{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T11:13:13Z","timestamp":1789902793114,"version":"4.0.1"},"reference-count":47,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2021,3,21]],"date-time":"2021-03-21T00:00:00Z","timestamp":1616284800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No. 31970746, 31771514"],"award-info":[{"award-number":["No. 31970746, 31771514"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Qing Lan Project in Jiangsu Province, Ningxia Hui Autonomous Region's key research and de-velopment plan","award":["2020BBF02023"],"award-info":[{"award-number":["2020BBF02023"]}]},{"name":"Ningxia Hui Autonomous Region's Flexible introduction project","award":["No. 021704000099"],"award-info":[{"award-number":["No. 021704000099"]}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["No. 2018M640455"],"award-info":[{"award-number":["No. 2018M640455"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National first-class discipline program of Light Industry Technology and Engineering","award":["No. LITE2018-11"],"award-info":[{"award-number":["No. LITE2018-11"]}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["No. JUSRP22029, JUSRP21824, JUSRP22047"],"award-info":[{"award-number":["No. JUSRP22029, JUSRP21824, JUSRP22047"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Hericium erinaceus (H. erinaceus) is widely studied as a medicinal and edible fungus. Recent studies have shown that H. erinaceus has protective effects for diseases, such as inflammatory bowel disease and cancer, which are related to gut microbiota. To investigate the benefits of H. erinaceus intake on gut microbiota and blood indices in adulthood, we recruited 13 healthy adults to consume H. erinaceus powder as a dietary supplement. Blood changes due to H. erinaceus consumption were determined by routine hematological examination and characterized by serum biochemical markers. Microbiota composition was profiled by 16S ribosomal RNA gene sequencing. Results showed that daily H. erinaceus supplementation increased the alpha diversity within the gut microbiota community, upregulated the relative abundance of some short-chain fatty acid (SCFA) producing bacteria (Kineothrix alysoides, Gemmiger formicilis, Fusicatenibacter saccharivorans, Eubacterium rectale, Faecalibacterium prausnitzii), and downregulated some pathobionts (Streptococcus thermophilus, Bacteroides caccae, Romboutsia timonensis). Changes within the gut microbiota were correlated with blood chemical indices including alkaline phosphatase (ALP), low-density lipoprotein (LDL), uric acid (UA), and creatinine (CREA). Thus, we found that the gut microbiota alterations may be part of physiological adaptations to a seven-day H. erinaceus supplementation, potentially influencing beneficial health effects.<\/jats:p>","DOI":"10.3390\/nu13031008","type":"journal-article","created":{"date-parts":[[2021,3,21]],"date-time":"2021-03-21T23:47:41Z","timestamp":1616370461000},"page":"1008","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Influence of Short-Term Consumption of Hericium erinaceus on Serum Biochemical Markers and the Changes of the Gut Microbiota: A Pilot Study"],"prefix":"10.3390","volume":"13","author":[{"given":"Xiao-Qian","family":"Xie","sequence":"first","affiliation":[{"name":"School of Pharmaceutical Sciences, Jiangnan University, Wuxi 214122, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8861-7686","authenticated-orcid":false,"given":"Yan","family":"Geng","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Jiangnan University, Wuxi 214122, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8441-9604","authenticated-orcid":false,"given":"Qijie","family":"Guan","sequence":"additional","affiliation":[{"name":"National Engineering Laboratory for Cereal Fermentation Technology, Jiangnan University, Wuxi 214122, China"},{"name":"Jiangsu Engineering Research Center for Bioactive Products Processing Technology, Jiangnan University, Wuxi 214122, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yilin","family":"Ren","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Jiangnan University, Wuxi 214122, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0242-2448","authenticated-orcid":false,"given":"Lin","family":"Guo","sequence":"additional","affiliation":[{"name":"National Engineering Laboratory for Cereal Fermentation Technology, Jiangnan University, Wuxi 214122, China"},{"name":"Jiangsu Engineering Research Center for Bioactive Products Processing Technology, Jiangnan University, Wuxi 214122, China"},{"name":"Key Laboratory of Industrial Biotechnology of Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiqi","family":"Lv","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Jiangnan University, Wuxi 214122, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen-Ming","family":"Lu","sequence":"additional","affiliation":[{"name":"National Engineering Laboratory for Cereal Fermentation Technology, Jiangnan University, Wuxi 214122, China"},{"name":"Jiangsu Engineering Research Center for Bioactive Products Processing Technology, Jiangnan University, Wuxi 214122, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Song","family":"Shi","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Jiangnan University, Wuxi 214122, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng-Hong","family":"Xu","sequence":"additional","affiliation":[{"name":"National Engineering Laboratory for Cereal Fermentation Technology, Jiangnan University, Wuxi 214122, China"},{"name":"Jiangsu Engineering Research Center for Bioactive Products Processing Technology, Jiangnan University, Wuxi 214122, China"},{"name":"Key Laboratory of Industrial Biotechnology of Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,3,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.aninu.2019.09.001","article-title":"Major cereal carbohydrates in relation to intestinal health of monogastric animals: A review","volume":"5","author":"Adebowale","year":"2019","journal-title":"Anim. 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