{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T02:12:54Z","timestamp":1789179174569,"version":"build-2803163510"},"reference-count":170,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2021,3,6]],"date-time":"2021-03-06T00:00:00Z","timestamp":1614988800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>According to the available data, environmental pollution is a serious problem all over the world. Between 2015 and 2016, pollution was responsible for approximately nine million deaths worldwide. They also include endocrine disrupting chemicals (EDCs) that can interfere with the functioning of the thyroid gland. They are characterized by high persistence in the environment. These substances can enter the body through the gastrointestinal tract, respiratory system, as well as contact with the skin and overcome the placental barrier. EDC can be found in food, water, and personal care products. They can get into food from the environment and as a result of their migration to food products and cosmetics from packaging. EDCs can disrupt the functioning of the thyroid gland through a number of mechanisms, including disrupting the activation of thyroid receptors and the expression of genes that are related to the metabolism, synthesis, and transport of thyroid hormones (HT). There is a need to strengthen the food safety policy that aimed at the use of appropriate materials in direct contact with food. At the same time, an important action is to reduce the production of all waste and, when possible, use biodegradable packaging, which may contribute to the improvement of the quality of the entire ecosystem and the health of food, thus reducing the risk of developing thyroid diseases.<\/jats:p>","DOI":"10.3390\/nu13030867","type":"journal-article","created":{"date-parts":[[2021,3,7]],"date-time":"2021-03-07T21:52:15Z","timestamp":1615153935000},"page":"867","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Dietary Intake of Endocrine Disrupting Substances Presents in Environment and Their Impact on Thyroid Function"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4727-8766","authenticated-orcid":false,"given":"Aneta","family":"Sokal","sequence":"first","affiliation":[{"name":"Institute of Health Sciences, Medical College of Rzeszow University, 35-959 Rzeszow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6896-4744","authenticated-orcid":false,"given":"Sara","family":"Jarmakiewicz-Czaja","sequence":"additional","affiliation":[{"name":"Institute of Health Sciences, Medical College of Rzeszow University, 35-959 Rzeszow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1264-2882","authenticated-orcid":false,"given":"Jacek","family":"Tabarkiewicz","sequence":"additional","affiliation":[{"name":"Institute of Medicine, Medical College of Rzeszow University, 35-959 Rzeszow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5954-151X","authenticated-orcid":false,"given":"Rafa\u0142","family":"Filip","sequence":"additional","affiliation":[{"name":"Institute of Medicine, Medical College of Rzeszow University, 35-959 Rzeszow, Poland"},{"name":"Department of Gastroenterology with IBD Unit, Clinical Hospital No. 2, 35-301 Rzeszow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,3,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/S0140-6736(17)32345-0","article-title":"The Lancet Commission on pollution and health","volume":"391","author":"Landrigan","year":"2018","journal-title":"Lancet"},{"key":"ref_2","first-page":"151","article-title":"Environmental Pollution Causes and Consequences: A Study. Project: Environment and Ecology","volume":"3","author":"Appannagari","year":"2017","journal-title":"IJSSHR J."},{"key":"ref_3","first-page":"2","article-title":"Causes and Effects of Pesticide and Metal Pollution on Different Ecosystems","volume":"2","year":"2020","journal-title":"Bioremed. Biotechnol."},{"key":"ref_4","unstructured":"World Health Organization (2017). Inheriting a Sustainable World? Atlas on Children\u2019s Health and the Environment, WHO. Available online: http:\/\/apps.who.int\/iris\/bitstream\/10665\/254677\/1\/9789241511773-eng.pdf?ua=1."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"A104","DOI":"10.1289\/ehp.1205448","article-title":"The impact of endocrine disruption: A consensus statement on the state of the science","volume":"121","author":"Bergman","year":"2013","journal-title":"Environ. Health Perspect."},{"key":"ref_6","unstructured":"European Commision (2020, June 10). Environment. Available online: https:\/\/ec.europa.eu\/environment\/chemicals\/endocrine\/index_en.htm."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/B978-0-08-046884-6.01135-0","article-title":"Genetic Mouse Models for Female Reproductive Toxicology Studie","volume":"Volume 11","author":"Gupta","year":"2010","journal-title":"Comprehensive Toxicology"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.bbagrm.2014.06.015","article-title":"Thyroid hormone signaling during early neurogenesis and its significance as a vulnerable window for endocrine disruption","volume":"1849","author":"Fini","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"204","DOI":"10.3389\/fendo.2018.00204","article-title":"Disruption in Thyroid Signaling Pathway: A Mechanism for the Effect of Endocrine-Disrupting Chemicals on Child Neurodevelopment","volume":"9","author":"Ghassabian","year":"2018","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"340","DOI":"10.3803\/EnM.2019.34.4.340","article-title":"Bisphenols and Thyroid Hormone","volume":"34","author":"Kim","year":"2019","journal-title":"Endocrinol. Metab. (Seoul)"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2909","DOI":"10.1210\/en.2010-1490","article-title":"Individual polychlorinated biphenyl (PCB) congeners produce tissue- and gene-specific effects on thyroid hormone signaling during development","volume":"152","author":"Giera","year":"2011","journal-title":"Endocrinology"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"110997","DOI":"10.1016\/j.mce.2020.110997","article-title":"The impact of endocrine-disrupting chemical exposure in the mammalian hypothalamic-pituitary axis","volume":"518","author":"Graceli","year":"2020","journal-title":"Mol. Cell Endocrinol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"134040","DOI":"10.1016\/j.scitotenv.2019.134040","article-title":"The molecular mechanism of the antagonistic activity of hydroxylated polybrominated biphenyl (OH-BB80) toward thyroid receptor \u03b2","volume":"697","author":"Zhang","year":"2019","journal-title":"Sci. Total Environ."