucus Barrier and Enhances Pathogen Susceptibility","volume":"167","author":"Desai","year":"2016","journal-title":"Cell"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"3655","DOI":"10.1128\/AEM.04050-14","article-title":"Akkermansia muciniphila Adheres to Enterocytes and Strengthens the Integrity of the Epithelial Cell Layer","volume":"81","author":"Reunanen","year":"2015","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.3389\/fmicb.2016.01157","article-title":"Characterization of Outer Membrane Proteome of Akkermansia muciniphila Reveals Sets of Novel Proteins Exposed to the Human Intestine","volume":"7","author":"Ottman","year":"2016","journal-title":"Front. Microbiol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"7767","DOI":"10.1128\/AEM.01477-07","article-title":"Intestinal integrity and Akkermansia muciniphila, a mucin-degrading member of the intestinal microbiota present in infants, adults, and the elderly","volume":"73","author":"Collado","year":"2007","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1136\/gutjnl-2012-303839","article-title":"An increase in the Akkermansia spp. population induced by metformin treatment improves glucose homeostasis in diet-induced obese mice","volume":"63","author":"Shin","year":"2014","journal-title":"Gut"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"9066","DOI":"10.1073\/pnas.1219451110","article-title":"Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity","volume":"110","author":"Everard","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"206","DOI":"10.3389\/fcimb.2019.00206","article-title":"Alterations to the Gut Microbiota and Their Correlation With Inflammatory Factors in Chronic Kidney Disease","volume":"9","author":"Li","year":"2019","journal-title":"Front. Cell Infect. Microbiol."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Brown, C.T., Davis-Richardson, A.G., Giongo, A., Gano, K.A., Crabb, D.B., Mukherjee, N., Casella, G., Drew, J.C., Ilonen, J., and Knip, M. (2011). Gut microbiome metagenomics analysis suggests a functional model for the development of autoimmunity for type 1 diabetes. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0025792"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.3389\/fmicb.2019.01137","article-title":"Elucidation of Akkermansia muciniphila Probiotic Traits Driven by Mucin Depletion","volume":"10","author":"Shin","year":"2019","journal-title":"Front. Microbiol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"2434","DOI":"10.1161\/CIRCULATIONAHA.115.019645","article-title":"Akkermansia Muciniphila Protects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation in Apoe-\/- Mice","volume":"133","author":"Li","year":"2016","journal-title":"Circulation"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1038\/nature09944","article-title":"Enterotypes of the human gut microbiome","volume":"473","author":"Arumugam","year":"2011","journal-title":"Nature"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1136\/gutjnl-2014-308778","article-title":"Akkermansia muciniphila and improved metabolic health during a dietary intervention in obesity: Relationship with gut microbiome richness and ecology","volume":"65","author":"Dao","year":"2016","journal-title":"Gut"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"18933","DOI":"10.1073\/pnas.1007028107","article-title":"Individuality in gut microbiota composition is a complex polygenic trait shaped by multiple environmental and host genetic factors","volume":"107","author":"Benson","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"McKnite, A.M., Perez-Munoz, M.E., Lu, L., Williams, E.G., Brewer, S., Andreux, P.A., Bastiaansen, J.W., Wang, X., Kachman, S.D., and Auwerx, J. (2012). Murine gut microbiota is defined by host genetics and modulates variation of metabolic traits. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0039191"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nature10809","article-title":"Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity","volume":"482","author":"Elinav","year":"2012","journal-title":"Nature"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.jaut.2014.03.005","article-title":"Long term effect of gut microbiota transfer on diabetes development","volume":"53","author":"Peng","year":"2014","journal-title":"J. Autoimmun."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"16016","DOI":"10.1038\/hgv.2016.16","article-title":"The Qatar genome: A population-specific tool for precision medicine in the Middle East","volume":"3","author":"Fakhro","year":"2016","journal-title":"Hum. Genome Var."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Fontana, A., Panebianco, C., Picchianti-Diamanti, A., Lagana, B., Cavalieri, D., Potenza, A., Pracella, R., Binda, E., Copetti, M., and Pazienza, V. (2019). Gut Microbiota Profiles Differ among Individuals Depending on Their Region of Origin: An Italian Pilot Study. Int. J. Environ. Res. Public Health, 16.","DOI":"10.3390\/ijerph16214065"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1038\/ng.3693","article-title":"Association of host genome with intestinal microbial composition in a large healthy cohort","volume":"48","author":"Turpin","year":"2016","journal-title":"Nat. Genet."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1146\/annurev-micro-090110-102830","article-title":"The human gut microbiome: Ecology and recent evolutionary changes","volume":"65","author":"Walter","year":"2011","journal-title":"Annu. Rev. Microbiol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s40168-018-0417-4","article-title":"Type 1 diabetes susceptibility alleles are associated with distinct alterations in the gut microbiota","volume":"6","author":"Mullaney","year":"2018","journal-title":"Microbiome"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"9671","DOI":"10.1073\/pnas.1712280114","article-title":"Protective major histocompatibility complex allele prevents type 1 diabetes by shaping the intestinal microbiota early in ontogeny","volume":"114","author":"Silverman","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"e37816","DOI":"10.7554\/eLife.37816","article-title":"Antibiotic-induced acceleration of type 1 diabetes alters maturation of innate intestinal immunity","volume":"7","author":"Zhang","year":"2018","journal-title":"Elife"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"16140","DOI":"10.1038\/nmicrobiol.2016.140","article-title":"Antibiotic-mediated gut microbiome perturbation accelerates development of type 1 diabetes in mice","volume":"1","author":"Livanos","year":"2016","journal-title":"Nat. Microbiol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1001\/jamapediatrics.2017.2905","article-title":"Association Between Early-Life Antibiotic Use and the Risk of Islet or Celiac Disease Autoimmunity","volume":"171","author":"Kemppainen","year":"2017","journal-title":"JAMA Pediatr."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"2306","DOI":"10.3389\/fmicb.2017.02306","article-title":"Antibiotic-Induced Alterations in Gut Microbiota Are Associated with Changes in Glucose Metabolism in Healthy Mice","volume":"8","author":"Rodrigues","year":"2017","journal-title":"Front. Microbiol."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/13\/3\/836\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T05:32:39Z","timestamp":1760160759000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/13\/3\/836"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,4]]},"references-count":66,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2021,3]]}},"alternative-id":["nu13030836"],"URL":"https:\/\/doi.org\/10.3390\/nu13030836","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,4]]}}}