{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:37:46Z","timestamp":1791218266489,"version":"4.1.0"},"reference-count":59,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2021,3,7]],"date-time":"2021-03-07T00:00:00Z","timestamp":1615075200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100015082","name":"Universidad Cat\u00f3lica de Valencia San Vicente M\u00e0rtir","doi-asserted-by":"publisher","award":["2021-275-001"],"award-info":[{"award-number":["2021-275-001"]}],"id":[{"id":"10.13039\/501100015082","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Iodine is an essential micronutrient for the synthesis of thyroid hormones. The proper functioning of the thyroid axis is essential for the normal development of the nervous system, especially in the first trimester of gestation. The aim of the present study was to analyze the perinatal outcomes, anthropometry, and APGAR test scores of newborns and to relate them to maternal thyroid status. A total of 190 newborns participated in the study. No correlation was found between thyroid stimulating hormone (TSH) and maternal ioduria values in the first trimester of gestation with the weight or length of the newborn, or the APGAR score at one minute after birth. However, we found significant differences between the APGAR scores of children whose mothers had an iodine sufficiency level in the first trimester compared to the children of mothers with iodine deficiency. Similarly, the APGAR scores of children whose mothers had a TSH &gt; 4 have significantly better APGAR scores than the children of mothers with a TSH &lt; 4. Likewise, we found significant differences between the measurements of the newborns depending on whether their mothers smoked. The children of mothers who took iodine supplements or iodized salt obtained the highest APGAR score at one and five minutes after birth. It is essential to focus on recommending adequate consumption of iodine supplements and iodized salt prior to gestation and at least during the first trimester to achieve better fetal well-being.<\/jats:p>","DOI":"10.3390\/nu13030872","type":"journal-article","created":{"date-parts":[[2021,3,7]],"date-time":"2021-03-07T21:52:15Z","timestamp":1615153935000},"page":"872","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Relationship between Thyroid Status during the First Trimester of Pregnancy and Neonatal Well-Being"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9905-0443","authenticated-orcid":false,"given":"Maria Teresa","family":"Murillo-Llorente","sequence":"first","affiliation":[{"name":"SONEV Research Group, School of Medicine and Health Sciences, Catholic University of Valencia San Vicente M\u00e1rtir, C\/Quevedo n\u00b0 2, 46001 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Llorca-Colomer","sequence":"additional","affiliation":[{"name":"School of Medicine and Health Sciences, Catholic University of Valencia San Vicente M\u00e1rtir, C\/Quevedo n\u00b0 2, 46001 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5027-4785","authenticated-orcid":false,"given":"Marcelino","family":"P\u00e9rez-Bermejo","sequence":"additional","affiliation":[{"name":"SONEV Research Group, School of Medicine and Health Sciences, Catholic University of Valencia San Vicente M\u00e1rtir, C\/Quevedo n\u00b0 2, 46001 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,3,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/S2213-8587(13)70109-8","article-title":"Hypothyroidism in pregnancy","volume":"3","author":"Teng","year":"2013","journal-title":"Lancet Diabetes Endocrinol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1159\/000492129","article-title":"Effect of Thyroid Hormones on Neurons and Neurodevelopment","volume":"2","author":"Prezioso","year":"2018","journal-title":"Horm. 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