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Vanderpump, M. (2019). Epidemiology of Thyroid Disorders. The Thyroid and Its Disease: A Comprehensive Guide for the Clinician, Springer Nature.","DOI":"10.1007\/978-3-319-72102-6_6"},{"key":"ref_15","unstructured":"Piekarzewska, M., Wieczorkowski, R., and Zajenkowska-Koz\u0142owska, A. (2016). Stan Zdrowia Ludno\u015bci Polski z 2014 r. G\u0142\u00f3wny Urz\u0105d Stat., 66\u201367. Available online: https:\/\/stat.gov.pl\/obszary-tematyczne\/zdrowie\/zdrowie\/stan-zdrowia-ludnosci-polski-w-2014-r-,6,6.html."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1097\/MED.0000000000000359","article-title":"The thyroid cancer epidemic, 2017 perspective","volume":"24","author":"Roman","year":"2017","journal-title":"Curr. Opin. Endocrinol. Diabetes Obes."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/thy.2015.0020","article-title":"2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer","volume":"26","author":"Haugen","year":"2016","journal-title":"Thyroid"},{"key":"ref_18","first-page":"1","article-title":"Bisfenol A adsorption using a low-cost adsorbent prepared from residues of babassu coconut peels","volume":"11","author":"Vidovix","year":"2019","journal-title":"Environ. Technol."},{"key":"ref_19","unstructured":"European Food Safety Authority (2020, June 15). Bisphenol A. Available online: https:\/\/www.efsa.europa.eu\/en\/topics\/topic\/bisphenol."},{"key":"ref_20","unstructured":"(2020, June 15). National Institute on Environmental Health Science, Available online: https:\/\/www.niehs.nih.gov\/health\/topics\/agents\/sya-bpa\/index.cfm."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Rajas\u00e4rkk\u00e4, J., Pernica, M., Kuta, J., La\u0161\u0148\u00e1k, J., \u0160imek, Z., and Bl\u00e1ha, L. (2016). Drinking water contaminants from epoxy resin-coated pipes: A field study. Water Res., 133\u2013140.","DOI":"10.1016\/j.watres.2016.07.027"},{"key":"ref_22","unstructured":"FDA (Food and Drug Administration) (2020, June 15). Bisphenol A (BPA): Use in Food Contact Application, Available online: https:\/\/www.fda.gov\/food\/food-additives-petitions\/bisphenol-bpa-use-food-contact-application."},{"key":"ref_23","unstructured":"European Commission (2020, June 15). Bisphenol A: EU Ban on Baby Bottles to Enter Into Force Tomorrow. Available online: https:\/\/ec.europa.eu\/commission\/presscorner\/detail\/en\/IP_11_664."},{"key":"ref_24","unstructured":"(2020, June 15). Enviromental Monitoring and Surveillance in Support of Chemical Management Plan. Bisphenol A in the Canadian Environment. Environment and Climate Change Canada, Government of Canada, 2020. Available online: https:\/\/www.canada.ca\/en\/environment-climate-change\/services\/evaluating-existing-substances\/environmental-monitoring-surveillance-support-chemicals-management-plan-bisphenol-a-canadian-environment.html."},{"key":"ref_25","unstructured":"European Food Safety Authority (2020, June 15). EFSA Re-Evaluates Safety of Bisphenol A and Sets Tolerable Daily Intake. Available online: https:\/\/www.efsa.europa.eu\/en\/news\/efsa-re-evaluates-safety-bisphenol-and-sets-tolerable-daily-intake."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Corrales, J., Kristofco, L.A., Steele, W.B., Yates, B.S., Breed, C.S., Williams, E.S., and Brooks, B.W. (2015). Global Assessment of Bisphenol A in the Environment: Review and Analysis of Its Occurrence and Bioaccumulation. Dose Response, 13.","DOI":"10.1177\/1559325815598308"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"110575","DOI":"10.1016\/j.fct.2019.110575","article-title":"Occurrence of Bisphenol A and its analogues in some foodstuff marketed in Europe","volume":"131","author":"Russo","year":"2019","journal-title":"Food Chem. Toxicol."},{"key":"ref_28","first-page":"571","article-title":"Exposure to bishenol A from drinking canned beverages increases blood pressure: Randomized reviewd","volume":"46","author":"Bae","year":"2014","journal-title":"Water Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"122419","DOI":"10.1016\/j.jhazmat.2020.122419","article-title":"Bisphenol A and its analogs in muscle and liver of fish from the North East Atlantic Ocean in relation to microplastic contamination. Exposure and risk to human consumers","volume":"393","author":"Barboza","year":"2020","journal-title":"J. Hazard. Mater."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"6523","DOI":"10.1021\/acsomega.8b00824","article-title":"Exposure to Bisphenol A, Bisphenol F, and Bisphenol S in U.S. Adults and Children: The National Health and Nutrition Examination Survey 2013-2014","volume":"3","author":"Lehmler","year":"2018","journal-title":"ACS Omega"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Gorini, F., Bustaffa, E., Coi, A., Iervasi, G., and Bianchi, F. (2020). Bisphenols as Environmental Triggers of Thyroid Dysfunction: Clues and Evidence. Int. J. Environ. Res. Public Health, 17.","DOI":"10.3390\/ijerph17082654"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.reprotox.2018.06.005","article-title":"Effects of bisphenol A and its analogs on reproductive health: A mini review","volume":"79","author":"Siracusa","year":"2018","journal-title":"Reprod. Toxicol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1093\/humrep\/dep381","article-title":"Occupational exposure to bisphenol-A (BPA) and the risk of self-reported male sexual dysfunction","volume":"25","author":"Li","year":"2010","journal-title":"Hum. Reprod."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.21873\/invivo.11619","article-title":"Bisphenol A: A Concise Review of Literature and a Discussion of Health and Regulatory Implications","volume":"33","author":"Wazir","year":"2019","journal-title":"In Vivo"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.reprotox.2010.02.007","article-title":"Placental transport and in vitro effects of Bisphenol A","volume":"30","author":"Sorda","year":"2010","journal-title":"Reprod. Toxicol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12403-020-00358-5","article-title":"Placenta is Capable of Protecting the Male Fetus from Exposure to Environmental Bisphenol A","volume":"13","author":"Lukasiewicz","year":"2020","journal-title":"Expo. Health"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.envres.2017.11.052","article-title":"Association between prenatal bisphenol A and phthalate exposures and fetal metabolic related biomarkers: The Hokkaido study on Environment and Children\u2019s Health","volume":"161","author":"Minatoya","year":"2018","journal-title":"Environ. Res."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Longo, M., Zatterale, F., Naderi, J., Nigro, C., Oriente, F., Formisano, P., Miele, C., and Beguinot, F. (2020). The Low-dose Bisphenol-A Promotes Epigenetic Changes at Ppar\u03b3 Promoter in Adipose Precursor Cells. Nutrients, 12.","DOI":"10.3390\/nu12113498"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"105123","DOI":"10.1016\/j.envint.2019.105123","article-title":"Association of urinary bisphenols and triclosan with thyroid function during early pregnancy","volume":"133","author":"Derakhshan","year":"2019","journal-title":"Environ. Int."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1289\/ehp.1205092","article-title":"Maternal urinary bisphenol a during pregnancy and maternal and neonatal thyroid function in the CHAMACOS study","volume":"121","author":"Chevrier","year":"2013","journal-title":"Environ. Health Perspect."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1097\/EDE.0b013e318280e02f","article-title":"Urinary bisphenol a concentration and thyroid function in Chinese adults","volume":"24","author":"Wang","year":"2013","journal-title":"Epidemiology"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"10939","DOI":"10.1007\/s11356-020-07705-8","article-title":"Maternal urinary bisphenol A concentration and thyroid hormone levels of Chinese mothers and newborns by maternal body mass index","volume":"27","author":"Wang","year":"2020","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"137887","DOI":"10.1016\/j.scitotenv.2020.137887","article-title":"Prenatal bisphenol A exposure, fetal thyroid hormones and neurobehavioral development in children at 2 and 4 years: A prospective cohort study","volume":"722","author":"Li","year":"2020","journal-title":"Sci. Total Environ."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"554","DOI":"10.4103\/2230-8210.183454","article-title":"Hypothyroidism and obesity: An intriguing link","volume":"20","author":"Sanyal","year":"2016","journal-title":"Indian J. Endocrinol. Metab."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1111\/jmwh.12500","article-title":"Endocrine-Disrupting Chemicals and Reproductive Health","volume":"61","author":"Zlatnik","year":"2016","journal-title":"J. Midwifery Womens Health"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1289\/ehp.1408989","article-title":"Bisphenol S and F: A Systematic Review and Comparison of the Hormonal Activity of Bisphenol A Substitutes","volume":"123","author":"Rochester","year":"2015","journal-title":"Environ. Health Perspect"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"26916","DOI":"10.1007\/s11356-018-2419-y","article-title":"Unraveling molecular targets of bisphenol A and S in the thyroid gland","volume":"25","author":"Ferreira","year":"2018","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1016\/j.envpol.2017.11.027","article-title":"Bisphenol A alternatives bisphenol S and bisphenol F interfere with thyroid hormone signaling pathway in vitro and in vivo","volume":"237","author":"Zhang","year":"2018","journal-title":"Environ. Pollut."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.aquatox.2011.04.007","article-title":"Generation of fluorescent zebrafish to study endocrine disruption and potential crosstalk between thyroid hormone and corticosteroids","volume":"105","author":"Terrien","year":"2011","journal-title":"Aquat. Toxicol."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Zhang, D.H., Zhou, E.X., and Yang, Z.L. (2017). Waterborne exposure to BPS causes thyroid endocrine disruption in zebrafish larvae. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0176927"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Andrianou, X.D., G\u00e4ngler, S., Piciu, A., Charisiadis, P., Zira, C., Aristidou, K., Piciu, D., Hauser, R., and Makris, K.C. (2016). Human Exposures to Bisphenol A, Bisphenol F and Chlorinated Bisphenol A Derivatives and Thyroid Function. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0155237"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"5185","DOI":"10.1210\/jc.2002-020209","article-title":"Thyroid hormone action is disrupted by bisphenol A as an antagonist","volume":"87","author":"Moriyama","year":"2002","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_53","unstructured":"World Health Organization (2007). Assessment of Iodine Deficiency Disorders and Monitoring Their Elimination, WHO. [3rd ed.]."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Wang, N., Zhou, Y., Fu, C., Wang, H., Huang, P., Wang, B., Su, M., Jiang, F., Fang, H., and Zhao, Q. (2015). Influence of Bisphenol A on Thyroid Volume and Structure Independent of Iodine in School Children. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0141248"},{"key":"ref_55","first-page":"677","article-title":"Phthalates\u2014Structure, Activity, Clinical Meaning","volume":"4","author":"Zdrojewicz","year":"2006","journal-title":"Adv. Clin. Exp. Med."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.jhazmat.2017.10.014","article-title":"An overview of chemical additives present in plastics: Migration, release, fate and environmental impact during their use, disposal and recycling","volume":"15","author":"Hahladakisa","year":"2018","journal-title":"J. Hazard. Mater."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1080\/15287390500227381","article-title":"Mono-(3-carboxypropyl) phthalate, a metabolite of di-n-octyl phthalate","volume":"69","author":"Calafat","year":"2006","journal-title":"J. Toxicol. Environ. Health A"},{"key":"ref_58","unstructured":"(2020, June 25). Centers for Disease Control and Prevention, Available online: https:\/\/www.cdc.gov\/biomonitoring\/Phthalates_FactSheet.html."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"105057","DOI":"10.1016\/j.envint.2019.105057","article-title":"Ultra-processed food consumption and exposure to phthalates and bisphenols in the US National Health and Nutrition Examination Survey, 2013\u20132014","volume":"131","author":"Buckley","year":"2019","journal-title":"Environ. Int."},{"key":"ref_60","unstructured":"(2020, June 30). Rozporz\u0105dzenie Komisji (UE) 2018\/2005 z Dnia 17 Grudnia 2018r. Available online: https:\/\/eur-lex.europa.eu\/legal-content\/PL\/TXT\/PDF\/?uri=CELEX:32018R2005&from=EN."},{"key":"ref_61","unstructured":"(2020, June 15). European Union Risk Assessment Report bis(2-ethylhexyl)phthalate (DEHP). EUR 23384 EN. Available online: https:\/\/echa.europa.eu\/documents\/10162\/e614617d-58e7-42d9-b7fb-d7bab8f26feb."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"113548","DOI":"10.1016\/j.ijheh.2020.113548","article-title":"Biomonitoring of occupational exposure to phthalates: A systematic review","volume":"229","author":"Santonen","year":"2020","journal-title":"Int. J. Hyg. Environ. Health"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/j.1541-4337.2009.00093.x","article-title":"Phthalate Esters in Foods: Sources, Occurrence, and Analytical Methods","volume":"9","author":"Cao","year":"2010","journal-title":"Compr. Rev. Food Sci. Food Saf."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1111\/1750-3841.15181","article-title":"Migration regularity of phthalates in polyethylene wrap film of food packaging","volume":"85","author":"Liu","year":"2020","journal-title":"J. Food Sci."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Giuliani, A., Zuccarini, M., Cichelli, A., Khan, H., and Reale, M. (2020). Critical Review on the Presence of Phthalates in Food and Evidence of Their Biological Impact. Int. J. Environ. Res. Public Health, 17.","DOI":"10.3390\/ijerph17165655"},{"key":"ref_66","unstructured":"EFSA Panel on Contaminants in the Food Chain (EFSA CONTAM Panel) (2020). Risk to human health related to the presence of perfluoroalkyl substances in food. EFSA journal. Eur. Food Saf. Auth."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.envres.2018.04.004","article-title":"Dose-response relationships between urinary phthalate metabolites and serum thyroid hormones among waste plastic recycling workers in China","volume":"165","author":"Wang","year":"2018","journal-title":"Environ. Res."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1111\/j.1365-2605.2007.00837.x","article-title":"Phthalates: Metabolism and exposure","volume":"31","author":"Wittassek","year":"2008","journal-title":"Int. J. Androl."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"108780","DOI":"10.1016\/j.envres.2019.108780","article-title":"Association between the exposure to phthalates and adiposity: A meta-analysis in children and adults","volume":"179","author":"Ribeiro","year":"2019","journal-title":"Environ. Res."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1080\/15376516.2019.1646367","article-title":"Oxidative stress markers, trace elements, and endocrine disrupting chemicals in children with Hashimoto\u2019s thyroiditis","volume":"29","author":"Sur","year":"2019","journal-title":"Toxicol. Mech. Methods"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"067007","DOI":"10.1289\/EHP6740","article-title":"Urinary Concentrations of Phthalate Metabolite Mixtures in Relation to Serum Biomarkers of Thyroid Function and Autoimmunity among Women from a Fertility Center","volume":"128","author":"Souter","year":"2020","journal-title":"Environ. Health Perspect."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"30589","DOI":"10.1038\/srep30589","article-title":"Intake of Phthalate-tainted Foods and Serum Thyroid Hormones in Taiwanese Children and Adolescents","volume":"6","author":"Tsai","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.envres.2018.01.039","article-title":"A cross sectional study of urinary phthalates, phenols and perchlorate on thyroid hormones in US adults using structural equation models (NHANES 2007\u20132008)","volume":"163","author":"Przybyla","year":"2018","journal-title":"Environ. Res."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.envint.2017.05.007","article-title":"Phthalates and thyroid function in preschool age children: Sex specific associations","volume":"106","author":"Morgenstern","year":"2017","journal-title":"Environ. Int."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"121189","DOI":"10.1016\/j.jhazmat.2019.121189","article-title":"Urinary biomarkers of phthalates exposure and risks of thyroid cancer and benign nodule","volume":"383","author":"Liu","year":"2020","journal-title":"J. Hazard. Mater."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.envres.2016.11.014","article-title":"Does exposure to phthalates influence thyroid function and growth hormone homeostasis? The Taiwan Environmental Sur-vey for Toxicants (TEST) 2013","volume":"153","author":"Huang","year":"2017","journal-title":"Environ. Res."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1016\/j.scitotenv.2016.06.146","article-title":"Exposure to phthalates in children aged 5-7years: Associations with thyroid function and insulin-like growth factors","volume":"579","author":"Wu","year":"2017","journal-title":"Sci. Total Environ."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.fct.2018.12.010","article-title":"Di-2-ethylhexylphthalate promotes thyroid cell proliferation and DNA damage through activating thyrotropin-receptor-mediated pathways in vitro and in vivo","volume":"124","author":"Kim","year":"2019","journal-title":"Food Chem. Toxicol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/bs.amb.2018.09.007","article-title":"Brominated Flame Retardants, Microplastics, and Biocides in the Marine Environment: Recent Updates of Occurrence, Analysis, and Impacts","volume":"81","author":"Lin","year":"2018","journal-title":"Adv. Mar. Biol."},{"key":"ref_80","unstructured":"European Food Safety Authority (2020, June 15). Brominated Flame Retardants. Available online: https:\/\/www.efsa.europa.eu\/en\/topics\/topic\/brominated-flame-retardants."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.chemosphere.2015.12.034","article-title":"Brominated flame retardants (BFRs): A review on environmental contamination in China","volume":"150","author":"Yu","year":"2016","journal-title":"Chemosphere"},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"European Food Safety Authority (2012). Update of the monitoring of levels of dioxins and PCBs in food and feed. EFSA J., 10, 2832. Scientific Report of EFSA.","DOI":"10.2903\/j.efsa.2012.2832"},{"key":"ref_83","unstructured":"U.S. Departament of Health and Human Services (2020, June 20). Public Health Service Agency for Toxic Substances and Disease Registry. Toxicological Profile for Polychlorinated Biphenyls, Available online: https:\/\/www.atsdr.cdc.gov\/toxprofiles\/tp17.pdf."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/j.envpol.2017.06.088","article-title":"Polychlorinated biphenyls and its potential role in endometriosis","volume":"229","author":"Yao","year":"2017","journal-title":"Environ. Pollut."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"132","DOI":"10.3109\/19396360903381023","article-title":"Dioxin-like PCBs and endometriosis","volume":"56","author":"Osteen","year":"2010","journal-title":"Syst. Biol. Reprod. Med."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/j.chemosphere.2007.01.050","article-title":"Dioxins in human milk and smoking of mothers","volume":"119","author":"Uehara","year":"2007","journal-title":"Chemosphere"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1289\/ehp.1002211","article-title":"Intrinsic Human Elimination Half-Lives of Polychlorinated Biphenyls Derived from the Temporal Evolution of Cross-Sectional Biomonitoring Data from the United Kingdom","volume":"119","author":"Ritter","year":"2011","journal-title":"Environ. Health Perspect."},{"key":"ref_88","first-page":"7","article-title":"Polichlorinated biphenyls (PCBs) in Poland: Occurrence, determination and degradation","volume":"19","author":"Grabowska","year":"2010","journal-title":"Pol. J. Environ. Stud."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.chemosphere.2007.09.044","article-title":"Organochlorines and endometriosis: A mini-review","volume":"71","author":"Heilier","year":"2008","journal-title":"Chemosphere"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"245","DOI":"10.3109\/10408444.2014.999365","article-title":"Metabolism and metabolites of polychlorinated biphenyls","volume":"45","author":"Grimm","year":"2015","journal-title":"Crit. Rev. Toxicol."},{"key":"ref_91","unstructured":"(2020, July 13). Rozporz\u0105dzenie Komisjii (UE) Nr 1259\/2011 z Dnia 2 Grudnia 2011 r. Available online: https:\/\/eur-lex.europa.eu\/LexUriServ\/LexUriServ.do?uri=OJ:L:2011:320:0018:0023:PL:PDF."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"2042","DOI":"10.1007\/s11356-015-4150-2","article-title":"Chiral polychlorinated biphenyls: Absorption, metabolism and excretion-a review","volume":"23","author":"Lehmler","year":"2016","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"ref_93","unstructured":"European Food Safety Authority (2018). Risk for animal and human health related to the presence of dioxins and dioxin-like PCBs in feed and food. EFSA J., 16, e05333."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"135","DOI":"10.2478\/aiht-2018-69-3120","article-title":"Levels of polychlorinated biphenyls in human milk samples in European countries","volume":"69","year":"2018","journal-title":"Arh. Hig. Rada Toksikol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"30988","DOI":"10.1007\/s11356-019-06201-y","article-title":"QuEChERS extraction coupled to GC-MS for a fast determination of polychlorinated biphenyls in breast milk from Polish women","volume":"26","author":"Kowalkowski","year":"2019","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"ref_96","unstructured":"United States Environmental Protection Agency (2021, February 26). Learn about Polychlorinated Biphenyls (PCBs) Retardants, Available online: https:\/\/www.epa.gov\/pcbs\/learn-about-polychlorinated-biphenyls-pcbs."},{"key":"ref_97","unstructured":"(2021, February 26). Ustawa z dnia 13 Czerwca 2008 r. o Ratyfikacji Konwencji Sztokholmskiej w Sprawie Trwa\u0142ych Zanieczyszcze\u0144 Organicznych, Sporz\u0105dzonej w Sztokholmie Dnia 22 maja 2001 r, Available online: http:\/\/isap.sejm.gov.pl\/isap.nsf\/DocDetails.xsp?id=WDU20081380864."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"174","DOI":"10.3389\/fnins.2016.00174","article-title":"Chemicals, Nutrition, and Autism Spectrum Dis-order: A Mini-Review","volume":"10","author":"Fujiwara","year":"2016","journal-title":"Front. Neurosci."},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Chen, X., Lin, Y., Dang, K., and Puschner, B. (2017). Quantification of Polychlorinated Biphenyls and Polybrominated Diphenyl Ethers in Commercial Cows\u2019 Milk from California by Gas Chromatography-Triple Quadruple Mass Spectrometry. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0170129"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/j.jfda.2016.02.006","article-title":"Temporal trend of polychlorinated dibenzo-p-dioxin\/polychlorinated dibenzofuran and dioxin like-polychlorinated biphenyl concentrations in food from Taiwan markets during 2004\u20132012","volume":"24","author":"Lee","year":"2016","journal-title":"J. Food Drug Anal."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.scitotenv.2018.03.283","article-title":"Differential contribution of animal and vegetable food items on persistent organic pollutant serum concentrations in Spanish adults. Data from BIOAMBIENT.ES project","volume":"634","author":"Arrebola","year":"2018","journal-title":"Sci. Total Environ."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.ecoenv.2019.01.052","article-title":"PCDDs, PCDFs and PCBs in locally produced foods as health risk factors in Silesia Province, Poland","volume":"172","author":"Rusin","year":"2019","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.envres.2016.03.022","article-title":"Exposure to polychlorinated biphenyls and the thyroid gland\u2014examining and discussing possible longitudinal health effects in humans","volume":"148","author":"Gaum","year":"2016","journal-title":"Environ. Res."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12940-019-0509-z","article-title":"Thyroid hormone levels associate with exposure to polychlorinated biphenyls and polybrominated biphenyls in adults exposed as children","volume":"18","author":"Curtis","year":"2019","journal-title":"Environ. Health."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.envres.2018.04.012","article-title":"A nested case-control study of polychlorinated biphenyls, organochlorine pesticides, and thyroid cancer in the Janus Serum Bank cohort","volume":"165","author":"Lerro","year":"2018","journal-title":"Environ. Res."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.chemosphere.2017.12.050","article-title":"Polychlorinated biphenyls, indicators of thyroid function and thyroid autoantibodies in the Anniston Community Health Survey I (ACHS-I)","volume":"159","author":"Benson","year":"2018","journal-title":"Chemosphere"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"e01870","DOI":"10.1016\/j.heliyon.2019.e01870","article-title":"Polychlorinated biphenyl serum levels, thyroid hormones and endocrine and metabolic diseases in people living in a highly polluted area in North Italy: A population-based study","volume":"5","author":"Zani","year":"2019","journal-title":"Heliyon"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.envres.2018.08.027","article-title":"Association of maternal serum concentration of hydroxylated polychlorinated biphenyls with maternal and neonatal thyroid hormones: The Hokkaido birth cohort study","volume":"167","author":"Itoh","year":"2018","journal-title":"Environ. Res."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1289\/ehp.0800219","article-title":"Thyroid hormone levels of pregnant inuit women and their infants exposed to environmental contaminants","volume":"117","author":"Dallai","year":"2009","journal-title":"Environ. Health Perspect."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.ijheh.2013.10.004","article-title":"Associations between levels of hydroxylated PCBs and PCBs in serum of pregnant women and blood thyroid hormone levels and body size of neonates","volume":"217","author":"Hisada","year":"2014","journal-title":"Int. J. Hyg. Environ. Health"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1055\/s-0032-1311569","article-title":"PCB153 disrupts thyroid hormone homeostasis by affecting its biosynthesis, biotransformation, feedback regulation, and metabolism","volume":"44","author":"Liu","year":"2012","journal-title":"Horm Metab Res."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1016\/j.scitotenv.2016.09.098","article-title":"Polychlorinated biphenyl exposure and deiodinase activity in young infants","volume":"574","author":"Soechitram","year":"2017","journal-title":"Sci. Total Environ."},{"key":"ref_113","doi-asserted-by":"crossref","unstructured":"Dirinck, E., Dirtu, A.C., Malarvannan, G., Covaci, A., Jorens, P.G., and Van Gaal, L.F. (2016). A Preliminary Link between Hydroxylated Metabolites of Polychlorinated Biphenyls and Free Thyroxin in Humans. Int. J. Environ. Res. Public Health, 13.","DOI":"10.3390\/ijerph13040421"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"191","DOI":"10.4149\/endo_2012_04_191","article-title":"Thyroid volume, iodine intake, autoimmune thyroid disorders, inborn factors, and endocrine disruptors: Twenty-year studies of multiple effects puzzle in Slovakia","volume":"46","author":"Langer","year":"2012","journal-title":"Endocr. Regul."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0048-9697(01)00852-X","article-title":"Polybrominated diphenyl ether (PBDE) flame retardants","volume":"275","author":"Rahman","year":"2001","journal-title":"Sci. Total Environ."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.envres.2008.08.008","article-title":"Overview of toxicological aspects of polybrominated diphenyl ethers: A flame-retardant additive in several consumer products","volume":"108","author":"Talsness","year":"2008","journal-title":"Environ. Res."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S1001-0742(11)60758-4","article-title":"A review of polybrominated diphenyl ethers and alternative brominated flame retardants in wildlife from China: Levels, trends, and bioaccumulation characteristics","volume":"24","author":"Wu","year":"2012","journal-title":"J. Environ. Sci. (China)"},{"key":"ref_118","unstructured":"(2021, January 26). Rozporz\u0105dzenie Komisji (UE) nr 757\/2010 z Dnia 24 Sierpnia 2010 r. Zmieniaj\u0105ce Rozporz\u0105dzenie (WE) nr 850\/2004,\u201d Parlamentu Europejskiego i Rady Dotycz\u0105ce Trwa\u0142ych. Available online: https:\/\/eur-lex.europa.eu\/legal-content\/PL\/TXT\/PDF\/?uri=CELEX:32010R0757&from=EN."},{"key":"ref_119","unstructured":"United States Environmental Protection Agency (2020, July 13). Polybrominated Diphenyl Ethers (PBDEs), Available online: https:\/\/www.epa.gov\/assessing-and-managing-chemicals-under-tsca\/polybrominated-diphenyl-ethers-pbdes."},{"key":"ref_120","doi-asserted-by":"crossref","unstructured":"Gorini, F., Iervasi, G., Coi, A., Pitto, L., and Bianchi, F. (2018). The Role of Polybrominated Diphenyl Ethers in Thyroid Carcinogenesis: Is It a Weak Hypothesis or a Hidden Reality? From Facts to New Perspectives. Int. J. Environ. Res. Public Health, 15.","DOI":"10.3390\/ijerph15091834"},{"key":"ref_121","doi-asserted-by":"crossref","unstructured":"Gibson, E.A., Siegel, E.L., Eniola, F., Herbstman, J.B., and Factor-Litvak, P. (2018). Effects of Polybrominated Diphenyl Ethers on Child Cognitive, Behavioral, and Motor Development. Int. J. Environ. Res. Public Health, 15.","DOI":"10.3390\/ijerph15081636"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.chemosphere.2016.12.035","article-title":"Alteration of thyroid hormone concentrations in juvenile Chinook salmon (Oncorhynchus tshawytscha) exposed to polybrominated diphenyl ethers, BDE-47 and BDE-99","volume":"171","author":"Arkoosh","year":"2017","journal-title":"Chemosphere"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.envint.2015.12.002","article-title":"Concentrations of polybrominated diphenyl ethers (PBDEs) and 2,4,6-tribromophenol in human placental tissues","volume":"88","author":"Leonetti","year":"2016","journal-title":"Environ. Int."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.chemosphere.2018.01.161","article-title":"Legacy and emerging brominated flame retardants in China: A review on food and human milk contamination, human dietary exposure and risk assessment","volume":"198","author":"Shi","year":"2018","journal-title":"Chemosphere"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.chemosphere.2017.11.179","article-title":"Occurrence of selected halogenated flame retardants in Belgian foodstuff","volume":"194","author":"Poma","year":"2018","journal-title":"Chemosphere"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.envint.2018.12.008","article-title":"Concentration, uptake and human dietary intake of novel brominated flame retardants in greenhouse and conventional vegetables","volume":"123","author":"Sun","year":"2019","journal-title":"Environ. Int."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/S0045-6535(01)00233-8","article-title":"Comparison of polybrominated diphenyl ethers in fish, vegetables, and meats and levels in human milk of nursing women in Japan","volume":"46","author":"Ohta","year":"2002","journal-title":"Chemosphere"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"126816","DOI":"10.1016\/j.chemosphere.2020.126816","article-title":"Novel brominated flame retardants\u2014A review of their occurrence in indoor air, dust, consumer goods and food","volume":"255","author":"Zuiderveen","year":"2020","journal-title":"Chemosphere"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.etap.2016.10.004","article-title":"Life-cycle exposure to BDE-47 results in thyroid endocrine disruption to adults and offsprings of zebrafish (Danio rerio)","volume":"48","author":"Zhao","year":"2016","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"ref_130","doi-asserted-by":"crossref","unstructured":"Hansen, J.F., Brorson, M.M., Boas, M., Frederiksen, H., Nielsen, C.H., Lindstr\u00f6m, E.S., Hofman-Bang, J., Hartoft-Nielsen, M.L., Frisch, T., and Main, K.M. (2016). Phthalates Are Metabolised by Primary Thyroid Cell Cultures but Have Limited Influence on Selected Thyroid Cell Functions In Vitro. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0151192"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1016\/j.chemosphere.2018.07.155","article-title":"Changes in thyroid axis responses in two ring-billed gull sub-populations differentially exposed to halogenated flame retardants","volume":"211","author":"Houde","year":"2018","journal-title":"Chemosphere"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1289\/ehp.1509755","article-title":"Polybrominated Diphenyl Ether Exposure and Thyroid Function Tests in North American Adults","volume":"124","author":"Makey","year":"2016","journal-title":"Environ. Health Perspect."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.envpol.2017.05.065","article-title":"Polybrominated diphenyl ethers (PBDEs) and thyroid hormones in cord blood","volume":"229","author":"Ding","year":"2017","journal-title":"Environ. Pollut."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1039\/C9EM00095J","article-title":"Binding and activity of polybrominated diphenyl ether sulfates to thyroid hormone transport proteins and nuclear receptors","volume":"21","author":"Qin","year":"2019","journal-title":"Environ. Sci. Process. Impacts"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.envres.2017.07.042","article-title":"Association of polybrominated diphenylethers (PBDEs) and hydroxylated metabolites (OH-PBDEs) serum levels with thyroid function in thyroid cancer patients","volume":"159","author":"Liu","year":"2017","journal-title":"Environ. Res."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"2198","DOI":"10.1038\/s41598-018-20443-9","article-title":"Associations between serum polybrominated diphenyl ethers and thyroid hormones in a cross sectional study of a remote Alaska Native population","volume":"8","author":"Byrne","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"112925","DOI":"10.1016\/j.envpol.2019.07.093","article-title":"Disruption of thyroid hormone regulated proteins and gene expression by polychlorinated biphenyls, polybrominated diphenyl ethers and new flame retardants in residents of an e-waste region","volume":"254","author":"Guo","year":"2019","journal-title":"Environ. Pollut."},{"key":"ref_138","first-page":"2215","article-title":"Relationships between polybrominated diphenyl ethers and transcription and activity of type 1 deiodinase in a gull highly exposed to flame retardants","volume":"35","author":"Houde","year":"2006","journal-title":"Environ Toxicol. Chem."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3322\/caac.21551","article-title":"Cancer statistics, 2019","volume":"69","author":"Siegel","year":"2019","journal-title":"CA Cancer J. Clin."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1158\/1055-9965.EPI-19-0526","article-title":"Exposure to Polybrominated Diphenyl Ethers and a Polybrominated Biphenyl and Risk of Thyroid Cancer in Women: Single and Multi-Pollutant Approaches","volume":"28","author":"Deziel","year":"2019","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.envint.2017.06.021","article-title":"Exposure to flame retardant chemicals and occurrence and severity of papillary thyroid cancer: A case-control study","volume":"107","author":"Hoffman","year":"2017","journal-title":"Environ. Int."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1093\/aje\/kwz229","article-title":"Polybrominated Diphenyl Ethers, Polybrominated Biphenyls, and Risk of Papillary Thyroid Cancer: A Nested Case-Control Study","volume":"189","author":"Huang","year":"2020","journal-title":"Am. J. Epidemiol."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1210\/jc.2015-2659","article-title":"Exposure to Polybrominated Diphenyl Ethers (PBDEs) and Hypothyroidism in Canadian Women","volume":"101","author":"Oulhote","year":"2016","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_144","doi-asserted-by":"crossref","unstructured":"Kronborg, T.M., Hansen, J.F., Rasmussen, \u00c5.K., Vorkamp, K., Nielsen, C.H., Frederiksen, M., Hofman-Bang, J., Hahn, C.H., Ramh\u00f8j, L., and Feldt-Rasmussen, U. (2017). The flame retardant DE-71 (a mixture of polybrominated diphenyl ethers) inhibits human differentiated thyroid cell function in vitro. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0179858"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.envint.2018.04.012","article-title":"Exposure to polybrominated diphenyl ethers and phthalates in healthy men living in the greater Montreal area: A study of hormonal balance and semen quality","volume":"116","author":"Albert","year":"2018","journal-title":"Environ. Int."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"37866","DOI":"10.1007\/s11356-020-09913-8","article-title":"Structural studies on the endocrine-disrupting role of polybrominated diphenyl ethers (PBDEs) in thyroid diseases","volume":"27","author":"Sheikh","year":"2020","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12940-016-0141-0","article-title":"PBDE flame retardants, thyroid disease, and menopausal status in U.S. women","volume":"15","author":"Allen","year":"2016","journal-title":"Environ. Health."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.ecoenv.2019.02.080","article-title":"A comparison of the thyroid disruption induced by decabrominated diphenyl ethers (BDE-209) and decabromodiphenyl ethane (DBDPE) in rats","volume":"174","author":"Wang","year":"2019","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/tox.20767","article-title":"Effects of decabromodiphenyl ether (BDE-209) on mRNA transcription of thyroid hormone pathway and spermatogenesis associated genes in Chinese rare minnow (Gobiocypris rarus)","volume":"29","author":"Li","year":"2014","journal-title":"Environ. Toxicol."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1289\/ehp.1408996","article-title":"Maternal Polybrominated Diphenyl Ether (PBDE) Exposure and Thyroid Hormones in Maternal and Cord Sera: The HOME Study, Cincinnati, USA","volume":"123","author":"Vuong","year":"2015","journal-title":"Environ. Health Perspect."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"105010","DOI":"10.1016\/j.envint.2019.105010","article-title":"Associations of prenatal exposures to low levels of Polybrominated Diphenyl Ether (PBDE) with thyroid hormones in cord plasma and neurobehavioral development in children at 2 and 4 years","volume":"131","author":"Ji","year":"2019","journal-title":"Environ. Int."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1089\/thy.2018.0417","article-title":"Pre- and Postnatal Polybrominated Diphenyl Ether Concentrations in Relation to Thyroid Parameters Measured During Early Childhood","volume":"29","author":"Cowell","year":"2019","journal-title":"Thyroid"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.envint.2015.09.015","article-title":"Associations of birth outcomes with maternal polybrominated diphenyl ethers and thyroid hormones during pregnancy","volume":"85","author":"Miranda","year":"2015","journal-title":"Environ. Int."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.envres.2016.05.022","article-title":"Serum polybrominated diphenyl ether concentrations and thyroid function in young children","volume":"149","author":"Jacobson","year":"2016","journal-title":"Environ. Res."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.taap.2019.04.008","article-title":"Parental exposure to 2,2\u2019,4,4\u20195\u2014pentain polybrominated diphenyl ethers (BDE-99) causes thyroid disruption and developmental toxicity in zebrafish","volume":"372","author":"Wu","year":"2019","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"2084","DOI":"10.1002\/etc.3366","article-title":"Sex-specific changes in thyroid gland function and circulating thyroid hormones in nestling American kestrels (Falco sparverius) following embryonic exposure to polybrominated diphenyl ethers by maternal transfer","volume":"35","author":"Fernie","year":"2016","journal-title":"Environ. Toxicol. Chem."},{"key":"ref_157","unstructured":"(2016). IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, No. 107. Polychlorinated Biphenyls and Polybrominated Biphenyls, No. 107, International Agency for Research on Cancer."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.chemosphere.2018.08.063","article-title":"Experimental and theoretical investigations on debromination pathways of polybrominated biphenyls (PBBs) under ultraviolet light","volume":"212","author":"Wang","year":"2018","journal-title":"Chemosphere"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"097020","DOI":"10.1289\/EHP1302","article-title":"Serum Polybrominated Biphenyls (PBBs) and Polychlorinated Biphenyls (PCBs) and Thyroid Function among Michigan Adults Several Decades after the 1973-1974 PBB Contamination of Livestock Feed","volume":"125","author":"Jacobson","year":"2017","journal-title":"Environ. Health Perspect."},{"key":"ref_160","unstructured":"Agency for Toxic Substances and Disease Registry (2021, February 26). Polybrominated Biphenyls ToxFAQs, Available online: https:\/\/www.atsdr.cdc.gov\/toxfaqs\/tfacts68.pdf."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"126109","DOI":"10.1016\/j.chemosphere.2020.126109","article-title":"Dioxin-like polybrominated biphenyls (PBBs) and ortho-substituted PBBs in edible cod (Gadus morhua) liver oils and canned cod livers","volume":"248","author":"Falandysz","year":"2020","journal-title":"Chemosphere"},{"key":"ref_162","unstructured":"Michigan Department of Community Health (1995). PBBs (Polybrominated Biphenyls) in Michigan."},{"key":"ref_163","unstructured":"(2020, August 10). Dyrektywa Parlamentu Europejskiego i Rady 2011\/65\/UE z Dnia 8 czerwca 2011 r w Sprawie Ograniczenia Stosowania Niekt\u00f3rych Niebezpiecznych Substancji w sprz\u0119cie. Available online: https:\/\/eur-lex.europa.eu\/legal-content\/PL\/TXT\/PDF\/?uri=CELEX:32011L0065&from=EN.2011."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"105526","DOI":"10.1016\/j.envint.2020.105526","article-title":"Serum concentrations of polybrominated biphenyls (PBBs), polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs) in the Michigan PBB Registry 40 years after the PBB contamination incident","volume":"137","author":"Chang","year":"2020","journal-title":"Environ. Int."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1016\/j.chemosphere.2009.12.031","article-title":"PBB levels in fish from the Baltic and North seas and in selected food products from Poland","volume":"78","author":"Grochowalski","year":"2010","journal-title":"Chemosphere"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1002\/mnfr.200700135","article-title":"Brominated and chlorinated dioxins, PCBs and brominated flame retardants in Scottish shellfish: Methodology, occurrence and human dietary exposure","volume":"52","author":"Fernandes","year":"2008","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1289\/ehp.782337","article-title":"Effects of processing and cooking on PBB residues","volume":"23","author":"Zabik","year":"1978","journal-title":"Environ. Health Perspect."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.bihy.2008.06.003","article-title":"Do Polybrominated Diphenyl Ethers (PBDEs) Increase the Risk of Thyroid Cancer?","volume":"1","author":"Zhang","year":"2008","journal-title":"Biosci. Hypotheses"},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.chemosphere.2018.03.120","article-title":"Association between serum polybrominated diphenyl ethers, new flame retardants and thyroid hormone levels for school students near a petrochemical complex, South China","volume":"202","author":"Guo","year":"2018","journal-title":"Chemosphere"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/j.chemosphere.2011.06.020","article-title":"Incidence of thyroid disease following exposure to polybrominated biphenyls and polychlorinated biphenyls, Michigan, 1974\u20132006","volume":"84","author":"Yard","year":"2011","journal-title":"Chemosphere"}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/13\/3\/867\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T05:34:02Z","timestamp":1760160842000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/13\/3\/867"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,6]]},"references-count":170,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2021,3]]}},"alternative-id":["nu13030867"],"URL":"https:\/\/doi.org\/10.3390\/nu13030867","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,6]]}}}